mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype
Herranz, Nicolás, Gallage, Suchira, Mellone, Massimiliano, Wuestefeld, Torsten, Klotz, Sabrina, Hanley, Christopher J, Raguz, Selina, Acosta, Juan Carlos, Innes, Andrew J, Banito, Ana, Georgilis, Athena, Montoya, Alex, Wolter, Katharina, Dharmalingam, Gopuraja, Faull, Peter, Carroll, Thomas, Martínez-Barbera, Juan Pedro, Cutillas, Pedro, Reisinger, Florian, Heikenwalder, Mathias, Miller, Richard A, Withers, Dominic, Zender, Lars, Thomas, Gareth J, Gil, Jesús
Published in Nature cell biology (01.09.2015)
Published in Nature cell biology (01.09.2015)
Get full text
Journal Article
Targeting the Myofibroblastic Cancer-Associated Fibroblast Phenotype Through Inhibition of NOX4
Hanley, Christopher J, Mellone, Massimiliano, Ford, Kirsty, Thirdborough, Steve M, Mellows, Toby, Frampton, Steven J, Smith, David M, Harden, Elena, Szyndralewiez, Cedric, Bullock, Marc, Noble, Fergus, Moutasim, Karwan A, King, Emma V, Vijayanand, Pandurangan, Mirnezami, Alex H, Underwood, Timothy J, Ottensmeier, Christian H, Thomas, Gareth J
Published in JNCI : Journal of the National Cancer Institute (01.01.2018)
Published in JNCI : Journal of the National Cancer Institute (01.01.2018)
Get full text
Journal Article
A subset of myofibroblastic cancer-associated fibroblasts regulate collagen fiber elongation, which is prognostic in multiple cancers
Hanley, Christopher J, Noble, Fergus, Ward, Matthew, Bullock, Marc, Drifka, Cole, Mellone, Massimiliano, Manousopoulou, Antigoni, Johnston, Harvey E, Hayden, Annette, Thirdborough, Steve, Liu, Yuming, Smith, David M, Mellows, Toby, Kao, W John, Garbis, Spiros D, Mirnezami, Alex, Underwood, Tim J, Eliceiri, Kevin W, Thomas, Gareth J
Published in Oncotarget (02.02.2016)
Published in Oncotarget (02.02.2016)
Get full text
Journal Article
Single-cell analysis reveals prognostic fibroblast subpopulations linked to molecular and immunological subtypes of lung cancer
Hanley, Christopher J, Waise, Sara, Ellis, Matthew J, Lopez, Maria A, Pun, Wai Y, Taylor, Julian, Parker, Rachel, Kimbley, Lucy M, Chee, Serena J, Shaw, Emily C, West, Jonathan, Alzetani, Aiman, Woo, Edwin, Ottensmeier, Christian H, Rose-Zerilli, Matthew J J, Thomas, Gareth J
Published in Nature communications (31.01.2023)
Published in Nature communications (31.01.2023)
Get full text
Journal Article
CTEN Induces Tumour Cell Invasion and Survival and Is Prognostic in Radiotherapy-Treated Head and Neck Cancer
Fleming, Jason C., Woo, Jeongmin, Moutasim, Karwan, Hanley, Christopher J., Frampton, Steven J., Wood, Oliver, Ward, Matthew, Woelk, Christopher H., Ottensmeier, Christian H., Hafizi, Sassan, Kim, Dae, Thomas, Gareth J.
Published in Cancers (01.10.2020)
Published in Cancers (01.10.2020)
Get full text
Journal Article
NOX4 Inhibition Potentiates Immunotherapy by Overcoming Cancer-Associated Fibroblast-Mediated CD8 T-cell Exclusion from Tumors
Ford, Kirsty, Hanley, Christopher J, Mellone, Massimiliano, Szyndralewiez, Cedric, Heitz, Freddy, Wiesel, Philippe, Wood, Oliver, Machado, Maria, Lopez, Maria-Antoinette, Ganesan, Anusha-Preethi, Wang, Chuan, Chakravarthy, Ankur, Fenton, Tim R, King, Emma V, Vijayanand, Pandurangan, Ottensmeier, Christian H, Al-Shamkhani, Aymen, Savelyeva, Natalia, Thomas, Gareth J
Published in Cancer research (Chicago, Ill.) (01.05.2020)
Published in Cancer research (Chicago, Ill.) (01.05.2020)
Get full text
Journal Article
Single-cell transcriptomic analysis of tissue-resident memory T cells in human lung cancer
Clarke, James, Panwar, Bharat, Madrigal, Ariel, Singh, Divya, Gujar, Ravindra, Wood, Oliver, Chee, Serena J, Eschweiler, Simon, King, Emma V, Awad, Amiera S, Hanley, Christopher J, McCann, Katy J, Bhattacharyya, Sourya, Woo, Edwin, Alzetani, Aiman, Seumois, Grégory, Thomas, Gareth J, Ganesan, Anusha-Preethi, Friedmann, Peter S, Sanchez-Elsner, Tilman, Ay, Ferhat, Ottensmeier, Christian H, Vijayanand, Pandurangan
Published in The Journal of experimental medicine (02.09.2019)
Published in The Journal of experimental medicine (02.09.2019)
Get full text
Journal Article
An optimised tissue disaggregation and data processing pipeline for characterising fibroblast phenotypes using single-cell RNA sequencing
