Exploration of the internal cavity of histone deacetylase (HDAC) with selective HDAC1/HDAC2 inhibitors (SHI-1:2)
Methot, Joey L., Chakravarty, Prasun K., Chenard, Melissa, Close, Joshua, Cruz, Jonathan C., Dahlberg, William K., Fleming, Judith, Hamblett, Christopher L., Hamill, Julie E., Harrington, Paul, Harsch, Andreas, Heidebrecht, Richard, Hughes, Bethany, Jung, Joon, Kenific, Candia M., Kral, Astrid M., Meinke, Peter T., Middleton, Richard E., Ozerova, Nicole, Sloman, David L., Stanton, Matthew G., Szewczak, Alexander A., Tyagarajan, Sriram, Witter, David J., Paul Secrist, J., Miller, Thomas A.
Published in Bioorganic & medicinal chemistry (01.02.2008)
Published in Bioorganic & medicinal chemistry (01.02.2008)
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Journal Article
Total Synthesis of Leucascandrolide A
Hornberger, Keith R, Hamblett, Christopher L, Leighton, James L
Published in Journal of the American Chemical Society (27.12.2000)
Published in Journal of the American Chemical Society (27.12.2000)
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Journal Article
SAR profiles of spirocyclic nicotinamide derived selective HDAC1/HDAC2 inhibitors (SHI-1:2)
METHOT, Joey L, HAMBLETT, Christopher L, HONGMEI WANG, KRAL, Astrid M, OZEROVA, Nicole, CRUZ, Jonathan C, HAINES, Brian, CHENARD, Melissa, KENIFIC, Candia M, SECRIST, J. Paul, MILLER, Thomas A, MAMPREIAN, Dawn M, JUNG, Joon, HARSCH, Andreas, SZEWCZAK, Alexander A, DAHLBERG, William K, MIDDLETON, Richard E, HUGHES, Bethany, FLEMING, Judith C
Published in Bioorganic & medicinal chemistry (01.12.2008)
Published in Bioorganic & medicinal chemistry (01.12.2008)
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Journal Article
The discovery of 6-amino nicotinamides as potent and selective histone deacetylase inhibitors
Hamblett, Christopher L., Methot, Joey L., Mampreian, Dawn M., Sloman, David L., Stanton, Matthew G., Kral, Astrid M., Fleming, Judith C., Cruz, Jonathan C., Chenard, Melissa, Ozerova, Nicole, Hitz, Anna M., Wang, Hongmei, Deshmukh, Sujal V., Nazef, Naim, Harsch, Andreas, Hughes, Bethany, Dahlberg, William K., Szewczak, Alex A., Middleton, Richard E., Mosley, Ralph T., Secrist, J. Paul, Miller, Thomas A.
Published in Bioorganic & medicinal chemistry letters (01.10.2007)
Published in Bioorganic & medicinal chemistry letters (01.10.2007)
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Journal Article
Purine derivatives as potent γ-secretase modulators
Rivkin, Alexey, Ahearn, Sean P., Chichetti, Stephanie M., Hamblett, Christopher L., Garcia, Yudith, Martinez, Michelle, Hubbs, Jed L., Reutershan, Michael H., Daniels, Matthew H., Siliphaivanh, Phieng, Otte, Karin M., Li, Chaomin, Rosenau, Andrew, Surdi, Laura M., Jung, Joon, Hughes, Bethany L., Crispino, Jamie L., Nikov, George N., Middleton, Richard E., Moxham, Christopher M., Szewczak, Alexander A., Shah, Sanjiv, Moy, Lily Y., Kenific, Candia M., Tanga, Flobert, Cruz, Jonathan C., Andrade, Paula, Angagaw, Minilik H., Shomer, Nirah H., Miller, Thomas, Munoz, Benito, Shearman, Mark S.
Published in Bioorganic & medicinal chemistry letters (01.04.2010)
Published in Bioorganic & medicinal chemistry letters (01.04.2010)
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Journal Article
Intramolecular Heck reactions of aryl chlorides with alkynes
Chapman, Lauren M., Adams, Bruce, Kliman, Laura T., Makriyannis, Alexandros, Hamblett, Christopher L.
Published in Tetrahedron letters (17.03.2010)
Published in Tetrahedron letters (17.03.2010)
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Journal Article
Delayed and Prolonged Histone Hyperacetylation with a Selective HDAC1/HDAC2 Inhibitor
Methot, Joey L, Hoffman, Dawn Mampreian, Witter, David J, Stanton, Matthew G, Harrington, Paul, Hamblett, Christopher, Siliphaivanh, Phieng, Wilson, Kevin, Hubbs, Jed, Heidebrecht, Richard, Kral, Astrid M, Ozerova, Nicole, Fleming, Judith C, Wang, Hongmei, Szewczak, Alexander A, Middleton, Richard E, Hughes, Bethany, Cruz, Jonathan C, Haines, Brian B, Chenard, Melissa, Kenific, Candia M, Harsch, Andreas, Secrist, J. Paul, Miller, Thomas A
Published in ACS medicinal chemistry letters (10.04.2014)
Published in ACS medicinal chemistry letters (10.04.2014)
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Journal Article
Fluorinated piperidine acetic acids as γ-secretase modulators
Stanton, Matthew G., Hubbs, Jed, Sloman, David, Hamblett, Christopher, Andrade, Paula, Angagaw, Minilik, Bi, Grace, Black, Regina M., Crispino, Jamie, Cruz, Jonathan C., Fan, Eric, Farris, Georgia, Hughes, Bethany L., Kenific, Candia M., Middleton, Richard E., Nikov, George, Sajonz, Peter, Shah, Sanjiv, Shomer, Nirah, Szewczak, Alexander A., Tanga, Flobert, Tudge, Matthew T., Shearman, Mark, Munoz, Benito
Published in Bioorganic & medicinal chemistry letters (15.01.2010)
Published in Bioorganic & medicinal chemistry letters (15.01.2010)
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Journal Article
Synthesis of C2-symmetric trans-2,6-diarylpiperidinones via aryl cuprate addition: an unexpected stereochemical outcome
Hamblett, Christopher L., Sloman, David L., Kliman, Laura T., Adams, Bruce, Ball, Richard G., Stanton, Matthew G.
