Identification of the Clinical Candidate (R)‑(1-(4-Fluorophenyl)-6-((1-methyl‑1H‑pyrazol-4-yl)sulfonyl)-4,4a,5,6,7,8-hexahydro‑1H‑pyrazolo[3,4‑g]isoquinolin-4a-yl)(4-(trifluoromethyl)pyridin-2-yl)methanone (CORT125134): A Selective Glucocorticoid Receptor (GR) Antagonist
Hunt, Hazel J, Belanoff, Joseph K, Walters, Iain, Gourdet, Benoit, Thomas, Jennifer, Barton, Naomi, Unitt, John, Phillips, Timothy, Swift, Denise, Eaton, Emily
Published in Journal of medicinal chemistry (27.04.2017)
Published in Journal of medicinal chemistry (27.04.2017)
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Corticosteroid Action in the Brain: The Potential of Selective Receptor Modulation
Viho, Eva M.G., Buurstede, Jacobus C., Mahfouz, Ahmed, Koorneef, Lisa L., van Weert, Lisa T.C.M., Houtman, René, Hunt, Hazel J., Kroon, Jan, Meijer, Onno C.
Published in Neuroendocrinology (01.09.2019)
Published in Neuroendocrinology (01.09.2019)
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Journal Article
Effect of Miricorilant, a Selective Glucocorticoid Receptor Modulator, on Olanzapine-Associated Weight Gain in Healthy Subjects: A Proof-of-Concept Study
Hunt, Hazel J, Donaldson, Kirsteen, Strem, Mark, Tudor, Iulia Cristina, Sweet-Smith, Suzanne, Sidhu, Sharan
Published in Journal of clinical psychopharmacology (01.11.2021)
Published in Journal of clinical psychopharmacology (01.11.2021)
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Glucocorticoid receptor antagonism decreases alcohol seeking in alcohol-dependent individuals
Vendruscolo, Leandro F, Estey, David, Goodell, Vivian, Macshane, Lauren G, Logrip, Marian L, Schlosburg, Joel E, McGinn, M Adrienne, Zamora-Martinez, Eva R, Belanoff, Joseph K, Hunt, Hazel J, Sanna, Pietro P, George, Olivier, Koob, George F, Edwards, Scott, Mason, Barbara J
Published in The Journal of clinical investigation (01.08.2015)
Published in The Journal of clinical investigation (01.08.2015)
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Journal Article
Glucocorticoid receptor modulators decrease alcohol self-administration in male rats
McGinn, M. Adrienne, Tunstall, Brendan J., Schlosburg, Joel E., Gregory-Flores, Adriana, George, Olivier, de Guglielmo, Giordano, Mason, Barbara J., Hunt, Hazel J., Koob, George F., Vendruscolo, Leandro F.
Published in Neuropharmacology (01.05.2021)
Published in Neuropharmacology (01.05.2021)
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Journal Article
Peripheral glucocorticoid receptor antagonism by relacorilant with modest HPA axis disinhibition
Viho, Eva M G, Kroon, Jan, Feelders, Richard A, Houtman, René, van den Dungen, Elisabeth S R, Pereira, Alberto M, Hunt, Hazel J, Hofland, Leo J, Meijer, Onno C
Published in Journal of endocrinology (01.02.2023)
Published in Journal of endocrinology (01.02.2023)
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Journal Article
Selection and early clinical evaluation of the brain‐penetrant 11β‐hydroxysteroid dehydrogenase type 1 (11β‐HSD1) inhibitor UE2343 (Xanamem™)
Webster, Scott P, McBride, Andrew, Binnie, Margaret, Sooy, Karen, Seckl, Jonathan R, Andrew, Ruth, Pallin, T David, Hunt, Hazel J, Perrior, Trevor R, Ruffles, Vincent S, Ketelbey, J William, Boyd, Alan, Walker, Brian R
Published in British journal of pharmacology (01.03.2017)
Published in British journal of pharmacology (01.03.2017)
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Journal Article
1H-Pyrazolo[3,4-g]hexahydro-isoquinolines as potent GR antagonists with reduced hERG inhibition and an improved pharmacokinetic profile
Hunt, Hazel J., Belanoff, Joseph K., Golding, Emily, Gourdet, Benoit, Phillips, Timothy, Swift, Denise, Thomas, Jennifer, Unitt, John F., Walters, Iain
Published in Bioorganic & medicinal chemistry letters (15.12.2015)
Published in Bioorganic & medicinal chemistry letters (15.12.2015)
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Journal Article
Discovery of a novel non-steroidal GR antagonist with in vivo efficacy in the olanzapine-induced weight gain model in the rat
Hunt, Hazel J., Ray, Nicholas C., Hynd, George, Sutton, Jon, Sajad, Mohammed, O’Connor, Elizabeth, Ahmed, Shahadat, Lockey, Peter, Daly, Steve, Buckley, Gerry, Clark, Robin D., Roe, Robert, Blasey, Christine, Belanoff, Joe
Published in Bioorganic & medicinal chemistry letters (15.12.2012)
Published in Bioorganic & medicinal chemistry letters (15.12.2012)
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Azepines and Piperidines with Dual Norepinephrine Dopamine Uptake Inhibition and Antidepressant Activity
Brown, Dean G, Bernstein, Peter R, Wu, Ye, Urbanek, Rebecca A, Becker, Christopher W, Throner, Scott R, Dembofsky, Bruce T, Steelman, Gary B, Lazor, Lois A, Scott, Clay W, Wood, Michael W, Wesolowski, Steven S, Nugiel, David A, Koch, Stephanie, Yu, Jian, Pivonka, Donald E, Li, Shuang, Thompson, Carol, Zacco, Anna, Elmore, Charles S, Schroeder, Patricia, Liu, JianWei, Hurley, Christopher A, Ward, Stuart, Hunt, Hazel J, Williams, Karen, McLaughlin, Joseph, Hoesch, Valerie, Sydserff, Simon, Maier, Donna, Aharony, David
Published in ACS medicinal chemistry letters (10.01.2013)
Published in ACS medicinal chemistry letters (10.01.2013)
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SAT-224 Pharmacokinetics of the selective glucocorticoid receptor modulator miricorilant in healthy volunteers and patients with presumed metabolic dysfunction-associated steatohepatitis (MASH)
Custodio, Joseph M., Donaldson, Kirsteen, Kunta, Jeevan, Juneja, Kavita, Alkhouri, Naim, Hunt, Hazel J.
