Targeting copper(II)-induced oxidative stress and the acetylcholinesterase system in Alzheimer's disease using multifunctional tacrine-coumarin hybrid molecules
Hamulakova, Slavka, Poprac, Patrik, Jomova, Klaudia, Brezova, Vlasta, Lauro, Peter, Drostinova, Lenka, Jun, Daniel, Sepsova, Vendula, Hrabinova, Martina, Soukup, Ondrej, Kristian, Pavol, Gazova, Zuzana, Bednarikova, Zuzana, Kuca, Kamil, Valko, Marian
Published in Journal of inorganic biochemistry (01.08.2016)
Published in Journal of inorganic biochemistry (01.08.2016)
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Tacrine-coumarin and Tacrine-7-chloroquinoline Hybrids with Thiourea Linkers: Cholinesterase Inhibition Properties, Kinetic Study, Molecular Docking and Permeability Assay for Blood-brain Barrier
Hamulakova, Slavka, Janovec, Ladislav, Soukup, Ondrej, Jun, Daniel, Janockova, Jana, Hrabinova, Martina, Sepsova, Vendula, Kuca, Kamil
Published in Current Alzheimer research (01.01.2018)
Published in Current Alzheimer research (01.01.2018)
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In vitro investigating of anticancer activity of new 7-MEOTA-tacrine heterodimers
Janockova, Jana, Korabecny, Jan, Plsikova, Jana, Babkova, Katerina, Konkolova, Eva, Kucerova, Dana, Vargova, Jana, Koval, Jan, Jendzelovsky, Rastislav, Fedorocko, Peter, Kasparkova, Jana, Brabec, Viktor, Rosocha, Jan, Soukup, Ondrej, Hamulakova, Slavka, Kuca, Kamil, Kozurkova, Maria
Published in Journal of enzyme inhibition and medicinal chemistry (01.01.2019)
Published in Journal of enzyme inhibition and medicinal chemistry (01.01.2019)
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Journal Article
Neuroactive Multifunctional Tacrine Congeners with Cholinesterase, Anti-Amyloid Aggregation and Neuroprotective Properties
Kozurkova, Maria, Hamulakova, Slavka, Gazova, Zuzana, Paulikova, Helena, Kristian, Pavol
Published in Pharmaceuticals (01.02.2011)
Published in Pharmaceuticals (01.02.2011)
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Book Review
Synthesis and Biological Evaluation of Novel Tacrine Derivatives and Tacrine–Coumarin Hybrids as Cholinesterase Inhibitors
Hamulakova, Slavka, Janovec, Ladislav, Hrabinova, Martina, Spilovska, Katarina, Korabecny, Jan, Kristian, Pavol, Kuca, Kamil, Imrich, Jan
Published in Journal of medicinal chemistry (28.08.2014)
Published in Journal of medicinal chemistry (28.08.2014)
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Journal Article
Synthesis, in vitro acetylcholinesterase inhibitory activity and molecular docking of new acridine-coumarin hybrids
Hamulakova, Slavka, Janovec, Ladislav, Soukup, Ondrej, Jun, Daniel, Kuca, Kamil
Published in International journal of biological macromolecules (01.11.2017)
Published in International journal of biological macromolecules (01.11.2017)
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Bis-coumarin homodimers—potential inhibitors of amyloid aggregation of globular and intrinsically disordered proteins
Spodniaková, Barbora, Krupa, Pawel, Bednarikova, Zuzana, Gancar, Miroslav, Antošová, Andrea, Hamulakova, Slavka, Li, Mai S., Gazova, Zuzana
Published in Biophysical journal (11.02.2022)
Published in Biophysical journal (11.02.2022)
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Journal Article
Novel tacrine/acridine anticholinesterase inhibitors with piperazine and thiourea linkers
Hamulakova, Slavka, Imrich, Jan, Janovec, Ladislav, Kristian, Pavol, Danihel, Ivan, Holas, Ondrej, Pohanka, Miroslav, Böhm, Stanislav, Kozurkova, Maria, Kuca, Kamil
Published in International journal of biological macromolecules (01.09.2014)
Published in International journal of biological macromolecules (01.09.2014)
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Journal Article
Synthesis, design and biological evaluation of novel highly potent tacrine congeners for the treatment of Alzheimer's disease
Hamulakova, Slavka, Janovec, Ladislav, Hrabinova, Martina, Kristian, Pavol, Kuca, Kamil, Banasova, Maria, Imrich, Jan
Published in European journal of medicinal chemistry (01.09.2012)
Published in European journal of medicinal chemistry (01.09.2012)
