Boosting NAD+ with a small molecule that activates NAMPT
Gardell, Stephen J., Hopf, Meghan, Khan, Asima, Dispagna, Mauro, Hampton Sessions, E., Falter, Rebecca, Kapoor, Nidhi, Brooks, Jeanne, Culver, Jeffrey, Petucci, Chris, Ma, Chen-Ting, Cohen, Steven E., Tanaka, Jun, Burgos, Emmanuel S., Hirschi, Jennifer S., Smith, Steven R., Sergienko, Eduard, Pinkerton, Anthony B.
Published in Nature communications (19.07.2019)
Published in Nature communications (19.07.2019)
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Journal Article
Molecular mechanism of a covalent allosteric inhibitor of SUMO E1 activating enzyme
Lv, Zongyang, Yuan, Lingmin, Atkison, James H., Williams, Katelyn M., Vega, Ramir, Sessions, E. Hampton, Divlianska, Daniela B., Davies, Christopher, Chen, Yuan, Olsen, Shaun K.
Published in Nature communications (04.12.2018)
Published in Nature communications (04.12.2018)
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Journal Article
Discovery of small molecule guanylyl cyclase A receptor positive allosteric modulators
Sangaralingham, S. Jeson, Whig, Kanupriya, Peddibhotla, Satyamaheshwar, Kirby, R. Jason, Sessions, Hampton E., Maloney, Patrick R., Hershberger, Paul M., Mose-Yates, Heather, Hood, Becky L., Vasile, Stefan, Pan, Shuchong, Zheng, Ye, Malany, Siobhan, Burnett, John C.
Published in Proceedings of the National Academy of Sciences - PNAS (28.12.2021)
Published in Proceedings of the National Academy of Sciences - PNAS (28.12.2021)
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Journal Article
Optimization of a urea-containing series of nicotinamide phosphoribosyltransferase (NAMPT) activators
Pinkerton, Anthony B., Sessions, E. Hampton, Hershberger, Paul, Maloney, Patrick R., Peddibhotla, Satyamaheshwar, Hopf, Meghan, Sergienko, Eduard, Ma, Chen-Ting, Smith, Layton H., Jackson, Michael R., Tanaka, Jun, Tsuji, Takashi, Akiu, Mayuko, Cohen, Steven E., Nakamura, Tsuyoshi, Gardell, Stephen J.
Published in Bioorganic & medicinal chemistry letters (01.06.2021)
Published in Bioorganic & medicinal chemistry letters (01.06.2021)
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Journal Article
Discovery of small molecule antagonists of chemokine receptor CXCR6 that arrest tumor growth in SK-HEP-1 mouse xenografts as a model of hepatocellular carcinoma
Peddibhotla, Satyamaheshwar, Hershberger, Paul M., Jason Kirby, R., Sugarman, Eliot, Maloney, Patrick R., Hampton Sessions, E., Divlianska, Daniela, Morfa, Camilo J., Terry, David, Pinkerton, Anthony B., Smith, Layton H., Malany, Siobhan
Published in Bioorganic & medicinal chemistry letters (15.02.2020)
Published in Bioorganic & medicinal chemistry letters (15.02.2020)
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Journal Article
Identification and characterization of small molecule inhibitors of the ubiquitin ligases Siah1/2 in melanoma and prostate cancer cells
Feng, Yongmei, Sessions, E. Hampton, Zhang, Fan, Ban, Fuqiang, Placencio-Hickok, Veronica, Ma, Chen-Ting, Zeng, Fu-Yue, Pass, Ian, Terry, David B., Cadwell, Gregory, Bankston, Laurie A., Liddington, Robert C., Chung, Thomas D.Y., Pinkerton, Anthony B., Sergienko, Eduard, Gleave, Martin, Bhowmick, Neil A., Jackson, Michael R., Cherkasov, Artem, Ronai, Ze'ev A.
