Targeting the unfolded protein response in disease
Hetz, Claudio, Chevet, Eric, Harding, Heather P
Published in Nature reviews. Drug discovery (01.09.2013)
Published in Nature reviews. Drug discovery (01.09.2013)
Get full text
Journal Article
GDF15 Provides an Endocrine Signal of Nutritional Stress in Mice and Humans
Patel, Satish, Alvarez-Guaita, Anna, Melvin, Audrey, Rimmington, Debra, Dattilo, Alessia, Miedzybrodzka, Emily L., Cimino, Irene, Maurin, Anne-Catherine, Roberts, Geoffrey P., Meek, Claire L., Virtue, Samuel, Sparks, Lauren M., Parsons, Stephanie A., Redman, Leanne M., Bray, George A., Liou, Alice P., Woods, Rachel M., Parry, Sion A., Jeppesen, Per B., Kolnes, Anders J., Harding, Heather P., Ron, David, Vidal-Puig, Antonio, Reimann, Frank, Gribble, Fiona M., Hulston, Carl J., Farooqi, I. Sadaf, Fafournoux, Pierre, Smith, Steven R., Jensen, Jorgen, Breen, Danna, Wu, Zhidan, Zhang, Bei B., Coll, Anthony P., Savage, David B., O’Rahilly, Stephen
Published in Cell metabolism (05.03.2019)
Published in Cell metabolism (05.03.2019)
Get full text
Journal Article
Mutations in a translation initiation factor identify the target of a memory-enhancing compound
Sekine, Yusuke, Zyryanova, Alisa, Crespillo-Casado, Ana, Fischer, Peter M., Harding, Heather P., Ron, David
Published in Science (American Association for the Advancement of Science) (29.05.2015)
Published in Science (American Association for the Advancement of Science) (29.05.2015)
Get full text
Journal Article
Higher-order phosphatase-substrate contacts terminate the integrated stress response
Yan, Yahui, Harding, Heather P, Ron, David
Published in Nature structural & molecular biology (01.10.2021)
Published in Nature structural & molecular biology (01.10.2021)
Get full text
Journal Article
ISRIB Blunts the Integrated Stress Response by Allosterically Antagonising the Inhibitory Effect of Phosphorylated eIF2 on eIF2B
Zyryanova, Alisa F., Kashiwagi, Kazuhiro, Rato, Claudia, Harding, Heather P., Crespillo-Casado, Ana, Perera, Luke A., Sakamoto, Ayako, Nishimoto, Madoka, Yonemochi, Mayumi, Shirouzu, Mikako, Ito, Takuhiro, Ron, David
Published in Molecular cell (07.01.2021)
Published in Molecular cell (07.01.2021)
Get full text
Journal Article
Predicting the mutations generated by repair of Cas9-induced double-strand breaks
Allen, Felicity, Crepaldi, Luca, Alsinet, Clara, Strong, Alexander J, Kleshchevnikov, Vitalii, De Angeli, Pietro, Páleníková, Petra, Khodak, Anton, Kiselev, Vladimir, Kosicki, Michael, Bassett, Andrew R, Harding, Heather, Galanty, Yaron, Muñoz-Martínez, Francisco, Metzakopian, Emmanouil, Jackson, Stephen P, Parts, Leopold
Published in Nature biotechnology (01.01.2019)
Published in Nature biotechnology (01.01.2019)
Get full text
Journal Article
Binding of ISRIB reveals a regulatory site in the nucleotide exchange factor eIF2B
Zyryanova, Alisa F, Weis, Félix, Faille, Alexandre, Alard, Akeel Abo, Crespillo-Casado, Ana, Sekine, Yusuke, Harding, Heather P, Allen, Felicity, Parts, Leopold, Fromont, Christophe, Fischer, Peter M, Warren, Alan J, Ron, David
Published in Science (American Association for the Advancement of Science) (30.03.2018)
Published in Science (American Association for the Advancement of Science) (30.03.2018)
Get full text
Journal Article
