Differential PROTAC substrate specificity dictated by orientation of recruited E3 ligase
Smith, Blake E, Wang, Stephen L, Jaime-Figueroa, Saul, Harbin, Alicia, Wang, Jing, Hamman, Brian D, Crews, Craig M
Published in Nature communications (10.01.2019)
Published in Nature communications (10.01.2019)
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Lessons in PROTAC Design from Selective Degradation with a Promiscuous Warhead
Bondeson, Daniel P., Smith, Blake E., Burslem, George M., Buhimschi, Alexandru D., Hines, John, Jaime-Figueroa, Saul, Wang, Jing, Hamman, Brian D., Ishchenko, Alexey, Crews, Craig M.
Published in Cell chemical biology (18.01.2018)
Published in Cell chemical biology (18.01.2018)
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Identification and Characterization of Von Hippel-Lindau-Recruiting Proteolysis Targeting Chimeras (PROTACs) of TANK-Binding Kinase 1
Crew, Andrew P, Raina, Kanak, Dong, Hanqing, Qian, Yimin, Wang, Jing, Vigil, Dominico, Serebrenik, Yevgeniy V, Hamman, Brian D, Morgan, Alicia, Ferraro, Caterina, Siu, Kam, Neklesa, Taavi K, Winkler, James D, Coleman, Kevin G, Crews, Craig M
Published in Journal of medicinal chemistry (25.01.2018)
Published in Journal of medicinal chemistry (25.01.2018)
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Journal Article
Selective PROTAC-mediated degradation of SMARCA2 is efficacious in SMARCA4 mutant cancers
Cantley, Jennifer, Ye, Xiaofen, Rousseau, Emma, Januario, Tom, Hamman, Brian D, Rose, Christopher M, Cheung, Tommy K, Hinkle, Trent, Soto, Leofal, Quinn, Connor, Harbin, Alicia, Bortolon, Elizabeth, Chen, Xin, Haskell, Roy, Lin, Eva, Yu, Shang-Fan, Del Rosario, Geoff, Chan, Emily, Dunlap, Debra, Koeppen, Hartmut, Martin, Scott, Merchant, Mark, Grimmer, Matt, Broccatelli, Fabio, Wang, Jing, Pizzano, Jennifer, Dragovich, Peter S, Berlin, Michael, Yauch, Robert L
Published in Nature communications (10.11.2022)
Published in Nature communications (10.11.2022)
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Journal Article
Genetic deletion of Mst1 alters T cell function and protects against autoimmunity
Salojin, Konstantin V, Hamman, Brian D, Chang, Wei Chun, Jhaver, Kanchan G, Al-Shami, Amin, Crisostomo, Jeannette, Wilkins, Carrie, Digeorge-Foushee, Ann Marie, Allen, Jason, Patel, Nita, Gopinathan, Suma, Zhou, Julia, Nouraldeen, Amr, Jessop, Theodore C, Bagdanoff, Jeffrey T, Augeri, David J, Read, Robert, Vogel, Peter, Swaffield, Jonathan, Wilson, Alan, Platt, Kenneth A, Carson, Kenneth G, Main, Alan, Zambrowicz, Brian P, Oravecz, Tamas
Published in PloS one (22.05.2014)
Published in PloS one (22.05.2014)
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PROTACs Targeting BRM (SMARCA2) Afford Selective In Vivo Degradation over BRG1 (SMARCA4) and Are Active in BRG1 Mutant Xenograft Tumor Models
Berlin, Michael, Cantley, Jennifer, Bookbinder, Mark, Bortolon, Elizabeth, Broccatelli, Fabio, Cadelina, Greg, Chan, Emily W., Chen, Huifen, Chen, Xin, Cheng, Yunxing, Cheung, Tommy K., Davenport, Kim, DiNicola, Dean, Gordon, Debbie, Hamman, Brian D., Harbin, Alicia, Haskell, Roy, He, Mingtao, Hole, Alison J., Januario, Thomas, Kerry, Philip S., Koenig, Stefan G., Li, Limei, Merchant, Mark, Pérez-Dorado, Inmaculada, Pizzano, Jennifer, Quinn, Connor, Rose, Christopher M., Rousseau, Emma, Soto, Leofal, Staben, Leanna R., Sun, Hongming, Tian, Qingping, Wang, Jing, Wang, Weifeng, Ye, Crystal S., Ye, Xiaofen, Zhang, Penghong, Zhou, Yuhui, Yauch, Robert, Dragovich, Peter S.
