Midbrain-like Organoids from Human Pluripotent Stem Cells Contain Functional Dopaminergic and Neuromelanin-Producing Neurons
Jo, Junghyun, Xiao, Yixin, Sun, Alfred Xuyang, Cukuroglu, Engin, Tran, Hoang-Dai, Göke, Jonathan, Tan, Zi Ying, Saw, Tzuen Yih, Tan, Cheng-Peow, Lokman, Hidayat, Lee, Younghwan, Kim, Donghoon, Ko, Han Seok, Kim, Seong-Oh, Park, Jae Hyeon, Cho, Nam-Joon, Hyde, Thomas M., Kleinman, Joel E., Shin, Joo Heon, Weinberger, Daniel R., Tan, Eng King, Je, Hyunsoo Shawn, Ng, Huck-Hui
Published in Cell stem cell (04.08.2016)
Published in Cell stem cell (04.08.2016)
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Developmental and genetic regulation of the human cortex transcriptome illuminate schizophrenia pathogenesis
Jaffe, Andrew E., Straub, Richard E., Shin, Joo Heon, Tao, Ran, Gao, Yuan, Collado-Torres, Leonardo, Kam-Thong, Tony, Xi, Hualin S., Quan, Jie, Chen, Qiang, Colantuoni, Carlo, Ulrich, William S., Maher, Brady J., Deep-Soboslay, Amy, Cross, Alan J., Brandon, Nicholas J., Leek, Jeffrey T., Hyde, Thomas M., Kleinman, Joel E., Weinberger, Daniel R.
Published in Nature neuroscience (01.08.2018)
Published in Nature neuroscience (01.08.2018)
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Dynamic regulation of RNA editing in human brain development and disease
Hwang, Taeyoung, Park, Chul-Kee, Leung, Anthony K L, Gao, Yuan, Hyde, Thomas M, Kleinman, Joel E, Rajpurohit, Anandita, Tao, Ran, Shin, Joo Heon, Weinberger, Daniel R
Published in Nature neuroscience (01.08.2016)
Published in Nature neuroscience (01.08.2016)
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DNA Methylation Signatures in Development and Aging of the Human Prefrontal Cortex
Numata, Shusuke, Ye, Tianzhang, Hyde, Thomas M., Guitart-Navarro, Xavier, Tao, Ran, Wininger, Michael, Colantuoni, Carlo, Weinberger, Daniel R., Kleinman, Joel E., Lipska, Barbara K.
Published in American journal of human genetics (10.02.2012)
Published in American journal of human genetics (10.02.2012)
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Temporal dynamics and genetic control of transcription in the human prefrontal cortex
Colantuoni, Carlo, Lipska, Barbara K., Ye, Tianzhang, Hyde, Thomas M., Tao, Ran, Leek, Jeffrey T., Colantuoni, Elizabeth A., Elkahloun, Abdel G., Herman, Mary M., Weinberger, Daniel R., Kleinman, Joel E.
Published in Nature (London) (27.10.2011)
Published in Nature (London) (27.10.2011)
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Large-Scale Cellular-Resolution Gene Profiling in Human Neocortex Reveals Species-Specific Molecular Signatures
Zeng, Hongkui, Shen, Elaine H., Hohmann, John G., Oh, Seung Wook, Bernard, Amy, Royall, Joshua J., Glattfelder, Katie J., Sunkin, Susan M., Morris, John A., Guillozet-Bongaarts, Angela L., Smith, Kimberly A., Ebbert, Amanda J., Swanson, Beryl, Kuan, Leonard, Page, Damon T., Overly, Caroline C., Lein, Ed S., Hawrylycz, Michael J., Hof, Patrick R., Hyde, Thomas M., Kleinman, Joel E., Jones, Allan R.
Published in Cell (13.04.2012)
Published in Cell (13.04.2012)
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Psychiatric Risk Gene Transcription Factor 4 Regulates Intrinsic Excitability of Prefrontal Neurons via Repression of SCN10a and KCNQ1
Rannals, Matthew D., Hamersky, Gregory R., Page, Stephanie Cerceo, Campbell, Morganne N., Briley, Aaron, Gallo, Ryan A., Phan, BaDoi N., Hyde, Thomas M., Kleinman, Joel E., Shin, Joo Heon, Jaffe, Andrew E., Weinberger, Daniel R., Maher, Brady J.
