Lead Optimization and Modulation of hERG Activity in a Series of Aminooxazoline Xanthene β‑Site Amyloid Precursor Protein Cleaving Enzyme (BACE1) Inhibitors
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Published in Journal of medicinal chemistry (11.12.2014)
Published in Journal of medicinal chemistry (11.12.2014)
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Discovery of Aryl Aminoquinazoline Pyridones as Potent, Selective, and Orally Efficacious Inhibitors of Receptor Tyrosine Kinase c-Kit
Hu, Essa, Tasker, Andrew, White, Ryan D, Kunz, Roxanne K, Human, Jason, Chen, Ning, Bürli, Roland, Hungate, Randall, Novak, Perry, Itano, Andrea, Zhang, Xuxia, Yu, Violeta, Nguyen, Yen, Tudor, Yanyan, Plant, Matthew, Flynn, Shaun, Xu, Yang, Meagher, Kristin L, Whittington, Douglas A, Ng, Gordon Y
Published in Journal of medicinal chemistry (12.06.2008)
Published in Journal of medicinal chemistry (12.06.2008)
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Development of 2-aminooxazoline 3-azaxanthenes as orally efficacious β-secretase inhibitors for the potential treatment of Alzheimer’s disease
Chen, Jian Jeffrey, Liu, Qingyian, Yuan, Chester, Gore, Vijay, Lopez, Patricia, Ma, Vu, Amegadzie, Albert, Qian, Wenyuan, Judd, Ted C., Minatti, Ana E., Brown, James, Cheng, Yuan, Xue, May, Zhong, Wenge, Dineen, Thomas A., Epstein, Oleg, Human, Jason, Kreiman, Charles, Marx, Isaac, Weiss, Matthew M., Hitchcock, Stephen A., Powers, Timothy S., Chen, Kui, Wen, Paul H., Whittington, Douglas A., Cheng, Alan C., Bartberger, Michael D., Hickman, Dean, Werner, Jonathan A., Vargas, Hugo M., Everds, Nancy E., Vonderfecht, Steven L., Dunn, Robert T., Wood, Stephen, Fremeau, Robert T., White, Ryan D., Patel, Vinod F.
Published in Bioorganic & medicinal chemistry letters (15.02.2015)
Published in Bioorganic & medicinal chemistry letters (15.02.2015)
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Discovery of dehydro-oxopiperazine acetamides as novel bradykinin B1 receptor antagonists with enhanced in vitro potency
Qian, Wenyuan, Chen, Jian Jeffrey, Human, Jason, Aya, Toshihiro, Zhu, Jiawang, Biswas, Kaustav, Peterkin, Tanya, Hungate, Randall W., Arik, Leyla, Johnson, Eileen, Kumar, Gondi, Joseph, Smriti, Jona, Janan, Guo, Hong-Xun, Wu, Zufan
Published in Bioorganic & medicinal chemistry letters (15.01.2012)
Published in Bioorganic & medicinal chemistry letters (15.01.2012)
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Structure-Based Design of Potent and Selective CK1γ Inhibitors
Huang, Hongbing, Acquaviva, Lisa, Berry, Virginia, Bregman, Howard, Chakka, Nagasree, O’Connor, Anne, DiMauro, Erin F, Dovey, Jennifer, Epstein, Oleg, Grubinska, Barbara, Goldstein, Jon, Gunaydin, Hakan, Hua, Zihao, Huang, Xin, Huang, Liyue, Human, Jason, Long, Alex, Newcomb, John, Patel, Vinod F, Saffran, Doug, Serafino, Randy, Schneider, Steve, Strathdee, Craig, Tang, Jin, Turci, Susan, White, Ryan, Yu, Violeta, Zhao, Huilin, Wilson, Cindy, Martin, Matthew W
Published in ACS medicinal chemistry letters (13.12.2012)
Published in ACS medicinal chemistry letters (13.12.2012)
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3-Oxo-2-piperazinyl acetamides as potent bradykinin B1 receptor antagonists for the treatment of pain and inflammation
Chen, Jian Jeffrey, Nguyen, Thomas, D’Amico, Derin C., Qian, Wenyuan, Human, Jason, Aya, Toshihiro, Biswas, Kaustav, Fotsch, Christopher, Han, Nianhe, Liu, Qingyian, Nishimura, Nobuko, Peterkin, Tanya A.N., Yang, Kevin, Zhu, Jiawang, Riahi, Babak Bobby, Hungate, Randall W., Andersen, Neil G., Colyer, John T., Faul, Margaret M., Kamassah, Augustus, Wang, Judy, Jona, Janan, Kumar, Gondi, Johnson, Eileen, Askew, Benny C.