Waise, Sara, Parker, Rachel, Rose-Zerilli, Matthew J J, Layfield, David M, Wood, Oliver, West, Jonathan, Ottensmeier, Christian H, Thomas, Gareth J, Hanley, Christopher J
Published in Scientific reports (03.07.2019)
Published in Scientific reports (03.07.2019)
Get full text
Journal Article
Author Correction: mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype
Herranz, Nicolás, Gallage, Suchira, Mellone, Massimiliano, Wuestefeld, Torsten, Klotz, Sabrina, Hanley, Christopher J, Raguz, Selina, Acosta, Juan Carlos, Innes, Andrew J, Banito, Ana, Georgilis, Athena, Montoya, Alex, Wolter, Katharina, Dharmalingam, Gopuraja, Faull, Peter, Carroll, Thomas, Martínez-Barbera, Juan Pedro, Cutillas, Pedro, Reisinger, Florian, Heikenwalder, Mathias, Miller, Richard A, Withers, Dominic, Zender, Lars, Thomas, Gareth J, Gil, Jesús
Published in Nature cell biology (01.06.2024)
Published in Nature cell biology (01.06.2024)
Get full text
Journal Article
ATM Regulates Differentiation of Myofibroblastic Cancer-Associated Fibroblasts and Can Be Targeted to Overcome Immunotherapy Resistance
Mellone, Massimiliano, Piotrowska, Klaudia, Venturi, Giulia, James, Lija, Bzura, Aleksandra, Lopez, Maria A, James, Sonya, Wang, Chuan, Ellis, Matthew J, Hanley, Christopher J, Buckingham, Josephine F, Cox, Kerry L, Hughes, Gareth, Valge-Archer, Viia, King, Emma V, Beers, Stephen A, Jaquet, Vincent, Jones, George D D, Savelyeva, Natalia, Sayan, Emre, Parsons, Jason L, Durant, Stephen, Thomas, Gareth J
Published in Cancer research (Chicago, Ill.) (16.12.2022)
Published in Cancer research (Chicago, Ill.) (16.12.2022)
Get full text
Journal Article
Induction of fibroblast senescence generates a non-fibrogenic myofibroblast phenotype that differentially impacts on cancer prognosis
Mellone, Massimiliano, Hanley, Christopher J, Thirdborough, Steve, Mellows, Toby, Garcia, Edwin, Woo, Jeongmin, Tod, Joanne, Frampton, Steve, Jenei, Veronika, Moutasim, Karwan A, Kabir, Tasnuva D, Brennan, Peter A, Venturi, Giulia, Ford, Kirsty, Herranz, Nicolas, Lim, Kue Peng, Clarke, James, Lambert, Daniel W, Prime, Stephen S, Underwood, Timothy J, Vijayanand, Pandurangan, Eliceiri, Kevin W, Woelk, Christopher, King, Emma V, Gil, Jesus, Ottensmeier, Christian H, Thomas, Gareth J
Published in Aging (Albany, NY.) (15.12.2016)
Published in Aging (Albany, NY.) (15.12.2016)
Get full text
Journal Article
Pro‐migratory and TGF‐β‐activating functions of αvβ6 integrin in pancreatic cancer are differentially regulated via an Eps8‐dependent GTPase switch
Tod, Jo, Hanley, Christopher J, Morgan, Mark R, Rucka, Marta, Mellows, Toby, Lopez, Maria‐Antoinette, Kiely, Philip, Moutasim, Karwan A, Frampton, Steven J, Sabnis, Durgagauri, Fine, David R, Johnson, Colin, Marshall, John F, Scita, Giorgio, Jenei, Veronika, Thomas, Gareth J
Published in The Journal of pathology (01.09.2017)
Published in The Journal of pathology (01.09.2017)
Get full text
Journal Article
Erratum: mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype
Herranz, Nicolás, Gallage, Suchira, Mellone, Massimiliano, Wuestefeld, Torsten, Klotz, Sabrina, Hanley, Christopher J, Raguz, Selina, Acosta, Juan Carlos, Innes, Andrew J, Banito, Ana, Georgilis, Athena, Montoya, Alex, Wolter, Katharina, Dharmalingam, Gopuraja, Faull, Peter, Carroll, Thomas, Martínez-Barbera, Juan Pedro, Cutillas, Pedro, Reisinger, Florian, Heikenwalder, Mathias, Miller, Richard A, Withers, Dominic, Zender, Lars, Thomas, Gareth J, Gil, Jesús
Published in Nature cell biology (01.10.2015)
Published in Nature cell biology (01.10.2015)
Get full text
Journal Article
An Optimized Method to Isolate Human Fibroblasts from Tissue for ex vivo Analysis
Waise, Sara, Parker, Rachel, Rose-Zerilli, Matthew J J, Layfield, David M, Wood, Oliver, West, Jonathan, Ottensmeier, Christian H, Thomas, Gareth J, Hanley, Christopher J
Published in Bio-protocol (05.12.2019)
Published in Bio-protocol (05.12.2019)
Get full text
Journal Article
Abstract 3762: Single-cell analysis of cancer-associated fibroblast heterogeneity in non-small cell lung cancer: Mapping molecular phenotypes in tumors
Waise, Sara, Hanley, Christopher J., Parker, Rachel, Ottensmeier, Christian H., Rose-Zerilli, Matthew, Thomas, Gareth J.
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Get full text
Journal Article