SLC46A3 Is Required to Transport Catabolites of Noncleavable Antibody Maytansine Conjugates from the Lysosome to the Cytoplasm
Hamblett, Kevin J, Jacob, Allison P, Gurgel, Jesse L, Tometsko, Mark E, Rock, Brooke M, Patel, Sonal K, Milburn, Robert R, Siu, Sophia, Ragan, Seamus P, Rock, Dan A, Borths, Christopher J, O'Neill, Jason W, Chang, Wesley S, Weidner, Margaret F, Bio, Matthew M, Quon, Kim C, Fanslow, William C
Published in Cancer research (Chicago, Ill.) (15.12.2015)
Published in Cancer research (Chicago, Ill.) (15.12.2015)
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Journal Article
AMG 595, an Anti-EGFRvIII Antibody-Drug Conjugate, Induces Potent Antitumor Activity against EGFRvIII-Expressing Glioblastoma
Hamblett, Kevin J, Kozlosky, Carl J, Siu, Sophia, Chang, Wesley S, Liu, Hua, Foltz, Ian N, Trueblood, Esther S, Meininger, David, Arora, Taruna, Twomey, Brian, Vonderfecht, Steven L, Chen, Qing, Hill, John S, Fanslow, William C
Published in Molecular cancer therapeutics (01.07.2015)
Published in Molecular cancer therapeutics (01.07.2015)
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Journal Article
Effects of Drug Loading on the Antitumor Activity of a Monoclonal Antibody Drug Conjugate
HAMBLETT, Kevin J, SENTER, Peter D, MEYER, Damon L, FRANCISCO, Joseph A, CHACE, Dana F, SUN, Michael M. C, LENOX, Joel, CERVENY, Charles G, KISSLER, Kim M, BERNHARDT, Starr X, KOPCHA, Anastasia K, ZABINSKI, Roger F
Published in Clinical cancer research (15.10.2004)
Published in Clinical cancer research (15.10.2004)
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Journal Article
Reduction−Alkylation Strategies for the Modification of Specific Monoclonal Antibody Disulfides
Sun, Michael M. C, Beam, Kevin S, Cerveny, Charles G, Hamblett, Kevin J, Blackmore, Richard S, Torgov, Michael Y, Handley, Felicia G. M, Ihle, Nathan C, Senter, Peter D, Alley, Stephen C
Published in Bioconjugate chemistry (01.09.2005)
Published in Bioconjugate chemistry (01.09.2005)
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Journal Article
Intracellular Catabolism of an Antibody Drug Conjugate with a Noncleavable Linker
Rock, Brooke M, Tometsko, Mark E, Patel, Sonal K, Hamblett, Kevin J, Fanslow, William C, Rock, Dan A
Published in Drug metabolism and disposition (01.09.2015)
Published in Drug metabolism and disposition (01.09.2015)
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Journal Article
Engineered antibody–drug conjugates with defined sites and stoichiometries of drug attachment
McDonagh, Charlotte F., Turcott, Eileen, Westendorf, Lori, Webster, Jennifer B., Alley, Stephen C., Kim, Kristine, Andreyka, Jamie, Stone, Ivan, Hamblett, Kevin J., Francisco, Joseph A., Carter, Paul
Published in Protein engineering, design and selection (01.07.2006)
Published in Protein engineering, design and selection (01.07.2006)
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Journal Article
1155 Activated regulatory T cells in solid tumors express CD30, which are selectively targeted by the novel anti-CD30 antibody drug conjugate SGN-35T
O’Connor, Brian P, Grogan, Bryan M, James, Reice D, Ulrich, Michelle L, Berndt, Jason D, Lu, Hailing, Conerly, Melissa, Clarke, Astrid, Hamblett, Kevin J, Heiser, Ryan A
Published in Journal for immunotherapy of cancer (01.11.2023)
Published in Journal for immunotherapy of cancer (01.11.2023)
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Journal Article
Altering Antibody–Drug Conjugate Binding to the Neonatal Fc Receptor Impacts Efficacy and Tolerability
Hamblett, Kevin J, Le, Tiep, Rock, Brooke M, Rock, Dan A, Siu, Sophia, Huard, Justin N, Conner, Kip P, Milburn, Robert R, O’Neill, Jason W, Tometsko, Mark E, Fanslow, William C
