Drug design via pharmacophore identification. Dopaminergic activity of 3H-benz[e]indol-8-amines and their mode of interaction with the dopamine receptor
Asselin, Andre A, Humber, Leslie G, Voith, Katherine, Metcalf, Geoffrey
Published in Journal of medicinal chemistry (01.05.1986)
Published in Journal of medicinal chemistry (01.05.1986)
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Journal Article
Etodolac, a novel antiinflammatory agent. The syntheses and biological evaluation of its metabolites
Humber, Leslie G, Ferdinandi, Eckhardt, Demerson, Christopher A, Ahmed, Syed, Shah, Uresh, Mobilio, Dominick, Sabatucci, Joseph, De Lange, Barbara, Labbadia, Francesco
Published in Journal of medicinal chemistry (01.09.1988)
Published in Journal of medicinal chemistry (01.09.1988)
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Journal Article
Synthesis of derivatives of isoindole and of pyrazino[2,1-a]isoindole
Ferland, Jean-Marie, Demerson, Christopher A, Humber, Leslie G
Published in Canadian journal of chemistry (01.02.1985)
Published in Canadian journal of chemistry (01.02.1985)
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Journal Article
Etodolac (1,8-diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid): a potent antiinflammatory drug. Conformation and absolute configuration of its active enantiomer
HUMBER, L. G, DEMERSON, C. A, SWAMINATHAN, P, BIRD, P. H
Published in Journal of medicinal chemistry (01.05.1986)
Published in Journal of medicinal chemistry (01.05.1986)
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Journal Article
Synthesis and biological evaluation of 4,6-diethyl-1,3,4,5-tetrahydropyrano[4,3-b]indole-4-acetic acid, an isomer of etodolac
Hughes, Philip, DeVirgilio, John, Humber, Leslie G, Chau Thuy, Weichman, Barry, Neuman, Glen
Published in Journal of medicinal chemistry (01.09.1989)
Published in Journal of medicinal chemistry (01.09.1989)
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Journal Article
Structure-activity relationships among analogues of pemedolac, cis-1-ethyl-1,3,4,9-tetrahydro-4-(phenylmethyl)pyrano[3,4-b]indole-1-acetic acid, a potent analgesic agent
Mobilio, Dominick, Humber, Leslie G, Katz, Alan H, Demerson, Christopher A, Hughes, Philip, Brigance, Robert, Conway, Kimberly, Shah, Uresh, Williams, Gail
Published in Journal of medicinal chemistry (01.11.1988)
Published in Journal of medicinal chemistry (01.11.1988)
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Journal Article
Synthesis and analgesic activity of pemedolac (cis-1-ethyl-1,3,4,9-tetrahydro-4-(phenylmethyl)pyrano[3,4-b]indole-1-acetic acid)
KATZ, A. H, DEMERSON, C. A, NOURELDIN, R, SCHMID, J, URESH SHAH, VAN ENGEN, D, CHAU, T. T, WEICHMAN, B. M, CHIA-CHENG SHAW, ASSELIN, A. A, HUMBER, L. G, CONWAY, K. M, GAVIN, G, GUINOSSO, C, JENSEN, N. P, MOBILIO, D
Published in Journal of medicinal chemistry (01.06.1988)
Published in Journal of medicinal chemistry (01.06.1988)
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Journal Article
(+)-Isobutaclamol: a crystallographic, pharmacological, and biochemical study
Humber, L. G, Philipp, A. H, Voith, K, Pugsley, T, Lippmann, W, Ahmed, F. R, Przybylska, M
Published in Journal of medicinal chemistry (01.08.1979)
Published in Journal of medicinal chemistry (01.08.1979)
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Journal Article
Indole-phenol-bioisosterism. Synthesis and antihypertensive activity of a pyrrolo analog of labetalol
Asselin, Andre A, Humber, Leslie G, Crosilla, Danilo, Oshiro, George, Wojdan, Alexandra, Grimes, David, Heaslip, Richard J, Rimele, Thomas J, Shaw, Chia Cheng
Published in Journal of medicinal chemistry (01.06.1986)
Published in Journal of medicinal chemistry (01.06.1986)
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Journal Article
Ligand-receptor interactions via hydrogen-bond formation. Synthesis and pharmacological evaluation of pyrrolo and pyrido analogs of the cardiotonic agent 7-hydroxycyclindole
Dionne, Gervais, Humber, Leslie G, Asselin, Andre, McQuillan, Juanita, Treasurywala, Adi M
Published in Journal of medicinal chemistry (01.08.1986)
Published in Journal of medicinal chemistry (01.08.1986)
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Journal Article
Synthesis and analgesic evaluation of 4-(2-heptyloxy)-7-[(Z)-(3-hydroxycyclohexyl)]indole: a caveat on indole-phenol bioisosterism
Soll, Richard M, Humber, Leslie G, Deininger, David, Asselin, Andre A, Chau, Thuy T, Weichman, Barry M
Published in Journal of medicinal chemistry (01.08.1986)
Published in Journal of medicinal chemistry (01.08.1986)
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Journal Article
Resolution of etodolac and antiinflammatory and prostaglandin synthetase inhibiting properties of the enantiomers
Demerson, Christopher A, Humber, Leslie G, Abraham, Nedumparambil A, Schilling, Gunther, Martel, Rene R, Pace-Asciak, Cecil
Published in Journal of medicinal chemistry (01.12.1983)
Published in Journal of medicinal chemistry (01.12.1983)
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Journal Article
Computer-assisted investigation of structure-activity relationships in serotonin-uptake blockers
G Humber, L, Lee, D, Rakhit, S, M Treasurywala, A
Published in Journal of molecular graphics (01.01.1985)
Published in Journal of molecular graphics (01.01.1985)
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Journal Article
The relationship between structure and activity in a novel series of serum cholesterol-lowering agents
Humber, L G, Chappel, C I, Marton, A V, Kraml, M, Dubuc, J
Published in Journal of medicinal chemistry (01.05.1966)
Published in Journal of medicinal chemistry (01.05.1966)
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Journal Article