Published in Bioorganic & medicinal chemistry letters (01.06.2011)
Published in Bioorganic & medicinal chemistry letters (01.06.2011)
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Aryl sulfones as novel Bradykinin B1 receptor antagonists for treatment of chronic pain
Biswas, Kaustav, Aya, Toshihiro, Qian, Wenyuan, Peterkin, Tanya A.N., Chen, Jian Jeffrey, Human, Jason, Hungate, Randall W., Kumar, Gondi, Arik, Leyla, Lester-Zeiner, Dianna, Biddlecome, Gloria, Manning, Barton H., Sun, Hong, Dong, Hong, Huang, Ming, Loeloff, Richard, Johnson, Eileen J., Askew, Benny C.
Published in Bioorganic & medicinal chemistry (01.09.2008)
Published in Bioorganic & medicinal chemistry (01.09.2008)
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Discovery of α-amidosulfones as potent and selective agonists of CB2 : Synthesis, SAR, and pharmacokinetic properties
MARX, Isaac E, DIMAURO, Erin F, MARTIN, Matthew W, WHITE, Ryan D, FREMEAU, Robert T, PATEL, Vinod F, CHENG, Alan, EMKEY, Renee, HITCHCOCK, Stephen A, LIYUE HUANG, HUANG, Ming Y, HUMAN, Jason, LEE, Josie H, XINGWEN LI
Published in Bioorganic & medicinal chemistry letters (2009)
Published in Bioorganic & medicinal chemistry letters (2009)
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Identification of a Nonpeptidic and Conformationally Restricted Bradykinin B1 Receptor Antagonist with Anti-Inflammatory Activity
D'Amico, Derin C, Aya, Toshi, Human, Jason, Fotsch, Christopher, Chen, Jian Jeffrey, Biswas, Kaustav, Riahi, Bobby, Norman, Mark H, Willoughby, Christopher A, Hungate, Randall, Reider, Paul J, Biddlecome, Gloria, Lester-Zeiner, Dianna, Van Staden, Carlo, Johnson, Eileen, Kamassah, Augustus, Arik, Leyla, Wang, Judy, Viswanadhan, Vellarkad N, Groneberg, Robert D, Zhan, James, Suzuki, Hideo, Toro, Andras, Mareska, David A, Clarke, David E, Harvey, Darren M, Burgess, Laurence E, Laird, Ellen R, Askew, Benny, Ng, Gordon
Published in Journal of medicinal chemistry (22.02.2007)
Published in Journal of medicinal chemistry (22.02.2007)
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Discovery of alpha -amidosulfones as potent and selective agonists of CB sub(2): Synthesis, SAR, and pharmacokinetic properties
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Published in Bioorganic & medicinal chemistry letters (01.01.2009)
Published in Bioorganic & medicinal chemistry letters (01.01.2009)
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Discovery of α-amidosulfones as potent and selective agonists of CB 2: Synthesis, SAR, and pharmacokinetic properties
Marx, Isaac E., DiMauro, Erin F., Cheng, Alan, Emkey, Renee, Hitchcock, Stephen A., Huang, Liyue, Huang, Ming Y., Human, Jason, Lee, Josie H., Li, Xingwen, Martin, Matthew W., White, Ryan D., Fremeau, Robert T., Patel, Vinod F.
Published in Bioorganic & medicinal chemistry letters (2009)
Published in Bioorganic & medicinal chemistry letters (2009)
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Year of Publication 09.12.2016
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Potent Nonpeptide Antagonists of the Bradykinin B1 Receptor: Structure−Activity Relationship Studies with Novel Diaminochroman Carboxamides
Biswas, Kaustav, Li, Aiwen, Chen, Jian Jeffrey, D'Amico, Derin C, Fotsch, Christopher, Han, Nianhe, Human, Jason, Liu, Qingyian, Norman, Mark H, Riahi, Bobby, Yuan, Chester, Suzuki, Hideo, Mareska, David A, Zhan, James, Clarke, David E, Toro, Andras, Groneberg, Robert D, Burgess, Laurence E, Lester-Zeiner, Dianna, Biddlecome, Gloria, Manning, Barton H, Arik, Leyla, Dong, Hong, Huang, Ming, Kamassah, Augustus, Loeloff, Richard, Sun, Hong, Hsieh, Feng-Yin, Kumar, Gondi, Ng, Gordon Y, Hungate, Randall W, Askew, Benny C, Johnson, Eileen
Published in Journal of medicinal chemistry (03.05.2007)
Published in Journal of medicinal chemistry (03.05.2007)
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SPIRO-TETRACYCLIC RING COMPOUNDS AS BETASECRETASE MODULATORS AND METHODS OF USE
BRYAN MARIAN C, AMEGADZIE ALBERT, EPSTEIN OLEG, MA VU VAN, WHITE RYAN, HUANG HONGBING, HUA ZIHAO, LA DANIEL, WEISS MATTHEW, GORE VIJAY KESHAV, CHENG ALAN C, MARX ISAAC, PATEL VINOD F, CHEN JIAN J, QIAN WENYUAN, YUAN CHESTER C, KREIMAN CHARLES, LIU QINGYIAN, HUMAN JASON B, DINEEN THOMAS
Year of Publication 29.06.2011
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Year of Publication 29.06.2011
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