Hepatocyte ELOVL Fatty Acid Elongase 6 Determines Ceramide Acyl‐Chain Length and Hepatic Insulin Sensitivity in Mice
Matsuzaka, Takashi, Kuba, Motoko, Koyasu, Saori, Yamamoto, Yuta, Motomura, Kaori, Arulmozhiraja, Sundaram, Ohno, Hiroshi, Sharma, Rahul, Shimura, Takuya, Okajima, Yuka, Han, Song‐iee, Aita, Yuichi, Mizunoe, Yuhei, Osaki, Yoshinori, Iwasaki, Hitoshi, Yatoh, Shigeru, Suzuki, Hiroaki, Sone, Hirohito, Takeuchi, Yoshinori, Yahagi, Naoya, Miyamoto, Takafumi, Sekiya, Motohiro, Nakagawa, Yoshimi, Ema, Masatsugu, Takahashi, Satoru, Tokiwa, Hiroaki, Shimano, Hitoshi
Published in Hepatology (Baltimore, Md.) (01.05.2020)
Published in Hepatology (Baltimore, Md.) (01.05.2020)
Get full text
Journal Article
Hepatocyte- or macrophage-specific SREBP-1a deficiency in mice exacerbates methionine- and choline-deficient diet-induced nonalcoholic fatty liver disease
Araki, Masaya, Nakagawa, Yoshimi, Saito, Hodaka, Yamada, Yasunari, Han, Song-Iee, Mizunoe, Yuhei, Ohno, Hiroshi, Miyamoto, Takafumi, Sekiya, Motohiro, Matsuzaka, Takashi, Sone, Hirohito, Shimano, Hitoshi
Published in American journal of physiology: Gastrointestinal and liver physiology (01.12.2022)
Published in American journal of physiology: Gastrointestinal and liver physiology (01.12.2022)
Get full text
Journal Article
The Peroxisome Proliferator-Activated Receptor α (PPARα) Agonist Pemafibrate Protects against Diet-Induced Obesity in Mice
Araki, Masaya, Nakagawa, Yoshimi, Oishi, Asayo, Han, Song-Iee, Wang, Yunong, Kumagai, Kae, Ohno, Hiroshi, Mizunoe, Yuhei, Iwasaki, Hitoshi, Sekiya, Motohiro, Matsuzaka, Takashi, Shimano, Hitoshi
Published in International journal of molecular sciences (01.07.2018)
Published in International journal of molecular sciences (01.07.2018)
Get full text
Journal Article
Obesity-induced metabolic imbalance allosterically modulates CtBP2 to inhibit PPAR-alpha transcriptional activity
Saito, Kenji, Sekiya, Motohiro, Kainoh, Kenta, Yoshino, Ryunosuke, Hayashi, Akio, Han, Song-Iee, Araki, Masaya, Ohno, Hiroshi, Takeuchi, Yoshinori, Tsuyuzaki, Tomomi, Yamazaki, Daichi, Wanpei, Chen, Hada, Lisa, Watanabe, Sho, Paramita Adi Putri, Putu Indah, Murayama, Yuki, Sugano, Yoko, Osaki, Yoshinori, Iwasaki, Hitoshi, Yahagi, Naoya, Suzuki, Hiroaki, Miyamoto, Takafumi, Matsuzaka, Takashi, Shimano, Hitoshi
Published in The Journal of biological chemistry (01.07.2023)
Published in The Journal of biological chemistry (01.07.2023)
Get full text
Journal Article
CREBH Systemically Regulates Lipid Metabolism by Modulating and Integrating Cellular Functions
Nakagawa, Yoshimi, Araki, Masaya, Han, Song-iee, Mizunoe, Yuhei, Shimano, Hitoshi
Published in Nutrients (15.09.2021)
Published in Nutrients (15.09.2021)
Get full text
Journal Article
Octacosanol and policosanol prevent high-fat diet-induced obesity and metabolic disorders by activating brown adipose tissue and improving liver metabolism
Sharma, Rahul, Matsuzaka, Takashi, Kaushik, Mahesh K., Sugasawa, Takehito, Ohno, Hiroshi, Wang, Yunong, Motomura, Kaori, Shimura, Takuya, Okajima, Yuka, Mizunoe, Yuhei, Ma, Yang, Saber, Zahara M., Iwasaki, Hitoshi, Yatoh, Shigeru, Suzuki, Hiroaki, Aita, Yuichi, Han, Song-iee, Takeuchi, Yoshinori, Yahagi, Naoya, Miyamoto, Takafumi, Sekiya, Motohiro, Nakagawa, Yoshimi, Shimano, Hitoshi
