Synthesis and Anti-Herpes Virus Activity of 2‘-Deoxy-4‘-thiopyrimidine Nucleosides
Rahim, S. George, Trivedi, Naimisha, Bogunovic-Batchelor, Mirjana V, Hardy, George W, Mills, Gail, Selway, John W. T, Snowden, Wendy, Littler, Edward, Coe, Paul L, Basnak, Ivan, Whale, Robert F, Walker, Richard T
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Published in Journal of medicinal chemistry (02.02.1996)
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Nonsteroidal Glucocorticoid Agonists: Tetrahydronaphthalenes with Alternative Steroidal A-Ring Mimetics Possessing Dissociated (Transrepression/Transactivation) Efficacy Selectivity
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Published in Journal of medicinal chemistry (27.12.2007)
Published in Journal of medicinal chemistry (27.12.2007)
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Highly tractable, sub-nanomolar non-steroidal glucocorticoid receptor agonists
Biggadike, Keith, Caivano, Matilde, Clackers, Margaret, Coe, Diane M., Hardy, George W., Humphreys, Davina, Jones, Haydn T., House, David, Miles-Williams, Annette, Skone, Philip A., Uings, Iain, Weller, Vicki, McLay, Iain M., Macdonald, Simon J.F.
Published in Bioorganic & medicinal chemistry letters (15.08.2009)
Published in Bioorganic & medicinal chemistry letters (15.08.2009)
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Non-steroidal glucocorticoid agonists—The discovery of aryl pyrazoles as A-ring mimetics
Clackers, Margaret, Coe, Diane M., Demaine, Derek A., Hardy, George W., Humphreys, Davina, Inglis, Graham G.A., Johnston, Michael J., Jones, Haydn T., House, David, Loiseau, Richard, Minick, Doug J., Skone, Philip A., Uings, Iain, McLay, Iain M., Macdonald, Simon J.F.
Published in Bioorganic & medicinal chemistry letters (01.09.2007)
Published in Bioorganic & medicinal chemistry letters (01.09.2007)
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Discovery of Further Pyrrolidine trans-Lactams as Inhibitors of Human Neutrophil Elastase (HNE) with Potential as Development Candidates and the Crystal Structure of HNE Complexed with an Inhibitor (GW475151)
Macdonald, Simon J. F, Dowle, Michael D, Harrison, Lee A, Clarke, Geoffrey D. E, Inglis, Graham G. A, Johnson, Martin R, Shah, Pritom, Smith, Robin A, Amour, Augustin, Fleetwood, Gill, Humphreys, Davina C, Molloy, Christopher R, Dixon, Mary, Godward, Rosalind E, Wonacott, Alan J, Singh, Onkar M. P, Hodgson, Simon T, Hardy, George W
Published in Journal of medicinal chemistry (29.08.2002)
Published in Journal of medicinal chemistry (29.08.2002)
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The discovery of a potent, intracellular, orally bioavailable, long duration inhibitor of human neutrophil elastase—GW311616A a development candidate
Macdonald, Simon J.F, Dowle, Michael D, Harrison, Lee A, Shah, Pritom, Johnson, Martin R, Inglis, Graham G.A, Clarke, Geoffrey D.E, Smith, Robin A, Humphreys, Davina, Molloy, Christopher R, Amour, Augustin, Dixon, Mary, Murkitt, Graham, Godward, Rosalind E, Padfield, Tony, Skarzynski, Tadeusz, Singh, Onkar M.P, Kumar, K.Abhhilash, Fleetwood, Gill, Hodgson, Simon T, Hardy, George W, Finch, Harry
Published in Bioorganic & medicinal chemistry letters (09.04.2001)
Published in Bioorganic & medicinal chemistry letters (09.04.2001)
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Conformation of two 4'-thio-2'-deoxynucleoside analogs studied by 5000-MHz proton NMR spectroscopy and x-ray crystallography
Koole, Leo H, Plavec, Janez, Liu, Hongying, Vincent, Beverly R, Dyson, Michael R, Coe, Paul L, Walker, Richard T, Hardy, George W, Rahim, S. George, Chattopadhyaya, Jyoti
Published in Journal of the American Chemical Society (01.12.1992)
Published in Journal of the American Chemical Society (01.12.1992)
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Intracellular inhibition of human neutrophil elastase by orally active pyrrolidine-trans-lactams
MACDONALD, Simon J. F, DOWLE, Michael D, MOLLOY, Christopher R, DIXON, Mary, MURKITT, Graham, GODWARD, Rosalind E, SKARZYNSKI, Tadeusz, SINGH, Onkar M. P, KUMAR, K. Abhhilash, HODGSON, Simon T, MCDONALD, Edward, HARDY, George W, HARRISON, Lee A, FINCH, Harry, SPOONER, Julie E, SHAH, Pritom, JOHNSON, Martin R, INGLIS, Graham G. A, CLARKE, Geoffrey D. E, BELTON, David J, SMITH, Robin A
Published in Bioorganic & medicinal chemistry letters (22.01.2001)
Published in Bioorganic & medicinal chemistry letters (22.01.2001)
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Efficient synthesis of an α-trifluoromethyl-α-tosyloxymethyl epoxide enabling stepwise double functionalisation to afford CF3-substituted tertiary alcohols
Keeling, Steven P., Campbell, Ian B., Coe, Diane M., Cooper, Tony W.J., Hardy, George W., Jack, Torquil I., Jones, Haydn T., Needham, Deborah, Shipley, Tracy J., Skone, Philip A., Sutton, Peter W., Weingarten, Gordon A., Macdonald, Simon J.F.
