Daclatasvir-Like Inhibitors of NS5A Block Early Biogenesis of Hepatitis C Virus–Induced Membranous Replication Factories, Independent of RNA Replication
Berger, Carola, Romero-Brey, Inés, Radujkovic, Danijela, Terreux, Raphael, Zayas, Margarita, Paul, David, Harak, Christian, Hoppe, Simone, Gao, Min, Penin, Francois, Lohmann, Volker, Bartenschlager, Ralf
Published in Gastroenterology (New York, N.Y. 1943) (01.11.2014)
Published in Gastroenterology (New York, N.Y. 1943) (01.11.2014)
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The lipid kinase phosphatidylinositol-4 kinase III alpha regulates the phosphorylation status of hepatitis C virus NS5A
Reiss, Simon, Harak, Christian, Romero-Brey, Inés, Radujkovic, Danijela, Klein, Rahel, Ruggieri, Alessia, Rebhan, Ilka, Bartenschlager, Ralf, Lohmann, Volker
Published in PLoS pathogens (01.05.2013)
Published in PLoS pathogens (01.05.2013)
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Novel perspectives for hepatitis A virus therapy revealed by comparative analysis of hepatitis C virus and hepatitis A virus RNA replication
Esser‐Nobis, Katharina, Harak, Christian, Schult, Philipp, Kusov, Yuri, Lohmann, Volker
Published in Hepatology (Baltimore, Md.) (01.08.2015)
Published in Hepatology (Baltimore, Md.) (01.08.2015)
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Modulation of the Host Lipid Landscape to Promote RNA Virus Replication: The Picornavirus Encephalomyocarditis Virus Converges on the Pathway Used by Hepatitis C Virus
Dorobantu, Cristina M, Albulescu, Lucian, Harak, Christian, Feng, Qian, van Kampen, Mirjam, Strating, Jeroen R P M, Gorbalenya, Alexander E, Lohmann, Volker, van der Schaar, Hilde M, van Kuppeveld, Frank J M
Published in PLoS pathogens (01.09.2015)
Published in PLoS pathogens (01.09.2015)
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Foot-and-mouth disease virus replicates independently of phosphatidylinositol 4-phosphate and type III phosphatidylinositol 4-kinases
Berryman, Stephen, Moffat, Katy, Harak, Christian, Lohmann, Volker, Jackson, Terry
Published in Journal of general virology (01.08.2016)
Published in Journal of general virology (01.08.2016)
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Tuning a cellular lipid kinase activity adapts hepatitis C virus to replication in cell culture
Harak, Christian, Meyrath, Max, Romero-Brey, Inés, Schenk, Christian, Gondeau, Claire, Schult, Philipp, Esser-Nobis, Katharina, Saeed, Mohsan, Neddermann, Petra, Schnitzler, Paul, Gotthardt, Daniel, Perez-del-Pulgar, Sofia, Neumann-Haefelin, Christoph, Thimme, Robert, Meuleman, Philip, Vondran, Florian W. R., De Francesco, Raffaele, Rice, Charles M., Bartenschlager, Ralf, Lohmann, Volker
Published in Nature microbiology (19.12.2016)
Published in Nature microbiology (19.12.2016)
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Mutations in Encephalomyocarditis Virus 3A Protein Uncouple the Dependency of Genome Replication on Host Factors Phosphatidylinositol 4-Kinase IIIα and Oxysterol-Binding Protein
Dorobantu, Cristina M, Albulescu, Lucian, Lyoo, Heyrhyoung, van Kampen, Mirjam, De Francesco, Raffaele, Lohmann, Volker, Harak, Christian, van der Schaar, Hilde M, Strating, Jeroen R P M, Gorbalenya, Alexander E, van Kuppeveld, Frank J M
Published in mSphere (01.05.2016)
Published in mSphere (01.05.2016)
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Erratum: Tuning a cellular lipid kinase activity adapts hepatitis C virus to replication in cell culture
Harak, Christian, Meyrath, Max, Romero-Brey, Inés, Schenk, Christian, Gondeau, Claire, Schult, Philipp, Esser-Nobis, Katharina, Saeed, Mohsan, Neddermann, Petra, Schnitzler, Paul, Gotthardt, Daniel, Perez-Del-Pulgar, Sofia, Neumann-Haefelin, Christoph, Thimme, Robert, Meuleman, Philip, Florian, W R Vondran, De Francesco, Raffaele, Rice, Charles M, Bartenschlager, Ralf, Lohmann, Volker
Published in Nature microbiology (23.01.2017)
Published in Nature microbiology (23.01.2017)
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Characterization of a Threonine-Rich Cluster in Hepatitis C Virus Nonstructural Protein 5A and Its Contribution to Hyperphosphorylation
Schenk, Christian, Meyrath, Max, Warnken, Uwe, Schnölzer, Martina, Mier, Walter, Harak, Christian, Lohmann, Volker
