Fyn inhibition rescues established memory and synapse loss in Alzheimer mice
Kaufman, Adam C., Salazar, Santiago V., Haas, Laura T., Yang, Jinhee, Kostylev, Mikhail A., Jeng, Amanda T., Robinson, Sophie A., Gunther, Erik C., van Dyck, Christopher H., Nygaard, Haakon B., Strittmatter, Stephen M.
Published in Annals of neurology (01.06.2015)
Published in Annals of neurology (01.06.2015)
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Journal Article
Silent Allosteric Modulation of mGluR5 Maintains Glutamate Signaling while Rescuing Alzheimer’s Mouse Phenotypes
Haas, Laura T., Salazar, Santiago V., Smith, Levi M., Zhao, Helen R., Cox, Timothy O., Herber, Charlotte S., Degnan, Andrew P., Balakrishnan, Anand, Macor, John E., Albright, Charles F., Strittmatter, Stephen M.
Published in Cell reports (Cambridge) (05.07.2017)
Published in Cell reports (Cambridge) (05.07.2017)
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Journal Article
Metabotropic glutamate receptor 5 couples cellular prion protein to intracellular signalling in Alzheimer's disease
Haas, Laura T, Salazar, Santiago V, Kostylev, Mikhail A, Um, Ji Won, Kaufman, Adam C, Strittmatter, Stephen M
Published in Brain (London, England : 1878) (01.02.2016)
Published in Brain (London, England : 1878) (01.02.2016)
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Journal Article
Alzheimer's Disease Risk Factor Pyk2 Mediates Amyloid-β-Induced Synaptic Dysfunction and Loss
Salazar, Santiago V, Cox, Timothy O, Lee, Suho, Brody, A Harrison, Chyung, Annabel S, Haas, Laura T, Strittmatter, Stephen M
Published in The Journal of neuroscience (23.01.2019)
Published in The Journal of neuroscience (23.01.2019)
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Journal Article
Therapeutic Molecules and Endogenous Ligands Regulate the Interaction between Brain Cellular Prion Protein (PrPC) and Metabotropic Glutamate Receptor 5 (mGluR5)
Haas, Laura T., Kostylev, Mikhail A., Strittmatter, Stephen M.
Published in The Journal of biological chemistry (10.10.2014)
Published in The Journal of biological chemistry (10.10.2014)
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Journal Article
Prion-Protein-interacting Amyloid-β Oligomers of High Molecular Weight Are Tightly Correlated with Memory Impairment in Multiple Alzheimer Mouse Models
Kostylev, Mikhail A., Kaufman, Adam C., Nygaard, Haakon B., Patel, Pujan, Haas, Laura T., Gunther, Erik C., Vortmeyer, Alexander, Strittmatter, Stephen M.
Published in The Journal of biological chemistry (10.07.2015)
Published in The Journal of biological chemistry (10.07.2015)
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Journal Article
Conditional Deletion of Prnp Rescues Behavioral and Synaptic Deficits after Disease Onset in Transgenic Alzheimer's Disease
Salazar, Santiago V, Gallardo, Christopher, Kaufman, Adam C, Herber, Charlotte S, Haas, Laura T, Robinson, Sophie, Manson, Jean C, Lee, Michael K, Strittmatter, Stephen M
Published in The Journal of neuroscience (20.09.2017)
Published in The Journal of neuroscience (20.09.2017)
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Journal Article
Early Activation of Experience-Independent Dendritic Spine Turnover in a Mouse Model of Alzheimer's Disease
Heiss, Jacqueline K, Barrett, Joshua, Yu, Zizi, Haas, Laura T, Kostylev, Mikhail A, Strittmatter, Stephen M
Published in Cerebral cortex (New York, N.Y. 1991) (01.07.2017)
Published in Cerebral cortex (New York, N.Y. 1991) (01.07.2017)
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Rescue of Transgenic Alzheimer’s Pathophysiology by Polymeric Cellular Prion Protein Antagonists
Gunther, Erik C., Smith, Levi M., Kostylev, Mikhail A., Cox, Timothy O., Kaufman, Adam C., Lee, Suho, Folta-Stogniew, Ewa, Maynard, George D., Um, Ji Won, Stagi, Massimiliano, Heiss, Jacqueline K., Stoner, Austin, Noble, Geoff P., Takahashi, Hideyuki, Haas, Laura T., Schneekloth, John S., Merkel, Janie, Teran, Christopher, Naderi, Zahra K., Supattapone, Surachai, Strittmatter, Stephen M.
Published in Cell reports (Cambridge) (02.01.2019)
Published in Cell reports (Cambridge) (02.01.2019)
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Journal Article
Rescue of Transgenic Alzheimer’s Pathophysiology by Polymeric Cellular Prion Protein Antagonists
Gunther, Erik C., Smith, Levi M., Kostylev, Mikhail A., Cox, Timothy O., Kaufman, Adam C., Lee, Suho, Folta-Stogniew, Ewa, Maynard, George D., Um, Ji Won, Stagi, Massimiliano, Heiss, Jacqueline K., Stoner, Austin, Noble, Geoff P., Takahashi, Hideyuki, Haas, Laura T., Schneekloth, John S., Merkel, Janie, Teran, Christopher, Naderi, Zahra K., Supattapone, Surachai, Strittmatter, Stephen M.
Published in Cell reports (Cambridge) (29.01.2019)
Published in Cell reports (Cambridge) (29.01.2019)
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Journal Article
Anti‐PrPC antibody rescues cognition and synapses in transgenic alzheimer mice
Cox, Timothy O., Gunther, Erik C., Brody, A. Harrison, Chiasseu, Marius T., Stoner, Austin, Smith, Levi M., Haas, Laura T., Hammersley, Jayne, Rees, Gareth, Dosanjh, Bhupinder, Groves, Maria, Gardener, Matthew, Dobson, Claire, Vaughan, Tristan, Chessell, Iain, Billinton, Andrew, Strittmatter, Stephen M.
Published in Annals of clinical and translational neurology (01.03.2019)
Published in Annals of clinical and translational neurology (01.03.2019)
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Journal Article
Anti-PrP C antibody rescues cognition and synapses in transgenic alzheimer mice
Cox, Timothy O, Gunther, Erik C, Brody, A Harrison, Chiasseu, Marius T, Stoner, Austin, Smith, Levi M, Haas, Laura T, Hammersley, Jayne, Rees, Gareth, Dosanjh, Bhupinder, Groves, Maria, Gardener, Matthew, Dobson, Claire, Vaughan, Tristan, Chessell, Iain, Billinton, Andrew, Strittmatter, Stephen M
Published in Annals of clinical and translational neurology (01.03.2019)
Published in Annals of clinical and translational neurology (01.03.2019)
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Journal Article
F yn inhibition rescues established memory and synapse loss in A lzheimer mice
Kaufman, Adam C., Salazar, Santiago V., Haas, Laura T., Yang, Jinhee, Kostylev, Mikhail A., Jeng, Amanda T., Robinson, Sophie A., Gunther, Erik C., van Dyck, Christopher H., Nygaard, Haakon B., Strittmatter, Stephen M.
Published in Annals of neurology (01.06.2015)
Published in Annals of neurology (01.06.2015)
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