Published in Molecular pharmaceutics (05.07.2016)
Published in Molecular pharmaceutics (05.07.2016)
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Journal Article
SGN-35C: A Novel CD30-Directed Antibody-Drug Conjugate for the Treatment of Lymphomas
Hamblett, Kevin J., Cochran, Julia, Snead, Katie, Jin, Steven, Yumul, Roma, Simmons, Jessica, Stone, Ivan, Lyski, Ryan, Schrum, Jason P., Lim, Andrea R., Clarke, Astrid
Published in Blood (02.11.2023)
Published in Blood (02.11.2023)
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Journal Article
Abstract 2633: Zanidatamab zovodotin (ZW49) induces hallmarks of immunogenic cell death and is active in patient-derived xenograft models of gastric cancer
Barnscher, Stuart D., Rojas, Andrea Hernández, Hamblett, Kevin J., Escalante, Nichole
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Published in Cancer research (Chicago, Ill.) (04.04.2023)
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Journal Article
Abstract 3912: Towards development of next-generation biparatopic ADCs using a novel linker-toxin with expanded therapeutic window
Davies, Rupert H., Barnscher, Stuart D., Chan, Peter W., Madera, Laurence, Rich, Jamie R., Vallejo, Marylou, Wickman, Grant R., Yin, Kevin, Fung, Vincent, Hamblett, Kevin J., Kaminker, Patrick G., Babcook, John S.
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Journal Article
Abstract 3914: ZW49, a HER2-targeted biparatopic antibody-drug conjugate for the treatment of HER2-expressing cancers
Hamblett, Kevin J., Hammond, Phil W., Barnscher, Stuart D., Fung, Vincent K., Davies, Rupert H., Wickman, Grant R., Hernandez, Andrea, Ding, Tong, Galey, Adam S., Winters, Geoffrey C., Rich, Jamie R., Babcook, John S.
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Journal Article
Abstract C132: SGN-35T: A novel CD30-directed antibody-drug conjugate for the treatment of lymphomas
Hamblett, Kevin J, Jin, Steven, Yumul, Roma, Chen, Yufei, Kwon, John, Simmons, Jessica, Henderson, Clark, Sun, Hao, Schrum, Jason P, Lim, Andrea R, Bindman, Noah A, Conerly, Melissa, Clarke, Astrid
Published in Molecular cancer therapeutics (01.12.2023)
Published in Molecular cancer therapeutics (01.12.2023)
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Journal Article
MRI apparent diffusion coefficient in a murine orthotopic glioblastoma model as a clinically translatable early readout of efficacy for AMG 595, an antibody drug conjugate targeting EGFRvIII
Yerby, Brittany, Estrada, Juan, Silva, Matthew D., Hamblett, Kevin J., Coberly, Suzanne K., Hill, John S., Ungersma, Sharon E., Beltran, Pedro J.
Published in Journal of clinical oncology (20.05.2013)
Published in Journal of clinical oncology (20.05.2013)
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Journal Article
SGN-35, an Anti-CD30 Antibody-Drug Conjugate, Exhibits Potent Antitumor Activity for the Treatment of CD30+ Malignancies
Hamblett, Kevin J., Barton, Jeremy, Cerveny, Charles G., Andreyka, Jamie B., Kissler, Kim M., Okeley, Nicole M., Stone, Ivan, Sutherland, May K., Sun, Michael M., Senter, Peter D., Wahl, Alan F., Ihle, Nathan C.
Published in Blood (16.11.2005)
Published in Blood (16.11.2005)
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Journal Article
The Anti-CD30 Monoclonal Antibody SGN-30 Inhibits Hodgkins Disease Growth and Sensitizes Cells to Established Chemotherapeutics
Cerveny, Charles G., Law, Che-Leung, McCormick, Renee S., Lenox, Joel S., Hamblett, Kevin J., Westendorf, Lori E., Yamane, Andrew K., Petroziello, Joseph M., Francisco, Joseph A., Wahl, Alan F.
Published in Blood (16.11.2004)
Published in Blood (16.11.2004)
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Journal Article