Human DPP9 represses NLRP1 inflammasome and protects against autoinflammatory diseases via both peptidase activity and FIIND domain binding
Zhong, Franklin L., Robinson, Kim, Teo, Daniel Eng Thiam, Tan, Kiat-Yi, Lim, Chrissie, Harapas, Cassandra R., Yu, Chien-Hsiung, Xie, William H., Sobota, Radoslaw M., Au, Veonice Bijin, Hopkins, Richard, D'Osualdo, Andrea, Reed, John C., Connolly, John E., Masters, Seth L., Reversade, Bruno
Published in The Journal of biological chemistry (07.12.2018)
Published in The Journal of biological chemistry (07.12.2018)
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Journal Article
Deficiency in coatomer complex I causes aberrant activation of STING signalling
Steiner, Annemarie, Hrovat-Schaale, Katja, Prigione, Ignazia, Yu, Chien-Hsiung, Laohamonthonkul, Pawat, Harapas, Cassandra R, Low, Ronnie Ren Jie, De Nardo, Dominic, Dagley, Laura F, Mlodzianoski, Michael J, Rogers, Kelly L, Zillinger, Thomas, Hartmann, Gunther, Gantier, Michael P, Gattorno, Marco, Geyer, Matthias, Volpi, Stefano, Davidson, Sophia, Masters, Seth L
Published in Nature communications (28.04.2022)
Published in Nature communications (28.04.2022)
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Journal Article
Organellar homeostasis and innate immune sensing
Harapas, Cassandra R, Idiiatullina, Elina, Al-Azab, Mahmoud, Hrovat-Schaale, Katja, Reygaerts, Thomas, Steiner, Annemarie, Laohamonthonkul, Pawat, Davidson, Sophia, Yu, Chien-Hsiung, Booty, Lee, Masters, Seth L
Published in Nature reviews. Immunology (01.09.2022)
Published in Nature reviews. Immunology (01.09.2022)
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Journal Article
An Update on Autoinflammatory Diseases: Interferonopathies
Davidson, Sophia, Steiner, Annemarie, Harapas, Cassandra R., Masters, Seth L.
Published in Current rheumatology reports (01.07.2018)
Published in Current rheumatology reports (01.07.2018)
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Journal Article
An Update on Autoinflammatory Diseases: Inflammasomopathies
Harapas, Cassandra R., Steiner, Annemarie, Davidson, Sophia, Masters, Seth L.
Published in Current rheumatology reports (01.07.2018)
Published in Current rheumatology reports (01.07.2018)
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Journal Article
ZAKα-driven ribotoxic stress response activates the human NLRP1 inflammasome
Robinson, Kim S, Toh, Gee Ann, Rozario, Pritisha, Chua, Rae, Bauernfried, Stefan, Sun, Zijin, Firdaus, Muhammad Jasrie, Bayat, Shima, Nadkarni, Rhea, Poh, Zhi Sheng, Tham, Khek Chian, Harapas, Cassandra R, Lim, Chrissie K, Chu, Werncui, Tay, Celest W S, Tan, Kiat Yi, Zhao, Tianyun, Bonnard, Carine, Sobota, Radoslaw, Connolly, John E, Common, John, Masters, Seth L, Chen, Kaiwen W, Ho, Lena, Wu, Bin, Hornung, Veit, Zhong, Franklin L
Published in Science (American Association for the Advancement of Science) (15.07.2022)
Published in Science (American Association for the Advancement of Science) (15.07.2022)
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Journal Article
An Update on Autoinflammatory Diseases: Relopathies
Steiner, Annemarie, Harapas, Cassandra R., Masters, Seth L., Davidson, Sophia
Published in Current rheumatology reports (01.07.2018)
Published in Current rheumatology reports (01.07.2018)
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Journal Article
Inflammasome sensor NLRP1 disease variant M1184V promotes autoproteolysis and DPP9 complex formation by stabilizing the FIIND domain
Moecking, Jonas, Laohamonthonkul, Pawat, Meşe, Kubilay, Hagelueken, Gregor, Steiner, Annemarie, Harapas, Cassandra R., Sandow, Jarrod J., Graves, Jonathan D., Masters, Seth L., Geyer, Matthias
Published in The Journal of biological chemistry (01.12.2022)
Published in The Journal of biological chemistry (01.12.2022)
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Journal Article
TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS
Yu, Chien-Hsiung, Davidson, Sophia, Harapas, Cassandra R., Hilton, James B., Mlodzianoski, Michael J., Laohamonthonkul, Pawat, Louis, Cynthia, Low, Ronnie Ren Jie, Moecking, Jonas, De Nardo, Dominic, Balka, Katherine R., Calleja, Dale J., Moghaddas, Fiona, Ni, Erya, McLean, Catriona A., Samson, Andre L., Tyebji, Shiraz, Tonkin, Christopher J., Bye, Christopher R., Turner, Bradley J., Pepin, Genevieve, Gantier, Michael P., Rogers, Kelly L., McArthur, Kate, Crouch, Peter J., Masters, Seth L.
