Discovery of novel, highly potent and selective β-hairpin mimetic CXCR4 inhibitors with excellent anti-HIV activity and pharmacokinetic profiles
DeMarco, Steven J., Henze, Heiko, Lederer, Alexander, Moehle, Kerstin, Mukherjee, Reshmi, Romagnoli, Barbara, Robinson, John A., Brianza, Federico, Gombert, Frank O., Lociuro, Sergio, Ludin, Christian, Vrijbloed, Jan Willem, Zumbrunn, Jürg, Obrecht, Jean-Pierre, Obrecht, Daniel, Brondani, Vincent, Hamy, François, Klimkait, Thomas
Published in Bioorganic & medicinal chemistry (15.12.2006)
Published in Bioorganic & medicinal chemistry (15.12.2006)
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An Inhibitor of the Tat/TAR RNA Interaction that Effectively Suppresses HIV-1 Replication
Hamy, Francois, Felder, Eduard R., Heizmann, Gerhard, Lazdins, Jains, Aboul-Ela, Fareed, Varani, Gabriele, Karn, Jonathan, Klimkait, Thomas
Published in Proceedings of the National Academy of Sciences - PNAS (15.04.1997)
Published in Proceedings of the National Academy of Sciences - PNAS (15.04.1997)
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Thiated derivatives of 2′,3′-dideoxy-3′-fluorothymidine: Synthesis, in vitro anti-HIV-1 activity and interaction with recombinant drug resistant HIV-1 reverse transcriptase forms
Miazga, Agnieszka, Hamy, François, Louvel, Séverine, Klimkait, Thomas, Pietrusiewicz, Zofia, Kurzyńska-Kokorniak, Anna, Figlerowicz, Marek, Wińska, Patrycja, Kulikowski, Tadeusz
Published in Antiviral research (01.10.2011)
Published in Antiviral research (01.10.2011)
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Journal Article
Recombination between variants from genital tract and plasma: evolution of multidrug-resistant HIV type 1
Kemal, Kimdar S, Ramirez, Christina M, Burger, Harold, Foley, Brian, Mayers, Douglas, Klimkait, Thomas, Hamy, François, Anastos, Kathryn, Petrovic, Katarina, Minin, Vladimir N, Suchard, Marc A, Weiser, Barbara
Published in AIDS research and human retroviruses (01.12.2012)
Published in AIDS research and human retroviruses (01.12.2012)
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Journal Article
Replicative phenotyping adds value to genotypic resistance testing in heavily pre-treated HIV-infected individuals--the Swiss HIV Cohort Study
Fehr, Jan, Glass, Tracy R, Louvel, Séverine, Hamy, François, Hirsch, Hans H, von Wyl, Viktor, Böni, Jürg, Yerly, Sabine, Bürgisser, Philippe, Cavassini, Matthias, Fux, Christoph A, Hirschel, Bernard, Vernazza, Pietro, Martinetti, Gladys, Bernasconi, Enos, Günthard, Huldrych F, Battegay, Manuel, Bucher, Heiner C, Klimkait, Thomas
Published in Journal of translational medicine (21.01.2011)
Published in Journal of translational medicine (21.01.2011)
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Journal Article
Library-Based Discovery and Characterization of Daphnane Diterpenes as Potent and Selective HIV Inhibitors in Daphne gnidium
Vidal, Vincent, Potterat, Olivier, Louvel, Séverine, Hamy, François, Mojarrab, Mahdi, Sanglier, Jean-Jacques, Klimkait, Thomas, Hamburger, Matthias
Published in Journal of natural products (Washington, D.C.) (23.03.2012)
Published in Journal of natural products (Washington, D.C.) (23.03.2012)
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Journal Article
Inhibition of HIV-1 Tat-TAR interaction by diphenylfuran derivatives: effects of the terminal basic side chains
Gelus, Nathalie, Bailly, Christian, Hamy, François, Klimkait, Thomas, Wilson, W.David, Boykin, David W.
Published in Bioorganic & medicinal chemistry (01.06.1999)
Published in Bioorganic & medicinal chemistry (01.06.1999)
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Journal Article
Discovery of Highly Potent and Selective CXCR4 Inhibitors Using Protein Epitope Mimetics (PEM) Technology
Alexander Lederer, John A. Robinson, Kerstin Moehle, Thomas Klimkait, François Hamy, Vincent Brondani, Sergio Lociuro, Jean-Pierre Obrecht, Jan Willem Vrijbloed, Christian Ludin, Frank O. Gombert, Federico Brianza, Jürg Zumbrunn, Reshmi Mukherjee, Barbara Romagnoli, Heiko Henze, Steven J. DeMarco, Daniel Obrecht
Published in Chimia (25.04.2007)
Published in Chimia (25.04.2007)
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The Camptothecin-Resistant Topoisomerase I Mutant F361S Is Cross-Resistant to Antitumor Rebeccamycin Derivatives. A Model for Topoisomerase I Inhibition by Indolocarbazoles
Bailly, Christian, Carrasco, Carolina, Hamy, François, Vezin, Hervé, Prudhomme, Michelle, Saleem, Ahamed, Rubin, Eric
Published in Biochemistry (Easton) (06.07.1999)
Published in Biochemistry (Easton) (06.07.1999)
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Journal Article
Cooperativity in the Binding of Echinomycin to DNA Fragments Containing Closely Spaced CpG Sites
Bailly, Christian, Hamy, François, Waring, Michael J
Published in Biochemistry (Easton) (30.01.1996)
Published in Biochemistry (Easton) (30.01.1996)
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Journal Article
Merged screening for human immunodeficiency virus Tat and Rev inhibitors
Hamy, F, Felder, E, Lipson, K, Klimkait, T
Published in Journal of biomolecular screening (01.06.2001)
Published in Journal of biomolecular screening (01.06.2001)
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Journal Article
A New Class of HIV-1 Tat Antagonist Acting through Tat−TAR Inhibition
Hamy, François, Brondani, Vincent, Flörsheimer, Andreas, Stark, Wilhelm, Blommers, Marcel J. J, Klimkait, Thomas
Published in Biochemistry (Easton) (14.04.1998)
Published in Biochemistry (Easton) (14.04.1998)
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Journal Article
Promoter of FGF8 Reveals a Unique Regulation by Unliganded RARα
Brondani, Vincent, Klimkait, Thomas, Egly, Jean-Marc, Hamy, François
Published in Journal of molecular biology (07.06.2002)
Published in Journal of molecular biology (07.06.2002)
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Journal Article
A Second Target for the Peptoid Tat/Transactivation Response Element Inhibitor CGP64222: Inhibition of Human Immunodeficiency Virus Replication by Blocking CXC-Chemokine Receptor 4-Mediated Virus Entry
Daelemans, D, Schols, D, Witvrouw, M, Pannecouque, C, Hatse, S, van Dooren, S, Hamy, F, Klimkait, T, de Clercq, E, VanDamme, A M
Published in Molecular pharmacology (01.01.2000)
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Published in Molecular pharmacology (01.01.2000)
Journal Article
Retinoic Acid Switches Differential Expression of FGF8 Isoforms in LNCaP Cells
Brondani, Vincent, Hamy, François
Published in Biochemical and biophysical research communications (27.05.2000)
Published in Biochemical and biophysical research communications (27.05.2000)
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Journal Article
Molecular basis of HIV-1 TAR RNA specific recognition by an acridine tat-antagonist
Gelus, Nathalie, Hamy, François, Bailly, Christian
Published in Bioorganic & medicinal chemistry (01.06.1999)
Published in Bioorganic & medicinal chemistry (01.06.1999)
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