Dimers of DNA-PK create a stage for DNA double-strand break repair
Chaplin, Amanda K, Hardwick, Steven W, Liang, Shikang, Kefala Stavridi, Antonia, Hnizda, Ales, Cooper, Lee R, De Oliveira, Taiana Maia, Chirgadze, Dimitri Y, Blundell, Tom L
Published in Nature structural & molecular biology (01.01.2021)
Published in Nature structural & molecular biology (01.01.2021)
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Journal Article
Nanopore-Based Identification of Individual Nucleotides for Direct RNA Sequencing
Ayub, Mariam, Hardwick, Steven W, Luisi, Ben F, Bayley, Hagan
Published in Nano letters (11.12.2013)
Published in Nano letters (11.12.2013)
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Journal Article
Structural basis for human mitochondrial tRNA maturation
Meynier, Vincent, Hardwick, Steven W, Catala, Marjorie, Roske, Johann J, Oerum, Stephanie, Chirgadze, Dimitri Y, Barraud, Pierre, Yue, Wyatt W, Luisi, Ben F, Tisné, Carine
Published in Nature communications (01.06.2024)
Published in Nature communications (01.06.2024)
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Structural and functional basis of inositol hexaphosphate stimulation of NHEJ through stabilization of Ku-XLF interaction
Kefala Stavridi, Antonia, Gontier, Amandine, Morin, Vincent, Frit, Philippe, Ropars, Virginie, Barboule, Nadia, Racca, Carine, Jonchhe, Sagun, Morten, Michael J, Andreani, Jessica, Rak, Alexey, Legrand, Pierre, Bourand-Plantefol, Alexa, Hardwick, Steven W, Chirgadze, Dimitri Y, Davey, Paul, De Oliveira, Taiana Maia, Rothenberg, Eli, Britton, Sebastien, Calsou, Patrick, Blundell, Tom L, Varela, Paloma F, Chaplin, Amanda K, Charbonnier, Jean-Baptiste
Published in Nucleic acids research (27.11.2023)
Published in Nucleic acids research (27.11.2023)
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Structure and dynamics of Toll immunoreceptor activation in the mosquito Aedes aegypti
Saucereau, Yoann, Wilson, Thomas H, Tang, Matthew C K, Moncrieffe, Martin C, Hardwick, Steven W, Chirgadze, Dimitri Y, Soares, Sandro G, Marcaida, Maria Jose, Gay, Nicholas J, Gangloff, Monique
Published in Nature communications (30.08.2022)
Published in Nature communications (30.08.2022)
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Journal Article
Structural elucidation of a novel mechanism for the bacteriophage-based inhibition of the RNA degradosome
Van den Bossche, An, Hardwick, Steven W, Ceyssens, Pieter-Jan, Hendrix, Hanne, Voet, Marleen, Dendooven, Tom, Bandyra, Katarzyna J, De Maeyer, Marc, Aertsen, Abram, Noben, Jean-Paul, Luisi, Ben F, Lavigne, Rob
Published in eLife (22.07.2016)
Published in eLife (22.07.2016)
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Single-particle cryo-EM at atomic resolution
Nakane, Takanori, Kotecha, Abhay, Sente, Andrija, McMullan, Greg, Masiulis, Simonas, Brown, Patricia M G E, Grigoras, Ioana T, Malinauskaite, Lina, Malinauskas, Tomas, Miehling, Jonas, Uchański, Tomasz, Yu, Lingbo, Karia, Dimple, Pechnikova, Evgeniya V, de Jong, Erwin, Keizer, Jeroen, Bischoff, Maarten, McCormack, Jamie, Tiemeijer, Peter, Hardwick, Steven W, Chirgadze, Dimitri Y, Murshudov, Garib, Aricescu, A Radu, Scheres, Sjors H W
Published in Nature (London) (05.11.2020)
Published in Nature (London) (05.11.2020)
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Journal Article
CryoEM structures of human CMG–ATPγS–DNA and CMG–AND-1 complexes
Rzechorzek, Neil J, Hardwick, Steven W, Jatikusumo, Vincentius A, Chirgadze, Dimitri Y, Pellegrini, Luca
Published in Nucleic acids research (09.07.2020)
Published in Nucleic acids research (09.07.2020)
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Journal Article
Structural insights into inhibitor regulation of the DNA repair protein DNA-PKcs
