Oral FXIIa inhibitor KV998086 suppresses FXIIa and single chain FXII mediated kallikrein kinin system activation
Clermont, Allen C, Murugesan, Nivetha, Edwards, Hannah J, Lee, Daniel K, Bayliss, Natasha P, Duckworth, Edward J, Pethen, Stephen J, Hampton, Sally L, Gailani, David, Feener, Edward P
Published in Frontiers in pharmacology (19.12.2023)
Published in Frontiers in pharmacology (19.12.2023)
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KVD900, an oral on-demand treatment for hereditary angioedema: Phase 1 study results
Maetzel, Andreas, Smith, Michael D., Duckworth, Edward J., Hampton, Sally L., De Donatis, Gian Marco, Murugesan, Nivetha, Rushbrooke, Louise J., Li, Lily, Francombe, Danielle, Feener, Edward P., Yea, Christopher M.
Published in Journal of allergy and clinical immunology (01.06.2022)
Published in Journal of allergy and clinical immunology (01.06.2022)
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Pharmacological suppression of the kallikrein kinin system with KVD900: An orally available plasma kallikrein inhibitor for the on‐demand treatment of hereditary angioedema
Duckworth, Edward J., Murugesan, Nivetha, Li, Lily, Rushbrooke, Louise J., Lee, Daniel K., De Donatis, Gian Marco, Maetzel, Andreas, Yea, Christopher M., Hampton, Sally L., Feener, Edward P.
Published in Clinical and experimental allergy (01.09.2022)
Published in Clinical and experimental allergy (01.09.2022)
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Sebetralstat (KVD900): A Potent and Selective Small Molecule Plasma Kallikrein Inhibitor Featuring a Novel P1 Group as a Potential Oral On-Demand Treatment for Hereditary Angioedema
Davie, Rebecca L., Edwards, Hannah J., Evans, D. Michael, Hodgson, Simon T., Stocks, Michael J., Smith, Alun J., Rushbrooke, Louise J., Pethen, Stephen J., Roe, Michael B., Clark, David E., McEwan, Paul A., Hampton, Sally L.
Published in Journal of medicinal chemistry (27.10.2022)
Published in Journal of medicinal chemistry (27.10.2022)
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KVD900 as a Single Dose, Rapid, Oral Plasma Kallikrein Inhibitor for the On-Demand Treatment of Hereditary Angioedema Attacks: Pharmacokinetic and Pharmacodynamic results from a Phase 1 Single Ascending Dose Study
Hampton, Sally L., De Donatis, Gian Marco, Murugesan, Nivetha I., Rushbrooke, Louise J., Li, Lily, Duckworth, Edward, Smith, Michael D., Morten, Rachel M., Maetzel, Andreas, Yea, Christopher M., Feener, Edward P.
Published in Journal of allergy and clinical immunology (01.02.2019)
Published in Journal of allergy and clinical immunology (01.02.2019)
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Sebetralstat: A Rapidly Acting Oral Plasma Kallikrein Inhibitor for the On-Demand Treatment of Hereditary Angioedema
Feener, Edward P., Davie, Rebecca L., Murugesan, Nivetha, Pethen, Stephen J., Hampton, Sally L., Smith, Michael D., Audhya, Paul K., Yea, Chris M.
Published in Drugs and drug candidates (07.04.2024)
Published in Drugs and drug candidates (07.04.2024)
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New Benzylureas as a Novel Series of Potent, Nonpeptidic Vasopressin V2 Receptor Agonists
Yea, Christopher M, Allan, Christine E, Ashworth, Doreen M, Barnett, James, Baxter, Andy J, Broadbridge, Janice D, Franklin, Richard J, Hampton, Sally L, Hudson, Peter, Horton, John A, Jenkins, Paul D, Penson, Andy M, Pitt, Gary R. W, Rivière, Pierre, Robson, Peter A, Rooker, David P, Semple, Graeme, Sheppard, Andy, Haigh, Robert M, Roe, Michael B
Published in Journal of medicinal chemistry (25.12.2008)
Published in Journal of medicinal chemistry (25.12.2008)
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