A structure-based mechanism of cisplatin resistance mediated by glutathione transferase P1-1
De Luca, Anastasia, Parker, Lorien J., Ang, Wee Han, Rodolfo, Carlo, Gabbarini, Valentina, Hancock, Nancy C., Palone, Francesca, Mazzetti, Anna P., Menin, Laure, Morton, Craig J., Parker, Michael W., Lo Bello, Mario, Dyson, Paul J.
Published in Proceedings of the National Academy of Sciences - PNAS (09.07.2019)
Published in Proceedings of the National Academy of Sciences - PNAS (09.07.2019)
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Small Molecule Binding to Alzheimer Risk Factor CD33 Promotes Aβ Phagocytosis
Miles, Luke A., Hermans, Stefan J., Crespi, Gabriela A.N., Gooi, Jonathan H., Doughty, Larissa, Nero, Tracy L., Markulić, Jasmina, Ebneth, Andreas, Wroblowski, Berthold, Oehlrich, Daniel, Trabanco, Andrés A., Rives, Marie-Laure, Royaux, Ines, Hancock, Nancy C., Parker, Michael W.
Published in iScience (27.09.2019)
Published in iScience (27.09.2019)
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Studies of Glutathione Transferase P1-1 Bound to a Platinum(IV)-Based Anticancer Compound Reveal the Molecular Basis of Its Activation
Parker, Lorien J., Italiano, Louis C., Morton, Craig J., Hancock, Nancy C., Ascher, David B., Aitken, Jade B., Harris, Hugh H., Campomanes, Pablo, Rothlisberger, Ursula, De Luca, Anastasia, Lo Bello, Mario, Ang, Wee Han, Dyson, Paul J., Parker, Michael W.
Published in Chemistry : a European journal (04.07.2011)
Published in Chemistry : a European journal (04.07.2011)
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Journal Article
Crystal structure of Alzheimer's disease phospholipase D3 provides a molecular basis for understanding its normal and pathological functions
Ishii, Kenta, Hermans, Stefan J, Georgopoulou, Maria Eleni, Nero, Tracy L, Hancock, Nancy C, Crespi, Gabriela A N, Gorman, Michael A, Gooi, Jonathan H, Parker, Michael W
Published in The FEBS journal (26.09.2024)
Published in The FEBS journal (26.09.2024)
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Journal Article
Crystal structure of human insulin‐regulated aminopeptidase with specificity for cyclic peptides
Hermans, Stefan J., Ascher, David B., Hancock, Nancy C., Holien, Jessica K., Michell, Belinda J., Chai, Siew Yeen, Morton, Craig J., Parker, Michael W.
Published in Protein science (01.02.2015)
Published in Protein science (01.02.2015)
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Development of [18F]MIPS15692, a radiotracer with in vitro proof-of-concept for the imaging of MER tyrosine kinase (MERTK) in neuroinflammatory disease
Wong, Siu Wai, Vivash, Lucy, Mudududdla, Ramesh, Nguyen, Nghi, Hermans, Stefan J., Shackleford, David M., Field, Judith, Xue, Lian, Aprico, Andrea, Hancock, Nancy C., Haskali, Mohammad, Stashko, Michael A., Frye, Stephen V., Wang, Xiaodong, Binder, Michele D., Ackermann, Uwe, Parker, Michael W., Kilpatrick, Trevor J., Baell, Jonathan B.
Published in European journal of medicinal chemistry (15.12.2021)
Published in European journal of medicinal chemistry (15.12.2021)
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Structural biology of cell surface receptors implicated in Alzheimer’s disease
Hermans, Stefan J., Nero, Tracy L., Morton, Craig J., Gooi, Jonathan H., Crespi, Gabriela A. N., Hancock, Nancy C., Gao, Chen, Ishii, Kenta, Markulić, Jasmina, Parker, Michael W.