Published in Neuron (Cambridge, Mass.) (06.04.2016)
Published in Neuron (Cambridge, Mass.) (06.04.2016)
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Spatio-temporal transcriptome of the human brain
Kang, Hyo Jung, Kawasawa, Yuka Imamura, Cheng, Feng, Zhu, Ying, Xu, Xuming, Li, Mingfeng, Sousa, André M. M., Pletikos, Mihovil, Meyer, Kyle A., Sedmak, Goran, Guennel, Tobias, Shin, Yurae, Johnson, Matthew B., Krsnik, Željka, Mayer, Simone, Fertuzinhos, Sofia, Umlauf, Sheila, Lisgo, Steven N., Vortmeyer, Alexander, Weinberger, Daniel R., Mane, Shrikant, Hyde, Thomas M., Huttner, Anita, Reimers, Mark, Kleinman, Joel E., Šestan, Nenad
Published in Nature (London) (27.10.2011)
Published in Nature (London) (27.10.2011)
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dotdotdot: an automated approach to quantify multiplex single molecule fluorescent in situ hybridization (smFISH) images in complex tissues
Maynard, Kristen R, Tippani, Madhavi, Takahashi, Yoichiro, Phan, BaDoi N, Hyde, Thomas M, Jaffe, Andrew E, Martinowich, Keri
Published in Nucleic acids research (19.06.2020)
Published in Nucleic acids research (19.06.2020)
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Somatic LINE-1 retrotransposition in cortical neurons and non-brain tissues of Rett patients and healthy individuals
Zhao, Boxun, Wu, Qixi, Ye, Adam Yongxin, Guo, Jing, Zheng, Xianing, Yang, Xiaoxu, Yan, Linlin, Liu, Qing-Rong, Hyde, Thomas M, Wei, Liping, Huang, August Yue
Published in PLoS genetics (11.04.2019)
Published in PLoS genetics (11.04.2019)
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Integrated DNA methylation and gene expression profiling across multiple brain regions implicate novel genes in Alzheimer’s disease
Semick, Stephen A., Bharadwaj, Rahul A., Collado-Torres, Leonardo, Tao, Ran, Shin, Joo Heon, Deep-Soboslay, Amy, Weiss, James R., Weinberger, Daniel R., Hyde, Thomas M., Kleinman, Joel E., Jaffe, Andrew E., Mattay, Venkata S.
Published in Acta neuropathologica (01.04.2019)
Published in Acta neuropathologica (01.04.2019)
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Modeling a Genetic Risk for Schizophrenia in iPSCs and Mice Reveals Neural Stem Cell Deficits Associated with Adherens Junctions and Polarity
Yoon, Ki-Jun, Nguyen, Ha Nam, Ursini, Gianluca, Zhang, Fengyu, Kim, Nam-Shik, Wen, Zhexing, Makri, Georgia, Nauen, David, Shin, Joo Heon, Park, Youngbin, Chung, Raeeun, Pekle, Eva, Zhang, Ce, Towe, Maxwell, Hussaini, Syed Mohammed Qasim, Lee, Yohan, Rujescu, Dan, St. Clair, David, Kleinman, Joel E., Hyde, Thomas M., Krauss, Gregory, Christian, Kimberly M., Rapoport, Judith L., Weinberger, Daniel R., Song, Hongjun, Ming, Guo-li
Published in Cell stem cell (03.07.2014)
Published in Cell stem cell (03.07.2014)
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A human-specific AS3MT isoform and BORCS7 are molecular risk factors in the 10q24.32 schizophrenia-associated locus
Li, Ming, Jaffe, Andrew E, Straub, Richard E, Tao, Ran, Shin, Joo Heon, Wang, Yanhong, Chen, Qiang, Li, Chao, Jia, Yankai, Ohi, Kazutaka, Maher, Brady J, Brandon, Nicholas J, Cross, Alan, Chenoweth, Joshua G, Hoeppner, Daniel J, Wei, Huijun, Hyde, Thomas M, McKay, Ronald, Kleinman, Joel E, Weinberger, Daniel R
Published in Nature medicine (01.06.2016)