Published in Journal of medicinal chemistry (25.01.2024)
Published in Journal of medicinal chemistry (25.01.2024)
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Discovery, Structure–Activity Relationships, and In Vivo Evaluation of Novel Aryl Amides as Brain Penetrant Adaptor Protein 2‑Associated Kinase 1 (AAK1) Inhibitors for the Treatment of Neuropathic Pain
Hartz, Richard A, Ahuja, Vijay T, Nara, Susheel J, Kumar, C.M. Vijaya, Brown, Jeffrey M, Bristow, Linda J, Rajamani, Ramkumar, Muckelbauer, Jodi K, Camac, Daniel, Kiefer, Susan E, Hunihan, Lisa, Gulianello, Michael, Lewis, Martin, Easton, Amy, Lippy, Jonathan S, Surti, Neha, Pattipati, Sreenivasulu N, Dokania, Manoj, Elavazhagan, Saravanan, Dandapani, Kumaran, Hamman, Brian D, Allen, Jason, Kostich, Walter, Bronson, Joanne J, Macor, John E, Dzierba, Carolyn D
Published in Journal of medicinal chemistry (12.08.2021)
Published in Journal of medicinal chemistry (12.08.2021)
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Bicyclic Heterocyclic Replacement of an Aryl Amide Leading to Potent and Kinase-Selective Adaptor Protein 2‑Associated Kinase 1 Inhibitors
Hartz, Richard A, Ahuja, Vijay T, Nara, Susheel J, Kumar, C. M. Vijaya, Manepalli, Raju K. V. L. P, Sarvasiddhi, Sarat Kumar, Honkhambe, Swarnamba, Patankar, Vidya, Dasgupta, Bireshwar, Rajamani, Ramkumar, Muckelbauer, Jodi K, Camac, Daniel M, Ghosh, Kaushik, Pokross, Matthew, Kiefer, Susan E, Brown, Jeffrey M, Hunihan, Lisa, Gulianello, Michael, Lewis, Martin, Lippy, Jonathan S, Surti, Neha, Hamman, Brian D, Allen, Jason, Kostich, Walter A, Bronson, Joanne J, Macor, John E, Dzierba, Carolyn D
Published in Journal of medicinal chemistry (10.03.2022)
Published in Journal of medicinal chemistry (10.03.2022)
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Journal Article
Discovery of a Type III Inhibitor of LIM Kinase 2 That Binds in a DFG-Out Conformation
Goodwin, Nicole C, Cianchetta, Giovanni, Burgoon, Hugh A, Healy, Jason, Mabon, Ross, Strobel, Eric D, Allen, Jason, Wang, Shuli, Hamman, Brian D, Rawlins, David B
Published in ACS medicinal chemistry letters (08.01.2015)
Published in ACS medicinal chemistry letters (08.01.2015)
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Journal Article
Discovery and Development of LX7101, a Dual LIM-Kinase and ROCK Inhibitor for the Treatment of Glaucoma
Harrison, Bryce A, Almstead, Zheng Y, Burgoon, Hugh, Gardyan, Michael, Goodwin, Nicole C, Healy, Jason, Liu, Ying, Mabon, Ross, Marinelli, Brett, Samala, Lakshman, Zhang, Yulian, Stouch, Terry R, Whitlock, N. Andrew, Gopinathan, Suma, McKnight, Beth, Wang, Shuli, Patel, Nita, Wilson, Alan G. E, Hamman, Brian D, Rice, Dennis S, Rawlins, David B
Published in ACS medicinal chemistry letters (08.01.2015)
Published in ACS medicinal chemistry letters (08.01.2015)
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Journal Article
Novel Class of LIM-Kinase 2 Inhibitors for the Treatment of Ocular Hypertension and Associated Glaucoma
