Design of Potent and Selective Hybrid Inhibitors of the Mitotic Kinase Nek2: Structure–Activity Relationship, Structural Biology, and Cellular Activity
Innocenti, Paolo, Cheung, Kwai-Ming J, Solanki, Savade, Mas-Droux, Corine, Rowan, Fiona, Yeoh, Sharon, Boxall, Kathy, Westlake, Maura, Pickard, Lisa, Hardy, Tara, Baxter, Joanne E, Aherne, G. Wynne, Bayliss, Richard, Fry, Andrew M, Hoelder, Swen
Published in Journal of medicinal chemistry (12.04.2012)
Published in Journal of medicinal chemistry (12.04.2012)
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Inhibition of Escherichia coli Heat-labile Enterotoxin B Subunit Pentamer (EtxB5) Assembly in Vitro Using Monoclonal Antibodies
Chung, Wen Yuan, Carter, Rachel, Hardy, Tara, Sack, Markus, Hirst, Timothy R., James, Roger F.L.
Published in The Journal of biological chemistry (22.12.2006)
Published in The Journal of biological chemistry (22.12.2006)
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Genomic discovery of an evolutionarily programmed modality for small-molecule targeting of an intractable protein surface
Shigdel, Uddhav K., Lee, Seung-Joo, Sowa, Mathew E., Bowman, Brian R., Robison, Keith, Zhou, Minyun, Pua, Khian Hong, Stiles, Dylan T., Blodgett, Joshua A. V., Udwary, Daniel W., Rajczewski, Andrew T., Mann, Alan S., Mostafavi, Siavash, Hardy, Tara, Arya, Sukrat, Weng, Zhigang, Stewart, Michelle, Kenyon, Kyle, Morgenstern, Jay P., Pan, Ende, Gray, Daniel C., Pollock, Roy M., Fry, Andrew M., Klausner, Richard D., Townson, Sharon A., Verdine, Gregory L.
Published in Proceedings of the National Academy of Sciences - PNAS (21.07.2020)
Published in Proceedings of the National Academy of Sciences - PNAS (21.07.2020)
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Multisite phosphorylation of C-Nap1 releases it from Cep135 to trigger centrosome disjunction
Hardy, Tara, Lee, Miseon, Hames, Rebecca S, Prosser, Suzanna L, Cheary, Donna-Marie, Samant, Mugdha D, Schultz, Francisca, Baxter, Joanne E, Rhee, Kunsoo, Fry, Andrew M
Published in Journal of cell science (01.06.2014)
Published in Journal of cell science (01.06.2014)
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An undecided coiled coil: the leucine zipper of Nek2 kinase exhibits atypical conformational exchange dynamics
Croasdale, Rebecca, Ivins, Frank J, Muskett, Fred, Daviter, Tina, Scott, David J, Hardy, Tara, Smerdon, Steven J, Fry, Andrew M, Pfuhl, Mark
Published in The Journal of biological chemistry (05.08.2011)
Published in The Journal of biological chemistry (05.08.2011)
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An Undecided Coiled Coil
Croasdale, Rebecca, Ivins, Frank J., Muskett, Fred, Daviter, Tina, Scott, David J., Hardy, Tara, Smerdon, Steven J., Fry, Andrew M., Pfuhl, Mark
Published in The Journal of biological chemistry (05.08.2011)
Published in The Journal of biological chemistry (05.08.2011)
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Journal Article
Design of potent and selective hybrid inhibitors of the mitotic kinase Nek2: SAR, structural biology and cellular activity
Innocenti, Paolo, Cheung, Kwai-Ming J., Solanki, Savade, Mas-Droux, Corine, Rowan, Fiona, Yeoh, Sharon, Boxall, Kathy, Westlake, Maura, Pickard, Lisa, Hardy, Tara, Baxter, Joanne E., Aherne, G. Wynne, Bayliss, Richard, Fry, Andrew M., Hoelder, Swen
Published in Journal of medicinal chemistry (23.03.2012)
Published in Journal of medicinal chemistry (23.03.2012)
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