Discovery and Development of Highly Potent and Orally Bioavailable Nonpeptidic α v β 6 Integrin Inhibitors
Procopiou, Panayiotis A, Barrett, John, Crawford, Matthew H J, Hatley, Richard J D, Hancock, Ashley P, Pritchard, John M, Rowedder, James E, Copley, Royston C B, Slack, Robert J, Sollis, Steven L, Thorp, Lee R, Lippa, Rhys A, Macdonald, Simon J F, Barrett, Tim N
Published in Journal of medicinal chemistry (10.10.2024)
Published in Journal of medicinal chemistry (10.10.2024)
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Journal Article
Discovery and Development of Highly Potent and Orally Bioavailable Nonpeptidic αvβ6 Integrin Inhibitors
Procopiou, Panayiotis A., Barrett, John, Crawford, Matthew H. J., Hatley, Richard J. D., Hancock, Ashley P., Pritchard, John M., Rowedder, James E., Copley, Royston C. B., Slack, Robert J., Sollis, Steven L., Thorp, Lee R., Lippa, Rhys A., Macdonald, Simon J. F., Barrett, Tim N.
Published in Journal of medicinal chemistry (10.10.2024)
Published in Journal of medicinal chemistry (10.10.2024)
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Journal Article
A knowledge-based, structural-aided discovery of a novel class of 2-phenylimidazo[1,2-a]pyridine-6-carboxamide H-PGDS inhibitors
Schulte, Christie A., Deaton, David N., Diaz, Elsie, Do, Young, Gampe, Robert T., Guss, Jeffrey H., Hancock, Ashley P., Hobbs, Heather, Hodgson, Simon T., Holt, Jason, Jeune, Michael R., Kahler, Kirsten M., Kramer, H. Fritz, Le, Joelle, Mortenson, Paul N., Musetti, Caterina, Nolte, Robert T., Orband-Miller, Lisa A., Peckham, Gregory E., Petrov, Kim G., Pietrak, Beth L., Poole, Chuck, Price, Daniel J., Saxty, Gordon, Shillings, Anthony, Smalley, Terrence L., Somers, Don O., Stewart, Eugene L., Stuart, J. Darren, Thomson, Stephen A.
Published in Bioorganic & medicinal chemistry letters (01.09.2021)
Published in Bioorganic & medicinal chemistry letters (01.09.2021)
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Journal Article
The discovery of quinoline-3-carboxamides as hematopoietic prostaglandin D synthase (H-PGDS) inhibitors
Deaton, David N., Do, Young, Holt, Jason, Jeune, Michael R., Kramer, H. Fritz, Larkin, Andrew L., Orband-Miller, Lisa A., Peckham, Gregory E., Poole, Chuck, Price, Daniel J., Schaller, Lee T., Shen, Ying, Shewchuk, Lisa M., Stewart, Eugene L., Stuart, J. Darren, Thomson, Stephen A., Ward, Paris, Wilson, Joseph W., Xu, Tianshun, Guss, Jeffrey H., Musetti, Caterina, Rendina, Alan R., Affleck, Karen, Anders, David, Hancock, Ashley P., Hobbs, Heather, Hodgson, Simon T., Hutchinson, Jonathan, Leveridge, Melanie V., Nicholls, Harry, Smith, Ian E.D., Somers, Don O., Sneddon, Helen F., Uddin, Sorif, Cleasby, Anne, Mortenson, Paul N., Richardson, Caroline, Saxty, Gordon
Published in Bioorganic & medicinal chemistry (15.04.2019)
Published in Bioorganic & medicinal chemistry (15.04.2019)
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Discovery of (S)‑3-(3-(3,5-Dimethyl‑1H‑pyrazol-1-yl)phenyl)-4-((R)‑3-(2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl)pyrrolidin-1-yl)butanoic Acid, a Nonpeptidic αvβ6 Integrin Inhibitor for the Inhaled Treatment of Idiopathic Pulmonary Fibrosis
Procopiou, Panayiotis A, Anderson, Niall A, Barrett, John, Barrett, Tim N, Crawford, Matthew H. J, Fallon, Brendan J, Hancock, Ashley P, Le, Joelle, Lemma, Seble, Marshall, Richard P, Morrell, Josie, Pritchard, John M, Rowedder, James E, Saklatvala, Paula, Slack, Robert J, Sollis, Steven L, Suckling, Colin J, Thorp, Lee R, Vitulli, Giovanni, Macdonald, Simon J. F
Published in Journal of medicinal chemistry (27.09.2018)
Published in Journal of medicinal chemistry (27.09.2018)
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Journal Article
Discovery of ( S)-3-(3-(3,5-Dimethyl-1 H-pyrazol-1-yl)phenyl)-4-(( R)-3-(2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl)pyrrolidin-1-yl)butanoic Acid, a Nonpeptidic α v β 6 Integrin Inhibitor for the Inhaled Treatment of Idiopathic Pulmonary Fibrosis
Procopiou, Panayiotis A, Anderson, Niall A, Barrett, John, Barrett, Tim N, Crawford, Matthew H J, Fallon, Brendan J, Hancock, Ashley P, Le, Joelle, Lemma, Seble, Marshall, Richard P, Morrell, Josie, Pritchard, John M, Rowedder, James E, Saklatvala, Paula, Slack, Robert J, Sollis, Steven L, Suckling, Colin J, Thorp, Lee R, Vitulli, Giovanni, Macdonald, Simon J F
Published in Journal of medicinal chemistry (27.09.2018)
Published in Journal of medicinal chemistry (27.09.2018)
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Journal Article
The discovery of quinoline based single-ligand human H-1 and H-3 receptor antagonists
Procopiou, Panayiotis A., Ancliff, Rachael A., Gore, Paul M., Hancock, Ashley P., Hodgson, Simon T., Holmes, Duncan S., Keeling, Steven P., Looker, Brian E., Parr, Nigel A., Rowedder, James E., Slack, Robert J.
