Modulation of pancreatic cancer cell sensitivity to FOLFIRINOX through microRNA-mediated regulation of DNA damage
Carotenuto, Pietro, Amato, Francesco, Lampis, Andrea, Rae, Colin, Hedayat, Somaieh, Previdi, Maria C., Zito, Domenico, Raj, Maya, Guzzardo, Vincenza, Sclafani, Francesco, Lanese, Andrea, Parisi, Claudia, Vicentini, Caterina, Said-Huntingford, Ian, Hahne, Jens C., Hallsworth, Albert, Kirkin, Vladimir, Young, Kate, Begum, Ruwaida, Wotherspoon, Andrew, Kouvelakis, Kyriakos, Azevedo, Sergio Xavier, Michalarea, Vasiliki, Upstill-Goddard, Rosie, Rao, Sheela, Watkins, David, Starling, Naureen, Sadanandam, Anguraj, Chang, David K., Biankin, Andrew V., Jamieson, Nigel B., Scarpa, Aldo, Cunningham, David, Chau, Ian, Workman, Paul, Fassan, Matteo, Valeri, Nicola, Braconi, Chiara
Published in Nature communications (18.11.2021)
Published in Nature communications (18.11.2021)
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Journal Article
Improved Binding Affinity and Pharmacokinetics Enable Sustained Degradation of BCL6 In Vivo
Huckvale, Rosemary, Harnden, Alice C., Cheung, Kwai-Ming J., Pierrat, Olivier A., Talbot, Rachel, Box, Gary M., Henley, Alan T., de Haven Brandon, Alexis K., Hallsworth, Albert E., Bright, Michael D., Akpinar, Hafize Aysin, Miller, Daniel S. J., Tarantino, Dalia, Gowan, Sharon, Hayes, Angela, Gunnell, Emma A., Brennan, Alfie, Davis, Owen A., Johnson, Louise D., de Klerk, Selby, McAndrew, Craig, Le Bihan, Yann-Vaï, Meniconi, Mirco, Burke, Rosemary, Kirkin, Vladimir, van Montfort, Rob L. M., Raynaud, Florence I., Rossanese, Olivia W., Bellenie, Benjamin R., Hoelder, Swen
Published in Journal of medicinal chemistry (23.06.2022)
Published in Journal of medicinal chemistry (23.06.2022)
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Journal Article
p53 Loss in MYC-Driven Neuroblastoma Leads to Metabolic Adaptations Supporting Radioresistance
Yogev, Orli, Barker, Karen, Sikka, Arti, Almeida, Gilberto S, Hallsworth, Albert, Smith, Laura M, Jamin, Yann, Ruddle, Ruth, Koers, Alexander, Webber, Hannah T, Raynaud, Florence I, Popov, Sergey, Jones, Chris, Petrie, Kevin, Robinson, Simon P, Keun, Hector C, Chesler, Louis
Published in Cancer research (Chicago, Ill.) (15.05.2016)
Published in Cancer research (Chicago, Ill.) (15.05.2016)
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Journal Article
Molecular and in vivo characterization of cancer-propagating cells derived from MYCN-dependent medulloblastoma
Ahmad, Zai, Jasnos, Lukasz, Gil, Veronica, Howell, Louise, Hallsworth, Albert, Petrie, Kevin, Sawado, Tomoyuki, Chesler, Louis
Published in PloS one (18.03.2015)
Published in PloS one (18.03.2015)
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Journal Article
miRNA expression profiling of the murine TH-MYCN neuroblastoma model reveals similarities with human tumors and identifies novel candidate miRNAs
Terrile, Marta, Bryan, Kenneth, Vaughan, Lynsey, Hallsworth, Albert, Webber, Hannah, Chesler, Louis, Stallings, Raymond L
Published in PloS one (02.12.2011)
Published in PloS one (02.12.2011)
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Journal Article
Intrinsic susceptibility MRI identifies tumors with ALKF1174L mutation in genetically-engineered murine models of high-risk neuroblastoma
Jamin, Yann, Glass, Laura, Hallsworth, Albert, George, Rani, Koh, Dow-Mu, Pearson, Andrew D J, Chesler, Louis, Robinson, Simon P
Published in PloS one (2014)
Published in PloS one (2014)
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Journal Article
The ALKF1174L Mutation Potentiates the Oncogenic Activity of MYCN in Neuroblastoma
Berry, Teeara, Luther, William, Bhatnagar, Namrata, Jamin, Yann, Poon, Evon, Sanda, Takaomi, Pei, Desheng, Sharma, Bandana, Vetharoy, Winston R., Hallsworth, Albert, Ahmad, Zai, Barker, Karen, Moreau, Lisa, Webber, Hannah, Wang, Wenchao, Liu, Qingsong, Perez-Atayde, Antonio, Rodig, Scott, Cheung, Nai-Kong, Raynaud, Florence, Hallberg, Bengt, Robinson, Simon P., Gray, Nathanael S., Pearson, Andrew D.J., Eccles, Suzanne A., Chesler, Louis, George, Rani E.