The ribosomal P-stalk couples amino acid starvation to GCN2 activation in mammalian cells
Harding, Heather P, Ordonez, Adriana, Allen, Felicity, Parts, Leopold, Inglis, Alison J, Williams, Roger L, Ron, David
Published in eLife (21.11.2019)
Published in eLife (21.11.2019)
Get full text
Journal Article
molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule
Cross, Benedict C. S, Bond, Peter J, Sadowski, Pawel G, Jha, Babal Kant, Zak, Jaroslav, Goodman, Jonathan M, Silverman, Robert H, Neubert, Thomas A, Baxendale, Ian R, Ron, David, Harding, Heather P
Published in Proceedings of the National Academy of Sciences - PNAS (10.04.2012)
Published in Proceedings of the National Academy of Sciences - PNAS (10.04.2012)
Get full text
Journal Article
ERO1-β, a pancreas-specific disulfide oxidase, promotes insulin biogenesis and glucose homeostasis
Zito, Ester, Chin, King-Tung, Blais, Jaime, Harding, Heather P, Ron, David
Published in The Journal of cell biology (22.03.2010)
Published in The Journal of cell biology (22.03.2010)
Get full text
Journal Article
Substrate recruitment via eIF2γ enhances catalytic efficiency of a holophosphatase that terminates the integrated stress response
Yan, Yahui, Shetty, Maithili, Harding, Heather P, George, Ginto, Zyryanova, Alisa, Labbé, Katherine, Mafi, Amirhossein, Hao, Qi, Sidrauski, Carmela, Ron, David
Published in Proceedings of the National Academy of Sciences - PNAS (02.04.2024)
Published in Proceedings of the National Academy of Sciences - PNAS (02.04.2024)
Get full text
Journal Article
Ppp1r15 gene knockout reveals an essential role for translation initiation factor 2 alpha (eIF2α) dephosphorylation in mammalian development
Harding, Heather P, Zhang, Yuhong, Scheuner, Donalyn, Chen, Jane-Jane, Kaufman, Randal J, Ron, David
Published in Proceedings of the National Academy of Sciences - PNAS (10.02.2009)
Published in Proceedings of the National Academy of Sciences - PNAS (10.02.2009)
Get full text
Journal Article
Cargo receptor-assisted endoplasmic reticulum export of pathogenic α1-antitrypsin polymers
Ordóñez, Adriana, Harding, Heather P., Marciniak, Stefan J., Ron, David
Published in Cell reports (Cambridge) (18.05.2021)
Published in Cell reports (Cambridge) (18.05.2021)
Get full text
Journal Article
The IRE1β-mediated unfolded protein response is repressed by the chaperone AGR2 in mucin producing cells
Neidhardt, Lisa, Cloots, Eva, Friemel, Natalie, Weiss, Caroline A M, Harding, Heather P, McLaughlin, Stephen H, Janssens, Sophie, Ron, David
Published in The EMBO journal (01.03.2024)
Published in The EMBO journal (01.03.2024)
Get full text
Journal Article
Defective ATG16L1-mediated removal of IRE1α drives Crohn's disease-like ileitis
Tschurtschenthaler, Markus, Adolph, Timon E, Ashcroft, Jonathan W, Niederreiter, Lukas, Bharti, Richa, Saveljeva, Svetlana, Bhattacharyya, Joya, Flak, Magdalena B, Shih, David Q, Fuhler, Gwenny M, Parkes, Miles, Kohno, Kenji, Iwawaki, Takao, Janneke van der Woude, C, Harding, Heather P, Smith, Andrew M, Peppelenbosch, Maikel P, Targan, Stephan R, Ron, David, Rosenstiel, Philip, Blumberg, Richard S, Kaser, Arthur
Published in The Journal of experimental medicine (01.02.2017)
Published in The Journal of experimental medicine (01.02.2017)
Get full text
Journal Article