The Emergence of Universal Chromatographic Methods in the Research and Development of New Drug Substances
Regalado, Erik L, Haidar Ahmad, Imad A, Bennett, Raffeal, D’Atri, Valentina, Makarov, Alexey A, Humphrey, Guy R, Mangion, Ian, Guillarme, Davy
Published in Accounts of chemical research (16.07.2019)
Published in Accounts of chemical research (16.07.2019)
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Journal Article
Development of a Commercial Manufacturing Route to 2‑Fluoroadenine, The Key Unnatural Nucleobase of Islatravir
Hong, Cynthia M, Xu, Yingju, Chung, John Y. L, Schultz, Danielle M, Weisel, Mark, Varsolona, Richard J, Zhong, Yong-Li, Purohit, Akasha K, He, Cyndi Q, Gauthier, Donald R, Humphrey, Guy R, Maloney, Kevin M, Lévesque, François, Wang, Zhixun, Whittaker, Aaron M, Sirota, Eric, McMullen, Jonathan P
Published in Organic process research & development (19.03.2021)
Published in Organic process research & development (19.03.2021)
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Combining traditional 2D and modern physical organic-derived descriptors to predict enhanced enantioselectivity for the key aza-Michael conjugate addition in the synthesis of Prevymis™ (letermovir)
Metsänen, Toni T, Lexa, Katrina W, Santiago, Celine B, Chung, Cheol K, Xu, Yingju, Liu, Zhijian, Humphrey, Guy R, Ruck, Rebecca T, Sherer, Edward C, Sigman, Matthew S
Published in Chemical science (Cambridge) (2018)
Published in Chemical science (Cambridge) (2018)
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Journal Article
Asymmetric Synthesis of Telcagepant, a CGRP Receptor Antagonist for the Treatment of Migraine
Xu, Feng, Zacuto, Michael, Yoshikawa, Naoki, Desmond, Richard, Hoerrner, Scott, Itoh, Tetsuji, Journet, Michel, Humphrey, Guy R, Cowden, Cameron, Strotman, Neil, Devine, Paul
Published in Journal of organic chemistry (19.11.2010)
Published in Journal of organic chemistry (19.11.2010)
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Journal Article
Asymmetric Synthesis of a Potent HIV‑1 Integrase Inhibitor
Kuethe, Jeffrey T, Humphrey, Guy R, Journet, Michel, Peng, Zhihui, Childers, Karla G
Published in Journal of organic chemistry (04.11.2016)
Published in Journal of organic chemistry (04.11.2016)
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Journal Article
Process Development of C–N Cross-Coupling and Enantioselective Biocatalytic Reactions for the Asymmetric Synthesis of Niraparib
Chung, Cheol K, Bulger, Paul G, Kosjek, Birgit, Belyk, Kevin M, Rivera, Nelo, Scott, Mark E, Humphrey, Guy R, Limanto, John, Bachert, Donald C, Emerson, Khateeta M
Published in Organic process research & development (17.01.2014)
Published in Organic process research & development (17.01.2014)
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Asymmetric Hydrogen Bonding Catalysis for the Synthesis of Dihydroquinazoline-Containing Antiviral, Letermovir
Chung, Cheol K, Liu, Zhijian, Lexa, Katrina W, Andreani, Teresa, Xu, Yingju, Ji, Yining, DiRocco, Daniel A, Humphrey, Guy R, Ruck, Rebecca T
Published in Journal of the American Chemical Society (09.08.2017)
Published in Journal of the American Chemical Society (09.08.2017)
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Journal Article
Development of a Robust Manufacturing Route for Molnupiravir, an Antiviral for the Treatment of COVID-19
Fier, Patrick S., Xu, Yingju, Poirier, Marc, Brito, Gilmar, Zheng, Michelle, Bade, Rachel, Sirota, Eric, Stone, Kevin, Tan, Lushi, Humphrey, Guy R., Chang, Darryl, Bothe, Jameson, Zhang, Yongqian, Bernardoni, Frank, Castro, Steve, Zompa, Michael A., Taylor, Jerry, Sirk, Kevin M., Diaz-Santana, Anthony, Diribe, Ike, Emerson, Khateeta M., Krishnamurthi, Bharath, Zhao, Ralph, Ward, Michael, Xiao, Chengqian, Ouyand, Honggui, Zhan, Jianfeng, Morris, William J.
