Development of a Binding Model to Protein Tyrosine Kinases for Substituted Pyrido[2,3-d]pyrimidine Inhibitors
Trumpp-Kallmeyer, Susanne, Rubin, J. Ronald, Humblet, Christine, Hamby, James M, Hollis Showalter, H. D
Published in Journal of medicinal chemistry (21.05.1998)
Published in Journal of medicinal chemistry (21.05.1998)
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Structure−Activity Relationships for a Novel Series of Pyrido[2,3-d]pyrimidine Tyrosine Kinase Inhibitors
Hamby, James M, Connolly, Cleo J. C, Schroeder, Mel C, Winters, R. Thomas, Showalter, H. D. Hollis, Panek, Robert L, Major, Terry C, Olsewski, Bronislawa, Ryan, Michael J, Dahring, Tawny, Lu, Gina H, Keiser, Joan, Amar, Aneesa, Shen, Cindy, Kraker, Alan J, Slintak, Veronika, Nelson, James M, Fry, David W, Bradford, Laura, Hallak, Hussein, Doherty, Annette M
Published in Journal of medicinal chemistry (18.07.1997)
Published in Journal of medicinal chemistry (18.07.1997)
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Soluble 2-Substituted Aminopyrido[2,3-d]pyrimidin-7-yl Ureas. Structure−Activity Relationships against Selected Tyrosine Kinases and Exploration of in Vitro and in Vivo Anticancer Activity
Schroeder, Mel C, Hamby, James M, Connolly, Cleo J. C, Grohar, Patrick J, Winters, R. Thomas, Barvian, Mark R, Moore, Charles W, Boushelle, Stacey L, Crean, Sheila M, Kraker, Alan J, Driscoll, Denise L, Vincent, Patrick W, Elliott, William L, Lu, Gina H, Batley, Brian L, Dahring, Tawny K, Major, Terry C, Panek, Robert L, Doherty, Annette M, Showalter, H. D. Hollis
Published in Journal of medicinal chemistry (07.06.2001)
Published in Journal of medicinal chemistry (07.06.2001)
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3-(3,5-Dimethoxyphenyl)-1,6-naphthyridine-2,7-diamines and Related 2-Urea Derivatives Are Potent and Selective Inhibitors of the FGF Receptor-1 Tyrosine Kinase
Thompson, Andrew M, Connolly, Cleo J. C, Hamby, James M, Boushelle, Stacey, Hartl, Brian G, Amar, Aneesa M, Kraker, Alan J, Driscoll, Denise L, Steinkampf, Randall W, Patmore, Sandra J, Vincent, Patrick W, Roberts, Bill J, Elliott, William L, Klohs, Wayne, Leopold, Wilbur R, Showalter, H. D. Hollis, Denny, William A
Published in Journal of medicinal chemistry (02.11.2000)
Published in Journal of medicinal chemistry (02.11.2000)
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Crystal structure of an angiogenesis inhibitor bound to the FGF receptor tyrosine kinase domain
Mohammadi, Moosa, Froum, Scott, Hamby, James M., Schroeder, Mel C., Panek, Robert L., Lu, Gina H., Eliseenkova, Anna V., Green, David, Schlessinger, Joseph, Hubbard, Stevan R.
Published in The EMBO journal (15.10.1998)
Published in The EMBO journal (15.10.1998)
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Discovery and structure-activity studies of a novel series of pyrido[2,3- d]pyrimidine tyrosine kinase inhibitors
Connolly, Cleo J.C., Hamby, James M., Schroeder, Mel C., Barvian, Mark, Lu, Gina H., Panek, Robert L., Amar, Aneesa, Shen, Cindy, Kraker, Alan J., Fry, David W., Klohs, Wayne D., Doherty, Annette M.