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Journal Article
Lysozyme amyloid fibrillization in presence of tacrine/acridone-coumarin heterodimers
Ulicna, Katarina, Bednarikova, Zuzana, Hsu, Wei-Tse, Holztragerova, Martina, Wu, Josephine W., Hamulakova, Slavka, Wang, Steven S.-S., Gazova, Zuzana
Published in Colloids and surfaces, B, Biointerfaces (01.06.2018)
Published in Colloids and surfaces, B, Biointerfaces (01.06.2018)
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Design and synthesis of novel tacrine–indole hybrids as potential multitarget-directed ligands for the treatment of Alzheimer's disease
Hamulakova, Slavka, Kudlickova, Zuzana, Janovec, Ladislav, Mezencev, Roman, Deckner, Zachery J, Chernoff, Yury O, Janockova, Jana, Ihnatova, Veronika, Bzonek, Petr, Novakova, Nikola, Hepnarova, Vendula, Hrabinova, Martina, Jun, Daniel, Korabecny, Jan, Soukup, Ondrej, Kuca, Kamil
Published in Future medicinal chemistry (01.05.2021)
Published in Future medicinal chemistry (01.05.2021)
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Journal Article
SYNTHESIS, STRUCTURE, AND CHOLINERGIC EFFECT OF NOVEL NEUROPROTECTIVE COMPOUNDS BEARING THE TACRINE PHARMACOPHORE
Hamul'akova, Slavka, Kristian, Pavol, Jun, Daniel, Kuca, Kamil, Imrich, Jan, Danihel, Ivan, Boehm, Stanislav, Klika, Karel D.
Published in Heterocycles (01.11.2008)
Published in Heterocycles (01.11.2008)
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Tacrine-Coumarin Derivatives as Topoisomerase Inhibitors with Antitumor Effects on A549 Human Lung Carcinoma Cancer Cell Lines
Konkoľová, Eva, Hudáčová, Monika, Hamuľaková, Slávka, Jendželovský, Rastislav, Vargová, Jana, Ševc, Juraj, Fedoročko, Peter, Kožurková, Mária
Published in Molecules (Basel, Switzerland) (20.02.2021)
Published in Molecules (Basel, Switzerland) (20.02.2021)
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Synthesis of New Biscoumarin Derivatives, In Vitro Cholinesterase Inhibition, Molecular Modelling and Antiproliferative Effect in A549 Human Lung Carcinoma Cells
Hudáčová, Monika, Hamuľaková, Slávka, Konkoľová, Eva, Jendželovský, Rastislav, Vargová, Jana, Ševc, Juraj, Fedoročko, Peter, Soukup, Ondrej, Janočková, Jana, Ihnatova, Veronika, Kučera, Tomáš, Bzonek, Petr, Novakova, Nikola, Jun, Daniel, Junova, Lucie, Korábečný, Jan, Kuča, Kamil, Kožurková, Mária
Published in International journal of molecular sciences (07.04.2021)
Published in International journal of molecular sciences (07.04.2021)
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Journal Article
Anti-Cancer Effect of Tacrine-Coumarin Derivatives on Diverse Human and Mouse Cancer Cell Lines
Solárová, Zuzana, Kello, Martin, Hamuľaková, Slávka, Mirossay, Ladislav, Solár, Peter
Published in Acta chimica Slovenica (01.12.2018)
Published in Acta chimica Slovenica (01.12.2018)
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DNA binding acridine–thiazolidinone agents affecting intracellular glutathione
Paulíková, Helena, Vantová, Zuzana, Hunáková, Ľuba, Čižeková, Lýdia, Čarná, Mária, Kožurková, Mária, Sabolová, Danica, Kristian, Pavol, Hamuľaková, Slávka, Imrich, Ján
Published in Bioorganic & medicinal chemistry (15.12.2012)
Published in Bioorganic & medicinal chemistry (15.12.2012)
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Inhibition of DNA topoisomerases I and II and growth inhibition of HL-60 cells by novel acridine-based compounds
Janočková, Jana, Plšíková, Jana, Kašpárková, Jana, Brabec, Viktor, Jendželovský, Rastislav, Mikeš, Jaromír, Kovaľ, Ján, Hamuľaková, Slávka, Fedoročko, Peter, Kuča, Kamil, Kožurková, Mária
Published in European journal of pharmaceutical sciences (30.08.2015)
Published in European journal of pharmaceutical sciences (30.08.2015)
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Proliferation inhibition of novel diphenylamine derivatives
Janovec, Ladislav, Janočková, Jana, Matejová, Mária, Konkoľová, Eva, Paulíková, Helena, Lichancová, Daniela, Júnošová, Lenka, Hamuľaková, Slávka, Imrich, Ján, Kožurková, Mária
Published in Bioorganic chemistry (01.03.2019)
Published in Bioorganic chemistry (01.03.2019)
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