Efficacious, Orally Bioavailable Thrombin Inhibitors Based on 3-Aminopyridinone or 3-Aminopyrazinone Acetamide Peptidomimetic Templates
Sanderson, Philip E. J, Lyle, Terry A, Cutrona, Kellie J, Dyer, Dona L, Dorsey, Bruce D, McDonough, Colleen M, Naylor-Olsen, Adel M, Chen, I-Wu, Chen, Zhongguo, Cook, Jacquelynn J, Cooper, Carolyn M, Gardell, Stephen J, Hare, Timothy R, Krueger, Julie A, Lewis, S. Dale, Lin, Jiunn H, Lucas, Bobby J, Lyle, Elizabeth A, Lynch, Joseph J, Stranieri, Maria T, Vastag, Kari, Yan, Youwei, Shafer, Jules A, Vacca, Joseph P
Published in Journal of medicinal chemistry (05.11.1998)
Published in Journal of medicinal chemistry (05.11.1998)
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Discovery of a Novel, Selective, and Orally Bioavailable Class of Thrombin Inhibitors Incorporating Aminopyridyl Moieties at the P1 Position
Feng, Dong-Mei, Gardell, Stephen J, Lewis, S. Dale, Bock, Mark G, Chen, Zhongguo, Freidinger, Roger M, Naylor-Olsen, Adel M, Ramjit, Harri G, Woltmann, Richard, Baskin, Elizabeth P, Lynch, Joseph J, Lucas, Robert, Shafer, Jules A, Dancheck, Kimberley B, Chen, I-Wu, Mao, Shi-Shan, Krueger, Julie A, Hare, Timothy R, Mulichak, Anne M, Vacca, Joseph P
Published in Journal of medicinal chemistry (07.11.1997)
Published in Journal of medicinal chemistry (07.11.1997)
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Antithrombotic Efficacy of Thrombin Inhibitor L-374,087: Intravenous Activity in a Primate Model of Venous Thrombus Extension and Oral Activity in a Canine Model of Primary Venous and Coronary Artery Thrombosis
Cook, J J, Gardell, S J, Holahan, M A, Sitko, G R, Stump, G L, Wallace, A A, Gilberto, D B, Hare, T R, Krueger, J A, Dyer, D L, Sanderson, P E, Vacca, J P, Shafer, J A, Lynch, Jr, J J
Published in The Journal of pharmacology and experimental therapeutics (01.04.1999)
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Published in The Journal of pharmacology and experimental therapeutics (01.04.1999)
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Vampire Bat Salivary Plasminogen Activator Is Quiescent in Human Plasma in the Absence of Fibrin Unlike Human Tissue Plasminogen Activator
Gardell, Stephen J., Hare, Timothy R., Bergum, Peter W., Cuca, Gregory C., O’Neill-Palladino, Linda, Zavodny, Susan M.
Published in Blood (15.12.1990)
Published in Blood (15.12.1990)
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Vampire bat salivary plasminogen activator evokes minimal bleeding relative to tissue-type plasminogen activator as assessed by a rabbit cuticle bleeding time model
Mellott, M J, Ramjit, D R, Stabilito, I I, Hare, T R, Senderak, E T, Lynch, Jr, J J, Gardell, S J
Published in Thrombosis and haemostasis (1995)
Published in Thrombosis and haemostasis (1995)
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Additional fucosyl residues on membrane glycoproteins but not a secreted glycoprotein from cystic fibrosis fibroblasts
Wang, Yu-Mei, Hare, Timothy R., Won, Bokran, Stowell, Christopher P., Scanlin, Thomas F., Glick, Mary Catherine, Hård, Karl, van Kuik, J.Albert, Vliegenthart, Johannes F.G.
Published in Clinica chimica acta (01.05.1990)
Published in Clinica chimica acta (01.05.1990)
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Purification and characterization of human plasminogen activator inhibitor type I expressed in Saccharomyces cerevisiae
Gardell, Stephen J., Hare, Timothy R., Han, Jang H., Markus, Henry Z., Keech, Bernice J., Carty, Christine E., Ellis, Ronald W., Schultz, Loren D.
Published in Archives of biochemistry and biophysics (01.05.1990)
Published in Archives of biochemistry and biophysics (01.05.1990)
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