Published in Journal of hepatology (01.06.2024)
Published in Journal of hepatology (01.06.2024)
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Journal Article
Identification of the Clinical Candidate ( R )-(1-(4-Fluorophenyl)-6-((1-methyl-1 H -pyrazol-4-yl)sulfonyl)-4,4a,5,6,7,8-hexahydro-1 H -pyrazolo[3,4- g ]isoquinolin-4a-yl)(4-(trifluoromethyl)pyridin-2-yl)methanone (CORT125134): A Selective Glucocorticoid Receptor (GR) Antagonist
Hunt, Hazel J., Belanoff, Joseph K., Walters, Iain, Gourdet, Benoit, Thomas, Jennifer, Barton, Naomi, Unitt, John, Phillips, Timothy, Swift, Denise, Eaton, Emily
Published in Journal of medicinal chemistry (27.04.2017)
Published in Journal of medicinal chemistry (27.04.2017)
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Journal Article
Abstract 3434: Selective glucocorticoid receptor modulation reveals a new role for CLEC10A in patients with solid tumors
Colombo, Nicoletta, Van Gorp, Toon, Matulonis, Ursula A., Oaknin, Ana, Grisham, Rachel N., Provencher, Diane, Fleming, Gini F., Olawaiye, Alexander B., Borazanci, Erkut H., Szmulewitz, Russell Z., Wadekar, Subhagya A., Mann, Grace, Hunt, Hazel J., Greenstein, Andrew E., Lorusso, Domenica
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Published in Cancer research (Chicago, Ill.) (04.04.2023)
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Journal Article
Selection and early clinical evaluation of the brain-penetrant 11[beta]-hydroxysteroid dehydrogenase type 1 (11[beta]-HSD1) inhibitor UE2343 (Xanamem(TM))
Webster, Scott P, McBride, Andrew, Binnie, Margaret, Sooy, Karen, Seckl, Jonathan R, Andrew, Ruth, Pallin, T David, Hunt, Hazel J, Perrior, Trevor R, Ruffles, Vincent S, Ketelbey, J William, Boyd, Alan, Walker, Brian R
Published in British journal of pharmacology (01.03.2017)
Published in British journal of pharmacology (01.03.2017)
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2,6-substituert-4-monosubstituert aminopyrimidin som prostaglandin D2 reseptorantagonister og farmasøytiske sammensetninger inneholdene disse, samt anvendelse av disse for fremstilling av et medikament
Gillespy, Timothy Alan, Dechaux, Elsa, Lim, Sungtaek, Cao, Bin, Boffey, Ray, Harris, Keith John, Aguiar, Joacy C, Hunt, Hazel J, Stefany, David, Gardner, Charles J
Year of Publication 30.01.2017
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Year of Publication 30.01.2017
Patent
ChemInform Abstract: Silicon Diols: Effective Inhibitors of Human Leukocyte Elastase
Showell, Graham A., Montana, John G., Chadwick, Jenny A., Higgs, Chris, Hunt, Hazel J., MacKenzie, Robert E., Price, Steve, Wilkinson, Tina J.
Published in ChemInform (03.03.2009)
Published in ChemInform (03.03.2009)
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2,6-SUBSTITUTED-4-MONOSUBSTITUTEDAMINO-PYRIMIDINES AS PROSTAGLANDIN D2 RECEPTOR ANTAGONISTS
GARDNER, CHARLES J, CAO, BIN, BOFFEY, RAY, AGUIAR, JOACY C, DECHAUX, ELSA A, GILLESPY, TIMOTHY A, HUNT, HAZEL J, HARRIS, KEITH JOHN, LIM, SUNGTAEK, STEFANY, DAVID
Year of Publication 31.12.2012
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Year of Publication 31.12.2012
Patent