Published in Cancer cell (10.07.2012)
Published in Cancer cell (10.07.2012)
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Journal Article
Application of meso scale technology for the measurement of phosphoproteins in human tumor xenografts
Gowan, Sharon M, Hardcastle, Anthea, Hallsworth, Albert E, Valenti, Melanie R, Hunter, Lisa-Jane K, de Haven Brandon, Alexis K, Garrett, Michelle D, Raynaud, Florence, Workman, Paul, Aherne, Wynne, Eccles, Suzanne A
Published in Assay and drug development technologies (01.06.2007)
Published in Assay and drug development technologies (01.06.2007)
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Journal Article
Abstract 1010: A study of combinatorial growth inhibition, cell death and DNA damage repair caused by CHK1 inhibitor SRA737 and WEE1 inhibitor adavosertib in TP53 mutated cell lines
Stewart, Adam, Pickard, Lisa, Hallsworth, Albert E., Sauvaigo, Sylvie, Muggiolu, Giovanna, Raynaud, Florence, BANERJI, UDAI
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
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Journal Article
The ALK(F1174L) mutation potentiates the oncogenic activity of MYCN in neuroblastoma
Berry, Teeara, Luther, William, Bhatnagar, Namrata, Jamin, Yann, Poon, Evon, Sanda, Takaomi, Pei, Desheng, Sharma, Bandana, Vetharoy, Winston R, Hallsworth, Albert, Ahmad, Zai, Barker, Karen, Moreau, Lisa, Webber, Hannah, Wang, Wenchao, Liu, Qingsong, Perez-Atayde, Antonio, Rodig, Scott, Cheung, Nai-Kong, Raynaud, Florence, Hallberg, Bengt, Robinson, Simon P, Gray, Nathanael S, Pearson, Andrew D J, Eccles, Suzanne A, Chesler, Louis, George, Rani E
Published in Cancer cell (10.07.2012)
Published in Cancer cell (10.07.2012)
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Journal Article
Orally bioavailable CDK9/2 inhibitor shows mechanism-based therapeutic potential in MYCN-driven neuroblastoma
Poon, Evon, Liang, Tong, Jamin, Yann, Walz, Susanne, Kwok, Colin, Hakkert, Anne, Barker, Karen, Urban, Zuzanna, Thway, Khin, Zeid, Rhamy, Hallsworth, Albert, Box, Gary, Ebus, Marli E, Licciardello, Marco P, Sbirkov, Yordan, Lazaro, Glori, Calton, Elizabeth, Costa, Barbara M, Valenti, Melanie, De Haven Brandon, Alexis, Webber, Hannah, Tardif, Nicolas, Almeida, Gilberto S, Christova, Rossitza, Boysen, Gunther, Richards, Mark W, Barone, Giuseppe, Ford, Anthony, Bayliss, Richard, Clarke, Paul A, De Bono, Johann, Gray, Nathanael S, Blagg, Julian, Robinson, Simon P, Eccles, Suzanne A, Zheleva, Daniella, Bradner, James E, Molenaar, Jan, Vivanco, Igor, Eilers, Martin, Workman, Paul, Lin, Charles Y, Chesler, Louis
Published in The Journal of clinical investigation (01.11.2020)
Published in The Journal of clinical investigation (01.11.2020)
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Journal Article
Combined MYC and P53 Defects Emerge at Medulloblastoma Relapse and Define Rapidly Progressive, Therapeutically Targetable Disease
Hill, Rebecca M., Kuijper, Sanne, Lindsey, Janet C., Petrie, Kevin, Schwalbe, Ed C., Barker, Karen, Boult, Jessica K.R., Williamson, Daniel, Ahmad, Zai, Hallsworth, Albert, Ryan, Sarra L., Poon, Evon, Robinson, Simon P., Ruddle, Ruth, Raynaud, Florence I., Howell, Louise, Kwok, Colin, Joshi, Abhijit, Nicholson, Sarah Leigh, Crosier, Stephen, Ellison, David W., Wharton, Stephen B., Robson, Keith, Michalski, Antony, Hargrave, Darren, Jacques, Thomas S., Pizer, Barry, Bailey, Simon, Swartling, Fredrik J., Weiss, William A., Chesler, Louis, Clifford, Steven C.
