The methyltransferase G9a regulates HoxA9-dependent transcription in AML
Lehnertz, Bernhard, Pabst, Caroline, Su, Le, Miller, Michelle, Liu, Feng, Yi, Lin, Zhang, Regan, Krosl, Jana, Yung, Eric, Kirschner, Jeanette, Rosten, Patty, Underhill, T Michael, Jin, Jian, Hébert, Josée, Sauvageau, Guy, Humphries, R Keith, Rossi, Fabio M
Published in Genes & development (15.02.2014)
Published in Genes & development (15.02.2014)
Get full text
Journal Article
Identification of miR-145 and miR-146a as mediators of the 5q- syndrome phenotype
Kuchenbauer, Florian, Lam, Wan, Hogge, Donna, Humphries, R Keith, Marra, Marco, Morin, Ryan, Wells, Richard A, Buckstein, Rena, Hirst, Martin, Starczynowski, Daniel T, Sung, Sandy, Muranyi, Andrew, Karsan, Aly, Argiropoulos, Bob
Published in Nature medicine (01.01.2010)
Published in Nature medicine (01.01.2010)
Get full text
Journal Article
The Lin28b–let-7–Hmga2 axis determines the higher self-renewal potential of fetal haematopoietic stem cells
Copley, Michael R., Babovic, Sonja, Benz, Claudia, Knapp, David J. H. F., Beer, Philip A., Kent, David G., Wohrer, Stefan, Treloar, David Q., Day, Christopher, Rowe, Keegan, Mader, Heidi, Kuchenbauer, Florian, Humphries, R. Keith, Eaves, Connie J.
Published in Nature cell biology (01.08.2013)
Published in Nature cell biology (01.08.2013)
Get full text
Journal Article
Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin
Marra, Marco A, Morin, Ryan D, Johnson, Nathalie A, Severson, Tesa M, Mungall, Andrew J, An, Jianghong, Goya, Rodrigo, Paul, Jessica E, Boyle, Merrill, Woolcock, Bruce W, Kuchenbauer, Florian, Yap, Damian, Humphries, R Keith, Griffith, Obi L, Shah, Sohrab, Zhu, Henry, Kimbara, Michelle, Shashkin, Pavel, Charlot, Jean F, Tcherpakov, Marianna, Corbett, Richard, Tam, Angela, Varhol, Richard, Smailus, Duane, Moksa, Michelle, Zhao, Yongjun, Delaney, Allen, Qian, Hong, Birol, Inanc, Schein, Jacqueline, Moore, Richard, Holt, Robert, Horsman, Doug E, Connors, Joseph M, Jones, Steven, Aparicio, Samuel, Hirst, Martin, Gascoyne, Randy D
Published in Nature genetics (01.02.2010)
Published in Nature genetics (01.02.2010)
Get full text
Journal Article
Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation
Yap, Damian B., Chu, Justin, Berg, Tobias, Schapira, Matthieu, Cheng, S.-W. Grace, Moradian, Annie, Morin, Ryan D., Mungall, Andrew J., Meissner, Barbara, Boyle, Merrill, Marquez, Victor E., Marra, Marco A., Gascoyne, Randy D., Humphries, R. Keith, Arrowsmith, Cheryl H., Morin, Gregg B., Aparicio, Samuel A.J.R.
