Discovery of Small-Molecule Antagonists of the PWWP Domain of NSD2
Ferreira de Freitas, Renato, Liu, Yanli, Szewczyk, Magdalena M, Mehta, Naimee, Li, Fengling, McLeod, David, Zepeda-Velázquez, Carlos, Dilworth, David, Hanley, Ronan P, Gibson, Elisa, Brown, Peter J, Al-Awar, Rima, James, Lindsey I, Arrowsmith, Cheryl H, Barsyte-Lovejoy, Dalia, Min, Jinrong, Vedadi, Masoud, Schapira, Matthieu, Allali-Hassani, Abdellah
Published in Journal of medicinal chemistry (11.02.2021)
Published in Journal of medicinal chemistry (11.02.2021)
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Discovery of a Potent and Selective Targeted NSD2 Degrader for the Reduction of H3K36me2
Hanley, Ronan P., Nie, David Y., Tabor, John R., Li, Fengling, Sobh, Amin, Xu, Chenxi, Barker, Natalie K., Dilworth, David, Hajian, Taraneh, Gibson, Elisa, Szewczyk, Magdalena M., Brown, Peter J., Barsyte-Lovejoy, Dalia, Herring, Laura E., Wang, Gang Greg, Licht, Jonathan D., Vedadi, Masoud, Arrowsmith, Cheryl H., James, Lindsey I.
Published in Journal of the American Chemical Society (12.04.2023)
Published in Journal of the American Chemical Society (12.04.2023)
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A chemical probe targeting the PWWP domain alters NSD2 nucleolar localization
Dilworth, David, Hanley, Ronan P., Ferreira de Freitas, Renato, Allali-Hassani, Abdellah, Zhou, Mengqi, Mehta, Naimee, Marunde, Matthew R., Ackloo, Suzanne, Carvalho Machado, Raquel Arminda, Khalili Yazdi, Aliakbar, Owens, Dominic D. G., Vu, Victoria, Nie, David Y., Alqazzaz, Mona, Marcon, Edyta, Li, Fengling, Chau, Irene, Bolotokova, Albina, Qin, Su, Lei, Ming, Liu, Yanli, Szewczyk, Magdalena M., Dong, Aiping, Kazemzadeh, Sina, Abramyan, Tigran, Popova, Irina K., Hall, Nathan W., Meiners, Matthew J., Cheek, Marcus A., Gibson, Elisa, Kireev, Dmitri, Greenblatt, Jack F., Keogh, Michael-C., Min, Jinrong, Brown, Peter J., Vedadi, Masoud, Arrowsmith, Cheryl H., Barsyte-Lovejoy, Dalia, James, Lindsey I., Schapira, Matthieu
Published in Nature chemical biology (01.01.2022)
Published in Nature chemical biology (01.01.2022)
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Targeting Regorafenib-Induced Toxicity through Inhibition of Gut Microbial β‑Glucuronidases
Ervin, Samantha M, Hanley, Ronan P, Lim, Lauren, Walton, William G, Pearce, Kenneth H, Bhatt, Aadra P, James, Lindsey I, Redinbo, Matthew R
Published in ACS chemical biology (20.12.2019)
Published in ACS chemical biology (20.12.2019)
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PROTAC Linkerology Leads to an Optimized Bivalent Chemical Degrader of Polycomb Repressive Complex 2 (PRC2) Components
Bashore, Frances M., Foley, Caroline A., Ong, Han Wee, Rectenwald, Justin M., Hanley, Ronan P., Norris-Drouin, Jacqueline L., Cholensky, Stephanie H., Mills, Christine A., Pearce, Kenneth H., Herring, Laura E., Kireev, Dmitri, Frye, Stephen V., James, Lindsey I.
Published in ACS chemical biology (17.03.2023)
Published in ACS chemical biology (17.03.2023)
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Recruitment of FBXO22 for targeted degradation of NSD2
Nie, David Y, Tabor, John R, Li, Jianping, Kutera, Maria, St-Germain, Jonathan, Hanley, Ronan P, Wolf, Esther, Paulakonis, Ethan, Kenney, Tristan M G, Duan, Shili, Shrestha, Suman, Owens, Dominic D G, Maitland, Matthew E R, Pon, Ailing, Szewczyk, Magdalena, Lamberto, Anthony Joseph, Menes, Michael, Li, Fengling, Penn, Linda Z, Barsyte-Lovejoy, Dalia, Brown, Nicholas G, Barsotti, Anthony M, Stamford, Andrew W, Collins, Jon L, Wilson, Derek J, Raught, Brian, Licht, Jonathan D, James, Lindsey I, Arrowsmith, Cheryl H
Published in Nature chemical biology (04.07.2024)
Published in Nature chemical biology (04.07.2024)
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Salicylates are interference compounds in TR-FRET assays
Hanley, Ronan P., Horvath, Shanti, An, Jianghong, Hof, Fraser, Wulff, Jeremy E.