Published in Cancer cell (12.01.2015)
Published in Cancer cell (12.01.2015)
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Journal Article
In Vivo Modeling of Chemoresistant Neuroblastoma Provides New Insights into Chemorefractory Disease and Metastasis
Yogev, Orli, Almeida, Gilberto S, Barker, Karen T, George, Sally L, Kwok, Colin, Campbell, James, Zarowiecki, Magdalena, Kleftogiannis, Dimitrios, Smith, Laura M, Hallsworth, Albert, Berry, Philip, Möcklinghoff, Till, Webber, Hannah T, Danielson, Laura S, Buttery, Bliss, Calton, Elizabeth A, da Costa, Barbara M, Poon, Evon, Jamin, Yann, Lise, Stefano, Veal, Gareth J, Sebire, Neil, Robinson, Simon P, Anderson, John, Chesler, Louis
Published in Cancer research (Chicago, Ill.) (15.10.2019)
Published in Cancer research (Chicago, Ill.) (15.10.2019)
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Journal Article
Identification of ovarian high-grade serous carcinoma cell lines that show estrogen-sensitive growth as xenografts in immunocompromised mice
De Haven Brandon, Alexis, Box, Gary, Hallsworth, Albert, Court, William, Matthews, Nicoll, Herodek, Balint, Arteagabeitia, Aitor Bermejo, Valenti, Melanie, Kirkin, Vladimir
Published in Scientific reports (01.07.2020)
Published in Scientific reports (01.07.2020)
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Journal Article
MYCN expression induces replication stress and sensitivity to PARP inhibition in neuroblastoma
King, David, Li, Xiao Dun, Almeida, Gilberto S, Kwok, Colin, Gravells, Polly, Harrison, Daniel, Burke, Saoirse, Hallsworth, Albert, Jamin, Yann, George, Sally, Robinson, Simon P, Lord, Christopher J, Poon, Evon, Yeomanson, Daniel, Chesler, Louis, Bryant, Helen E
Published in Oncotarget (09.06.2020)
Published in Oncotarget (09.06.2020)
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Journal Article
Correction: MYCN expression induces replication stress and sensitivity to PARP inhibition in neuroblastoma
King, David, Li, Xiao Dun, Almeida, Gilberto S, Kwok, Colin, Gravells, Polly, Harrison, Daniel, Burke, Saoirse, Hallsworth, Albert, Jamin, Yann, George, Sally, Robinson, Simon P, Lord, Christopher J, Poon, Evon, Yeomanson, Daniel, Chesler, Louis, Bryant, Helen E
Published in Oncotarget (12.01.2023)
Published in Oncotarget (12.01.2023)
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Journal Article
Cyclin-Dependent Kinase Inhibitor AT7519 as a Potential Drug for MYCN-Dependent Neuroblastoma
Dolman, M Emmy M, Poon, Evon, Ebus, Marli E, den Hartog, Ilona J M, van Noesel, Carel J M, Jamin, Yann, Hallsworth, Albert, Robinson, Simon P, Petrie, Kevin, Sparidans, Rolf W, Kok, Robbert J, Versteeg, Rogier, Caron, Huib N, Chesler, Louis, Molenaar, Jan J
Published in Clinical cancer research (15.11.2015)
Published in Clinical cancer research (15.11.2015)
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Journal Article
Pre-clinical imaging of transgenic mouse models of neuroblastoma using a dedicated 3-element solenoid coil on a clinical 3T platform
Almeida, Gilberto S, Panek, Rafal, Hallsworth, Albert, Webber, Hannah, Papaevangelou, Efthymia, Boult, Jessica KR, Jamin, Yann, Chesler, Louis, Robinson, Simon P
Published in British journal of cancer (05.09.2017)
Published in British journal of cancer (05.09.2017)
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Journal Article
CCT244747 Is a Novel Potent and Selective CHK1 Inhibitor with Oral Efficacy Alone and in Combination with Genotoxic Anticancer Drugs
WALTON, Mike I, EVE, Paul D, MATTHEWS, Thomas P, JAMIN, Yann, ROBINSON, Simon P, WYNNEAHERNE, G, READER, John C, CHESLER, Louis, RAYNAUD, Florence I, ECCLES, Suzanne A, COLLINS, Ian, GARRETT, Michelle D, HAYES, Angela, VALENTI, Melanie R, DE HAVEN BRANDON, Alexis K, BOX, Gary, HALLSWORTH, Albert, SMITH, Elizabeth L, BOXALL, Kathy J, LAINCHBURY, Michael
Published in Clinical cancer research (15.10.2012)
Published in Clinical cancer research (15.10.2012)
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Journal Article
Orally bioavailable CDK9/2 inhibitor shows mechanism-based therapeutic potential in MYCN-driven neuroblastoma
Poon, Evon, Liang, Tong, Jamin, Yann, Walz, Susanne, Kwok, Colin, Hakkert, Anne, Barker, Karen, Urban, Zuzanna, Thway, Khin, Zeid, Rhamy, Hallsworth, Albert, Box, Gary, Ebus, Marli E, Licciardello, Marco P, Sbirkov, Yordan, Lazaro, Glori, Calton, Elizabeth, Costa, Barbara M, Valenti, Melanie, Brandon, Alexis De Haven, Webber, Hannah, Tardif, Nicolas, Almeida, Gilberto S, Christova, Rossitza, Boysen, Gunther, Richards, Mark W, Barone, Giuseppe, d, Anthony, Bayliss, Richard, Clarke, Paul A, DE BONO, Johann, Gray, Nathanael S, Blagg, Julian, Robinson, Simon P, Eccles, Suzanne A, Zheleva, Daniella, Bradner, James E, Molenaar, Jan, Vivanco, Igor, Eilers, Martin, Workman, Paul, Lin, Charles Y, Chesler, Louis
Published in The Journal of clinical investigation (01.11.2020)
Published in The Journal of clinical investigation (01.11.2020)
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Journal Article