Pharmacological Characterization of Apraglutide, a Novel Long-Acting Peptidic Glucagon-Like Peptide-2 Agonist, for the Treatment of Short Bowel Syndrome
Hargrove, Diane M, Alagarsamy, Sudarkodi, Croston, Glenn, Laporte, Régent, Qi, Steve, Srinivasan, Karthik, Sueiras-Diaz, Javier, Wiśniewski, Kazimierz, Hartwig, Jennifer, Lu, Mark, Posch, Alexander P, Wiśniewska, Halina, Schteingart, Claudio D, Rivière, Pierre J-M, Dimitriadou, Violetta
Published in The Journal of pharmacology and experimental therapeutics (01.05.2020)
Published in The Journal of pharmacology and experimental therapeutics (01.05.2020)
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Bioluminescent imaging in induced mouse models of endometriosis reveals differences in four model variations
Dorning, Ashley, Dhami, Priya, Panir, Kavita, Hogg, Chloe, Park, Emma, Ferguson, Gregory D, Hargrove, Diane, Karras, James, Horne, Andrew W, Greaves, Erin
Published in Disease models & mechanisms (01.08.2021)
Published in Disease models & mechanisms (01.08.2021)
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Discovery of Potent, Selective, and Short-Acting Peptidic V-2 Receptor Agonists
Wisniewski, Kazimierz, Qi, Steve, Kraus, John, Ly, Brian, Srinivasan, Karthik, Tariga, Hiroe, Croston, Glenn, La, Erin, Wisniewska, Halina, Ortiz, Carlos, Laporte, Regent, Riviere, Pierre J. -M., Neyer, Gebhard, Hargrove, Diane M., Schteingart, Claudio D.
Published in Journal of medicinal chemistry (23.05.2019)
Published in Journal of medicinal chemistry (23.05.2019)
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Exenatide does not evoke pancreatitis and attenuates chemically induced pancreatitis in normal and diabetic rodents
Tatarkiewicz, Krystyna, Smith, Pamela A, Sablan, Emmanuel J, Polizzi, Clara J, Aumann, Donald E, Villescaz, Christiane, Hargrove, Diane M, Gedulin, Bronislava R, Lu, Melissa G W, Adams, Lisa, Whisenant, Tina, Roy, Denis, Parkes, David G
Published in American journal of physiology: endocrinology and metabolism (01.12.2010)
Published in American journal of physiology: endocrinology and metabolism (01.12.2010)
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Journal Article
Discovery of Potent, Selective, and Short-Acting Peptidic V2 Receptor Agonists
Wiśniewski, Kazimierz, Qi, Steve, Kraus, John, Ly, Brian, Srinivasan, Karthik, Tariga, Hiroe, Croston, Glenn, La, Erin, Wiśniewska, Halina, Ortiz, Carlos, Laporte, Régent, Rivière, Pierre J.-M, Neyer, Gebhard, Hargrove, Diane M, Schteingart, Claudio D
Published in Journal of medicinal chemistry (23.05.2019)
Published in Journal of medicinal chemistry (23.05.2019)
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Journal Article
Synthesis and Pharmacological Characterization of Novel Glucagon-like Peptide‑2 (GLP-2) Analogues with Low Systemic Clearance
Wiśniewski, Kazimierz, Sueiras-Diaz, Javier, Jiang, Guangcheng, Galyean, Robert, Lu, Mark, Thompson, Dorain, Wang, Yung-Chih, Croston, Glenn, Posch, Alexander, Hargrove, Diane M, Wiśniewska, Halina, Laporte, Régent, Dwyer, John J, Qi, Steve, Srinivasan, Karthik, Hartwig, Jennifer, Ferdyan, Nicky, Mares, Monica, Kraus, John, Alagarsamy, Sudarkodi, Rivière, Pierre J. M, Schteingart, Claudio D
Published in Journal of medicinal chemistry (14.04.2016)
Published in Journal of medicinal chemistry (14.04.2016)
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Isozyme-nonselective N-Substituted Bipiperidylcarboxamide Acetyl-CoA Carboxylase Inhibitors Reduce Tissue Malonyl-CoA Concentrations, Inhibit Fatty Acid Synthesis, and Increase Fatty Acid Oxidation in Cultured Cells and in Experimental Animals
Harwood, H.James, Petras, Stephen F., Shelly, Lorraine D., Zaccaro, Lawrence M., Perry, David A., Makowski, Michael R., Hargrove, Diane M., Martin, Kelly A., Tracey, W.Ross, Chapman, Justin G., Magee, William P., Dalvie, Deepak K., Soliman, Victor F., Martin, William H., Mularski, Christian J., Eisenbeis, Shane A.
