Optimized libraries for CRISPR-Cas9 genetic screens with multiple modalities
Sanson, Kendall R, Hanna, Ruth E, Hegde, Mudra, Donovan, Katherine F, Strand, Christine, Sullender, Meagan E, Vaimberg, Emma W, Goodale, Amy, Root, David E, Piccioni, Federica, Doench, John G
Published in Nature communications (21.12.2018)
Published in Nature communications (21.12.2018)
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Genetic screens in isogenic mammalian cell lines without single cell cloning
DeWeirdt, Peter C, Sangree, Annabel K, Hanna, Ruth E, Sanson, Kendall R, Hegde, Mudra, Strand, Christine, Persky, Nicole S, Doench, John G
Published in Nature communications (06.02.2020)
Published in Nature communications (06.02.2020)
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Optimization of AsCas12a for combinatorial genetic screens in human cells
DeWeirdt, Peter C, Sanson, Kendall R, Sangree, Annabel K, Hegde, Mudra, Hanna, Ruth E, Feeley, Marissa N, Griffith, Audrey L, Teng, Teng, Borys, Samantha M, Strand, Christine, Joung, J Keith, Kleinstiver, Benjamin P, Pan, Xuewen, Huang, Alan, Doench, John G
Published in Nature biotechnology (01.01.2021)
Published in Nature biotechnology (01.01.2021)
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CRISPR-Switch regulates sgRNA activity by Cre recombination for sequential editing of two loci
Chylinski, Krzysztof, Hubmann, Maria, Hanna, Ruth E, Yanchus, Connor, Michlits, Georg, Uijttewaal, Esther C H, Doench, John, Schramek, Daniel, Elling, Ulrich
Published in Nature communications (29.11.2019)
Published in Nature communications (29.11.2019)
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DYRK1A promotes viral entry of highly pathogenic human coronaviruses in a kinase-independent manner
Strine, Madison S, Cai, Wesley L, Wei, Jin, Alfajaro, Mia Madel, Filler, Renata B, Biering, Scott B, Sarnik, Sylvia, Chow, Ryan D, Patil, Ajinkya, Cervantes, Kasey S, Collings, Clayton K, DeWeirdt, Peter C, Hanna, Ruth E, Schofield, Kevin, Hulme, Christopher, Konermann, Silvana, Doench, John G, Hsu, Patrick D, Kadoch, Cigall, Yan, Qin, Wilen, Craig B
Published in PLoS biology (13.06.2023)
Published in PLoS biology (13.06.2023)
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Transforming Growth Factor Beta and Epithelial to Mesenchymal Transition Alter Homologous Recombination Repair Gene Expression and Sensitize BRCA Wild-Type Ovarian Cancer Cells to Olaparib
Roberts, Cai M, Rojas-Alexandre, Mehida, Hanna, Ruth E, Lin, Z Ping, Ratner, Elena S
Published in Cancers (01.08.2023)
Published in Cancers (01.08.2023)
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Positive selection CRISPR screens reveal a druggable pocket in an oligosaccharyltransferase required for inflammatory signaling to NF-κB
Lampson, Benjamin L., Ramίrez, Ana S., Baro, Marta, He, Lixia, Hegde, Mudra, Koduri, Vidyasagar, Pfaff, Jamie L., Hanna, Ruth E., Kowal, Julia, Shirole, Nitin H., He, Yanfeng, Doench, John G., Contessa, Joseph N., Locher, Kaspar P., Kaelin, William G.
Published in Cell (25.04.2024)
Published in Cell (25.04.2024)
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Pharmacological disruption of mSWI/SNF complex activity restricts SARS-CoV-2 infection
Wei, Jin, Patil, Ajinkya, Collings, Clayton K, Alfajaro, Mia Madel, Liang, Yu, Cai, Wesley L, Strine, Madison S, Filler, Renata B, DeWeirdt, Peter C, Hanna, Ruth E, Menasche, Bridget L, Ökten, Arya, Peña-Hernández, Mario A, Klein, Jon, McNamara, Andrew, Rosales, Romel, McGovern, Briana L, Luis Rodriguez, M, García-Sastre, Adolfo, White, Kris M, Qin, Yiren, Doench, John G, Yan, Qin, Iwasaki, Akiko, Zwaka, Thomas P, Qi, Jun, Kadoch, Cigall, Wilen, Craig B
Published in Nature genetics (01.03.2023)
Published in Nature genetics (01.03.2023)
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Genome-wide CRISPR Screens Reveal Host Factors Critical for SARS-CoV-2 Infection
Wei, Jin, Alfajaro, Mia Madel, DeWeirdt, Peter C., Hanna, Ruth E., Lu-Culligan, William J., Cai, Wesley L., Strine, Madison S., Zhang, Shang-Min, Graziano, Vincent R., Schmitz, Cameron O., Chen, Jennifer S., Mankowski, Madeleine C., Filler, Renata B., Ravindra, Neal G., Gasque, Victor, de Miguel, Fernando J., Patil, Ajinkya, Chen, Huacui, Oguntuyo, Kasopefoluwa Y., Abriola, Laura, Surovtseva, Yulia V., Orchard, Robert C., Lee, Benhur, Lindenbach, Brett D., Politi, Katerina, van Dijk, David, Kadoch, Cigall, Simon, Matthew D., Yan, Qin, Doench, John G., Wilen, Craig B.
Published in Cell (07.01.2021)
Published in Cell (07.01.2021)
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Genome-wide CRISPR screen reveals host genes that regulate SARS-CoV-2 infection
Wei, Jin, Alfajaro, Mia Madel, Hanna, Ruth E, DeWeirdt, Peter C, Strine, Madison S, Lu-Culligan, William J, Zhang, Shang-Min, Graziano, Vincent R, Schmitz, Cameron O, Chen, Jennifer S, Mankowski, Madeleine C, Filler, Renata B, Gasque, Victor, de Miguel, Fernando, Chen, Huacui, Oguntuyo, Kasopefoluwa, Abriola, Laura, Surovtseva, Yulia V, Orchard, Robert C, Lee, Benhur, Lindenbach, Brett, Politi, Katerina, van Dijk, David, Simon, Matthew D, Yan, Qin, Doench, John G, Wilen, Craig B
Published in bioRxiv : the preprint server for biology (17.06.2020)
Published in bioRxiv : the preprint server for biology (17.06.2020)
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Optimization of AsCas12a for combinatorial genetic screens in human cells
Sanson, Kendall R, Deweirdt, Peter C, Sangree, Annabel K, Hanna, Ruth E, Hegde, Mudra, Teng, Teng, Borys, Samantha M, Strand, Christine, Joung, J Keith, Kleinstiver, Benjamin P, Pan, Xuewen, Huang, Alan, Doench, John G
Published in bioRxiv (28.08.2019)
Published in bioRxiv (28.08.2019)
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Up, down, and out: optimized libraries for CRISPRa, CRISPRi, and CRISPR-knockout genetic screens
Sanson, Kendall R, Hanna, Ruth E, Hegde, Mudra, Donovan, Katherine F, Strand, Christine, Sullender, Meagan E, Vaimberg, Emma W, Goodale, Amy, Root, David E, Piccioni, Federica, Doench, John G
Published in bioRxiv (02.07.2018)
Published in bioRxiv (02.07.2018)
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