Discovery of a Bromodomain and Extraterminal Inhibitor with a Low Predicted Human Dose through Synergistic Use of Encoded Library Technology and Fragment Screening
Wellaway, Christopher R, Amans, Dominique, Bamborough, Paul, Barnett, Heather, Bit, Rino A, Brown, Jack A, Carlson, Neil R, Chung, Chun-wa, Cooper, Anthony W. J, Craggs, Peter D, Davis, Robert P, Dean, Tony W, Evans, John P, Gordon, Laurie, Harada, Isobel L, Hirst, David J, Humphreys, Philip G, Jones, Katherine L, Lewis, Antonia J, Lindon, Matthew J, Lugo, Dave, Mahmood, Mahnoor, McCleary, Scott, Medeiros, Patricia, Mitchell, Darren J, O’Sullivan, Michael, Le Gall, Armelle, Patel, Vipulkumar K, Patten, Chris, Poole, Darren L, Shah, Rishi R, Smith, Jane E, Stafford, Kayleigh A. J, Thomas, Pamela J, Vimal, Mythily, Wall, Ian D, Watson, Robert J, Wellaway, Natalie, Yao, Gang, Prinjha, Rab K
Published in Journal of medicinal chemistry (23.01.2020)
Published in Journal of medicinal chemistry (23.01.2020)
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The heat shock protein 90 inhibitor, AT13387, displays a long duration of action in vitro and in vivo in non‐small cell lung cancer
Graham, Brent, Curry, Jayne, Smyth, Tomoko, Fazal, Lynsey, Feltell, Ruth, Harada, Isobel, Coyle, Joe, Williams, Brian, Reule, Matthias, Angove, Hayley, Cross, David M., Lyons, John, Wallis, Nicola G., Thompson, Neil T.
Published in Cancer science (01.03.2012)
Published in Cancer science (01.03.2012)
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Receptor-interacting protein 1 kinase inhibition therapeutically ameliorates experimental T cell-dependent colitis in mice
Gobbetti, Thomas, Berger, Scott B., Fountain, Kathryn, Slocombe, Tom, Rowles, Alison, Pearse, Gail, Harada, Isobel, Bertin, John, Haynes, Andrea C., Beal, Allison M.
Published in Cell death & disease (06.04.2020)
Published in Cell death & disease (06.04.2020)
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BET bromodomain inhibitors show anti-papillomavirus activity in vitro and block CRPV wart growth in vivo
Morse, Mary A., Balogh, Karla K., Brendle, Sarah A., Campbell, Colin A., Chen, Mao X., Furze, Rebecca C., Harada, Isobel L., Holyer, Ian D., Kumar, Umesh, Lee, Kevin, Prinjha, Rab K., Rüdiger, Martin, Seal, Jonathan T., Taylor, Simon, Witherington, Jason, Christensen, Neil D.
Published in Antiviral research (01.06.2018)
Published in Antiviral research (01.06.2018)
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Structure- and Property-Based Optimization of Efficient Pan-Bromodomain and Extra Terminal Inhibitors to Identify Oral and Intravenous Candidate I‑BET787
Hirst, David J., Bamborough, Paul, Al-Mahdi, Niam, Angell, Davina C., Barnett, Heather A., Baxter, Andrew, Bit, Rino A., Brown, Jack A., Chung, Chun-wa, Craggs, Peter D., Davis, Robert P., Demont, Emmanuel H., Ferrie, Alan, Gordon, Laurie J., Harada, Isobel, Ho, Tim C. T., Holyer, Ian D., Hooper-Greenhill, Edward, Jones, Katherine L., Lindon, Matthew J., Lovatt, Cerys, Lugo, David, Maller, Claire, McGonagle, Grant, Messenger, Cassie, Mitchell, Darren J., Pascoe, David D., Patel, Vipulkumar K., Patten, Christopher, Poole, Darren L., Shah, Rishi R., Rioja, Inmaculada, Stafford, Kayleigh A. J., Tape, Daniel, Taylor, Simon, Theodoulou, Natalie H., Tomlinson, Laura, Wall, Ian D., Wellaway, Christopher R., White, Gemma, Prinjha, Rab K., Humphreys, Philip G.
Published in Journal of medicinal chemistry (27.06.2024)
Published in Journal of medicinal chemistry (27.06.2024)
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Abstract A217: Comparison of long-term pharmacodynamic actions of the synthetic small molecule HSP90 inhibitor AT13387 in multiple xenograft models
Lyons, John, Curry, Jayne, Smyth, Tomoko, Harada, Isobel, Fazal, Lynsey, Reule, Matthias, Graham, Brent, Thompson, Neil
Published in Molecular cancer therapeutics (10.12.2009)
Published in Molecular cancer therapeutics (10.12.2009)
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Journal Article
The heat shock protein 90 inhibitor, AT 13387, displays a long duration of action in vitro and in vivo in non‐small cell lung cancer
Graham, Brent, Curry, Jayne, Smyth, Tomoko, Fazal, Lynsey, Feltell, Ruth, Harada, Isobel, Coyle, Joe, Williams, Brian, Reule, Matthias, Angove, Hayley, Cross, David M., Lyons, John, Wallis, Nicola G., Thompson, Neil T.
Published in Cancer science (01.03.2012)
Published in Cancer science (01.03.2012)
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Abstract 3626: Development of inhibitors of the fibroblast growth factor receptor (FGFR) kinase using a fragment based approach
Squires, Matthew S., Perera, Timothy, Saxty, Gordon, Murray, Chris, King, Peter, Ward, George, Feltell, Ruth, Rich, Sharna, Angibaud, Patrik, Lewis, Edward J., Gilissen, Ron, Harada, Isobel, Fazal, Lynsey, Irving, Julie A., Batey, Mike A., Zhao, Yan, Newell, David R., Thompson, Neil T.
Published in Cancer research (Chicago, Ill.) (15.04.2010)
Published in Cancer research (Chicago, Ill.) (15.04.2010)
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