The autoimmune disease-associated PTPN22 variant promotes calpain-mediated Lyp/Pep degradation associated with lymphocyte and dendritic cell hyperresponsiveness
Siminovitch, Katherine A, Zhang, Jinyi, Zahir, Naima, Jiang, Qiuhong, Miliotis, Helen, Heyraud, Stephanie, Meng, Xianwang, Dong, Baoxia, Xie, Gang, Qiu, Frank, Hao, Zhenyue, McCulloch, Christopher A, Keystone, Edward C, Peterson, Alan C
Published in Nature genetics (01.09.2011)
Published in Nature genetics (01.09.2011)
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Mutant IDH1 Downregulates ATM and Alters DNA Repair and Sensitivity to DNA Damage Independent of TET2
Inoue, Satoshi, Li, Wanda Y., Tseng, Alan, Beerman, Isabel, Elia, Andrew J., Bendall, Sean C., Lemonnier, François, Kron, Ken J., Cescon, David W., Hao, Zhenyue, Lind, Evan F., Takayama, Naoya, Planello, Aline C., Shen, Shu Yi, Shih, Alan H., Larsen, Dana M., Li, Qinxi, Snow, Bryan E., Wakeham, Andrew, Haight, Jillian, Gorrini, Chiara, Bassi, Christian, Thu, Kelsie L., Murakami, Kiichi, Elford, Alisha R., Ueda, Takeshi, Straley, Kimberly, Yen, Katharine E., Melino, Gerry, Cimmino, Luisa, Aifantis, Iannis, Levine, Ross L., De Carvalho, Daniel D., Lupien, Mathieu, Rossi, Derrick J., Nolan, Garry P., Cairns, Rob A., Mak, Tak W.
Published in Cancer cell (08.08.2016)
Published in Cancer cell (08.08.2016)
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Journal Article
Estrogen controls the survival of BRCA1-deficient cells via a PI3K–NRF2-regulated pathway
Gorrini, Chiara, Gang, Bevan P., Bassi, Christian, Wakeham, Andrew, Baniasadi, Shakiba Pegah, Hao, Zhenyue, Li, Wanda Y., Cescon, David W., Li, Yen-Ting, Molyneux, Sam, Penrod, Nadia, Lupien, Mathieu, Schmidt, Edward E., Stambolic, Vuk, Gauthier, Mona L., Mak, Tak W.
Published in Proceedings of the National Academy of Sciences - PNAS (25.03.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (25.03.2014)
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Mule/Huwe1/Arf-BP1 suppresses Ras-driven tumorigenesis by preventing c-Myc/Miz1-mediated down-regulation of p21 and p15
Inoue, Satoshi, Hao, Zhenyue, Elia, Andrew J, Cescon, David, Zhou, Lily, Silvester, Jennifer, Snow, Bryan, Harris, Isaac S, Sasaki, Masato, Li, Wanda Y, Itsumi, Momoe, Yamamoto, Kazuo, Ueda, Takeshi, Dominguez-Brauer, Carmen, Gorrini, Chiara, Chio, Iok In Christine, Haight, Jillian, You-Ten, Annick, McCracken, Susan, Wakeham, Andrew, Ghazarian, Danny, Penn, Linda J Z, Melino, Gerry, Mak, Tak W
Published in Genes & development (15.05.2013)
Published in Genes & development (15.05.2013)
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Journal Article
Mule determines the apoptotic response to HDAC inhibitors by targeted ubiquitination and destruction of HDAC2
Zhang, Jing, Kan, Shu, Huang, Brian, Hao, Zhenyue, Mak, Tak W, Zhong, Qing
Published in Genes & development (15.12.2011)
Published in Genes & development (15.12.2011)
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Journal Article
Tracking Germinal Center B Cells Expressing Germ-Line Immunoglobulin γ1 Transcripts by Conditional Gene Targeting
Casola, Stefano, Cattoretti, Giorgio, Uyttersprot, Nathalie, Koralov, Sergei B., Seagal, Jane, Segal, Jane, Hao, Zhenyue, Waisman, Ari, Egert, Angela, Ghitza, Dvora, Rajewsky, Klaus
Published in Proceedings of the National Academy of Sciences - PNAS (09.05.2006)
Published in Proceedings of the National Academy of Sciences - PNAS (09.05.2006)
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Journal Article
K48-linked KLF4 ubiquitination by E3 ligase Mule controls T-cell proliferation and cell cycle progression
Hao, Zhenyue, Sheng, Yi, Duncan, Gordon S., Li, Wanda Y., Dominguez, Carmen, Sylvester, Jennifer, Su, Yu-Wen, Lin, Gloria H.Y., Snow, Bryan E., Brenner, Dirk, You-Ten, Annick, Haight, Jillian, Inoue, Satoshi, Wakeham, Andrew, Elford, Alisha, Hamilton, Sara, Liang, Yi, Zúñiga-Pflücker, Juan C., He, Housheng Hansen, Ohashi, Pamela S., Mak, Tak W.