Published in Blood (24.02.2011)
Published in Blood (24.02.2011)
Get full text
Journal Article
The miR-185/PAK6 axis predicts therapy response and regulates survival of drug-resistant leukemic stem cells in CML
Lin, Hanyang, Rothe, Katharina, Chen, Min, Wu, Andrew, Babaian, Artem, Yen, Ryan, Zeng, Jonathan, Ruschmann, Jens, Petriv, Oleh I., O'Neill, Kieran, Maetzig, Tobias, Knapp, David J.H.F., Nakamichi, Naoto, Brinkman, Ryan, Birol, Inanc, Forrest, Donna L., Hansen, Carl, Humphries, R. Keith, Eaves, Connie J., Jiang, Xiaoyan
Published in Blood (30.07.2020)
Published in Blood (30.07.2020)
Get full text
Journal Article
Hoxa9 and Meis1 Cooperatively Induce Addiction to Syk Signaling by Suppressing miR-146a in Acute Myeloid Leukemia
Mohr, Sebastian, Doebele, Carmen, Comoglio, Federico, Berg, Tobias, Beck, Julia, Bohnenberger, Hanibal, Alexe, Gabriela, Corso, Jasmin, Ströbel, Philipp, Wachter, Astrid, Beissbarth, Tim, Schnütgen, Frank, Cremer, Anjali, Haetscher, Nadine, Göllner, Stefanie, Rouhi, Arefeh, Palmqvist, Lars, Rieger, Michael A., Schroeder, Timm, Bönig, Halvard, Müller-Tidow, Carsten, Kuchenbauer, Florian, Schütz, Ekkehard, Green, Anthony R., Urlaub, Henning, Stegmaier, Kimberly, Humphries, R. Keith, Serve, Hubert, Oellerich, Thomas
Published in Cancer cell (10.04.2017)
Published in Cancer cell (10.04.2017)
Get full text
Journal Article
High-throughput analysis of single hematopoietic stem cell proliferation in microfluidic cell culture arrays
Lecault, Véronique, VanInsberghe, Michael, Sekulovic, Sanja, Knapp, David J H F, Wohrer, Stefan, Bowden, William, Viel, Francis, McLaughlin, Thomas, Jarandehei, Asefeh, Miller, Michelle, Falconnet, Didier, White, Adam K, Kent, David G, Copley, Michael R, Taghipour, Fariborz, Eaves, Connie J, Humphries, R Keith, Piret, James M, Hansen, Carl L
Published in Nature methods (01.07.2011)
Published in Nature methods (01.07.2011)
Get full text
Journal Article
Meis1 establishes the pre-hemogenic endothelial state prior to Runx1 expression
Coulombe, Patrick, Cole, Grace, Fentiman, Amanda, Parker, Jeremy D. K., Yung, Eric, Bilenky, Misha, Degefie, Lemlem, Lac, Patrick, Ling, Maggie Y. M., Tam, Derek, Humphries, R. Keith, Karsan, Aly
Published in Nature communications (27.07.2023)
Published in Nature communications (27.07.2023)
Get full text
Journal Article
Endogenous Tumor Suppressor microRNA-193b: Therapeutic and Prognostic Value in Acute Myeloid Leukemia
Bhayadia, Raj, Krowiorz, Kathrin, Haetscher, Nadine, Jammal, Razan, Emmrich, Stephan, Obulkasim, Askar, Fiedler, Jan, Schwarzer, Adrian, Rouhi, Arefeh, Heuser, Michael, Wingert, Susanne, Bothur, Sabrina, Döhner, Konstanze, Mätzig, Tobias, Ng, Michelle, Reinhardt, Dirk, Döhner, Hartmut, Zwaan, C Michel, van den Heuvel Eibrink, Marry, Heckl, Dirk, Fornerod, Maarten, Thum, Thomas, Humphries, R Keith, Rieger, Michael A, Kuchenbauer, Florian, Klusmann, Jan-Henning
Published in Journal of clinical oncology (01.04.2018)
Published in Journal of clinical oncology (01.04.2018)
Get full text
Journal Article
Loss-of-function Additional sex combs like 1 mutations disrupt hematopoiesis but do not cause severe myelodysplasia or leukemia
Fisher, Cynthia L., Pineault, Nicolas, Brookes, Christy, Helgason, Cheryl D., Ohta, Hideaki, Bodner, Caroline, Hess, Jay L., Humphries, R. Keith, Brock, Hugh W.
