Effects of carvedilol on structural and functional outcomes and plasma biomarkers in the mouse transverse aortic constriction heart failure model
Hampton, Caryn, Rosa, Raymond, Szeto, Daphne, Forrest, Gail, Campbell, Barry, Kennan, Richard, Wang, Shubing, Huang, Chin-Hu, Gichuru, Loise, Ping, Xiaoli, Shen, Xiaolan, Small, Kersten, Madwed, Jeffrey, Lynch, Joseph J
Published in SAGE open medicine (01.01.2017)
Published in SAGE open medicine (01.01.2017)
Get full text
Journal Article
Discovery of MK-8153, a Potent and Selective ROMK Inhibitor and Novel Diuretic/Natriuretic
Jiang, Jinlong, Ding, Fa-Xiang, Zhou, Xiaoyan, Bateman, Thomas J, Dong, Shuzhi, Gu, Xin, Keh deJesus, Reynalda, Pio, Barbara, Tang, Haifeng, Chobanian, Harry R, Levorse, Dorothy, Hu, Mengwei, Thomas-Fowlkes, Brande, Margulis, Michael, Koehler, Martin, Weinglass, Adam, Gibson, Jack, Houle, Kevin, Yudkovitz, Joel, Hampton, Caryn, Pai, Lee-Yuh, Samuel, Koppara, Cutarelli, Timothy, Sullivan, Kathleen, Parmee, Emma R, Davies, Ian, Pasternak, Alexander
Published in Journal of medicinal chemistry (10.06.2021)
Published in Journal of medicinal chemistry (10.06.2021)
Get full text
Journal Article
Early echocardiographic predictors of outcomes in the mouse transverse aortic constriction heart failure model
Hampton, Caryn, Rosa, Raymond, Campbell, Barry, Kennan, Richard, Gichuru, Loise, Ping, Xiaoli, Shen, Xiaolan, Small, Kersten, Madwed, Jeffrey, Lynch, Joseph J.
Published in Journal of pharmacological and toxicological methods (01.03.2017)
Published in Journal of pharmacological and toxicological methods (01.03.2017)
Get full text
Journal Article
The design and synthesis of novel spirocyclic heterocyclic sulfone ROMK inhibitors as diuretics
Chobanian, Harry R., Guo, Yan, Pio, Barbara, Tang, Haifeng, Teumelsan, Nardos, Clements, Matthew, Frie, Jessica, Ferguson, Ronald, Guo, Zach, Thomas-Fowlkes, Brande S., Felix, John P., Liu, Jessica, Kohler, Martin, Priest, Birgit, Hampton, Caryn, Pai, Lee-Yuh, Corona, Aaron, Metzger, Joseph, Tong, Vincent, Joshi, Elizabeth M., Xu, Ling, Owens, Karen, Maloney, Kevin, Sullivan, Kathleen, Pasternak, Alexander
Published in Bioorganic & medicinal chemistry letters (15.02.2017)
Published in Bioorganic & medicinal chemistry letters (15.02.2017)
Get full text
Journal Article
Improvement of hERG-ROMK index of spirocyclic ROMK inhibitors through scaffold optimization and incorporation of novel pharmacophores
Dong, Shuzhi, VanGelder, Kelsey, Shi, Zhi-Cai, Yu, Yang, Wu, Zhicai, Ferguson, Ron, Guo, Zack Zhiqiang, Tang, Haifeng, Frie, Jessica, Fu, Qinghong, Gu, Xin, Priest, Birgit T., Thomas-Fowlkes, Brande, Weinglass, Adam, Margulis, Michael, Liu, Jessica, Pai, Lee-Yuh, Hampton, Caryn, Haimbach, Robin E., Owens, Karen, Tong, Vincent, Xu, Shiyao, Hu, Mengwei, Zingaro, Gloria J., Morissette, Pierre, Ehrhart, Juliann, Roy, Sophie, Sullivan, Kathleen, Pasternak, Alexander
Published in Bioorganic & medicinal chemistry letters (01.06.2017)
Published in Bioorganic & medicinal chemistry letters (01.06.2017)
Get full text
Journal Article
Discovery of a potent and selective ROMK inhibitor with improved pharmacokinetic properties based on an octahydropyrazino[2,1-c][1,4]oxazine scaffold
Zhu, Yuping, de Jesus, Reynalda K., Tang, Haifeng, Walsh, Shawn P., Jiang, Jinlong, Gu, Xin, Teumelsan, Nardos, Shahripour, Aurash, Pio, Barbara, Ding, Fa-Xiang, Ha, Sookhee, Priest, Birgit T., Swensen, Andrew M., Alonso-Galicia, Magdalena, Felix, John P., Brochu, Richard M., Bailey, Timothy, Thomas-Fowlkes, Brande, Zhou, Xiaoyan, Pai, Lee-Yuh, Hampton, Caryn, Hernandez, Melba, Owens, Karen, Ehrhart, Juliann, Roy, Sophie, Kaczorowski, Gregory J., Yang, Lihu, Parmee, Emma R., Sullivan, Kathleen, Garcia, Maria L., Pasternak, Alexander
Published in Bioorganic & medicinal chemistry letters (01.12.2016)
Published in Bioorganic & medicinal chemistry letters (01.12.2016)