Published in Nature communications (13.01.2017)
Published in Nature communications (13.01.2017)
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The Rho-guanine nucleotide exchange factor PDZ-RhoGEF governs susceptibility to diet-induced obesity and type 2 diabetes
Chang, Ying-Ju, Pownall, Scott, Jensen, Thomas E, Mouaaz, Samar, Foltz, Warren, Zhou, Lily, Liadis, Nicole, Woo, Minna, Hao, Zhenyue, Dutt, Previn, Bilan, Philip J, Klip, Amira, Mak, Tak, Stambolic, Vuk
Published in eLife (29.10.2015)
Published in eLife (29.10.2015)
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Ablation of thymic export causes accelerated decay of naïve CD4 T cells in the periphery because of activation by environmental antigen
Bourgeois, Christine, Hao, Zhenyue, Rajewsky, Klaus, Potocnik, Alexandre J, Stockinger, Brigitta
Published in Proceedings of the National Academy of Sciences - PNAS (24.06.2008)
Published in Proceedings of the National Academy of Sciences - PNAS (24.06.2008)
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Journal Article
Idh1 mutations contribute to the development of T-cell malignancies in genetically engineered mice
Hao, Zhenyue, Cairns, Rob A., Inoue, Satoshi, Li, Wanda Y., Sheng, Yi, Lemonnier, François, Wakeham, Andrew, Snow, Bryan E., Dominguez-Brauer, Carmen, Ye, Jing, Larsen, Dana M., Straley, Kimberly S., Tobin, Erica R., Narayanaswamy, Rohini, Gaulard, Philippe, Mak, Tak W.
Published in Proceedings of the National Academy of Sciences - PNAS (02.02.2016)
Published in Proceedings of the National Academy of Sciences - PNAS (02.02.2016)
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Specific Ablation of the Apoptotic Functions of Cytochrome c Reveals a Differential Requirement for Cytochrome c and Apaf-1 in Apoptosis
Hao, Zhenyue, Duncan, Gordon S., Chang, Chia-Che, Elia, Andrew, Fang, Min, Wakeham, Andrew, Okada, Hitoshi, Calzascia, Thomas, Jang, YingJu, You-Ten, Annick, Yeh, Wen-Chen, Ohashi, Pamela, Wang, Xiaodong, Mak, Tak W.