Published in Bioorganic & medicinal chemistry letters (15.12.2016)
Published in Bioorganic & medicinal chemistry letters (15.12.2016)
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Journal Article
Identification of selective 8-(piperidin-4-yloxy)quinoline sulfone and sulfonamide histamine H 1 receptor antagonists for use in allergic rhinitis
Procopiou, Panayiotis A, Ford, Alison J, Gore, Paul M, Hancock, Ashley P, Hodgson, Simon T, Holmes, Duncan S, Looker, Brian E, Vile, Sadie, Clark, Kenneth L, Saunders, Ken A, Slack, Robert J, Watts, Clarissa J
Published in Bioorganic & medicinal chemistry letters (01.11.2017)
Published in Bioorganic & medicinal chemistry letters (01.11.2017)
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Journal Article
Identification of selective 8-(piperidin-4-yloxy)quinoline sulfone and sulfonamide histamine H1 receptor antagonists for use in allergic rhinitis
Procopiou, Panayiotis A., Ford, Alison J., Gore, Paul M., Hancock, Ashley P., Hodgson, Simon T., Holmes, Duncan S., Looker, Brian E., Vile, Sadie, Clark, Kenneth L., Saunders, Ken A., Slack, Robert J., Watts, Clarissa J.
Published in Bioorganic & medicinal chemistry letters (01.11.2017)
Published in Bioorganic & medicinal chemistry letters (01.11.2017)
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Journal Article
Synthesis and Structure–Activity Relationships of Indazole Arylsulfonamides as Allosteric CC-Chemokine Receptor 4 (CCR4) Antagonists
Procopiou, Panayiotis A, Barrett, John W, Barton, Nicholas P, Begg, Malcolm, Clapham, David, Copley, Royston C. B, Ford, Alison J, Graves, Rebecca H, Hall, David A, Hancock, Ashley P, Hill, Alan P, Hobbs, Heather, Hodgson, Simon T, Jumeaux, Coline, Lacroix, Yannick M. L, Miah, Afjal H, Morriss, Karen M. L, Needham, Deborah, Sheriff, Emma B, Slack, Robert J, Smith, Claire E, Sollis, Steven L, Staton, Hugo
Published in Journal of medicinal chemistry (14.03.2013)
Published in Journal of medicinal chemistry (14.03.2013)
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Journal Article
The discovery of quinoline based single-ligand human H1 and H3 receptor antagonists
Procopiou, Panayiotis A., Ancliff, Rachael A., Gore, Paul M., Hancock, Ashley P., Hodgson, Simon T., Holmes, Duncan S., Keeling, Steven P., Looker, Brian E., Parr, Nigel A., Rowedder, James E., Slack, Robert J.
Published in Bioorganic & medicinal chemistry letters (15.12.2016)
Published in Bioorganic & medicinal chemistry letters (15.12.2016)
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Journal Article
The Discovery of Phthalazinone-Based Human H1 and H3 Single-Ligand Antagonists Suitable for Intranasal Administration for the Treatment of Allergic Rhinitis
Procopiou, Panayiotis A, Browning, Christopher, Buckley, Jennifer M, Clark, Kenneth L, Fechner, Lise, Gore, Paul M, Hancock, Ashley P, Hodgson, Simon T, Holmes, Duncan S, Kranz, Michael, Looker, Brian E, Morriss, Karen M. L, Parton, Daniel L, Russell, Linda J, Slack, Robert J, Sollis, Steven L, Vile, Sadie, Watts, Clarissa J
Published in Journal of medicinal chemistry (14.04.2011)
Published in Journal of medicinal chemistry (14.04.2011)
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Journal Article
Selective Plasma Hydrolysis of Glucocorticoid γ-Lactones and Cyclic Carbonates by the Enzyme Paraoxonase: An Ideal Plasma Inactivation Mechanism
Biggadike, Keith, Angell, Richard M, Burgess, Colin M, Farrell, Rosanne M, Hancock, Ashley P, Harker, Andy J, Irving, Wendy R, Ioannou, Chris, Procopiou, Panayiotis A, Shaw, Rupert E, Solanke, Yemisi E, Singh, Onkar M. P, Snowden, Michael A, Stubbs, Rob J, Walton, Sarah, Weston, Helen E
Published in Journal of medicinal chemistry (13.01.2000)
Published in Journal of medicinal chemistry (13.01.2000)
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Journal Article
Oxazolidinones as novel human CCR8 antagonists
Jin, Jian, Wang, Yonghui, Wang, Feng, Kerns, Jeffery K., Vinader, Victoria M., Hancock, Ashley P., Lindon, Matthew J., Stevenson, Graeme I., Morrow, Dwight M., Rao, Parvathi, Nguyen, Cuc, Barrett, Victoria J., Browning, Chris, Hartmann, Guido, Andrew, David P., Sarau, Henry M., Foley, James J., Jurewicz, Anthony J., Fornwald, James A., Harker, Andy J., Moore, Michael L., Rivero, Ralph A., Belmonte, Kristen E., Connor, Helen E.