Published in Scientific reports (26.03.2019)
Published in Scientific reports (26.03.2019)
Get full text
Journal Article
Morphological and functional adaptation of pancreatic islet blood vessels to insulin resistance is impaired in diabetic db/db mice
Okajima, Yuka, Matsuzaka, Takashi, Miyazaki, Shun, Motomura, Kaori, Ohno, Hiroshi, Sharma, Rahul, Shimura, Takuya, Istiqamah, Nurani, Han, Song-iee, Mizunoe, Yuhei, Osaki, Yoshinori, Iwasaki, Hitoshi, Yatoh, Shigeru, Suzuki, Hiroaki, Sone, Hirohito, Miyamoto, Takafumi, Aita, Yuichi, Takeuchi, Yoshinori, Sekiya, Motohiro, Yahagi, Naoya, Nakagawa, Yoshimi, Tomita, Tsutomu, Shimano, Hitoshi
Published in Biochimica et biophysica acta. Molecular basis of disease (01.04.2022)
Published in Biochimica et biophysica acta. Molecular basis of disease (01.04.2022)
Get full text
Journal Article
Transgenic Mice Overexpressing SREBP-1a in Male ob/ob Mice Exhibit Lipodystrophy and Exacerbate Insulin Resistance
Ohno, Hiroshi, Matsuzaka, Takashi, Tang, Nie, Sharma, Rahul, Motomura, Kaori, Shimura, Takuya, Satoh, Aoi, Han, Song-iee, Takeuchi, Yoshinori, Aita, Yuichi, Iwasaki, Hitoshi, Yatoh, Shigeru, Suzuki, Hiroaki, Sekiya, Motohiro, Nakagawa, Yoshimi, Sone, Hirohito, Yahagi, Naoya, Yamada, Nobuhiro, Higami, Yoshikazu, Shimano, Hitoshi
Published in Endocrinology (Philadelphia) (01.06.2018)
Published in Endocrinology (Philadelphia) (01.06.2018)
Get full text
Journal Article
Effects of K-877, a novel selective PPARα modulator, on small intestine contribute to the amelioration of hyperlipidemia in low-density lipoprotein receptor knockout mice
Takei, Kenta, Nakagawa, Yoshimi, Wang, Yunong, Han, Song-iee, Satoh, Aoi, Sekiya, Motohiro, Matsuzaka, Takashi, Shimano, Hitoshi
Published in Journal of pharmacological sciences (01.04.2017)
Published in Journal of pharmacological sciences (01.04.2017)
Get full text
Journal Article
Selective peroxisome proliferator‐activated receptor‐α modulator K‐877 efficiently activates the peroxisome proliferator‐activated receptor‐α pathway and improves lipid metabolism in mice
Takei, Kenta, Han, Song‐iee, Murayama, Yuki, Satoh, Aoi, Oikawa, Fusaka, Ohno, Hiroshi, Osaki, Yoshinori, Matsuzaka, Takashi, Sekiya, Motohiro, Iwasaki, Hitoshi, Yatoh, Shigeru, Yahagi, Naoya, Suzuki, Hiroaki, Yamada, Nobuhiro, Nakagawa, Yoshimi, Shimano, Hitoshi
Published in Journal of diabetes investigation (01.07.2017)
Published in Journal of diabetes investigation (01.07.2017)
Get full text
Journal Article
MafA Stability in Pancreatic β Cells Is Regulated by Glucose and Is Dependent on Its Constitutive Phosphorylation at Multiple Sites by Glycogen Synthase Kinase 3
Han, Song-iee, Aramata, Shinsaku, Yasuda, Kunio, Kataoka, Kohsuke
Published in Molecular and Cellular Biology (01.10.2007)
Published in Molecular and Cellular Biology (01.10.2007)
Get full text
Journal Article
Identification of key microRNAs regulating ELOVL6 and glioblastoma tumorigenesis
Istiqamah, Nurani, Matsuzaka, Takashi, Shimizu, Momo, Motomura, Kaori, Ohno, Hiroshi, Hasebe, Shiho, Sharma, Rahul, Okajima, Yuka, Matsuda, Erika, Han, Song-Iee, Mizunoe, Yuhei, Osaki, Yoshinori, Aita, Yuichi, Suzuki, Hiroaki, Sone, Hirohito, Takeuchi, Yoshinori, Sekiya, Motohiro, Yahagi, Naoya, Nakagawa, Yoshimi, Shimano, Hitoshi
Published in BBA advances (01.01.2023)