Published in Cell (20.05.2005)
Published in Cell (20.05.2005)
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Journal Article
The E3 ubiquitin ligase Mule acts through the ATM-p53 axis to maintain B lymphocyte homeostasis
Hao, Zhenyue, Duncan, Gordon S, Su, Yu-Wen, Li, Wanda Y, Silvester, Jennifer, Hong, Claire, You, Han, Brenner, Dirk, Gorrini, Chiara, Haight, Jillian, Wakeham, Andrew, You-Ten, Annick, McCracken, Susan, Elia, Andrew, Li, Qinxi, Detmar, Jacqui, Jurisicova, Andrea, Hobeika, Elias, Reth, Michael, Sheng, Yi, Lang, Philipp A, Ohashi, Pamela S, Zhong, Qing, Wang, Xiaodong, Mak, Tak W
Published in The Journal of experimental medicine (16.01.2012)
Published in The Journal of experimental medicine (16.01.2012)
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Journal Article
Autophagy-independent functions of UVRAG are essential for peripheral naive T-cell homeostasis
Afzal, Samia, Hao, Zhenyue, Itsumi, Momoe, Abouelkheer, Yasser, Brenner, Dirk, Gao, Yunfei, Wakeham, Andrew, Hong, Claire, Li, Wanda Y., Sylvester, Jennifer, Gilani, Syed O., Brüstle, Anne, Haight, Jillian, You-Ten, Annick J., Lin, Gloria H. Y., Inoue, Satoshi, Mak, Tak W.
Published in Proceedings of the National Academy of Sciences - PNAS (27.01.2015)
Published in Proceedings of the National Academy of Sciences - PNAS (27.01.2015)
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Journal Article
Crucial role for TNF receptor-associated factor 2 (TRAF2) in regulating NFκB2 signaling that contributes to autoimmunity
Lin, Wen-Jye, Su, Yu-Wen, Lu, Yong-Chen, Hao, Zhenyue, Chio, Iok In Christine, Chen, Nien-Jung, Brüstle, Anne, Li, Wanda Y, Mak, Tak Wah
Published in Proceedings of the National Academy of Sciences - PNAS (08.11.2011)
Published in Proceedings of the National Academy of Sciences - PNAS (08.11.2011)
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Journal Article
Mule Regulates the Intestinal Stem Cell Niche via the Wnt Pathway and Targets EphB3 for Proteasomal and Lysosomal Degradation
Dominguez-Brauer, Carmen, Hao, Zhenyue, Elia, Andrew J., Fortin, Jérôme M., Nechanitzky, Robert, Brauer, Patrick M., Sheng, Yi, Mana, Miyeko D., Chio, Iok In Christine, Haight, Jillian, Pollett, Aaron, Cairns, Robert, Tworzyanski, Leanne, Inoue, Satoshi, Reardon, Colin, Marques, Ana, Silvester, Jennifer, Cox, Maureen A., Wakeham, Andrew, Yilmaz, Omer H., Sabatini, David M., van Es, Johan H., Clevers, Hans, Sato, Toshiro, Mak, Tak W.
Published in Cell stem cell (04.08.2016)
Published in Cell stem cell (04.08.2016)
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Journal Article
Dichotomous role of pancreatic HUWE1/MULE/ARF-BP1 in modulating beta cell apoptosis in mice under physiological and genotoxic conditions
Wang, Linyuan, Luk, Cynthia T., Schroer, Stephanie A., Smith, Alannah M., Li, Xie, Cai, Erica P., Gaisano, Herbert, MacDonald, Patrick E., Hao, Zhenyue, Mak, Tak W., Woo, Minna
Published in Diabetologia (01.09.2014)
Published in Diabetologia (01.09.2014)
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Apoptosis of Oligodendrocytes via Fas and TNF-R1 Is a Key Event in the Induction of Experimental Autoimmune Encephalomyelitis
Hovelmeyer, Nadine, Hao, Zhenyue, Kranidioti, Ksanthi, Kassiotis, George, Buch, Thorsten, Frommer, Friederike, von Hoch, Lennart, Kramer, Dana, Minichiello, Liliana, Kollias, George, Lassmann, Hans, Waisman, Ari
Published in The Journal of immunology (1950) (01.11.2005)
Published in The Journal of immunology (1950) (01.11.2005)
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Journal Article
XB130 deficiency affects tracheal epithelial differentiation during airway repair
Zhao, Jinbo, Wang, Yingchun, Wakeham, Andrew, Hao, Zhenyue, Toba, Hiroaki, Bai, Xiaohui, Keshavjee, Shaf, Mak, Tak W, Liu, Mingyao
Published in PloS one (01.10.2014)
Published in PloS one (01.10.2014)
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