Pharmacokinetic and pharmacodynamic characterization of an oral lysophosphatidic acid type 1 receptor-selective antagonist
Swaney, J S, Chapman, C, Correa, L D, Stebbins, K J, Broadhead, A R, Bain, G, Santini, A M, Darlington, J, King, C D, Baccei, C S, Lee, C, Parr, T A, Roppe, J R, Seiders, T J, Ziff, J, Prasit, P, Hutchinson, J H, Evans, J F, Lorrain, D S
Published in The Journal of pharmacology and experimental therapeutics (01.03.2011)
Published in The Journal of pharmacology and experimental therapeutics (01.03.2011)
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Pharmacodynamics and pharmacokinetics of AM103, a novel inhibitor of 5-lipoxygenase-activating protein (FLAP)
Bain, G, King, C D, Rewolinski, M, Schaab, K, Santini, A M, Shapiro, D, Moran, M, van de Wetering de Rooij, S, Roffel, A F, Schuilenga-Hut, P, Milne, G L, Lorrain, D S, Li, Y, Arruda, J M, Hutchinson, J H, Prasit, P, Evans, J F
Published in Clinical pharmacology and therapeutics (01.04.2010)
Published in Clinical pharmacology and therapeutics (01.04.2010)
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A novel, orally active LPA(1) receptor antagonist inhibits lung fibrosis in the mouse bleomycin model
Swaney, J. S., Chapman, C., Correa, L. D., Stebbins, K. J., Bundey, R. A., Prodanovich, P. C., Fagan, P., Baccei, C. S., Santini, A. M., Hutchinson, J. H., Seiders, T. J., Parr, T. A., Prasit, P., Evans, J. F., Lorrain, D. S.
Published in British journal of pharmacology (01.08.2010)
Published in British journal of pharmacology (01.08.2010)
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Journal Article
A novel, orally active LPA1 receptor antagonist inhibits lung fibrosis in the mouse bleomycin model
Swaney, JS, Chapman, C, Correa, LD, Stebbins, KJ, Bundey, RA, Prodanovich, PC, Fagan, P, Baccei, CS, Santini, AM, Hutchinson, JH, Seiders, TJ, Parr, TA, Prasit, P, Evans, JF, Lorrain, DS
Published in British journal of pharmacology (01.08.2010)
Published in British journal of pharmacology (01.08.2010)
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Journal Article
A novel, orally active LPA 1 receptor antagonist inhibits lung fibrosis in the mouse bleomycin model
Swaney, JS, Chapman, C, Correa, LD, Stebbins, KJ, Bundey, RA, Prodanovich, PC, Fagan, P, Baccei, CS, Santini, AM, Hutchinson, JH, Seiders, TJ, Parr, TA, Prasit, P, Evans, JF, Lorrain, DS
Published in British journal of pharmacology (01.08.2010)
Published in British journal of pharmacology (01.08.2010)
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Pharmacodynamics, pharmacokinetics, and safety of AM211: a novel and potent antagonist of the prostaglandin D2 receptor type 2
Bain, G, King, C D, Brittain, J, Hartung, J P, Dearmond, I, Stearns, B, Truong, Y P, Hutchinson, J H, Evans, J F, Holme, K
Published in Journal of clinical pharmacology (01.10.2012)
Published in Journal of clinical pharmacology (01.10.2012)
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Substituted thiopyrano[2,3,4-c,d]indoles as potent, selective, and orally active inhibitors of 5-lipoxygenase. Synthesis and biological evaluation of L-691,816
Hutchinson, J. H, Riendeau, D, Brideau, C, Chan, C, Delorme, D, Denis, D, Falgueyret, J. P, Fortin, R, Guay, J
Published in Journal of medicinal chemistry (01.09.1993)
Published in Journal of medicinal chemistry (01.09.1993)
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Potent, non-thiol inhibitors of farnesyltransferase
Breslin, Michael J., deSolms, S.Jane, Giuliani, Elizabeth A., Stokker, Gerald E., Graham, Samuel L., Pompliano, David L., Mosser, Scott D., Hamilton, Kelly A., Hutchinson, John H.
