Modern Organic Synthesis with α‑Diazocarbonyl Compounds
Ford, Alan, Miel, Hugues, Ring, Aoife, Slattery, Catherine N, Maguire, Anita R, McKervey, M. Anthony
Published in Chemical reviews (23.09.2015)
Published in Chemical reviews (23.09.2015)
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Journal Article
Discovery and characterization of highly potent and selective allosteric USP7 inhibitors
Gavory, Gerald, O'Dowd, Colin R, Helm, Matthew D, Flasz, Jakub, Arkoudis, Elias, Dossang, Anthony, Hughes, Caroline, Cassidy, Eamon, McClelland, Keeva, Odrzywol, Ewa, Page, Natalie, Barker, Oliver, Miel, Hugues, Harrison, Timothy
Published in Nature chemical biology (01.02.2018)
Published in Nature chemical biology (01.02.2018)
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Journal Article
Abstract 4869: Discovery and characterization of highly potent and selective USP7 inhibitors and benchmarking against clinical MDM2 antagonists
Gavory, Gerald, O'Dowd, Colin, Arkoudis, Elias, Barker, Oliver, Cassidy, Eamon, Dossang, Anthony, Flasz, Jakub, Helm, Matt, Hughes, Caroline, McClelland, Keeva, Miel, Hugues, Odrzywol, Ewa, Page, Natalie, Harrison, Tim
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Journal Article
Modern Organic Synthesis with alpha-Diazcarbonyl Compounds
d, Alan, Miel, Hugues, Ring, Aoife, Slattery, Catherine N, Maguire, Anita R, McKervey, M Anthony
Published in Chemical reviews (23.09.2015)
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Published in Chemical reviews (23.09.2015)
Journal Article
Identification and Structure-Guided Development of Pyrimidinone Based USP7 Inhibitors
O’Dowd, Colin R, Helm, Matthew D, Rountree, J. S. Shane, Flasz, Jakub T, Arkoudis, Elias, Miel, Hugues, Hewitt, Peter R, Jordan, Linda, Barker, Oliver, Hughes, Caroline, Rozycka, Ewelina, Cassidy, Eamon, McClelland, Keeva, Odrzywol, Ewa, Page, Natalie, Feutren-Burton, Stephanie, Dvorkin, Scarlett, Gavory, Gerald, Harrison, Timothy
Published in ACS medicinal chemistry letters (08.03.2018)
Published in ACS medicinal chemistry letters (08.03.2018)
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Abstract 1181: Discovery and development of novel highly potent and selective inhibitors of USP19 using UbiPlex
Gavory, Gerald, O'Dowd, Colin, Rozycka, Ewelina, Dossang, Anthony, Henderson, Ashling, Hughes, Caroline, Miel, Hugues, Barker, Oliver, Costa, Joana, Hewitt, Peter, McFarland, Mary, Proctor, Lauren, Harrison, Tim
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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Journal Article
Abstract LB-087: Discovery and development of first-in-class orally bioavailable USP19 inhibitors
Jacq, Xavier, Gavory, Gerald, O'Dowd, Colin, Cranston, Aaron, Baker, Oliver, Bell, Christina, Burton, Stephanie, Cassidy, Eamon, Costa, Joana, Henderson, Ashling, Helm, Matthew, Hewitt, Peter, Hughes, Caroline, McFarland, Mary, Miel, Hugues, Proctor, Lauren, Roundtree, Shane, Church, Rachel, Rozycka, Ewelina, Wappett, Mark, Whitehead, Steven, Harrison, Tim, Bedard, Nathalie, Wing, Simon S.
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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Abstract 1935: Accessing the cancer DUBome with UbiPlex: A bespoke drug discovery platform for deubiquitinase enzymes
Gavory, Gerald, O'Dowd, Colin, Barker, Oliver, Bell, Christina, Burkamp, Frank, Burton, Stephanie, Cassidy, Eamon, Costa, Joana, Dossang, Anthony, Helm, Matt, Henderson, Ashling, Hewitt, Peter, Hughes, Caroline, McFarland, Mary, Miel, Hugues, Page, Natalie, Proctor, Lauren, Rountree, Shane, Rozycka, Ewelina, Shepherd, Steven, Treder, Adam, Wappett, Mark, Whitehead, Steven, Harrison, Tim
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Abstract LB022: A novel first-in-class USP19 inhibitor for the treatment of cancer-induced muscle atrophy
Page, Natalie, Karthikaisamy, Vignesh, O'Hara, Darren, Cranston, Aaron N., O'Dowd, Colin R., Jacq, Xavier, Wilkinson, Richard, Burton, Stephanie, Gibson, Hayley, Costa, Joana, Longley, Daniel, Helm, Matthew, McGivern, Chris, Shepherd, Steven, Bell, Christina, Hewitt, Peter, McFarland, Mary, Miel, Hugues, Whitehead, Steven, Proctor, Lauren, Rountree, Shane J., Wappett, Mark, Diaz, Mauricio Berriel, Herzig, Stephan, Harrison, Timothy
Published in Cancer research (Chicago, Ill.) (14.04.2023)
Published in Cancer research (Chicago, Ill.) (14.04.2023)
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유비퀴틴 특이적 프로테아제 7의 억제제로서 피페리딘 유도체
JORDAN LINDA, WERTZ INGRID, O'DOWD COLIN, LEE WENDY, BROCCATELLI FABIO, HUGUES MIEL, HELM MATTHEW, ROUNTREE SHANE, HEWITT PETER, CRAWFORD JAMES JOHN, BURKAMP FRANK, GAZZARD LEWIS, HARRISON TIM
Year of Publication 19.06.2019
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Year of Publication 19.06.2019
Patent
PYRIMIDOPYRIMIDINONES USEFUL AS WEE-1 KINASE INHIBITORS
HEWITT, Peter, O'DOWD, Colin, MIEL, Hugues, BURKAMP, Frank, WILKINSON, Andrew
Year of Publication 02.02.2023
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Year of Publication 02.02.2023
Patent
PYRIMIDOPYRIMIDINONES USEFUL AS WEE-1 KINASE INHIBITORS
HEWITT, Peter, O'DOWD, Colin, MIEL, Hugues, BURKAMP, Frank, WILKINSON, Andrew
Year of Publication 23.06.2022
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Year of Publication 23.06.2022
Patent
Pyrimidopyrimidinones useful as Wee-1 kinase inhibitors
O'Dowd, Colin, Hewitt, Peter, Wilkinson, Andrew, Burkamp, Frank, Miel, Hugues
Year of Publication 24.03.2022
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Year of Publication 24.03.2022
Patent
PYRIMIDOPYRIMIDINONES USEFUL AS WEE-1 KINASE INHIBITORS
HEWITT, Peter, O'DOWD, Colin, MIEL, Hugues, BURKAMP, Frank, WILKINSON, Andrew
Year of Publication 28.02.2022
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Year of Publication 28.02.2022
Patent
PYRIMIDOPYRIMIDINONES USEFUL AS WEE-1 KINASE INHIBITORS
O'Dowd, Colin, Hewitt, Peter, Wilkinson, Andrew, Burkamp, Frank, Miel, Hugues
Year of Publication 04.02.2022
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Year of Publication 04.02.2022
Patent