Published in Bioorganic & medicinal chemistry letters (01.02.2016)
Published in Bioorganic & medicinal chemistry letters (01.02.2016)
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ISX-9 can potentiate cell proliferation and neuronal commitment in the rat dentate gyrus
Bettio, Luis E.B, Patten, Anna R, Gil-Mohapel, Joana, O’Rourke, Natasha F, Hanley, Ronan P, Kennedy, Samantha, Gopalakrishnan, Karthik, Rodrigues, Ana Lúcia S, Wulff, Jeremy, Christie, Brian R
Published in Neuroscience (22.09.2016)
Published in Neuroscience (22.09.2016)
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Effects of Isx-9 and stress on adult hippocampal neurogenesis: Experimental considerations and future perspectives
Bettio, Luis E. B., Gil-Mohapel, Joana, Patten, Anna R., O'Rourke, Natasha F., Hanley, Ronan P., Gopalakrishnan, Karthik, Wulff, Jeremy E., Christie, Brian R.
Published in Neurogenesis (Philadelphia, Pa.) (2017)
Published in Neurogenesis (Philadelphia, Pa.) (2017)
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Recruitment of FBXO22 for Targeted Degradation of NSD2
Nie, David Y, Tabor, John R, Li, Jianping, Kutera, Maria, St-Germain, Jonathan, Hanley, Ronan P, Wolf, Esther, Paulakonis, Ethan, Kenney, Tristan M G, Duan, Shili, Shrestha, Suman, Owens, Dominic D G, Pon, Ailing, Szewczyk, Magdalena, Lamberto, Anthony Joseph, Menes, Michael, Li, Fengling, Barsyte-Lovejoy, Dalia, Brown, Nicholas G, Barsotti, Anthony M, Stamford, Andrew W, Collins, Jon L, Wilson, Derek J, Raught, Brian, Licht, Jonathan D, James, Lindsey I, Arrowsmith, Cheryl H
Published in bioRxiv (30.11.2023)
Published in bioRxiv (30.11.2023)
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Journal Article
Discovery of Small-Molecule Antagonists of the PWWP Domain of NSD2
Ferreira De Freitas, Renato, Liu, Yanli, Szewczyk, Magdalena M, Mehta, Naimee, Li, Fengling, Mcleod, David, Zepeda-Velázquez, Carlos, Dilworth, David, Hanley, Ronan P, Gibson, Elisa, Brown, Peter J, Al-Awar, Rima, Lindsey Ingerman James, Arrowsmith, Cheryl H, Barsyte-Lovejoy, Dalia, Min, Jinrong, Vedadi, Masoud, Schapira, Matthieu, Allali-Hassani, Abdellah
Published in bioRxiv (27.11.2020)
Published in bioRxiv (27.11.2020)
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Pharmacological targeting of a PWWP domain demonstrates cooperative control of NSD2 localization
Dilworth, David, Hanley, Ronan P, Ferreira De Freitas, Renato, Allali-Hassani, Abdellah, Zhou, Mengqi, Mehta, Naimee, Marunde, Matthew R, Ackloo, Suzanne, Marcon, Edyta, Li, Fengling, Chau, Irene, Bolotokova, Albina, Su, Qin, Lei, Ming, Liu, Yanli, Szewczyk, Magdalena M, Dong, Aiping, Kazemzadeh, Sina, Abramyan, Tigran, Popova, Irina K, Hall, Nathan W, Meiners, Matthew J, Cheek, Marcus A, Gibson, Elisa, Kireev, Dmitri, Greenblatt, Jack F, Michael-C Keogh, Min, Jinrong, Brown, Peter J, Vedadi, Masoud, Arrowsmith, Cheryl H, Barsyte-Lovejoy, Dalia, James, Lindsey I, Schapira, Matthieu
Published in bioRxiv (07.03.2021)
Published in bioRxiv (07.03.2021)
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