Published in Bioorganic & medicinal chemistry letters (01.12.1998)
Published in Bioorganic & medicinal chemistry letters (01.12.1998)
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Substituted indoles as potent and orally active 5-lipoxygenase activating protein (FLAP) inhibitors
Frenette, Richard, Hutchinson, John H., Léger, Serge, Thérien, Michel, Brideau, Christine, Chan, Chi C., Charleson, Stella, Ethier, Diane, Guay, Jocelyne, Jones, Tom R., McAuliffe, Malia, Piechuta, Hanna, Riendeau, Denis, Tagari, Philip, Girard, Yves
Published in Bioorganic & medicinal chemistry letters (16.08.1999)
Published in Bioorganic & medicinal chemistry letters (16.08.1999)
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Pharmacology of MK-0591 (3-[1-(4-chlorobenzyl)-3-(t-butylthio)-5-(quinolin-2-yl-methoxy)- indol-2-yl]-2,2-dimethyl propanoic acid), a potent, orally active leukotriene biosynthesis inhibitor
Brideau, C, Chan, C, Charleson, S, Denis, D, Evans, J F, Ford-Hutchinson, A W, Fortin, R, Gillard, J W, Guay, J, Guévremont, D
Published in Canadian journal of physiology and pharmacology (01.06.1992)
Published in Canadian journal of physiology and pharmacology (01.06.1992)
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Thiopyrano[2,3,4-cd]indoles as 5-Lipoxygenase Inhibitors: Synthesis, Biological Profile, and Resolution of 2-[2-[1-(4-Chlorobenzyl)-4-methyl-6-[(5-phenylpyridin-2-yl)methoxy]-4,5-dihydro-1H-thiopyrano[2,3,4-cd]indol-2-yl]ethoxy]butanoic Acid
Hutchinson, J. H, Riendeau, D, Brideau, C, Chan, C, Falgueyret, J.-P, Guay, J, Jones, T. R, Lepine, C, Macdonald, D
Published in Journal of medicinal chemistry (01.04.1994)
Published in Journal of medicinal chemistry (01.04.1994)
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In vitro and in vivo evaluations of the metabolism, pharmacokinetics, and bioavailability of ester prodrugs of L-767,679, a potent fibrinogen receptor antagonist : An approach for the selection of a prodrug candidate
PRUEKSARITANONT, T, GORHAM, L. M, BRESLIN, M. J, HUTCHINSON, J. H, HARTMAN, G. D, VYAS, K. P, BAILLIE, T. A
Published in Drug metabolism and disposition (01.08.1997)
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Published in Drug metabolism and disposition (01.08.1997)
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Naphthalenic Lignan Lactones as Selective, Nonredox 5-Lipoxygenase Inhibitors. Synthesis and Biological Activity of (Methoxyalkyl)thiazole and Methoxytetrahydropyran Hybrids
Ducharme, Yves, Brideau, Christine, Dube, Daniel, Chan, Chi Chung, Falgueyret, Jean Pierre, Gillard, John W, Guay, Jocelyne, Hutchinson, John H, McFarlane, Cyryl S
Published in Journal of medicinal chemistry (01.02.1994)
Published in Journal of medicinal chemistry (01.02.1994)
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Nonpeptide GPIIB/IIIA receptor antagonists. Part 21: C-6 flexibility and amide bond orientation are important factors in determining the affinity of compounds for activated or resting platelet receptors
Egbertson, Melissa S, Bednar, Bohumil, Askew, Ben C, Bednar, Rodney A, Brashear, Karen, Breslin, Michael J, Duggan, Mark E, Fisher, Thorsten E, Halczenko, Wasyl, Hutchinson, John H, Ihle, Nathan, Prugh, John D, Wai, John S, Gould, Robert J, Hartman, George D
Published in Bioorganic & medicinal chemistry letters (04.09.2000)
Published in Bioorganic & medicinal chemistry letters (04.09.2000)
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Non-Peptide Glycoprotein IIb/IIIa Antagonists. 11. Design and in Vivo Evaluation of 3,4-Dihydro-1(1H)-isoquinolinone-Based Antagonists and Ethyl Ester Prodrugs
Hutchinson, John H, Cook, Jacquelynn J, Brashear, Karen M, Breslin, Michael J, Glass, Joan D, Gould, Robert J, Halczenko, Wasyl, Holahan, Marie A, Lynch, Robert J, Sitko, Gary R, Stranieri, Maria T, Hartman, George D
Published in Journal of medicinal chemistry (08.11.1996)
Published in Journal of medicinal chemistry (08.11.1996)
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Criteria for the identification of non-redox inhibitors of 5-lipoxygenase
Falgueyret, Jean-Pierre, Hutchinson, John H., Riendeau, Denis
Published in Biochemical pharmacology (24.02.1993)
Published in Biochemical pharmacology (24.02.1993)
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Journal Article
Selective Inhibition of Autotaxin Is Efficacious in Mouse Models of Liver Fibrosis
Bain, Gretchen, Shannon, Kristen E, Huang, Fei, Darlington, Janice, Goulet, Lance, Prodanovich, Patricia, Ma, Gina L, Santini, Angelina M, Stein, Adam J, Lonergan, Dave, King, Christopher D, Calderon, Imelda, Lai, Andiliy, Hutchinson, John H, Evans, Jilly F
Published in The Journal of pharmacology and experimental therapeutics (01.01.2017)
Published in The Journal of pharmacology and experimental therapeutics (01.01.2017)
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