Get full text
Journal Article
Discovery of a novel sub-class of ROMK channel inhibitors typified by 5-(2-(4-(2-(4-(1H-Tetrazol-1-yl)phenyl)acetyl)piperazin-1-yl)ethyl)isobenzofuran-1(3H)-one
Tang, Haifeng, de Jesus, Reynald K., Walsh, Shawn P., Zhu, Yuping, Yan, Yan, Priest, Birgit T., Swensen, Andrew M., Alonso-Galicia, Magdalena, Felix, John P., Brochu, Richard M., Bailey, Timothy, Thomas-Fowlkes, Brande, Zhou, Xiaoyan, Pai, Lee-Yuh, Hampton, Caryn, Hernandez, Melba, Owens, Karen, Roy, Sophie, Kaczorowski, Gregory J., Yang, Lihu, Garcia, Maria L., Pasternak, Alexander
Published in Bioorganic & medicinal chemistry letters (01.11.2013)
Published in Bioorganic & medicinal chemistry letters (01.11.2013)
Get full text
Journal Article
Discovery of MK-7145, an Oral Small Molecule ROMK Inhibitor for the Treatment of Hypertension and Heart Failure
Tang, Haifeng, Zhu, Yuping, Teumelsan, Nardos, Walsh, Shawn P, Shahripour, Aurash, Priest, Birgit T, Swensen, Andrew M, Felix, John P, Brochu, Richard M, Bailey, Timothy, Thomas-Fowlkes, Brande, Pai, Lee-Yuh, Hampton, Caryn, Corona, Aaron, Hernandez, Melba, Metzger, Joseph, Forrest, Michael, Zhou, Xiaoyan, Owens, Karen, Tong, Vincent, Parmee, Emma, Roy, Sophie, Kaczorowski, Gregory J, Yang, Lihu, Alonso-Galicia, Magdalena, Garcia, Maria L, Pasternak, Alexander
Published in ACS medicinal chemistry letters (14.07.2016)
Published in ACS medicinal chemistry letters (14.07.2016)
Get full text
Journal Article
The Renal Outer Medullary Potassium Channel Inhibitor, MK-7145, Lowers Blood Pressure, and Manifests Features of Bartter's Syndrome Type II Phenotype
Hampton, Caryn, Zhou, Xiaoyan, Priest, Birgit T, Pai, Lee-Yuh, Felix, John P, Thomas-Fowlkes, Brande, Liu, Jessica, Kohler, Martin, Xiao, Jianying, Corona, Aaron, Price, Olga, Gill, Charles, Shah, Kashmira, Rasa, Cordelia, Tong, Vince, Owens, Karen, Ormes, James, Tang, Haifeng, Roy, Sophie, Sullivan, Kathleen A, Metzger, Joseph M, Alonso-Galicia, Magdalena, Kaczorowski, Gregory J, Pasternak, Alexander, Garcia, Maria L
Published in The Journal of pharmacology and experimental therapeutics (01.10.2016)
Published in The Journal of pharmacology and experimental therapeutics (01.10.2016)
Get full text
Journal Article
Differentiation of ROMK potency from hERG potency in the phenacetyl piperazine series through heterocycle incorporation
Walsh, Shawn P., Shahripour, Aurash, Tang, Haifeng, de Jesus, Reynalda K., Teumelsan, Nardos, Zhu, Yuping, Frie, Jessica, Priest, Birgit T., Swensen, Andrew M., Alonso-Galicia, Magdalena, Felix, John P., Brochu, Richard M., Bailey, Timothy, Thomas-Fowlkes, Brande, Zhou, Xiaoyan, Pai, Lee-Yuh, Hampton, Caryn, Hernandez, Melba, Owens, Karen, Ehrhart, Juliann, Roy, Sophie, Kaczorowski, Gregory J., Yang, Lihu, Garcia, Maria L., Pasternak, Alexander
Published in Bioorganic & medicinal chemistry letters (01.05.2016)
Published in Bioorganic & medicinal chemistry letters (01.05.2016)
Get full text
Journal Article
Discovery of a Potent and Selective ROMK Inhibitor with Pharmacokinetic Properties Suitable for Preclinical Evaluation
Walsh, Shawn P, Shahripour, Aurash, Tang, Haifeng, Teumelsan, Nardos, Frie, Jessica, Zhu, Yuping, Priest, Birgit T, Swensen, Andrew M, Liu, Jessica, Margulis, Michael, Visconti, Richard, Weinglass, Adam, Felix, John P, Brochu, Richard M, Bailey, Timothy, Thomas-Fowlkes, Brande, Alonso-Galicia, Magdalena, Zhou, Xiaoyan, Pai, Lee-Yuh, Corona, Aaron, Hampton, Caryn, Hernandez, Melba, Bentley, Ross, Chen, Jing, Shah, Kashmira, Metzger, Joseph, Forrest, Michael, Owens, Karen, Tong, Vincent, Ha, Sookhee, Roy, Sophie, Kaczorowski, Gregory J, Yang, Lihu, Parmee, Emma, Garcia, Maria L, Sullivan, Kathleen, Pasternak, Alexander
Published in ACS medicinal chemistry letters (09.07.2015)
Published in ACS medicinal chemistry letters (09.07.2015)
Get full text
Journal Article