Search Results - "Harikumar, G" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

Structures of the human cholecystokinin 1 (CCK1) receptor bound to Gs and Gq mimetic proteins provide insight into mechanisms of G protein selectivity

Structures of the human cholecystokinin 1 (CCK1) receptor bound to Gs and Gq mimetic proteins provide insight into mechanisms of G protein selectivity

by Mobbs, Jesse I., Belousoff, Matthew J., Harikumar, Kaleeckal G., Piper, Sarah J., Xu, Xiaomeng, Furness, Sebastian G. B., Venugopal, Hari, Christopoulos, Arthur, Danev, Radostin, Wootten, Denise, Thal, David M., Miller, Laurence J., Sexton, Patrick M.
Published in PLoS biology (01.06.2021)

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Impact of secretin receptor homo-dimerization on natural ligand binding

Impact of secretin receptor homo-dimerization on natural ligand binding

by Harikumar, Kaleeckal G, Piper, Sarah J, Christopoulos, Arthur, Wootten, Denise, Sexton, Patrick M, Miller, Laurence J
Published in Nature communications (23.05.2024)

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Crystal structure of the Frizzled 4 receptor in a ligand-free state

Crystal structure of the Frizzled 4 receptor in a ligand-free state

by Yang, Shifan, Wu, Yiran, Xu, Ting-Hai, de Waal, Parker W, He, Yuanzheng, Pu, Mengchen, Chen, Yuxiang, DeBruine, Zachary J, Zhang, Bingjie, Zaidi, Saheem A, Popov, Petr, Guo, Yu, Han, Gye Won, Lu, Yang, Suino-Powell, Kelly, Dong, Shaowei, Harikumar, Kaleeckal G, Miller, Laurence J, Katritch, Vsevolod, Xu, H Eric, Shui, Wenqing, Stevens, Raymond C, Melcher, Karsten, Zhao, Suwen, Xu, Fei
Published in Nature (London) (01.08.2018)

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Wnt5a promotes Frizzled-4 signalosome assembly by stabilizing cysteine-rich domain dimerization

Wnt5a promotes Frizzled-4 signalosome assembly by stabilizing cysteine-rich domain dimerization

by DeBruine, Zachary J, Ke, Jiyuan, Harikumar, Kaleeckal G, Gu, Xin, Borowsky, Peter, Williams, Bart O, Xu, Wenqing, Miller, Laurence J, Xu, H Eric, Melcher, Karsten
Published in Genes & development (01.05.2017)

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Structure and dynamics of the active Gs-coupled human secretin receptor

Structure and dynamics of the active Gs-coupled human secretin receptor

by Dong, Maoqing, Deganutti, Giuseppe, Piper, Sarah J., Liang, Yi-Lynn, Khoshouei, Maryam, Belousoff, Matthew J., Harikumar, Kaleeckal G., Reynolds, Christopher A., Glukhova, Alisa, Furness, Sebastian G. B., Christopoulos, Arthur, Danev, Radostin, Wootten, Denise, Sexton, Patrick M., Miller, Laurence J.
Published in Nature communications (18.08.2020)

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Environment-Sensitive Fluorescence of 7-Nitrobenz-2-oxa-1,3-diazol-4-yl (NBD)-Labeled Ligands for Serotonin Receptors

Environment-Sensitive Fluorescence of 7-Nitrobenz-2-oxa-1,3-diazol-4-yl (NBD)-Labeled Ligands for Serotonin Receptors

by Sarkar, Parijat, Harikumar, Kaleeckal G., Rawat, Satinder S., Das, Sanjib, Chakraborty, Tushar K., Chattopadhyay, Amitabha
Published in Molecules (Basel, Switzerland) (24.06.2021)

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Spatial intensity distribution analysis quantifies the extent and regulation of homodimerization of the secretin receptor

Spatial intensity distribution analysis quantifies the extent and regulation of homodimerization of the secretin receptor

by Ward, Richard J, Pediani, John D, Harikumar, Kaleeckal G, Miller, Laurence J, Milligan, Graeme
Published in Biochemical journal (24.05.2017)

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Cholesterol-dependent dynamic changes in the conformation of the type 1 cholecystokinin receptor affect ligand binding and G protein coupling

Cholesterol-dependent dynamic changes in the conformation of the type 1 cholecystokinin receptor affect ligand binding and G protein coupling

by Harikumar, Kaleeckal G., Zhao, Peishen, Cary, Brian P., Xu, Xiaomeng, Desai, Aditya J., Dong, Maoqing, Mobbs, Jesse I., Toufaily, Chirine, Furness, Sebastian G. B., Christopoulos, Arthur, Belousoff, Matthew J., Wootten, Denise, Sexton, Patrick M., Miller, Laurence J.
Published in PLoS biology (31.07.2024)

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Structure and function of Norrin in assembly and activation of a Frizzled 4-Lrp5/6 complex

Structure and function of Norrin in assembly and activation of a Frizzled 4-Lrp5/6 complex

by Ke, Jiyuan, Harikumar, Kaleeckal G, Erice, Clara, Chen, Chen, Gu, Xin, Wang, Liren, Parker, Naomi, Cheng, Zhihong, Xu, Wenqing, Williams, Bart O, Melcher, Karsten, Miller, Laurence J, Xu, H Eric
Published in Genes & development (01.11.2013)