Published in Tetrahedron letters (19.03.2007)
Published in Tetrahedron letters (19.03.2007)
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Journal Article
Synthesis of C 2-symmetric trans-2,6-diarylpiperidinones via aryl cuprate addition: an unexpected stereochemical outcome
Hamblett, Christopher L., Sloman, David L., Kliman, Laura T., Adams, Bruce, Ball, Richard G., Stanton, Matthew G.
Published in Tetrahedron letters (19.03.2007)
Published in Tetrahedron letters (19.03.2007)
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Journal Article
Fluorinated piperidine acetic acids as g-secretase modulators
Stanton, Matthew G, Hubbs, Jed, Sloman, David, Hamblett, Christopher, Andrade, Paula, Angagaw, Minilik, Bi, Grace, Black, Regina M, Crispino, Jamie, Cruz, Jonathan C, Fan, Eric, Farris, Georgia, Hughes, Bethany L, Kenific, Candia M, Middleton, Richard E, Nikov, George, Sajonz, Peter, Shah, Sanjiv, Shomer, Nirah, Szewczak, Alexander A, Tanga, Flobert, Tudge, Matthew T, Shearman, Mark, Munoz, Benito
Published in Bioorganic & medicinal chemistry letters (15.01.2010)
Published in Bioorganic & medicinal chemistry letters (15.01.2010)
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Journal Article
Purine derivatives as potent g-secretase modulators
Rivkin, Alexey, Ahearn, Sean P, Chichetti, Stephanie M, Hamblett, Christopher L, Garcia, Yudith, Martinez, Michelle, Hubbs, Jed L, Reutershan, Michael H, Daniels, Matthew H, Siliphaivanh, Phieng, Otte, Karin M, Li, Chaomin, Rosenau, Andrew, Surdi, Laura M, Jung, Joon, Hughes, Bethany L, Crispino, Jamie L, Nikov, George N, Middleton, Richard E, Moxham, Christopher M, Szewczak, Alexander A, Shah, Sanjiv, Moy, Lily Y, Kenific, Candia M, Tanga, Flobert, Cruz, Jonathan C, Andrade, Paula, Angagaw, Minilik H, Shomer, Nirah H, Miller, Thomas, Munoz, Benito, Shearman, Mark S
Published in Bioorganic & medicinal chemistry letters (01.04.2010)
Published in Bioorganic & medicinal chemistry letters (01.04.2010)
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Journal Article
ARYL-FUSED SPIROCYCLIC COMPOUNDS
KATTAR, SOLOMON, MILLER, THOMAS, MAMPREIAN, DAWN, TEMPEST, PAUL, HAMBLETT, CHRISTOPHER, METHOT, JOEY
Year of Publication 03.08.2016
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Year of Publication 03.08.2016
Patent
ChemInform Abstract: Intramolecular Heck Reactions of Aryl Chlorides with Alkynes
Chapman, Lauren M., Adams, Bruce, Kliman, Laura T., Makriyannis, Alexandros, Hamblett, Christopher L.
Published in ChemInform (06.07.2010)
Published in ChemInform (06.07.2010)
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Journal Article
DIFLUORIERTE PIPERIDINE ZUR BEHANDLUNG VON MORBUS ALZHEIMER UND VERWANDTEN LEIDEN
MUNOZ, BENITO, SLOMAN, DAVID, HAMBLETT, CHRISTOPHER, HUBBS, JED, STANTON, MATTHEW
Year of Publication 15.02.2011
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Year of Publication 15.02.2011
Patent
composto, composição farmacêutica, e, uso do composto
SOLOMON D. KATTAR, DAVID L. SLOMAN, MATTHEW G. STANTON, JOSHUA CLOSE, THOMAS MILLER, CHRISTOPHER HAMBLETT, RICHARD W. HEIDEBRECHT, DAWN M. MAMPREIAN, LAURA T. KLIMAN, JOEY L. METHOT, ANNA A. ZABIEREK, PAUL TEMPEST, SCOTT C. BERK
Year of Publication 13.09.2016
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Year of Publication 13.09.2016
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Silylated piperidine derivatives
HAMBLETT CHRISTOPHER L, HUBBS JED, ZHOU HUA, MARTINEZ MICHELLE, MUNOZ BENITO
Year of Publication 16.04.2013
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Year of Publication 16.04.2013
Patent
Spirocyclic compounds
METHOT JOEY L, TEMPEST PAUL, HAMBLETT CHRISTOPHER, STANTON MATTHEW G, ZABIEREK ANNA A, MILLER THOMAS, SLOMAN DAVID L
Year of Publication 01.04.2014
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Year of Publication 01.04.2014
Patent