Published in Nature medicine (01.06.2016)
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Divergent neuronal DNA methylation patterns across human cortical development reveal critical periods and a unique role of CpH methylation
Price, Amanda J, Collado-Torres, Leonardo, Ivanov, Nikolay A, Xia, Wei, Burke, Emily E, Shin, Joo Heon, Tao, Ran, Ma, Liang, Jia, Yankai, Hyde, Thomas M, Kleinman, Joel E, Weinberger, Daniel R, Jaffe, Andrew E
Published in Genome Biology (26.09.2019)
Published in Genome Biology (26.09.2019)
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Genome-wide sequencing-based identification of methylation quantitative trait loci and their role in schizophrenia risk
Perzel Mandell, Kira A., Eagles, Nicholas J., Wilton, Richard, Price, Amanda J., Semick, Stephen A., Collado-Torres, Leonardo, Ulrich, William S., Tao, Ran, Han, Shizhong, Szalay, Alexander S., Hyde, Thomas M., Kleinman, Joel E., Weinberger, Daniel R., Jaffe, Andrew E.
Published in Nature communications (02.09.2021)
Published in Nature communications (02.09.2021)
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P-selectin axis plays a key role in microglia immunophenotype and glioblastoma progression
Yeini, Eilam, Ofek, Paula, Pozzi, Sabina, Albeck, Nitzan, Ben-Shushan, Dikla, Tiram, Galia, Golan, Sapir, Kleiner, Ron, Sheinin, Ron, Israeli Dangoor, Sahar, Reich-Zeliger, Shlomit, Grossman, Rachel, Ram, Zvi, Brem, Henry, Hyde, Thomas M., Magod, Prerna, Friedmann-Morvinski, Dinorah, Madi, Asaf, Satchi-Fainaro, Ronit
Published in Nature communications (26.03.2021)
Published in Nature communications (26.03.2021)
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Reduced kynurenine pathway metabolism and cytokine expression in the prefrontal cortex of depressed individuals
Clark, Sarah M., PhD, Pocivavsek, Ana, PhD, Nicholson, James D., PhD, Notarangelo, Francesca M., PhD, Langenberg, Patricia, PhD, McMahon, Robert P., PhD, Kleinman, Joel E., MD, PhD, Hyde, Thomas M., MD, PhD, Stiller, John, MD, Postolache, Teodor T., MD, Schwarcz, Robert, PhD, Tonelli, Leonardo H., PhD
Published in Journal of psychiatry & neuroscience (01.11.2016)
Published in Journal of psychiatry & neuroscience (01.11.2016)
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Investigating trait variability of gene co-expression network architecture in brain by controlling for genomic risk of schizophrenia
Radulescu, Eugenia, Chen, Qiang, Pergola, Giulio, Di Carlo, Pasquale, Han, Shizhong, Shin, Joo Heon, Hyde, Thomas M, Kleinman, Joel E, Weinberger, Daniel R
Published in PLoS genetics (13.10.2023)
Published in PLoS genetics (13.10.2023)
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A single-cell transcriptome atlas of glial diversity in the human hippocampus across the postnatal lifespan
Su, Yijing, Zhou, Yi, Bennett, Mariko L., Li, Shiying, Carceles-Cordon, Marc, Lu, Lu, Huh, Sooyoung, Jimenez-Cyrus, Dennisse, Kennedy, Benjamin C., Kessler, Sudha K., Viaene, Angela N., Helbig, Ingo, Gu, Xiaosong, Kleinman, Joel E., Hyde, Thomas M., Weinberger, Daniel R., Nauen, David W., Song, Hongjun, Ming, Guo-li
Published in Cell stem cell (03.11.2022)
Published in Cell stem cell (03.11.2022)
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