Published in The Journal of biological chemistry (26.09.2003)
Published in The Journal of biological chemistry (26.09.2003)
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Journal Article
Discovery and evaluation of pyrazolo[1,5- a]pyrimidines as neuropeptide Y1 receptor antagonists
Griffith, David A., Hargrove, Diane M., Maurer, Tristan S., Blum, Charles A., De Lombaert, Stéphane, Inthavongsay, John K., Klade, Lee E., Mack, Christine M., Rose, Colin R., Sanders, Martin J., Carpino, Philip A.
Published in Bioorganic & medicinal chemistry letters (01.05.2011)
Published in Bioorganic & medicinal chemistry letters (01.05.2011)
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In vitro and in vivo pharmacology of CP-945,598, a potent and selective cannabinoid CB1 receptor antagonist for the management of obesity
Hadcock, John R., Griffith, David A., Iredale, Phillip A., Carpino, Phillip A., Dow, Robert L., Black, Shawn C., O’Connor, Rebecca, Gautreau, Denise, Lizano, Jeffrey S., Ward, Karen, Hargrove, Diane M., Kelly-Sullivan, Dawn, Scott, Dennis O.
Published in Biochemical and biophysical research communications (02.04.2010)
Published in Biochemical and biophysical research communications (02.04.2010)
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Discovery of N-benzyl-2-[(4S)-4-(1H-indol-3-ylmethyl)-5-oxo-1-phenyl-4,5-dihydro-6H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-6-yl]-N-isopropylacetamide, an orally active, gut-selective CCK1 receptor agonist for the potential treatment of obesity
Elliott, Richard L., Cameron, Kimberly O., Chin, Janice E., Bartlett, Jeremy A., Beretta, Elena E., Chen, Yue, Jardine, Paul Da Silva, Dubins, Jeffrey S., Gillaspy, Melissa L., Hargrove, Diane M., Kalgutkar, Amit S., LaFlamme, Janet A., Lame, Mary E., Martin, Kelly A., Maurer, Tristan S., Nardone, Nancy A., Oliver, Robert M., Scott, Dennis O., Sun, Dexue, Swick, Andrew G., Trebino, Catherine E., Zhang, Yingxin
Published in Bioorganic & medicinal chemistry letters (15.11.2010)
Published in Bioorganic & medicinal chemistry letters (15.11.2010)
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Journal Article
Biological activity of AC3174, a peptide analog of exendin-4
Hargrove, Diane M., Kendall, Eric S., Reynolds, James M., Lwin, Aung N., Herich, John P., Smith, Pamela A., Gedulin, Bronislava R., Flanagan, Shawn D., Jodka, Carolyn M., Hoyt, Julie A., McCowen, Kevin M., Parkes, David G., Anderson, Christen M.
