How We Think about Targeting RNA with Small Molecules
Costales, Matthew G, Childs-Disney, Jessica L, Haniff, Hafeez S, Disney, Matthew D
Published in Journal of medicinal chemistry (10.09.2020)
Published in Journal of medicinal chemistry (10.09.2020)
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Journal Article
Targeted Degradation of the Oncogenic MicroRNA 17-92 Cluster by Structure-Targeting Ligands
Liu, Xiaohui, Haniff, Hafeez S, Childs-Disney, Jessica L, Shuster, Anton, Aikawa, Haruo, Adibekian, Alexander, Disney, Matthew D
Published in Journal of the American Chemical Society (15.04.2020)
Published in Journal of the American Chemical Society (15.04.2020)
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Journal Article
Programming inactive RNA-binding small molecules into bioactive degraders
Tong, Yuquan, Lee, Yeongju, Liu, Xiaohui, Childs-Disney, Jessica L., Suresh, Blessy M., Benhamou, Raphael I., Yang, Chunying, Li, Weimin, Costales, Matthew G., Haniff, Hafeez S., Sievers, Sonja, Abegg, Daniel, Wegner, Tristan, Paulisch, Tiffany O., Lekah, Elizabeth, Grefe, Maison, Crynen, Gogce, Van Meter, Montina, Wang, Tenghui, Gibaut, Quentin M. R., Cleveland, John L., Adibekian, Alexander, Glorius, Frank, Waldmann, Herbert, Disney, Matthew D.
Published in Nature (London) (01.06.2023)
Published in Nature (London) (01.06.2023)
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Journal Article
Targeting the SARS-CoV‑2 RNA Genome with Small Molecule Binders and Ribonuclease Targeting Chimera (RIBOTAC) Degraders
Haniff, Hafeez S, Tong, Yuquan, Liu, Xiaohui, Chen, Jonathan L, Suresh, Blessy M, Andrews, Ryan J, Peterson, Jake M, O’Leary, Collin A, Benhamou, Raphael I, Moss, Walter N, Disney, Matthew D
Published in ACS central science (28.10.2020)
Published in ACS central science (28.10.2020)
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Journal Article
Approved Anti-cancer Drugs Target Oncogenic Non-coding RNAs
Velagapudi, Sai Pradeep, Costales, Matthew G, Vummidi, Balayeshwanth R, Nakai, Yoshio, Angelbello, Alicia J, Tran, Tuan, Haniff, Hafeez S, Matsumoto, Yasumasa, Wang, Zi Fu, Chatterjee, Arnab K, Childs-Disney, Jessica L, Disney, Matthew D
Published in Cell chemical biology (20.09.2018)
Published in Cell chemical biology (20.09.2018)
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Journal Article
A structure-specific small molecule inhibits a miRNA-200 family member precursor and reverses a type 2 diabetes phenotype
Haniff, Hafeez S., Liu, Xiaohui, Tong, Yuquan, Meyer, Samantha M., Knerr, Laurent, Lemurell, Malin, Abegg, Daniel, Aikawa, Haruo, Adibekian, Alexander, Disney, Matthew D.
Published in Cell chemical biology (17.02.2022)
Published in Cell chemical biology (17.02.2022)
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Journal Article
Design of a small molecule that stimulates vascular endothelial growth factor A enabled by screening RNA fold–small molecule interactions
Haniff, Hafeez S., Knerr, Laurent, Liu, Xiaohui, Crynen, Gogce, Boström, Jonas, Abegg, Daniel, Adibekian, Alexander, Lekah, Elizabeth, Wang, Kye Won, Cameron, Michael D., Yildirim, Ilyas, Lemurell, Malin, Disney, Matthew D.
