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Published in Proceedings of the National Academy of Sciences - PNAS (01.07.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (01.07.2014)
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RVX-208, an inducer of ApoA-I in humans, is a BET bromodomain antagonist
McLure, Kevin G, Gesner, Emily M, Tsujikawa, Laura, Kharenko, Olesya A, Attwell, Sarah, Campeau, Eric, Wasiak, Sylwia, Stein, Adam, White, Andre, Fontano, Eric, Suto, Robert K, Wong, Norman C W, Wagner, Gregory S, Hansen, Henrik C, Young, Peter R
Published in PloS one (31.12.2013)
Published in PloS one (31.12.2013)
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RVX-297, a BET Bromodomain Inhibitor, Has Therapeutic Effects in Preclinical Models of Acute Inflammation and Autoimmune Disease
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Published in Molecular pharmacology (01.12.2017)
Published in Molecular pharmacology (01.12.2017)
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RVX-297- a novel BD2 selective inhibitor of BET bromodomains
Kharenko, Olesya A., Gesner, Emily M., Patel, Reena G., Norek, Karen, White, Andre, Fontano, Eric, Suto, Robert K., Young, Peter R., McLure, Kevin G., Hansen, Henrik C.
Published in Biochemical and biophysical research communications (12.08.2016)
Published in Biochemical and biophysical research communications (12.08.2016)
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In vitro biosynthesis, isolation, and identification of predominant metabolites of 2-(4-(2-hydroxyethoxy)-3,5-dimethylphenyl)-5,7-dimethoxyquinazolin-4(3H)-one (RVX-208)
Khmelnitsky, Yuri L., Mozhaev, Vadim V., Cotterill, Ian C., Michels, Peter C., Boudjabi, Sihem, Khlebnikov, Vladimir, Madhava Reddy, M., Wagner, Gregory S., Hansen, Henrik C.
Published in European journal of medicinal chemistry (01.06.2013)
Published in European journal of medicinal chemistry (01.06.2013)
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Synthesis of NVS-BPTF-1 and evaluation of its biological activity
Mélin, Léa, Calosing, Cyrus, Kharenko, Olesya A., Hansen, Henrik C., Gagnon, Alexandre
Published in Bioorganic & medicinal chemistry letters (01.09.2021)
Published in Bioorganic & medicinal chemistry letters (01.09.2021)
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A novel BET bromodomain inhibitor, RVX-208, shows reduction of atherosclerosis in hyperlipidemic ApoE deficient mice
Jahagirdar, Ravi, Zhang, Haiyan, Azhar, Salman, Tobin, Jennifer, Attwell, Sarah, Yu, Raymond, Wu, Jin, McLure, Kevin G, Hansen, Henrik C, Wagner, Gregory S, Young, Peter R, Srivastava, Rai Ajit K, Wong, Norman C.W, Johansson, Jan
Published in Atherosclerosis (01.09.2014)
Published in Atherosclerosis (01.09.2014)
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RVX-208: A Small Molecule That Increases Apolipoprotein A-I and High-Density Lipoprotein Cholesterol In Vitro and In Vivo
BAILEY, Dana, JAHAGIRDAR, Ravi, KRIMBOU, Larbi, WONG, Norman C. W, GENEST, Jacques, GORDON, Allan, HAFIANE, Anouar, CAMPBELL, Steven, CHATUR, Safia, WAGNER, Gregory S, HANSEN, Henrik C, CHIACCHIA, Fabrizio S, JOHANSSON, Jan
Published in Journal of the American College of Cardiology (08.06.2010)
Published in Journal of the American College of Cardiology (08.06.2010)
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Design and Characterization of Novel Covalent Bromodomain and Extra-Terminal Domain (BET) Inhibitors Targeting a Methionine
Kharenko, Olesya A, Patel, Reena G, Brown, S. David, Calosing, Cyrus, White, Andre, Lakshminarasimhan, Damodharan, Suto, Robert K, Duffy, Bryan C, Kitchen, Douglas B, McLure, Kevin G, Hansen, Henrik C, van der Horst, Edward H, Young, Peter R
Published in Journal of medicinal chemistry (27.09.2018)
Published in Journal of medicinal chemistry (27.09.2018)
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Discovery of a new chemical series of BRD4(1) inhibitors using protein-ligand docking and structure-guided design
Duffy, Bryan C., Liu, Shuang, Martin, Gregory S., Wang, Ruifang, Hsia, Ming Min, Zhao, He, Guo, Cheng, Ellis, Michael, Quinn, John F., Kharenko, Olesya A., Norek, Karen, Gesner, Emily M., Young, Peter R., McLure, Kevin G., Wagner, Gregory S., Lakshminarasimhan, Damodharan, White, Andre, Suto, Robert K., Hansen, Henrik C., Kitchen, Douglas B.
Published in Bioorganic & medicinal chemistry letters (15.07.2015)
Published in Bioorganic & medicinal chemistry letters (15.07.2015)
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Identification of Novel Macrocyclic Peptidase Substrates via On-Bead Enzymatic Cyclization
Hansen, Kristina K, Hansen, Henrik C, Clark, Ryan C, Bartlett, Paul A
Published in Journal of organic chemistry (31.10.2003)
Published in Journal of organic chemistry (31.10.2003)
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Stilbene analogs as inducers of apolipoprotein-I transcription
Hansen, Henrik C., Chiacchia, Fabrizio S., Patel, Reena, Wong, Norman C.W., Khlebnikov, Vladimir, Jankowska, Renata, Patel, Kalpesh, Reddy, M. Madhava
Published in European journal of medicinal chemistry (01.05.2010)
Published in European journal of medicinal chemistry (01.05.2010)
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Novel anti-inflammatory agents
KULIKOWSKI EWELINA B, ATTWELL SARAH C, HANSEN HENRIK C, WAGNER GREGORY S, MCLURE KEVIN G
Year of Publication 07.10.2020
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Year of Publication 07.10.2020
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