Published in Organic process research & development (17.12.2021)
Published in Organic process research & development (17.12.2021)
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Journal Article
Development of a Novel, Highly Efficient Halide-Catalyzed Sulfenylation of Indoles
Tudge, Matthew, Tamiya, Minoru, Savarin, Cecile, Humphrey, Guy R
Published in Organic letters (16.02.2006)
Published in Organic letters (16.02.2006)
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Journal Article
A Green Chemistry Continuum for a Robust and Sustainable Active Pharmaceutical Ingredient Supply Chain
Koenig, Stefan G, Bee, Cisco, Borovika, Alina, Briddell, Christiana, Colberg, Juan, Humphrey, Guy R, Kopach, Michael E, Martinez, Isamir, Nambiar, Sudhir, Plummer, Scott V, Ribe, Seth D, Roschangar, Frank, Scott, Jeremy P, Sneddon, Helen F
Published in ACS sustainable chemistry & engineering (21.10.2019)
Published in ACS sustainable chemistry & engineering (21.10.2019)
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Journal Article
Development of a Green and Sustainable Manufacturing Process for Gefapixant Citrate (MK-7264) Part 2: Development of a Robust Process for Phenol Synthesis
Peng, Feng, Humphrey, Guy R, Maloney, Kevin M, Lehnherr, Dan, Weisel, Mark, Lévesque, Francois, Naber, John R, Brunskill, Andrew P. J, Larpent, Patrick, Zhang, Si-Wei, Lee, Alfred Y, Arvary, Rebecca A, Lee, Claire H, Bishara, Daniel, Narsimhan, Karthik, Sirota, Eric, Whittington, Michael
Published in Organic process research & development (20.11.2020)
Published in Organic process research & development (20.11.2020)
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Journal Article
Asymmetric Synthesis of Functionalized trans-Cyclopropoxy Building Block for Grazoprevir
Xu, Feng, Zhong, Yong-Li, Li, Hongming, Qi, Ji, Desmond, Richard, Song, Zhiguo J, Park, Jeonghan, Wang, Tao, Truppo, Matthew, Humphrey, Guy R, Ruck, Rebecca T
Published in Organic letters (03.11.2017)
Published in Organic letters (03.11.2017)
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Journal Article
Development of a Scalable and Safer Synthesis of Diazeniumdiolates
Zhong, Yong-Li, Muzzio, Daniel J, Weisel, Mark, Zhang, Li, Humphrey, Guy R, Maloney, Kevin M, Campos, Kevin R
Published in Organic process research & development (18.09.2020)
Published in Organic process research & development (18.09.2020)
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Journal Article
Scalable Synthesis of Diazeniumdiolates: Application to the Preparation of MK-8150
Zhong, Yong-Li, Weisel, Mark, Humphrey, Guy R, Muzzio, Daniel J, Zhang, Li, Huffman, Mark A, Zhong, Wendy, Maloney, Kevin M, Campos, Kevin R
Published in Organic letters (07.06.2019)
Published in Organic letters (07.06.2019)
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Journal Article
Development of a Green and Sustainable Manufacturing Process for Gefapixant Citrate (MK-7264) Part 1: Introduction and Process Overview
Ren, Hong, Maloney, Kevin M, Basu, Kallol, Di Maso, Michael J, Humphrey, Guy R, Peng, Feng, Desmond, Richard, Otte, Douglas A. L, Alwedi, Embarek, Liu, Wenjun, Zhang, Si-Wei, Song, Siqing, Arvary, Rebecca A, Zompa, Michael A, Lehnherr, Dan, Martin, Gary E, Chang, Hsieh Yao D, Mohan, Anne E, Guzman, Francisco J, Jellett, Lisa, Lee, Alfred Y, Spencer, Glenn, Fisher, Elizabeth S, Naber, John R, Gao, Hong, Lohani, Sachin, Ruck, Rebecca T, Campeau, Louis-Charles
Published in Organic process research & development (20.11.2020)
Published in Organic process research & development (20.11.2020)
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Journal Article
Development of a Multikilogram Scale Synthesis of a TRPV1 Antagonist
Kuethe, Jeffrey T, Journet, Michel, Peng, Zhihui, Zhao, Dalian, McKeown, Arlene, Humphrey, Guy R
Published in Organic process research & development (19.02.2016)
Published in Organic process research & development (19.02.2016)
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Journal Article
Direct conversion of activated alcohols to azides using diphenyl phosphorazidate. A practical alternative to Mitsunobu conditions
Thompson, Andrew S, Humphrey, Guy R, DeMarco, Anthony M, Mathre, David J, Grabowski, Edward J. J
Published in Journal of organic chemistry (01.10.1993)
Published in Journal of organic chemistry (01.10.1993)
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Journal Article
Development of a Green and Sustainable Manufacturing Process for Gefapixant Citrate (MK-7264). Part 6: Development of an Improved Commercial Salt Formation Process
Maloney, Kevin M, Zhang, Si-Wei, Mohan, Anne E, Lee, Alfred Y, Larpent, Patrick, Ren, Hong, Humphrey, Guy R, Desmond, Richard, DiBenedetto, Michael, Liu, Wenjun, Lee, Ivan H, Sirota, Eric, Di Maso, Michael J, Alwedi, Embarek, Song, Siqing, Chang, Hsieh Yao D
Published in Organic process research & development (20.11.2020)
Published in Organic process research & development (20.11.2020)
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