IMI – Oral biopharmaceutics tools project – Evaluation of bottom-up PBPK prediction success part 2: An introduction to the simulation exercise and overview of results
Margolskee, Alison, Darwich, Adam S., Pepin, Xavier, Aarons, Leon, Galetin, Aleksandra, Rostami-Hodjegan, Amin, Carlert, Sara, Hammarberg, Maria, Hilgendorf, Constanze, Johansson, Pernilla, Karlsson, Eva, Murphy, Dónal, Tannergren, Christer, Thörn, Helena, Yasin, Mohammed, Mazuir, Florent, Nicolas, Olivier, Ramusovic, Sergej, Xu, Christine, Pathak, Shriram M., Korjamo, Timo, Laru, Johanna, Malkki, Jussi, Pappinen, Sari, Tuunainen, Johanna, Dressman, Jennifer, Hansmann, Simone, Kostewicz, Edmund, He, Handan, Heimbach, Tycho, Wu, Fan, Hoft, Carolin, Laplanche, Loic, Pang, Yan, Bolger, Michael B., Huehn, Eva, Lukacova, Viera, Mullin, James M., Szeto, Ke X., Costales, Chester, Lin, Jian, McAllister, Mark, Modi, Sweta, Rotter, Charles, Varma, Manthena, Wong, Mei, Mitra, Amitava, Bevernage, Jan, Biewenga, Jeike, Van Peer, Achiel, Lloyd, Richard, Shardlow, Carole, Langguth, Peter, Mishenzon, Irina, Nguyen, Mai Anh, Brown, Jonathan, Lennernäs, Hans, Abrahamsson, Bertil
Published in European journal of pharmaceutical sciences (01.01.2017)
Published in European journal of pharmaceutical sciences (01.01.2017)
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An in silico approach to determine challenges in the bioavailability of ciprofloxacin, a poorly soluble weak base with borderline solubility and permeability characteristics
Hansmann, Simone, Miyaji, Yoshihiro, Dressman, Jennifer
Published in European journal of pharmaceutics and biopharmaceutics (01.01.2018)
Published in European journal of pharmaceutics and biopharmaceutics (01.01.2018)
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Journal Article
Forecasting oral absorption across biopharmaceutics classification system classes with physiologically based pharmacokinetic models
Hansmann, Simone, Darwich, Adam, Margolskee, Alison, Aarons, Leon, Dressman, Jennifer
Published in Journal of pharmacy and pharmacology (01.12.2016)
Published in Journal of pharmacy and pharmacology (01.12.2016)
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Journal Article
Usefulness of the BioGIT system in screening for differences in early exposure in the fasted state on an a priori basis
Kostantini, Christina, Spilioti, Evanthia, Bevernage, Jan, Ceulemans, Jens, Hansmann, Simone, Hellemans, Katleen, Jede, Christian, Kourentas, Alexandros, Reggane, Maude, Shah, Lipa, Wagner, Christian, Reppas, Christos, Vertzoni, Maria
Published in International journal of pharmaceutics (05.03.2023)
Published in International journal of pharmaceutics (05.03.2023)
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Screening for Differences in Early Exposure in the Fasted State with in Vitro Methodologies can be Challenging: Experience with the BioGIT System
Kostantini, Christina, Spilioti, Evanthia, Bevernage, Jan, Ceulemans, Jens, Hansmann, Simone, Hellemans, Katleen, Jede, Christian, Kourentas, Alexandros, Reggane, Maude, Shah, Lipa, Wagner, Christian, Vertzoni, Maria, Reppas, Christos
Published in Journal of pharmaceutical sciences (01.08.2023)
Published in Journal of pharmaceutical sciences (01.08.2023)
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Journal Article
An IQ Consortium Perspective on Connecting Dissolution Methods to In Vivo Performance: Analysis of an Industrial Database and Case Studies to Propose a Workflow
Aburub, Aktham, Chen, Yuan, Chung, John, Gao, Ping, Good, David, Hansmann, Simone, Hawley, Michael, Heimbach, Tycho, Hingle, Martin, Kesisoglou, Filippos, Li, Rong, Rose, John, Tisaert, Christophe
Published in The AAPS journal (01.05.2022)
Published in The AAPS journal (01.05.2022)
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Integration of advanced methods and models to study drug absorption and related processes: An UNGAP perspective
Wilson, Clive G., Aarons, Leon, Augustijns, Patrick, Brouwers, Joachim, Darwich, Adam S., De Waal, Tom, Garbacz, Grzegorz, Hansmann, Simone, Hoc, Dagmara, Ivanova, Anela, Koziolek, Mirko, Reppas, Christos, Schick, Philipp, Vertzoni, Maria, García-Horsman, J. Arturo
Published in European journal of pharmaceutical sciences (01.05.2022)
Published in European journal of pharmaceutical sciences (01.05.2022)
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IMI – Oral biopharmaceutics tools project – Evaluation of bottom-up PBPK prediction success part 3: Identifying gaps in system parameters by analysing In Silico performance across different compound classes
Darwich, Adam S., Margolskee, Alison, Pepin, Xavier, Aarons, Leon, Galetin, Aleksandra, Rostami-Hodjegan, Amin, Carlert, Sara, Hammarberg, Maria, Hilgendorf, Constanze, Johansson, Pernilla, Karlsson, Eva, Murphy, Dónal, Tannergren, Christer, Thörn, Helena, Yasin, Mohammed, Mazuir, Florent, Nicolas, Olivier, Ramusovic, Sergej, Xu, Christine, Pathak, Shriram M., Korjamo, Timo, Laru, Johanna, Malkki, Jussi, Pappinen, Sari, Tuunainen, Johanna, Dressman, Jennifer, Hansmann, Simone, Kostewicz, Edmund, He, Handan, Heimbach, Tycho, Wu, Fan, Hoft, Carolin, Pang, Yan, Bolger, Michael B., Huehn, Eva, Lukacova, Viera, Mullin, James M., Szeto, Ke X., Costales, Chester, Lin, Jian, McAllister, Mark, Modi, Sweta, Rotter, Charles, Varma, Manthena, Wong, Mei, Mitra, Amitava, Bevernage, Jan, Biewenga, Jeike, Van Peer, Achiel, Lloyd, Richard, Shardlow, Carole, Langguth, Peter, Mishenzon, Irina, Nguyen, Mai Anh, Brown, Jonathan, Lennernäs, Hans, Abrahamsson, Bertil
Published in European journal of pharmaceutical sciences (01.01.2017)
Published in European journal of pharmaceutical sciences (01.01.2017)
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Journal Article