Liang, Shikang, Thomas, Sherine E, Chaplin, Amanda K, Hardwick, Steven W, Chirgadze, Dimitri Y, Blundell, Tom L
Published in Nature (London) (27.01.2022)
Published in Nature (London) (27.01.2022)
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Journal Article
Differential assembly diversifies GABA A receptor structures and signalling
Sente, Andrija, Desai, Rooma, Naydenova, Katerina, Malinauskas, Tomas, Jounaidi, Youssef, Miehling, Jonas, Zhou, Xiaojuan, Masiulis, Simonas, Hardwick, Steven W, Chirgadze, Dimitri Y, Miller, Keith W, Aricescu, A Radu
Published in Nature (London) (07.04.2022)
Published in Nature (London) (07.04.2022)
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Journal Article
Differential assembly diversifies GABAA receptor structures and signalling
Sente, Andrija, Desai, Rooma, Naydenova, Katerina, Malinauskas, Tomas, Jounaidi, Youssef, Miehling, Jonas, Zhou, Xiaojuan, Masiulis, Simonas, Hardwick, Steven W., Chirgadze, Dimitri Y., Miller, Keith W., Aricescu, A. Radu
Published in Nature (London) (07.04.2022)
Published in Nature (London) (07.04.2022)
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Journal Article
Cryo-EM of NHEJ supercomplexes provides insights into DNA repair
Chaplin, Amanda K., Hardwick, Steven W., Stavridi, Antonia Kefala, Buehl, Christopher J., Goff, Noah J., Ropars, Virginie, Liang, Shikang, De Oliveira, Taiana Maia, Chirgadze, Dimitri Y., Meek, Katheryn, Charbonnier, Jean-Baptiste, Blundell, Tom L.
Published in Molecular cell (19.08.2021)
Published in Molecular cell (19.08.2021)
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Journal Article
Mechanisms of inhibition and activation of extrasynaptic αβ GABAA receptors
Kasaragod, Vikram Babu, Mortensen, Martin, Hardwick, Steven W., Wahid, Ayla A., Dorovykh, Valentina, Chirgadze, Dimitri Y., Smart, Trevor G., Miller, Paul S.
Published in Nature (London) (17.02.2022)
Published in Nature (London) (17.02.2022)
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Journal Article
Two distinct long-range synaptic complexes promote different aspects of end processing prior to repair of DNA breaks by non-homologous end joining
Buehl, Christopher J., Goff, Noah J., Hardwick, Steven W., Gellert, Martin, Blundell, Tom L., Yang, Wei, Chaplin, Amanda K., Meek, Katheryn
Published in Molecular cell (02.03.2023)
Published in Molecular cell (02.03.2023)
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Journal Article
Structural basis for the interaction of SARS‐CoV‐2 virulence factor nsp1 with DNA polymerase α–primase
Kilkenny, Mairi L., Veale, Charlotte E., Guppy, Amir, Hardwick, Steven W., Chirgadze, Dimitri Y., Rzechorzek, Neil J., Maman, Joseph D., Pellegrini, Luca
Published in Protein science (01.02.2022)
Published in Protein science (01.02.2022)
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Journal Article
Functional and Structural Characterization of RsbU, a Stress Signaling Protein Phosphatase 2C
Delumeau, Olivier, Dutta, Sujit, Brigulla, Matthias, Kuhnke, Grit, Hardwick, Steven W., Völker, Uwe, Yudkin, Michael D., Lewis, Richard J.
Published in The Journal of biological chemistry (24.09.2004)
Published in The Journal of biological chemistry (24.09.2004)
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Journal Article
Cryo-EM structure of a DNA-PK trimer: higher order oligomerisation in NHEJ
Hardwick, Steven W., Stavridi, Antonia Kefala, Chirgadze, Dimitri Y., De Oliveira, Taiana Maia, Charbonnier, Jean-Baptiste, Ropars, Virginie, Meek, Katheryn, Blundell, Tom L., Chaplin, Amanda K.
Published in Structure (London) (03.08.2023)
Published in Structure (London) (03.08.2023)
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