Published in Bioorganic & medicinal chemistry letters (15.03.2007)
Published in Bioorganic & medicinal chemistry letters (15.03.2007)
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Journal Article
Novel glucocorticoid antedrugs possessing a 21-(gamma-lactone) ring
Angell, RM, Biggadike, K, Farrell, RM, Flack, SS, Hancock, AP, Irving, WR, Lynn, SM, Procopiou, PA
Published in Perkin 1 : an international journal of organic and bio-organic chemistry (08.03.2002)
Published in Perkin 1 : an international journal of organic and bio-organic chemistry (08.03.2002)
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Journal Article
Novel Glucocorticoid Antedrugs Possessing a 17β-(γ-Lactone) Ring
Procopiou, Panayiotis A, Biggadike, Keith, English, Alan F, Farrell, Rosanne M, Hagger, Graham N, Hancock, Ashley P, Haase, Michael V, Irving, Wendy R, Sareen, Meenu, Snowden, Michael A, Solanke, Yemisi E, Tralau-Stewart, Cathy J, Walton, Sarah E, Wood, Jenny A
Published in Journal of medicinal chemistry (15.02.2001)
Published in Journal of medicinal chemistry (15.02.2001)
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Journal Article
Discovery of (S)-3-(3-(3,5-Dimethyl-1H-pyrazol-1-yl)phenyl)-4-((R)-3(2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl)pyrrolidin-1-yl)butanoic Acid, a Nonpeptidic alpha(v)beta(6) Integrin Inhibitor for the Inhaled Treatment of Idiopathic Pulmonary Fibrosis
Procopiou, Panayiotis A., Anderson, Niall A., Barrett, John, Barrett, Tim N., Crawford, Matthew H. J., Fallon, Brendan J., Hancock, Ashley P., Le, Joelle, Lemma, Seble, Marshall, Richard P., Morrell, Josie, Pritchard, John M., Rowedder, James E., Saklatvala, Paula, Slack, Robert J., Sollis, Steven L., Suckling, Colin J., Thorp, Lee R., Vitulli, Giovanni, Macdonald, Simon J. F.
Published in Journal of medicinal chemistry (27.09.2018)
Published in Journal of medicinal chemistry (27.09.2018)
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Journal Article
A knowledge-based, structural-aided discovery of a novel class of 2-phe-nylimidazo[1,2-a]pyridine-6-carboxamide H-PGDS inhibitors
Schulte, Christie A., Deaton, David N., Diaz, Elsie, Do, Young, Gampe, Robert T., Guss, Jeffrey H., Hancock, Ashley P., Hobbs, Heather, Hodgson, Simon T., Holt, Jason, Jeune, Michael R., Kahler, Kirsten M., Kramer, H. Fritz, Le, Joelle, Mortenson, Paul N., Musetti, Caterina, Nolte, Robert T., Orband-Miller, Lisa A., Peckham, Gregory E., Petrov, Kim G., Pietrak, Beth L., Poole, Chuck, Price, Daniel J., Saxty, Gordon, Shillings, Anthony, Smalley, Terrence L., Somers, Don O., Stewart, Eugene L., Stuart, J. Darren, Thomson, Stephen A.
Published in Bioorganic & medicinal chemistry letters (01.09.2021)
Published in Bioorganic & medicinal chemistry letters (01.09.2021)
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Journal Article
Synthesis and anti-HIV-1 activity of a series of imidazo[1,5-b]pyridazines
Livermore, David G. H, Bethell, Richard C, Cammack, Nicholas, Hancock, Ashley P, Hann, Michael M, Green, Darren V. S, Lamont, R. Brian, Noble, Stewart A, Orr, David C
Published in Journal of medicinal chemistry (26.11.1993)
Published in Journal of medicinal chemistry (26.11.1993)
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6,6′-Bis(2-hydroxyphenyl)-2,2′-bipyridine manganese(III) complexes: A novel series of superoxide dismutase and catalase mimetics
Giblin, Gerard M.P, Box, Philip C, Campbell, Ian B, Hancock, Ashley P, Roomans, Susan, Mills, Gary I, Molloy, Christopher, Tranter, George E, Walker, Ann L, Doctrow, Susan R, Huffman, Karl, Malfroy, Bernard
Published in Bioorganic & medicinal chemistry letters (04.06.2001)
Published in Bioorganic & medicinal chemistry letters (04.06.2001)
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