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Roles of Cholecystokinin in the Nutritional Continuum. Physiology and Potential Therapeutics

Roles of Cholecystokinin in the Nutritional Continuum. Physiology and Potential Therapeutics

by Miller, Laurence J, Harikumar, Kaleeckal G, Wootten, Denise, Sexton, Patrick M
Published in Frontiers in endocrinology (Lausanne) (02.06.2021)

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Mechanism of Action and Structure-Activity Relationships of Tetracyclic Small Molecules Acting as Universal Positive Allosteric Modulators of the Cholecystokinin Receptor

Mechanism of Action and Structure-Activity Relationships of Tetracyclic Small Molecules Acting as Universal Positive Allosteric Modulators of the Cholecystokinin Receptor

by Dengler, Daniela G, Harikumar, Kaleeckal G, Yen, Alice, Sergienko, Eduard A, Miller, Laurence J
Published in Membranes (Basel) (24.01.2023)

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Transmembrane Segment IV Contributes a Functionally Important Interface for Oligomerization of the Class II G Protein-coupled Secretin Receptor

Transmembrane Segment IV Contributes a Functionally Important Interface for Oligomerization of the Class II G Protein-coupled Secretin Receptor

by Harikumar, Kaleeckal G., Pinon, Delia I., Miller, Laurence J.
Published in The Journal of biological chemistry (19.10.2007)

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Differential sensitivity of types 1 and 2 cholecystokinin receptors to membrane cholesterol

Differential sensitivity of types 1 and 2 cholecystokinin receptors to membrane cholesterol

by Potter, Ross M., Harikumar, Kaleeckal G., Wu, S.Vincent, Miller, Laurence J.
Published in Journal of lipid research (01.01.2012)

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Glucagon-like peptide-1 receptor dimerization differentially regulates agonist signaling but does not affect small molecule allostery

Glucagon-like peptide-1 receptor dimerization differentially regulates agonist signaling but does not affect small molecule allostery

by Harikumar, Kaleeckal G, Wootten, Denise, Pinon, Delia I, Koole, Cassandra, Ball, Alicja M, Furness, Sebastian G. B, Graham, Bim, Dong, Maoqing, Christopoulos, Arthur, Miller, Laurence J, Sexton, Patrick M
Published in Proceedings of the National Academy of Sciences - PNAS (06.11.2012)

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Screening for positive allosteric modulators of cholecystokinin type 1 receptor potentially useful for management of obesity

Screening for positive allosteric modulators of cholecystokinin type 1 receptor potentially useful for management of obesity

by Dengler, Daniela G., Sun, Qing, Harikumar, Kaleeckal G., Miller, Laurence J., Sergienko, Eduard A.
Published in SLAS discovery (01.10.2022)

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Discovery of a Positive Allosteric Modulator of Cholecystokinin Action at CCK1R in Normal and Elevated Cholesterol

Discovery of a Positive Allosteric Modulator of Cholecystokinin Action at CCK1R in Normal and Elevated Cholesterol

by Harikumar, Kaleeckal G, Coudrat, Thomas, Desai, Aditya J, Dong, Maoqing, Dengler, Daniela G, Furness, Sebastian G B, Christopoulos, Arthur, Wootten, Denise, Sergienko, Eduard A, Sexton, Patrick M, Miller, Laurence J
Published in Frontiers in endocrinology (Lausanne) (07.12.2021)

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Dimeric Arrangement of the Parathyroid Hormone Receptor and a Structural Mechanism for Ligand-induced Dissociation

Dimeric Arrangement of the Parathyroid Hormone Receptor and a Structural Mechanism for Ligand-induced Dissociation

by Pioszak, Augen A., Harikumar, Kaleeckal G., Parker, Naomi R., Miller, Laurence J., Xu, H.Eric
Published in The Journal of biological chemistry (16.04.2010)

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Structure-activity relationships of thiadiazole agonists of the human secretin receptor

Structure-activity relationships of thiadiazole agonists of the human secretin receptor

by Ardecky, Robert, Dengler, Daniela G., Harikumar, Kaleeckal G., Abelman, Mathew M., Zou, Jiwen, Kramer, Bryan A., Ganji, Santhi Reddy, Olson, Steve, Ly, Alina, Puvvula, Nikhil, Ma, Chen-Ting, Ramachandra, Raghuveer, Sergienko, Eduard A., Miller, Laurence J.
Published in SLAS discovery (01.09.2024)

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Signaling Modification by GPCR Heteromer and Its Implication on X-Linked Nephrogenic Diabetes Insipidus

Signaling Modification by GPCR Heteromer and Its Implication on X-Linked Nephrogenic Diabetes Insipidus

by Ng, Hans K H, Harikumar, Kaleeckal G, Miller, Laurence J, Chow, Billy K C
Published in PloS one (20.09.2016)

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Functional Importance of a Structurally Distinct Homodimeric Complex of the Family B G Protein-Coupled Secretin Receptor

Functional Importance of a Structurally Distinct Homodimeric Complex of the Family B G Protein-Coupled Secretin Receptor

by Gao, Fan, Harikumar, Kaleeckal G, Dong, Maoqing, Lam, Polo C-H, Sexton, Patrick M, Christopoulos, Arthur, Bordner, Andrew, Abagyan, Ruben, Miller, Laurence J
Published in Molecular pharmacology (01.08.2009)

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