Published in Journal of virology (15.12.2018)
Published in Journal of virology (15.12.2018)
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PI4KIII inhibitor enviroxime impedes the replication of the hepatitis C virus by inhibiting PI3 kinases
Delang, Leen, Harak, Christian, Benkheil, Mohammed, Khan, Hayat, Leyssen, Pieter, Andrews, Martin, Lohmann, Volker, Neyts, Johan
Published in Journal of antimicrobial chemotherapy (01.12.2018)
Published in Journal of antimicrobial chemotherapy (01.12.2018)
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Mapping of functional domains of the lipid kinase phosphatidylinositol 4-kinase type III alpha involved in enzymatic activity and hepatitis C virus replication
Harak, Christian, Radujkovic, Danijela, Taveneau, Cyntia, Reiss, Simon, Klein, Rahel, Bressanelli, Stéphane, Lohmann, Volker
Published in Journal of virology (01.09.2014)
Published in Journal of virology (01.09.2014)
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Analysis of hepatitis C virus resistance to silibinin in vitro and in vivo points to a novel mechanism involving nonstructural protein 4B
Esser‐Nobis, Katharina, Romero‐Brey, Inés, Ganten, Tom M., Gouttenoire, Jérôme, Harak, Christian, Klein, Rahel, Schemmer, Peter, Binder, Marco, Schnitzler, Paul, Moradpour, Darius, Bartenschlager, Ralf, Polyak, Stephen J., Stremmel, Wolfgang, Penin, François, Eisenbach, Christoph, Lohmann, Volker
Published in Hepatology (Baltimore, Md.) (01.03.2013)
Published in Hepatology (Baltimore, Md.) (01.03.2013)
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Tyrphostin AG1478 Inhibits Encephalomyocarditis Virus and Hepatitis C Virus by Targeting Phosphatidylinositol 4-Kinase IIIα
Dorobantu, Cristina M, Harak, Christian, Klein, Rahel, van der Linden, Lonneke, Strating, Jeroen R P M, van der Schaar, Hilde M, Lohmann, Volker, van Kuppeveld, Frank J M
Published in Antimicrobial agents and chemotherapy (01.10.2016)
Published in Antimicrobial agents and chemotherapy (01.10.2016)
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Journal Article
Modulation of the Host Lipid Landscape to Promote RNA Virus Replication: The Picornavirus Encephalomyocarditis Virus Converges on the Pathway Used by Hepatitis C Virus: e1005185
Dorobantu, Cristina M, Albulescu, Lucian, Harak, Christian, Feng, Qian, Kampen, Mirjam van, Strating, R PM, Gorbalenya, Alexander E, Lohmann, Volker, Schaar, M vander, Kuppeveld, J Mvan
Published in PLoS pathogens (01.09.2015)
Published in PLoS pathogens (01.09.2015)
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Journal Article
Daclatasvir-like Inhibitors of NS5A Block Early Biogenesis of HCV-induced Membranous Replication Factories, Independent of RNA Replication
Berger, Carola, Romero-Brey, Inés, Radujkovic, Danijela, Terreux, Raphael, Zayas, Margarita, Paul, David, Harak, Christian, Hoppe, Simone, Gao, Min, Penin, Francois, Lohmann, Volker, Bartenschlager, Ralf
Published in Gastroenterology (New York, N.Y. 1943) (18.07.2014)
Published in Gastroenterology (New York, N.Y. 1943) (18.07.2014)
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The Lipid Kinase Phosphatidylinositol-4 Kinase III Alpha Regulates the Phosphorylation Status of Hepatitis C Virus NS5A: e1003359
Reiss, Simon, Harak, Christian, Romero-Brey, Inés, Radujkovic, Danijela, Klein, Rahel, Ruggieri, Alessia, Rebhan, Ilka, Bartenschlager, Ralf, Lohmann, Volker
Published in PLoS pathogens (01.05.2013)
Published in PLoS pathogens (01.05.2013)
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Journal Article
Erratum: Tuning a cellular lipid kinase activity adapts hepatitis C virus to replication in cell culture
Harak, Christian, Meyrath, Max, Romero-Brey, Inés, Schenk, Christian, Gondeau, Claire, Schult, Philipp, Esser-Nobis, Katharina, Saeed, Mohsan, Neddermann, Petra, Schnitzler, Paul, Gotthardt, Daniel, Perez-del-Pulgar, Sofia, Neumann-Haefelin, Christoph, Thimme, Robert, Meuleman, Philip, Florian, W. R. Vondran, De Francesco, Raffaele, Rice, Charles M., Bartenschlager, Ralf, Lohmann, Volker
Published in Nature microbiology (01.03.2017)
Published in Nature microbiology (01.03.2017)
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