Published in Nature chemistry (01.10.2020)
Published in Nature chemistry (01.10.2020)
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Journal Article
Selective Small Molecule Recognition of RNA Base Pairs
Haniff, Hafeez S, Graves, Amanda, Disney, Matthew D
Published in ACS combinatorial science (13.08.2018)
Published in ACS combinatorial science (13.08.2018)
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Journal Article
Decreasing the intrinsically disordered protein α-synuclein levels by targeting its structured mRNA with a ribonuclease-targeting chimera
Tong, Yuquan, Zhang, Peiyuan, Yang, Xueyi, Liu, Xiaohui, Zhang, Jie, Grudniewska, Magda, Jung, Ikrak, Abegg, Daniel, Liu, Jun, Childs-Disney, Jessica L, Gibaut, Quentin M R, Haniff, Hafeez S, Adibekian, Alexander, Mouradian, M Maral, Disney, Matthew D
Published in Proceedings of the National Academy of Sciences - PNAS (09.01.2024)
Published in Proceedings of the National Academy of Sciences - PNAS (09.01.2024)
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Journal Article
A map of the SARS-CoV-2 RNA structurome
Andrews, Ryan J, O’Leary, Collin A, Tompkins, Van S, Peterson, Jake M, Haniff, Hafeez S, Williams, Christopher, Disney, Matthew D, Moss, Walter N
Published in NAR genomics and bioinformatics (01.06.2021)
Published in NAR genomics and bioinformatics (01.06.2021)
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Journal Article
Citrullination profile analysis reveals peptidylarginine deaminase 3 as an HSV-1 target to dampen the activity of candidate antiviral restriction factors
Pasquero, Selina, Gugliesi, Francesca, Biolatti, Matteo, Dell'Oste, Valentina, Albano, Camilla, Bajetto, Greta, Griffante, Gloria, Trifirò, Linda, Brugo, Bianca, Raviola, Stefano, Lacarbonara, Davide, Yang, Qiao, Sudeshna, Sen, Barasa, Leonard, Haniff, Hafeez, Thompson, Paul R, Landolfo, Santo, De Andrea, Marco
Published in PLoS pathogens (01.12.2023)
Published in PLoS pathogens (01.12.2023)
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Journal Article
Systematically Studying the Effect of Small Molecules Interacting with RNA in Cellular and Preclinical Models
Bush, Jessica A, Williams, Christopher C, Meyer, Samantha M, Tong, Yuquan, Haniff, Hafeez S, Childs-Disney, Jessica L, Disney, Matthew D
Published in ACS chemical biology (16.07.2021)
Published in ACS chemical biology (16.07.2021)
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Journal Article
Rational Approach to Identify RNA Targets of Natural Products Enables Identification of Nocathiacin as an Inhibitor of an Oncogenic RNA
Ye, Fei, Haniff, Hafeez S, Suresh, Blessy M, Yang, Dong, Zhang, Peiyuan, Crynen, Gogce, Teijaro, Christiana N, Yan, Wei, Abegg, Daniel, Adibekian, Alexander, Shen, Ben, Disney, Matthew D
Published in ACS chemical biology (18.02.2022)
Published in ACS chemical biology (18.02.2022)
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Journal Article
Defining RNA–Small Molecule Affinity Landscapes Enables Design of a Small Molecule Inhibitor of an Oncogenic Noncoding RNA
Velagapudi, Sai Pradeep, Luo, Yiling, Tran, Tuan, Haniff, Hafeez S, Nakai, Yoshio, Fallahi, Mohammad, Martinez, Gustavo J, Childs-Disney, Jessica L, Disney, Matthew D
Published in ACS central science (22.03.2017)
Published in ACS central science (22.03.2017)
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Journal Article
Target-Directed Approaches for Screening Small Molecules against RNA Targets
Haniff, Hafeez S., Knerr, Laurent, Chen, Jonathan L., Disney, Matthew D., Lightfoot, Helen L.
Published in SLAS DISCOVERY: Advancing the Science of Drug Discovery (01.09.2020)
Published in SLAS DISCOVERY: Advancing the Science of Drug Discovery (01.09.2020)
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Book Review
Journal Article
A Massively Parallel Selection of Small Molecule-RNA Motif Binding Partners Informs Design of an Antiviral from Sequence
Childs-Disney, Jessica L., Tran, Tuan, Vummidi, Balayeshwanth R., Velagapudi, Sai Pradeep, Haniff, Hafeez S., Matsumoto, Yasumasa, Crynen, Gogce, Southern, Mark R., Biswas, Avik, Wang, Zi-Fu, Tellinghuisen, Timothy L., Disney, Matthew D.
Published in Chem (11.10.2018)
Published in Chem (11.10.2018)
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Journal Article
An in silico map of the SARS-CoV-2 RNA Structurome
Andrews, Ryan J, Peterson, Jake M, Haniff, Hafeez S, Chen, Jonathan, Williams, Christopher, Grefe, Maison, Disney, Matthew D, Moss, Walter N
Published in bioRxiv (18.04.2020)
Published in bioRxiv (18.04.2020)
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