Published in BBA advances (01.01.2023)
Get full text
Journal Article
Absence of Elovl6 attenuates steatohepatitis but promotes gallstone formation in a lithogenic diet-fed Ldlr−/− mouse model
Kuba, Motoko, Matsuzaka, Takashi, Matsumori, Rie, Saito, Ryo, Kaga, Naoko, Taka, Hikari, Ikehata, Kei, Okada, Naduki, Kikuchi, Takuya, Ohno, Hiroshi, Han, Song-iee, Takeuchi, Yoshinori, Kobayashi, Kazuto, Iwasaki, Hitoshi, Yatoh, Shigeru, Suzuki, Hiroaki, Sone, Hirohito, Yahagi, Naoya, Arakawa, Yoji, Fujimura, Tsutomu, Nakagawa, Yoshimi, Yamada, Nobuhiro, Shimano, Hitoshi
Published in Scientific reports (01.12.2015)
Published in Scientific reports (01.12.2015)
Get full text
Journal Article
Hepatic rRNA Transcription Regulates High-Fat-Diet-Induced Obesity
Oie, Shohei, Matsuzaki, Kazuya, Yokoyama, Wataru, Tokunaga, Shinji, Waku, Tsuyoshi, Han, Song-Iee, Iwasaki, Naoya, Mikogai, Aya, Yasuzawa-Tanaka, Kayoko, Kishimoto, Hiroyuki, Hiyoshi, Hiromi, Nakajima, Yuka, Araki, Toshiyuki, Kimura, Keiji, Yanagisawa, Junn, Murayama, Akiko
Published in Cell reports (Cambridge) (01.05.2014)
Published in Cell reports (Cambridge) (01.05.2014)
Get full text
Journal Article
Rhomboid protease RHBDL4/RHBDD1 cleaves SREBP-1c at endoplasmic reticulum monitoring and regulating fatty acids
Han, Song-Iee, Nakakuki, Masanori, Nakagawa, Yoshimi, Wang, Yunong, Araki, Masaya, Yamamoto, Yuta, Tokiwa, Hiroaki, Takeda, Hiroyuki, Mizunoe, Yuhei, Motomura, Kaori, Ohno, Hiroshi, Kainoh, Kenta, Murayama, Yuki, Aita, Yuichi, Takeuchi, Yoshinori, Osaki, Yoshinori, Miyamoto, Takafumi, Sekiya, Motohiro, Matsuzaka, Takashi, Yahagi, Naoya, Sone, Hirohito, Daitoku, Hiroaki, Sato, Ryuichiro, Kawano, Hiroyuki, Shimano, Hitoshi
Published in PNAS nexus (01.11.2023)
Published in PNAS nexus (01.11.2023)
Get full text
Journal Article
Rapid manipulation of mitochondrial morphology in a living cell with iCMM
Miyamoto, Takafumi, Uosaki, Hideki, Mizunoe, Yuhei, Han, Song-Iee, Goto, Satoi, Yamanaka, Daisuke, Masuda, Masato, Yoneyama, Yosuke, Nakamura, Hideki, Hattori, Naoko, Takeuchi, Yoshinori, Ohno, Hiroshi, Sekiya, Motohiro, Matsuzaka, Takashi, Hakuno, Fumihiko, Takahashi, Shin-Ichiro, Yahagi, Naoya, Ito, Koichi, Shimano, Hitoshi
Published in Cell reports methods (23.08.2021)
Published in Cell reports methods (23.08.2021)
Get full text
Journal Article
Intestinal CREBH overexpression prevents high-cholesterol diet-induced hypercholesterolemia by reducing Npc1l1 expression
Kikuchi, Takuya, Orihara, Kana, Oikawa, Fusaka, Han, Song-iee, Kuba, Motoko, Okuda, Kanako, Satoh, Aoi, Osaki, Yoshinori, Takeuchi, Yoshinori, Aita, Yuichi, Matsuzaka, Takashi, Iwasaki, Hitoshi, Yatoh, Shigeru, Sekiya, Motohiro, Yahagi, Naoya, Suzuki, Hiroaki, Sone, Hirohito, Nakagawa, Yoshimi, Yamada, Nobuhiro, Shimano, Hitoshi
Published in Molecular metabolism (Germany) (01.11.2016)
Published in Molecular metabolism (Germany) (01.11.2016)
Get full text
Journal Article
SUMOylation negatively regulates transcriptional and oncogenic activities of MafA
Kanai, Kenichi, Reza, Hasan Mahmud, Kamitani, Akiyo, Hamazaki, Yuri, Han, Song-iee, Yasuda, Kunio, Kataoka, Kohsuke
Published in Genes to cells : devoted to molecular & cellular mechanisms (01.09.2010)
Published in Genes to cells : devoted to molecular & cellular mechanisms (01.09.2010)
Get full text
Journal Article