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Qualification and application of a liquid chromatography-tandem mass spectrometric method for the determination of human $A{\beta}1$-40 and $A{\beta}1$-42 peptides in transgenic mouse plasma using
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Discovery of 7‑Tetrahydropyran-2-yl Chromans: β‑Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors That Reduce Amyloid β‑Protein (Aβ) in the Central Nervous System
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8‑Tetrahydropyran-2-yl Chromans: Highly Selective Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors
Thomas, Allen A, Hunt, Kevin W, Newhouse, Brad, Watts, Ryan J, Liu, Xingrong, Vigers, Guy, Smith, Darin, Rhodes, Susan P, Brown, Karin D, Otten, Jennifer N, Burkard, Michael, Cox, April A, Geck Do, Mary K, Dutcher, Darrin, Rana, Sumeet, DeLisle, Robert K, Regal, Kelly, Wright, Albion D, Groneberg, Robert, Liao, Jiangpeng, Scearce-Levie, Kimberly, Siu, Michael, Purkey, Hans E, Lyssikatos, Joseph P
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Synthesis, characterization, and PK/PD studies of a series of spirocyclic pyranochromene BACE1 inhibitors
Volgraf, Matthew, Chan, Lina, Huestis, Malcolm P., Purkey, Hans E., Burkard, Michael, Geck Do, Mary, Harris, Julie, Hunt, Kevin W., Liu, Xingrong, Lyssikatos, Joseph P., Rana, Sumeet, Thomas, Allen A., Vigers, Guy P.A., Siu, Michael
Published in Bioorganic & medicinal chemistry letters (01.06.2014)
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Mechanistic pharmacokinetic-pharmacodynamic modeling of BACE1 inhibition in monkeys: development of a predictive model for amyloid precursor protein processing
Liu, Xingrong, Wong, Harvey, Scearce-Levie, Kimberly, Watts, Ryan J, Coraggio, Melis, Shin, Young G, Peng, Kun, Wildsmith, Kristin R, Atwal, Jasvinder K, Mango, Jason, Schauer, Stephen P, Regal, Kelly, Hunt, Kevin W, Thomas, Allen A, Siu, Michael, Lyssikatos, Joseph, Deshmukh, Gauri, Hop, Cornelis E C A
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Elucidating the mechanism of cytochrome P450-mediated pyrimidine ring conversion to pyrazole metabolites with the BACE1 inhibitor GNE-892 in rats
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Qualification and application of a liquid chromatography–tandem mass spectrometric method for the determination of human Aβ1-40 and Aβ1-42 peptides in transgenic mouse plasma using micro-elution solid phase extraction
Shin, Young G., Hamm, Lee, Murakami, Stanley, Buirst, Kenji, Buonarati, Michael H., Cox, April, Regal, Kelly, Hunt, Kevin W., Scearce-Levie, Kimberly, Watts, Ryan J., Liu, Xingrong
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Dose-dependent exposure and metabolism of GNE-892, a β-secretase inhibitor, in monkeys: contributions by P450, AO, and P-gp
Takahashi, Ryan, Ma, Shuguang, Yue, Qin, Kim-Kang, Heasook, Yi, Yijun, Lyssikatos, Joseph P., Regal, Kelly, Hunt, Kevin W., Kallan, Nicholas C., Siu, Michael, Hop, Cornelis E. C. A., Liu, Xingrong, Khojasteh, S. Cyrus
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MORENO DAVID A, MOHR PETER J, NEWHOUSE BRAD, THOMAS ALLEN A, SCHMIDT JANE, TANG TONY P, BLAKE JAMES F, HUNT KEVIN W, REN LI, SCHWARZ JACOB, CHEN HUIFEN, GUNAWARDANA INDRANI W, LYON MICHAEL, METCALF ANDREW T, GAZZARD LEWIS, COOK ADAM
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Year of Publication 02.09.2016
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MORENO DAVID A, MOHR PETER J, NEWHOUSE BRAD, SCHMIDT JANE, GAUDINO JOHN, BLAKE JAMES F, HUNT KEVIN W, HICKEN ERIK JAMES, REN LI, SCHWARZ JACOB, CHEN HUIFEN, DO STEVE, GUNAWARDANA INDRANI W, LYON MICHAEL, METCALF ANDREW T, GAZZARD LEWIS, COOK ADAM
Year of Publication 02.09.2016
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Year of Publication 02.09.2016
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KIM GANGHYEOK, CLARK CHRISTOPHER T, DOHERTY GEORGE A, ROMOFF TODD, BURGESS LAURENCE E, DELISLE ROBERT KIRK, CORRETTE CHRISTOPHER P, COOK ADAM, HUNT KEVIN W
Year of Publication 16.03.2011
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Year of Publication 16.03.2011
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Diethylaminosulfur trifluoride-mediated intramolecular cyclization of 2-hydroxycycloalkylureas to fused bicyclic aminooxazoline compounds and evaluation of their biochemical activity against β-secretase-1 (BACE-1)
Huestis, Malcolm P., Liu, Wendy, Volgraf, Matthew, Purkey, Hans E., Yu, Christine, Wang, Weiru, Smith, Darin, Vigers, Guy, Dutcher, Darrin, Hunt, Kevin W., Siu, Michael
Published in Tetrahedron letters (23.10.2013)
Published in Tetrahedron letters (23.10.2013)
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