Published in Bioorganic & medicinal chemistry letters (23.09.1997)
Published in Bioorganic & medicinal chemistry letters (23.09.1997)
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Derivatives of 5-[[1-4(4-carboxybenzyl)imidazolyl]methylidene]hydantoins as orally active angiotensin II receptor antagonists
Edmunds, Jeremy J, Klutchko, Sylvester, Hamby, James M, Bunker, Amy M, Connolly, Cleo J. C, Winters, R. Thomas, Quin, John, Sircar, Ila, Hodges, John C
Published in Journal of medicinal chemistry (01.09.1995)
Published in Journal of medicinal chemistry (01.09.1995)
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INHIBITION OF FGF-1 RECEPTOR TYROSINE KINASE ACTIVITY BY PD 161570, A NEW PROTEIN-TYROSINE KINASE INHIBITOR
Batley, Brian L, Doherty, Annette M, Hamby, James M, Lu, Gina H, Keller, Paul, Dahring, Tawny K, Hwang, Ok, Crickard, Kent, Panek, Robert L
Published in Life sciences (1973) (1998)
Published in Life sciences (1973) (1998)
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2-Substituted Aminopyrido[2,3-d]pyrimidin-7(8H)-ones. Structure−Activity Relationships Against Selected Tyrosine Kinases and in Vitro and in Vivo Anticancer Activity
Klutchko, Sylvester R, Hamby, James M, Boschelli, Diane H, Wu, Zhipei, Kraker, Alan J, Amar, Aneesa M, Hartl, Brian G, Shen, Cynthia, Klohs, Wayne D, Steinkampf, Randall W, Driscoll, Denise L, Nelson, James M, Elliott, William L, Roberts, Billy J, Stoner, Chad L, Vincent, Patrick W, Dykes, Donald J, Panek, Robert L, Lu, Gina H, Major, Terry C, Dahring, Tawny K, Hallak, Hussein, Bradford, Laura A, Showalter, H. D. Hollis, Doherty, Annette M
Published in Journal of medicinal chemistry (13.08.1998)
Published in Journal of medicinal chemistry (13.08.1998)
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In Vitro Pharmacological Characterization of PD 166285, a New Nanomolar Potent and Broadly Active Protein Tyrosine Kinase Inhibitor
Panek, R L, Lu, G H, Klutchko, S R, Batley, B L, Dahring, T K, Hamby, J M, Hallak, H, Doherty, A M, Keiser, J A
Published in The Journal of pharmacology and experimental therapeutics (01.12.1997)
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Published in The Journal of pharmacology and experimental therapeutics (01.12.1997)
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Synthesis and Tyrosine Kinase Inhibitory Activity of a Series of 2-Amino-8H-pyrido[2,3-d]pyrimidines: Identification of Potent, Selective Platelet-Derived Growth Factor Receptor Tyrosine Kinase Inhibitors
Boschelli, Diane H, Wu, Zhipei, Klutchko, Sylvester R, Showalter, H. D. Hollis, Hamby, James M, Lu, Gina H, Major, Terry C, Dahring, Tawny K, Batley, Brian, Panek, Robert L, Keiser, Joan, Hartl, Brian G, Kraker, Alan J, Klohs, Wayne D, Roberts, Bill J, Patmore, Sandra, Elliott, William L, Steinkampf, Randy, Bradford, Laura A, Hallak, Hussein, Doherty, Annette M
Published in Journal of medicinal chemistry (22.10.1998)
Published in Journal of medicinal chemistry (22.10.1998)
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Renin inhibitors containing .alpha.-heteroatom amino acids as P2 residues
Repine, Joseph T, Kaltenbronn, James S, Doherty, Annette M, Hamby, James M, Himmelsbach, Richard J, Kornberg, Brian E, Taylor, Michael D, Lunney, ELizabeth A, Humblet, Christine
Published in Journal of medicinal chemistry (01.03.1992)
Published in Journal of medicinal chemistry (01.03.1992)
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In Vitro Biological Characterization and Antiangiogenic Effects of PD 166866, a Selective Inhibitor of the FGF-1 Receptor Tyrosine Kinase
Panek, R L, Lu, G H, Dahring, T K, Batley, B L, Connolly, C, Hamby, J M, Brown, K J
Published in The Journal of pharmacology and experimental therapeutics (01.07.1998)
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Published in The Journal of pharmacology and experimental therapeutics (01.07.1998)
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Structure−Activity Relationships for 1-Phenylbenzimidazoles as Selective ATP Site Inhibitors of the Platelet-Derived Growth Factor Receptor
Palmer, Brian D, Smaill, Jeff B, Boyd, Maruta, Boschelli, Diane H, Doherty, Annette M, Hamby, James M, Khatana, Sonya S, Kramer, James B, Kraker, Alan J, Panek, Robert L, Lu, Gina H, Dahring, Tawny K, Winters, R. Thomas, Showalter, H. D. Hollis, Denny, William A
Published in Journal of medicinal chemistry (31.12.1998)
Published in Journal of medicinal chemistry (31.12.1998)
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Inhibition of Growth Factor-Mediated Tyrosine Phosphorylation in Vascular Smooth Muscle by PD 089828, a New Synthetic Protein Tyrosine Kinase Inhibitor
Dahring, T K, Lu, G H, Hamby, J M, Batley, B L, Kraker, A J, Panek, R L
Published in The Journal of pharmacology and experimental therapeutics (01.06.1997)
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Published in The Journal of pharmacology and experimental therapeutics (01.06.1997)
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1-oxo-3-aryl-1H-indene-2-carboxylic acid derivatives as selective inhibitors of fibroblast growth factor receptor-1 tyrosine kinase
BARVIAN, M. R, PANEK, R. L, LU, G. H, KRAKER, A. J, AMAR, A, HARTL, B, HAMBY, J. M, SHOWALTER, H. D. H
Published in Bioorganic & medicinal chemistry letters (18.11.1997)
Published in Bioorganic & medicinal chemistry letters (18.11.1997)
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Design and Synthesis of Renin Inhibitors: Incorporation of Transition-State Isostere Side Chains That Span from the S1 to the S3 Binding Pockets and Examination of P3-Modified Renin Inhibitors
Shahripour, Aurash, Kaltenbronn, James S, Lunney, Elizabeth A, Steinbaugh, Bruce A, Hamby, James M, Hamilton, Harriet W, Sawyer, Tomi K, Humblet, Christine, Doherty, Annette M
Published in Journal of medicinal chemistry (01.07.1995)
Published in Journal of medicinal chemistry (01.07.1995)
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