Published in Tetrahedron letters (18.08.2008)
Published in Tetrahedron letters (18.08.2008)
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Efficient synthesis of an alpha-trifluoromethyl-alpha-tosyloxymethyl epoxide enabling stepwise double functionalisation to afford CF(3)-substituted tertiary alcohols
Keeling, Steven P., Campbell, Ian B., Coe, Diane M., Cooper, Tony W. J., Hardy, George W., Jack, Torquil I., Jones, Haydn T., Needham, Deborah, Shipley, Tracy J., Skone, Philip A., Sutton, Peter W., Weingarten, Gordon A., Macdonald, Simon J. F.
Published in Tetrahedron letters (18.08.2008)
Published in Tetrahedron letters (18.08.2008)
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Peripherally acting enkephalin analogs. 1. Polar pentapeptides
Hardy, George W, Lowe, Lawrence A, Sang, Pang Yih, Simpkin, Dean S. A, Wilkinson, Samuel, Follenfant, Rhonda L, Smith, Terence W
Published in Journal of medicinal chemistry (01.05.1988)
Published in Journal of medicinal chemistry (01.05.1988)
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Efficient synthesis of an α-trifluoromethyl-α-tosyloxymethyl epoxide enabling stepwise double functionalisation to afford CF 3-substituted tertiary alcohols
Keeling, Steven P., Campbell, Ian B., Coe, Diane M., Cooper, Tony W.J., Hardy, George W., Jack, Torquil I., Jones, Haydn T., Needham, Deborah, Shipley, Tracy J., Skone, Philip A., Sutton, Peter W., Weingarten, Gordon A., Macdonald, Simon J.F.
Published in Tetrahedron letters (2008)
Published in Tetrahedron letters (2008)
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Amino-acids and peptides. Part 42. Synthesis of a protected docosa peptide having the sequence of mast-cell degranulating peptide
Bratby, Dilys M., Coyle, Susan, Gregson, Richard P., Hardy, George W., Young, Geoffrey T.
Published in Journal of the Chemical Society, Perkin Transactions 1 (1979)
Published in Journal of the Chemical Society, Perkin Transactions 1 (1979)
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Synthesis of tetrasubstituted bicyclo[3.2.1]octenes as potential inhibitors of influenza virus sialidase
Jones, Paul S., Smith, Paul W., Hardy, George W., Howes, Peter D., Upton, Richard J., Bethell, Richard C.
Published in Bioorganic & medicinal chemistry letters (22.02.1999)
Published in Bioorganic & medicinal chemistry letters (22.02.1999)
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Corrigendum to “Intracellular inhibition of human neutrophil elastase by orally active pyrrolidine- trans-lactams” : [Bioorg. Med. Chem. Lett. 11 (2001) 243]
Macdonald, Simon J.F., Dowle, Michael D., Harrison, Lee A., Spooner, Julie E., Shah, Pritom, Johnson, Martin R., Inglis, Graham G.A., Clarke, Geoffrey D.E., Belton, David J., Smith, Robin A., Molloy, Christopher R., Dixon, Mary, Murkitt, Graham, Godward, Rosalind E., Skarzynski, Tadeusz, Singh, Onkar M.P., Kumar, K.Abhhilash, Hodgson, Simon T., McDonald, Edward, Hardy, George W., Finch, Harry, Humphreys, Davina C., Fleetwood, Gill
Published in Bioorganic & medicinal chemistry letters (01.05.2001)
Published in Bioorganic & medicinal chemistry letters (01.05.2001)
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