Harrison, Bryce A, Whitlock, N. Andrew, Voronkov, Michael V, Almstead, Zheng Y, Gu, Kun-jian, Mabon, Ross, Gardyan, Michael, Hamman, Brian D, Allen, Jason, Gopinathan, Suma, McKnight, Beth, Crist, Mike, Zhang, Yulian, Liu, Ying, Courtney, Lawrence F, Key, Billie, Zhou, Julia, Patel, Nita, Yates, Phil W, Liu, Qingyun, Wilson, Alan G. E, Kimball, S. David, Crosson, Craig E, Rice, Dennis S, Rawlins, David B
Published in Journal of medicinal chemistry (12.11.2009)
Published in Journal of medicinal chemistry (12.11.2009)
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Journal Article
Profound Obesity Secondary to Hyperphagia in Mice Lacking Kinase Suppressor of Ras 2
Revelli, Jean‐Pierre, Smith, Deon, Allen, Jason, Jeter‐Jones, Sabrina, Shadoan, Melanie K., Desai, Urvi, Schneider, Matthias, Sligtenhorst, Isaac, Kirkpatrick, Laura, Platt, Kenneth A., Suwanichkul, Adisak, Savelieva, Katerina, Gerhardt, Brenda, Mitchell, Jay, Syrewicz, James, Zambrowicz, Brian, Hamman, Brian D., Vogel, Peter, Powell, David R.
Published in Obesity (Silver Spring, Md.) (01.05.2011)
Published in Obesity (Silver Spring, Md.) (01.05.2011)
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Identification of a Membrane-Spanning Domain of the Thiol-Activated Pore-Forming Toxin Clostridium perfringens Perfringolysin O: An α-Helical to β-Sheet Transition Identified by Fluorescence Spectroscopy
Shepard, Laura A, Heuck, Alejandro P, Hamman, Brian D, Rossjohn, Jamie, Parker, Michael W, Ryan, Kathleen R, Johnson, Arthur E, Tweten, Rodney K
Published in Biochemistry (Easton) (13.10.1998)
Published in Biochemistry (Easton) (13.10.1998)
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A FRET-based assay platform for ultra-high density drug screening of protein kinases and phosphatases
Rodems, Steven M, Hamman, Brian D, Lin, Christina, Zhao, Jane, Shah, Sundeep, Heidary, David, Makings, Lew, Stack, Jeffrey H, Pollok, Brian A
Published in Assay and drug development technologies (01.11.2002)
Published in Assay and drug development technologies (01.11.2002)
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A high-throughput screen for receptor protein tyrosine phosphatase-gamma selective inhibitors
Appiah, Kingsley K, Kostich, Walter A, Gerritz, Samuel W, Huang, Yanling, Hamman, Brian D, Allen, Jason, Zhang, Wandong, Lanthorn, Thomas H, Albright, Charles F, Westphal, Ryan, Banks, Martyn N, O'Connell, Jonathan C
Published in Journal of biomolecular screening (01.06.2011)
Published in Journal of biomolecular screening (01.06.2011)
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Journal Article
Rotational and Conformational Dynamics of Escherichia coli Ribosomal Protein L7/L12
Hamman, Brian D, Oleinikov, Andrew V, Jokhadze, George G, Traut, Robert R, Jameson, David M
Published in Biochemistry (Easton) (24.12.1996)
Published in Biochemistry (Easton) (24.12.1996)
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