Published in Blood (07.01.2010)
Published in Blood (07.01.2010)
Get full text
Journal Article
Hepatic leukemia factor is a novel leukemic stem cell regulator in DNMT3A, NPM1, and FLT3-ITD triple-mutated AML
Garg, Swati, Reyes-Palomares, Armando, He, Lixiazi, Bergeron, Anne, Lavallée, Vincent-Philippe, Lemieux, Sébastien, Gendron, Patrick, Rohde, Christian, Xia, Jianglong, Jagdhane, Prarabdha, Müller-Tidow, Carsten, Lipka, Daniel B., Imren, Suzan, Humphries, R. Keith, Waskow, Claudia, Vick, Binje, Jeremias, Irmela, Richard-Carpentier, Guillaume, Hébert, Josée, Sauvageau, Guy, Zaugg, Judith B., Barabé, Frédéric, Pabst, Caroline
Published in Blood (18.07.2019)
Published in Blood (18.07.2019)
Get full text
Journal Article
Effective drug treatment identified by in vivo screening in a transplantable patient-derived xenograft model of chronic myelomonocytic leukemia
Kloos, Arnold, Mintzas, Konstantinos, Winckler, Lina, Gabdoulline, Razif, Alwie, Yasmine, Jyotsana, Nidhi, Kattre, Nadine, Schottmann, Renate, Scherr, Michaela, Gupta, Charu, Adams, Felix F., Schwarzer, Adrian, Heckl, Dirk, Schambach, Axel, Imren, Suzan, Humphries, R. Keith, Ganser, Arnold, Thol, Felicitas, Heuser, Michael
Published in Leukemia (01.11.2020)
Published in Leukemia (01.11.2020)
Get full text
Journal Article
Reversible switching of leukemic cells to a drug-resistant, stem-like subset via IL-4-mediated cross-talk with mesenchymal stroma
Lee, Hae-Ri, Lee, Ga-Young, Kim, Eung-Won, Kim, Hee-Je, Lee, Minho, Humphries, R Keith, Oh, Il-Hoan
Published in Haematologica (Roma) (01.02.2022)
Published in Haematologica (Roma) (01.02.2022)
Get full text
Journal Article
Clonal Analysis via Barcoding Reveals Diverse Growth and Differentiation of Transplanted Mouse and Human Mammary Stem Cells
Nguyen, Long V., Makarem, Maisam, Carles, Annaick, Moksa, Michelle, Kannan, Nagarajan, Pandoh, Pawan, Eirew, Peter, Osako, Tomo, Kardel, Melanie, Cheung, Alice M.S., Kennedy, William, Tse, Kane, Zeng, Thomas, Zhao, Yongjun, Humphries, R. Keith, Aparicio, Samuel, Eaves, Connie J., Hirst, Martin
Published in Cell stem cell (06.02.2014)
Published in Cell stem cell (06.02.2014)
Get full text
Journal Article
Genome-wide identification of human microRNAs located in leukemia-associated genomic alterations
Starczynowski, Daniel T., Morin, Ryan, McPherson, Andrew, Lam, Jeff, Chari, Raj, Wegrzyn, Joanna, Kuchenbauer, Florian, Hirst, Martin, Tohyama, Kaoru, Humphries, R. Keith, Lam, Wan L., Marra, Marco, Karsan, Aly
Published in Blood (13.01.2011)
Published in Blood (13.01.2011)
Get full text
Journal Article
A transgenic mouse model demonstrating the oncogenic role of mutations in the polycomb-group gene EZH2 in lymphomagenesis
Berg, Tobias, Thoene, Silvia, Yap, Damian, Wee, Tracee, Schoeler, Nathalie, Rosten, Patty, Lim, Emilia, Bilenky, Misha, Mungall, Andrew J., Oellerich, Thomas, Lee, Sherry, Lai, Courteney K., Umlandt, Patricia, Salmi, Anisa, Chang, Harry, Yue, Lisa, Lai, David, Cheng, S.-W. Grace, Morin, Ryan D., Hirst, Martin, Serve, Hubert, Marra, Marco A., Morin, Gregg B., Gascoyne, Randy D., Aparicio, Samuel A., Humphries, R. Keith
Published in Blood (19.06.2014)
Published in Blood (19.06.2014)
Get full text
Journal Article