Published in Cancer letters (01.05.2019)
Published in Cancer letters (01.05.2019)
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Journal Article
Benzimidazole- and benzoxazole-based inhibitors of Rho kinase
Sessions, E. Hampton, Yin, Yan, Bannister, Thomas D., Weiser, Amiee, Griffin, Evelyn, Pocas, Jennifer, Cameron, Michael D., Ruiz, Claudia, Lin, Li, Schürer, Stephan C., Schröter, Thomas, LoGrasso, Philip, Feng, Yangbo
Published in Bioorganic & medicinal chemistry (15.12.2008)
Published in Bioorganic & medicinal chemistry (15.12.2008)
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Journal Article
Discovery and optimization of indoles and 7-azaindoles as Rho kinase (ROCK) inhibitors (part-I)
Chowdhury, Sarwat, Sessions, E. Hampton, Pocas, Jennifer R., Grant, Wayne, Schröter, Thomas, Lin, Li, Ruiz, Claudia, Cameron, Michael D., Schürer, Stephan, LoGrasso, Philip, Bannister, Thomas D., Feng, Yangbo
Published in Bioorganic & medicinal chemistry letters (01.12.2011)
Published in Bioorganic & medicinal chemistry letters (01.12.2011)
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Journal Article
Synthesis and biological evaluation of 4-quinazolinones as Rho kinase inhibitors
Fang, Xingang, Chen, Yen Ting, Sessions, E. Hampton, Chowdhury, Sarwat, Vojkovsky, Tomas, Yin, Yan, Pocas, Jennifer R., Grant, Wayne, Schröter, Thomas, Lin, Li, Ruiz, Claudia, Cameron, Michael D., LoGrasso, Philip, Bannister, Thomas D., Feng, Yangbo
Published in Bioorganic & medicinal chemistry letters (15.03.2011)
Published in Bioorganic & medicinal chemistry letters (15.03.2011)
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Journal Article
Discovery and optimization of indole and 7-azaindoles as Rho kinase (ROCK) inhibitors (Part-II)
Sessions, E. Hampton, Chowdhury, Sarwat, Yin, Yan, Pocas, Jennifer R., Grant, Wayne, Schröter, Thomas, Lin, Li, Ruiz, Claudia, Cameron, Michael D., LoGrasso, Philip, Bannister, Thomas D., Feng, Yangbo
Published in Bioorganic & medicinal chemistry letters (01.12.2011)
Published in Bioorganic & medicinal chemistry letters (01.12.2011)
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Journal Article
The development of benzimidazoles as selective rho kinase inhibitors
Sessions, E. Hampton, Smolinski, Michael, Wang, Bo, Frackowiak, Bozena, Chowdhury, Sarwat, Yin, Yan, Chen, Yen Ting, Ruiz, Claudia, Lin, Li, Pocas, Jennifer, Schröter, Thomas, Cameron, Michael D., LoGrasso, Philip, Feng, Yangbo, Bannister, Thomas D.
Published in Bioorganic & medicinal chemistry letters (15.03.2010)
Published in Bioorganic & medicinal chemistry letters (15.03.2010)
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Journal Article
Synthesis and physicochemical characterization of novel phenotypic probes targeting the nuclear factor-kappa B signaling pathway
Hershberger, Paul M, Peddibhotla, Satyamaheshwar, Sessions, E Hampton, Divlianska, Daniela B, Correa, Ricardo G, Pinkerton, Anthony B, Reed, John C, Roth, Gregory P
Published in Beilstein journal of organic chemistry (08.05.2013)
Published in Beilstein journal of organic chemistry (08.05.2013)
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Journal Article
Discovery of 1-[2-(1-methyl-1H-pyrazol-5-yl)-[1,2,4]triazolo[1,5-a]pyridin-6-yl]-3-(pyridin-4-ylmethyl)urea as a potent NAMPT (nicotinamide phosphoribosyltransferase) activator with attenuated CYP inhibition
Akiu, Mayuko, Tsuji, Takashi, Sogawa, Yoshitaka, Terayama, Koji, Yokoyama, Mika, Tanaka, Jun, Asano, Daigo, Sakurai, Ken, Sergienko, Eduard, Sessions, E. Hampton, Gardell, Stephen J., Pinkerton, Anthony B., Nakamura, Tsuyoshi
Published in Bioorganic & medicinal chemistry letters (01.07.2021)
Published in Bioorganic & medicinal chemistry letters (01.07.2021)
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Journal Article
Discovery of Novel Small-Molecule Inducers of Heme Oxygenase-1 That Protect Human iPSC-Derived Cardiomyocytes from Oxidative Stress
Kirby, R Jason, Divlianska, Daniela B, Whig, Kanupriya, Bryan, Nadezda, Morfa, Camilo J, Koo, Ada, Nguyen, Kevin H, Maloney, Patrick, Peddibhotla, Satayamaheshwar, Sessions, E Hampton, Hershberger, Paul M, Smith, Layton H, Malany, Siobhan
Published in The Journal of pharmacology and experimental therapeutics (01.01.2018)
Published in The Journal of pharmacology and experimental therapeutics (01.01.2018)
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Journal Article
Structure-Guided Strategy for the Development of Potent Bivalent ERK Inhibitors
Lechtenberg, Bernhard C, Mace, Peter D, Sessions, E. Hampton, Williamson, Robert, Stalder, Romain, Wallez, Yann, Roth, Gregory P, Riedl, Stefan J, Pasquale, Elena B
Published in ACS medicinal chemistry letters (13.07.2017)
Published in ACS medicinal chemistry letters (13.07.2017)
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Journal Article
Identification of Inhibitors of NOD1-Induced Nuclear Factor-κB Activation
Khan, Pasha M, Correa, Ricardo G, Divlianska, Daniela B, Peddibhotla, Satyamaheshwar, Sessions, E. Hampton, Magnuson, Gavin, Brown, Brock, Suyama, Eigo, Yuan, Hongbin, Mangravita-Novo, Arianna, Vicchiarelli, Michael, Su, Ying, Vasile, Stefan, Smith, Layton H, Diaz, Paul W, Reed, John C, Roth, Gregory P
Published in ACS medicinal chemistry letters (13.10.2011)
Published in ACS medicinal chemistry letters (13.10.2011)
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Journal Article
Two-Step Electrochemical Annulation for the Assembly of Polycyclic Systems
Whitehead, Christopher R, Sessions, E. Hampton, Ghiviriga, Ion, Wright, Dennis L
Published in Organic letters (17.10.2002)
Published in Organic letters (17.10.2002)
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Journal Article