Altering Metabolic Profiles of Drugs by Precision Deuteration 2: Discovery of a Deuterated Analog of Ivacaftor with Differentiated Pharmacokinetics for Clinical Development
Harbeson, Scott L, Morgan, Adam J, Liu, Julie F, Aslanian, Ara M, Nguyen, Sophia, Bridson, Gary W, Brummel, Christopher L, Wu, Lijun, Tung, Roger D, Pilja, Lana, Braman, Virginia, Uttamsingh, Vinita
Published in The Journal of pharmacology and experimental therapeutics (01.08.2017)
Published in The Journal of pharmacology and experimental therapeutics (01.08.2017)
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Journal Article
Altering metabolic profiles of drugs by precision deuteration: reducing mechanism-based inhibition of CYP2D6 by paroxetine
Uttamsingh, Vinita, Gallegos, Richard, Liu, Julie F, Harbeson, Scott L, Bridson, Gary W, Cheng, Changfu, Wells, David S, Graham, Philip B, Zelle, Robert, Tung, Roger
Published in The Journal of pharmacology and experimental therapeutics (01.07.2015)
Published in The Journal of pharmacology and experimental therapeutics (01.07.2015)
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Preclinical Profile of VX-950, a Potent, Selective, and Orally Bioavailable Inhibitor of Hepatitis C Virus NS3-4A Serine Protease
PERNI, Robert B, ALMQUIST, Susan J, HEISER, Angela, KALKERI, Gururaj, KOLACZKOWSKI, Elaine, KAI LIN, LUONG, Yu-Ping, GOVINDA RAO, B, TAYLOR, William P, THOMSON, John A, TUNG, Roger D, YUNYI WEI, BYRN, Randal A, KWONG, Ann D, CHAO LIN, CHANDORKAR, Gurudatt, CHATURVEDI, Pravin R, COURTNEY, Lawrence F, DECKER, Caroline J, DINEHART, Kirk, GATES, Cynthia A, HARBESON, Scott L
Published in Antimicrobial Agents and Chemotherapy (01.03.2006)
Published in Antimicrobial Agents and Chemotherapy (01.03.2006)
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Inhibitors of hepatitis C virus NS3·4A protease. Part 3: P 2 proline variants
Perni, Robert B, Farmer, Luc J, Cottrell, Kevin M, Court, John J, Courtney, Lawrence F, Deininger, David D, Gates, Cynthia A, Harbeson, Scott L, Kim, Joseph L, Lin, Chao, Lin, Kai, Luong, Yu-Ping, Maxwell, John P, Murcko, Mark A, Pitlik, Janos, Rao, B.Govinda, Schairer, Wayne C, Tung, Roger D, Van Drie, John H, Wilson, Keith, Thomson, John A
Published in Bioorganic & medicinal chemistry letters (19.04.2004)
Published in Bioorganic & medicinal chemistry letters (19.04.2004)
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Stereospecific Synthesis of Peptidyl .alpha.-Keto Amides as Inhibitors of Calpain
Harbeson, Scott L, Abelleira, Susan M, Akiyama, Alan, Barrett, Robert, Carroll, Renee M, Straub, Julie Ann, Tkacz, Jaroslaw N, Wu, Chichih, Musso, Gary F
Published in Journal of medicinal chemistry (01.09.1994)
Published in Journal of medicinal chemistry (01.09.1994)
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Selective deuteration of bupropion slows epimerization and reduces metabolism
Shi, Yuanyuan, Dinh, Jean, Pelletier, Robert, Raccor, Brianne, Yusuff, Naeem, Morgan, Adam J., Harbeson, Scott, Uttamsingh, Vinita, Totah, Rheem A.
Published in Bioorganic & medicinal chemistry letters (15.11.2022)
Published in Bioorganic & medicinal chemistry letters (15.11.2022)
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Journal Article
DEUTERATED DERIVATIVES OF RUXOLITINIB
LIU JULIE F, SILVERMAN I. ROBERT, HARBESON SCOTT L, MORGAN ADAM J, PANDYA BHAUMIK
Year of Publication 15.06.2021
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Year of Publication 15.06.2021
Patent
Identification and structural elucidation of in vitro metabolites of atazanavir by HPLC and tandem mass spectrometry
Cheng, Changfu, Gallegos, Richard, Bridson, Gary, Wu, Lijun, Harbeson, Scott, Zelle, Robert, Tung, Roger
Published in Journal of mass spectrometry. (01.06.2013)
Published in Journal of mass spectrometry. (01.06.2013)
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Journal Article
Inhibitors of hepatitis C virus NS3·4A protease. Part 3: P2 proline variants
Perni, Robert B, Farmer, Luc J, Cottrell, Kevin M, Court, John J, Courtney, Lawrence F, Deininger, David D, Gates, Cynthia A, Harbeson, Scott L, Kim, Joseph L, Lin, Chao, Lin, Kai, Luong, Yu-Ping, Maxwell, John P, Murcko, Mark A, Pitlik, Janos, Rao, B.Govinda, Schairer, Wayne C, Tung, Roger D, Van Drie, John H, Wilson, Keith, Thomson, John A
Published in Bioorganic & medicinal chemistry letters (01.04.2004)
Published in Bioorganic & medicinal chemistry letters (01.04.2004)
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Journal Article
DEUTERATED DERIVATIVES OF LUXOLITINIB
LIU JULIE F, SILVERMAN I. ROBERT, HARBESON SCOTT L, MORGAN ADAM J, PANDYA BHAUMIK
Year of Publication 26.06.2015
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Year of Publication 26.06.2015
Patent