Published in Biophysical reviews (01.02.2022)
Published in Biophysical reviews (01.02.2022)
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Journal Article
The Anti-cancer Drug Chlorambucil as a Substrate for the Human Polymorphic Enzyme Glutathione Transferase P1-1: Kinetic Properties and Crystallographic Characterisation of Allelic Variants
Parker, Lorien J., Ciccone, Sarah, Italiano, Louis C., Primavera, Alessandra, Oakley, Aaron J., Morton, Craig J., Hancock, Nancy C., Bello, Mario Lo, Parker, Michael W.
Published in Journal of molecular biology (27.06.2008)
Published in Journal of molecular biology (27.06.2008)
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Journal Article
Elucidation of the Substrate Binding Site of Siah Ubiquitin Ligase
House, Colin M., Hancock, Nancy C., Möller, Andreas, Cromer, Brett A., Fedorov, Victor, Bowtell, David D.L., Parker, Michael W., Polekhina, Galina
Published in Structure (London) (01.04.2006)
Published in Structure (London) (01.04.2006)
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Journal Article
Thiophene inhibitors of PDE4: Crystal structures show a second binding mode at the catalytic domain of PDE4D2
Nankervis, Jacob L., Feil, Susanne C., Hancock, Nancy C., Zheng, Zhaohua, Ng, Hooi-Ling, Morton, Craig J., Holien, Jessica K., Ho, Patricia W.M., Frazzetto, Mark M., Jennings, Ian G., Manallack, David T., John Martin, T., Thompson, Philip E., Parker, Michael W.
Published in Bioorganic & medicinal chemistry letters (01.12.2011)
Published in Bioorganic & medicinal chemistry letters (01.12.2011)
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Journal Article
Cover Picture: Studies of Glutathione Transferase P1-1 Bound to a Platinum(IV)-Based Anticancer Compound Reveal the Molecular Basis of Its Activation (Chem. Eur. J. 28/2011)
Parker, Lorien J., Italiano, Louis C., Morton, Craig J., Hancock, Nancy C., Ascher, David B., Aitken, Jade B., Harris, Hugh H., Campomanes, Pablo, Rothlisberger, Ursula, De Luca, Anastasia, Lo Bello, Mario, Ang, Wee Han, Dyson, Paul J., Parker, Michael W.
Published in Chemistry : a European journal (04.07.2011)
Published in Chemistry : a European journal (04.07.2011)
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Journal Article
P1‐156: BISPECIFIC DIABODIES TO IMPROVE CLEARANCE OF Aβ IN ALZHEIMER'S DISEASE
Crespi, Gabriela A.N., Hancock, Nancy C., Parker, Michael W., Miles, Luke A.
Published in Alzheimer's & dementia (01.07.2019)
Published in Alzheimer's & dementia (01.07.2019)
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Journal Article
BISPECIFIC DIABODIES TO IMPROVE CLEARANCE OF Aβ IN ALZHEIMER’S DISEASE
Crespi, Gabriela A.N., Hancock, Nancy C., Parker, Michael W., Miles, Luke A.
Published in Alzheimer's & dementia (01.07.2019)
Published in Alzheimer's & dementia (01.07.2019)
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Journal Article
P2‐053: ENGINEERED ANTIBODIES TO TREAT OR PREVENT ALZHEIMER'S DISEASE
Crespi, Gabriela A.N., Watt, Andrew D., Hancock, Nancy C., Nero, Tracy, Hermans, Stefan, Barnham, Kevin J., Parker, Michael W., Miles, Luke A.
Published in Alzheimer's & dementia (01.07.2018)
Published in Alzheimer's & dementia (01.07.2018)
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Journal Article
ENGINEERED ANTIBODIES TO TREAT OR PREVENT ALZHEIMER'S DISEASE
Crespi, Gabriela A.N., Watt, Andrew D., Hancock, Nancy C., Nero, Tracy, Hermans, Stefan, Barnham, Kevin J., Parker, Michael W., Miles, Luke A.
Published in Alzheimer's & dementia (01.07.2018)
Published in Alzheimer's & dementia (01.07.2018)
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