Published in Regulatory peptides (07.06.2007)
Published in Regulatory peptides (07.06.2007)
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Pharmacological Characterization of FE 203799, a Novel Long Acting Peptide Analog of Glucagon-Like Peptide-2 (GLP-2)
Hargrove, Diane M, Alagarsamy, Sudar, Qi, Steve, Srinivasan, Karthik, Croston, Glenn, Laporte, Regent, Sueiras-Diaz, Javier, Wisniewski, Kazimierz, Hartwig, Jennifer, Wisniewska, Halina T, Lu, Mark, Posch, Alexander P, Schteingart, Claudio D, Rivière, Pierre J
Published in Gastroenterology (New York, N.Y. 1943) (2011)
Published in Gastroenterology (New York, N.Y. 1943) (2011)
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Journal Article
Discovery of potent and orally bioavailable heterocycle-based β3-adrenergic receptor agonists, potential therapeutics for the treatment of obesity
LAFONTAINE, Jennifer A, DAY, Robert F, DASILVA-JARDINE, Paul, DIBRINO, Joe, HADCOCK, John R, HARGROVE, Diane M, LINHARES, Michael, MARTIN, Kelly A, MAURER, Tristan S, NARDONE, Nancy A, TESS, David A
Published in Bioorganic & medicinal chemistry letters (01.09.2007)
Published in Bioorganic & medicinal chemistry letters (01.09.2007)
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Journal Article
Discovery of Potent, Nonsteroidal, and Highly Selective Glucocorticoid Receptor Antagonists
Morgan, Bradley P, Swick, Andrew G, Hargrove, Diane M, LaFlamme, Janet A, Moynihan, Melinda S, Carroll, Richard S, Martin, Kelly A, Lee, Eunsun, Decosta, Debra, Bordner, Jon
Published in Journal of medicinal chemistry (06.06.2002)
Published in Journal of medicinal chemistry (06.06.2002)
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Journal Article
GLUT4 Overexpression in db/db Mice Dose-Dependently Ameliorates Diabetes But Is Not a Lifelong Cure
BROZINICK, Joseph T, MCCOID, Scott C, REYNOLDS, Thomas H, NARDONE, Nancy A, HARGROVE, Diane M, STEVENSON, Ralph W, CUSHMAN, Samuel W, GIBBS, E. Michael
Published in Diabetes (New York, N.Y.) (01.03.2001)
Published in Diabetes (New York, N.Y.) (01.03.2001)
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Discovery of a novel series of 6-azauracil-based thyroid hormone receptor ligands: potent, TRβ subtype-selective thyromimetics
Dow, Robert L., Schneider, Steven R., Paight, Ernest S., Hank, Richard F., Chiang, Phoebe, Cornelius, Peter, Lee, Eunsun, Newsome, William P., Swick, Andrew G., Spitzer, Josephine, Hargrove, Diane M., Patterson, Terrell A., Pandit, Jayvardhan, Chrunyk, Boris A., LeMotte, Peter K., Danley, Dennis E., Rosner, Michele H., Ammirati, Mark J., Simons, Samuel P., Schulte, Gayle K., Tate, Bonnie F., DaSilva-Jardine, Paul
Published in Bioorganic & medicinal chemistry letters (10.02.2003)
Published in Bioorganic & medicinal chemistry letters (10.02.2003)
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Journal Article
Potent and selective, sulfamide-based human β3-adrenergic receptor agonists
DOW, Robert L, PAIGHT, Ernest S, SCHNEIDER, Steven R, HADCOCK, John R, HARGROVE, Diane M, MARTIN, Kelly A, MAURER, Tristan S, NARDONE, Nancy A, TESS, David A, DASILVA-JARDINE, Paul
Published in Bioorganic & medicinal chemistry letters (21.06.2004)
Published in Bioorganic & medicinal chemistry letters (21.06.2004)
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In Vitro and in Vivo Characterization of 3-{2-[6-(2-tert-Butoxyethoxy)pyridin-3-yl]-1H-imidazol-4-yl}benzonitrile Hydrochloride Salt, a Potent and Selective NPY5 Receptor Antagonist
Elliott, Richard L, Oliver, Robert M, Hammond, Marlys, Patterson, Terrell A, She, Li, Hargrove, Diane M, Martin, Kelly A, Maurer, Tristan S, Kalvass, J. Cory, Morgan, Bradley P, DaSilva-Jardine, Paul A, Stevenson, Ralph W, Mack, Christine M, Cassella, James V
Published in Journal of medicinal chemistry (27.02.2003)
Published in Journal of medicinal chemistry (27.02.2003)
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Journal Article
Pharmacological, Pharmacokinetic, Pharmacodynamic and Physicochemical Characterization of FE 205030: A Potent, Fast Acting, Injectable CGRP Receptor Antagonist for the Treatment of Acute Episodic Migraine
Srinivasan, Karthik, Kozminski, Kirk, Zhang, Ying, Wisniewski, Kazimierz, Kohout, Trudy, Wisniewska, Halina, Harris, Geoffrey, Lindstrom, Beatriz, Hargrove, Diane
Published in Journal of pharmaceutical sciences (01.01.2022)
Published in Journal of pharmaceutical sciences (01.01.2022)
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