Published in Cell (29.10.2020)
Published in Cell (29.10.2020)
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Journal Article
FGFR3-TACC3 is an oncogenic fusion protein in respiratory epithelium
Best, Sarah A, Harapas, Cassandra R, Kersbergen, Ariena, Rathi, Vivek, Asselin-Labat, Marie-Liesse, Sutherland, Kate D
Published in Oncogene (01.11.2018)
Published in Oncogene (01.11.2018)
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Journal Article
NLRP1 variant M1184V decreases inflammasome activation in the context of DPP9 inhibition and asthma severity
Moecking, Jonas, Laohamonthonkul, Pawat, Chalker, Katelyn, White, Marquitta J., Harapas, Cassandra R., Yu, Chien-Hsiung, Davidson, Sophia, Hrovat-Schaale, Katja, Hu, Donglei, Eng, Celeste, Huntsman, Scott, Calleja, Dale J., Horvat, Jay C., Hansbro, Phil M., O’Donoghue, Robert J.J., Ting, Jenny P., Burchard, Esteban G., Geyer, Matthias, Gerlic, Motti, Masters, Seth L.
Published in Journal of allergy and clinical immunology (01.06.2021)
Published in Journal of allergy and clinical immunology (01.06.2021)
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Journal Article
Protein kinase R is an innate immune sensor of proteotoxic stress via accumulation of cytoplasmic IL-24
Davidson, Sophia, Yu, Chien-Hsiung, Steiner, Annemarie, Ebstein, Frédéric, Baker, Paul J, Jarur-Chamy, Valentina, Hrovat Schaale, Katja, Laohamonthonkul, Pawat, Kong, Klara, Calleja, Dale J, Harapas, Cassandra R, Balka, Katherine R, Mitchell, Jacob, Jackson, Jacob T, Geoghegan, Niall D, Moghaddas, Fiona, Rogers, Kelly L, Mayer-Barber, Katrin D, De Jesus, Adriana A, De Nardo, Dominic, Kile, Benjamin T, Sadler, Anthony J, Poli, M Cecilia, Krüger, Elke, Goldbach Mansky, Raphaela, Masters, Seth L
Published in Science immunology (11.02.2022)
Published in Science immunology (11.02.2022)
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Journal Article
DPP9 deficiency: An inflammasomopathy that can be rescued by lowering NLRP1/IL-1 signaling
Harapas, Cassandra R, Robinson, Kim S, Lay, Kenneth, Wong, Jasmine, Moreno Traspas, Ricardo, Nabavizadeh, Nasrin, Rass-Rothschild, Annick, Boisson, Bertrand, Drutman, Scott B, Laohamonthonkul, Pawat, Bonner, Devon, Xiong, Jingwei Rachel, Gorrell, Mark D, Davidson, Sophia, Yu, Chien-Hsiung, Fleming, Mark D, Gudera, Jonas, Stein, Jerry, Ben-Harosh, Miriam, Groopman, Emily, Shimamura, Akiko, Tamary, Hannah, Kayserili, Hülya, Hatipoğlu, Nevin, Casanova, Jean-Laurent, Bernstein, Jonathan A, Zhong, Franklin L, Masters, Seth L, Reversade, Bruno
Published in Science immunology (16.09.2022)
Published in Science immunology (16.09.2022)
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Journal Article
NLRP1 restricts butyrate producing commensals to exacerbate inflammatory bowel disease
Tye, Hazel, Yu, Chien-Hsiung, Simms, Lisa A, de Zoete, Marcel R, Kim, Man Lyang, Zakrzewski, Martha, Penington, Jocelyn S, Harapas, Cassandra R, Souza-Fonseca-Guimaraes, Fernando, Wockner, Leesa F, Preaudet, Adele, Mielke, Lisa A, Wilcox, Stephen A, Ogura, Yasunori, Corr, Sinead C, Kanojia, Komal, Kouremenos, Konstantinos A, De Souza, David P, McConville, Malcolm J, Flavell, Richard A, Gerlic, Motti, Kile, Benjamin T, Papenfuss, Anthony T, Putoczki, Tracy L, Radford-Smith, Graham L, Masters, Seth L
Published in Nature communications (13.09.2018)
Published in Nature communications (13.09.2018)
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Journal Article
Activation of STING due to COPI-deficiency
Steiner, Annemarie, Katja Hrovat Schaale, Prigione, Ignazia, De Nardo, Dominic, Dagley, Laura F, Chien-Hsiung, Yu, Laohamonthonkul, Pawat, Harapas, Cassandra R, Gantier, Michael P, Gattorno, Marco, Volpi, Stefano, Davidson, Sophia, Masters, Seth L
Published in bioRxiv (09.07.2020)
Published in bioRxiv (09.07.2020)
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Paper
DPP9 is an endogenous and direct inhibitor of the NLRP1 inflammasome that guards against human auto-inflammatory diseases
Zhong, Franklin L, Robinson, Kim, Lim, Chrissie, Harapas, Cassandra R, Chien-Hsiung, Yu, Xie, William, Sobota, Radoslaw M, Au, Veonice Bijin, Hopkins, Richard, Connolly, John E, Masters, Seth, Reversade, Bruno
Published in bioRxiv (07.02.2018)
Published in bioRxiv (07.02.2018)
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