L-Type amino acid transporter 1 as a target for drug delivery
Puris, Elena, Gynther, Mikko, Auriola, Seppo, Huttunen, Kristiina M.
Published in Pharmaceutical research (01.05.2020)
Published in Pharmaceutical research (01.05.2020)
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L-type amino acid transporter 1 utilizing prodrugs: How to achieve effective brain delivery and low systemic exposure of drugs
Puris, Elena, Gynther, Mikko, Huttunen, Johanna, Petsalo, Aleksanteri, Huttunen, Kristiina M.
Published in Journal of controlled release (10.09.2017)
Published in Journal of controlled release (10.09.2017)
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L-Type amino acid transporter 1 (LAT1)-utilizing prodrugs are carrier-selective despite having low affinity for organic anion transporting polypeptides (OATPs)
Huttunen, Johanna, Gynther, Mikko, Vellonen, Kati-Sisko, Huttunen, Kristiina M.
Published in International journal of pharmaceutics (25.11.2019)
Published in International journal of pharmaceutics (25.11.2019)
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Prodrugs - an efficient way to breach delivery and targeting barriers
Huttunen, Kristiina M, Rautio, Jarkko
Published in Current topics in medicinal chemistry (01.09.2011)
Published in Current topics in medicinal chemistry (01.09.2011)
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Comparative Modelling of Organic Anion Transporting Polypeptides: Structural Insights and Comparison of Binding Modes
Tonduru, Arun Kumar, Adla, Santosh Kumar, Huttunen, Kristiina M, Kronenberger, Thales, Poso, Antti
Published in Molecules (Basel, Switzerland) (03.12.2022)
Published in Molecules (Basel, Switzerland) (03.12.2022)
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A Selective and Slowly Reversible Inhibitor of l‑Type Amino Acid Transporter 1 (LAT1) Potentiates Antiproliferative Drug Efficacy in Cancer Cells
Huttunen, Kristiina M, Gynther, Mikko, Huttunen, Johanna, Puris, Elena, Spicer, Julie A, Denny, William A
Published in Journal of medicinal chemistry (23.06.2016)
Published in Journal of medicinal chemistry (23.06.2016)
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Incorporation of Sulfonamide Moiety into Biguanide Scaffold Results in Apoptosis Induction and Cell Cycle Arrest in MCF-7 Breast Cancer Cells
Markowicz-Piasecka, Magdalena, Sadowski, Karol, Huttunen, Johanna, Sikora, Joanna, Huttunen, Kristiina M.
Published in International journal of molecular sciences (26.05.2021)
Published in International journal of molecular sciences (26.05.2021)
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Ganciclovir and Its Hemocompatible More Lipophilic Derivative Can Enhance the Apoptotic Effects of Methotrexate by Inhibiting Breast Cancer Resistance Protein (BCRP)
Markowicz-Piasecka, Magdalena, Huttunen, Johanna, Montaser, Ahmed, Adla, Santosh Kumar, Auriola, Seppo, Lehtonen, Marko, Huttunen, Kristiina M.
Published in International journal of molecular sciences (20.07.2021)
Published in International journal of molecular sciences (20.07.2021)
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Neurosteroids: Structure-Uptake Relationships and Computational Modeling of Organic Anion Transporting Polypeptides (OATP)1A2
Adla, Santosh Kumar, Tonduru, Arun Kumar, Kronenberger, Thales, Kudova, Eva, Poso, Antti, Huttunen, Kristiina M
Published in Molecules (Basel, Switzerland) (17.09.2021)
Published in Molecules (Basel, Switzerland) (17.09.2021)
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Effective Cellular Transport of Ortho -Halogenated Sulfonamide Derivatives of Metformin Is Related to Improved Antiproliferative Activity and Apoptosis Induction in MCF-7 Cells
Markowicz-Piasecka, Magdalena, Komeil, Ibrahim, Huttunen, Johanna, Sikora, Joanna, Huttunen, Kristiina M
Published in International journal of molecular sciences (30.03.2020)
Published in International journal of molecular sciences (30.03.2020)
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Species differences in the intra-brain distribution of an L-type amino acid transporter 1 (LAT1) -utilizing compound between mice and rats
Jalkanen, Aaro J., Ihalainen, Jouni, Lehtonen, Marko, Forsberg, Markus M., Rautio, Jarkko, Huttunen, Kristiina M., Gynther, Mikko
Published in International journal of pharmaceutics (01.03.2021)
Published in International journal of pharmaceutics (01.03.2021)
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Astrocyte-Targeted Transporter-Utilizing Derivatives of Ferulic Acid Can Have Multifunctional Effects Ameliorating Inflammation and Oxidative Stress in the Brain
Huttunen, Kristiina M., Ibrahim, Sherihan Abdelhamid, Huttunen, Johanna, Montaser, Ahmed
Published in Oxidative medicine and cellular longevity (2019)
Published in Oxidative medicine and cellular longevity (2019)
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Increased/Targeted Brain (Pro)Drug Delivery via Utilization of Solute Carriers (SLCs)
Huttunen, Johanna, Adla, Santosh Kumar, Markowicz-Piasecka, Magdalena, Huttunen, Kristiina M.
Published in Pharmaceutics (10.06.2022)
Published in Pharmaceutics (10.06.2022)
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