Light‐Driven Radiochemistry with Fluorine‐18, Carbon‐11 and Zirconium‐89
Lin, Daniel, Lechermann, Laura M., Huestis, Malcolm P., Marik, Jan, Sap, Jeroen B. I.
Published in Angewandte Chemie International Edition (02.04.2024)
Published in Angewandte Chemie International Edition (02.04.2024)
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Dual Photoredox/Nickel-Catalyzed Conversion of Aryl Halides to Aryl Aminooxetanes: Computational Evidence for a Substrate-Dependent Switch in Mechanism
Kolahdouzan, Kavoos, Khalaf, Ryan, Grandner, Jessica M, Chen, Yongsheng, Terrett, Jack A, Huestis, Malcolm P
Published in ACS catalysis (03.01.2020)
Published in ACS catalysis (03.01.2020)
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Design and Evaluation of Highly Selective Human Immunoproteasome Inhibitors Reveal a Compensatory Process That Preserves Immune Cell Viability
Ladi, Ena, Everett, Christine, Stivala, Craig E, Daniels, Blake E, Durk, Matthew R, Harris, Seth F, Huestis, Malcolm P, Purkey, Hans E, Staben, Steven T, Augustin, Martin, Blaesse, Michael, Steinbacher, Stefan, Eidenschenk, Celine, Pappu, Rajita, Siu, Michael
Published in Journal of medicinal chemistry (08.08.2019)
Published in Journal of medicinal chemistry (08.08.2019)
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Journal Article
Targeting KRAS Mutant Cancers via Combination Treatment: Discovery of a 5‑Fluoro-4-(3H)‑quinazolinone Aryl Urea pan-RAF Kinase Inhibitor
Huestis, Malcolm P, Dela Cruz, Darlene, DiPasquale, Antonio G, Durk, Matthew R, Eigenbrot, Charles, Gibbons, Paul, Gobbi, Alberto, Hunsaker, Thomas L, La, Hank, Leung, Dennis H, Liu, Wendy, Malek, Shiva, Merchant, Mark, Moffat, John G, Muli, Christine S, Orr, Christine J, Parr, Brendan T, Shanahan, Frances, Sneeringer, Christopher J, Wang, Weiru, Yen, Ivana, Yin, Jianping, Siu, Michael, Rudolph, Joachim
Published in Journal of medicinal chemistry (08.04.2021)
Published in Journal of medicinal chemistry (08.04.2021)
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Journal Article
CpRh(III)‐Catalyzed C8 C−H Alkylation of Quinoline N‐Oxides with Diazo Meldrum's Acid
Huestis, Malcolm P., Leclerc, Jean‐Philippe, Larouche‐Gauthier, Robin, Aubert‐Nicol, Samuel, Yadav, Arun, Sivamuthuraman, Koilpitchai
Published in European journal of organic chemistry (22.01.2021)
Published in European journal of organic chemistry (22.01.2021)
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Journal Article
Sequential C3 and C5 Direct C-H Arylation of Imidazo[1,2-a]pyrazines with (Hetero)aryl Bromides
Johnson, Brett M., Huestis, Malcolm P.
Published in European journal of organic chemistry (01.03.2014)
Published in European journal of organic chemistry (01.03.2014)
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Journal Article
Discovery of Dual Leucine Zipper Kinase (DLK, MAP3K12) Inhibitors with Activity in Neurodegeneration Models
Patel, Snahel, Cohen, Frederick, Dean, Brian J., De La Torre, Kelly, Deshmukh, Gauri, Estrada, Anthony A., Ghosh, Arundhati Sengupta, Gibbons, Paul, Gustafson, Amy, Huestis, Malcolm P., Le Pichon, Claire E., Lin, Han, Liu, Wendy, Liu, Xingrong, Liu, Yichin, Ly, Cuong Q., Lyssikatos, Joseph P., Ma, Changyou, Scearce-Levie, Kimberly, Shin, Young G., Solanoy, Hilda, Stark, Kimberly L., Wang, Jian, Wang, Bei, Zhao, Xianrui, Lewcock, Joseph W., Siu, Michael
Published in Journal of medicinal chemistry (08.01.2015)
Published in Journal of medicinal chemistry (08.01.2015)
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Optimization of a Novel DEL Hit That Binds in the Cbl‑b SH2 Domain and Blocks Substrate Binding
Liang, Jun, Lambrecht, Michael J., Arenzana, Teresita L., Aubert-Nicol, Samuel, Bao, Linda, Broccatelli, Fabio, Cai, Jianping, Eidenschenk, Celine, Everett, Christine, Garner, Thomas, Gruber, Felix, Haghshenas, Pouyan, Huestis, Malcolm P., Hsu, Peter L., Kou, Ponien, Jakalian, Araz, Larouche-Gauthier, Robin, Leclerc, Jean-Philippe, Leung, Dennis H., Martin, Aaron, Murray, Jeremy, Prangley, Madeleine, Rutz, Sascha, Kakiuchi-Kiyota, Satoko, Satz, Alexander Lee, Skelton, Nicholas J., Steffek, Micah, Stoffler, Daniel, Sudhamsu, Jawahar, Tan, Sophia, Wang, Jian, Wang, Shouliang, Wang, Qiuyue, Wendorff, Timothy J., Wichert, Moreno, Yadav, Arun, Yu, Christine, Wang, Xiaojing
Published in ACS medicinal chemistry letters (13.06.2024)
Published in ACS medicinal chemistry letters (13.06.2024)
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Journal Article
Preparation of 2-Azabicyclo[2.1.1]hexane Hydrochloride
Liao, Haili, Li, Aimin, Chen, Xingsong, Liang, Kun, Shen, Yang, Liang, Qingfeng, Xu, Kewei, Shore, Daniel G. M., Villemure, Elisia, Siu, Michael, Huestis, Malcolm P.
Published in Synlett (19.09.2016)
Published in Synlett (19.09.2016)
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Journal Article
Targeting KRAS Mutant Cancers via Combination Treatment: Discovery of a Pyridopyridazinone pan-RAF Kinase Inhibitor
Huestis, Malcolm P, Durk, Matthew R, Eigenbrot, Charles, Gibbons, Paul, Hunsaker, Thomas L, La, Hank, Leung, Dennis H, Liu, Wendy, Malek, Shiva, Merchant, Mark, Moffat, John G, Muli, Christine S, Orr, Christine J, Parr, Brendan T, Shanahan, Frances, Sneeringer, Christopher J, Wang, Weiru, Yen, Ivana, Yin, Jianping, Rudolph, Joachim, Siu, Michael
Published in ACS medicinal chemistry letters (13.05.2021)
Published in ACS medicinal chemistry letters (13.05.2021)
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Journal Article
Synthesis, characterization, and PK/PD studies of a series of spirocyclic pyranochromene BACE1 inhibitors
Volgraf, Matthew, Chan, Lina, Huestis, Malcolm P., Purkey, Hans E., Burkard, Michael, Geck Do, Mary, Harris, Julie, Hunt, Kevin W., Liu, Xingrong, Lyssikatos, Joseph P., Rana, Sumeet, Thomas, Allen A., Vigers, Guy P.A., Siu, Michael
Published in Bioorganic & medicinal chemistry letters (01.06.2014)
Published in Bioorganic & medicinal chemistry letters (01.06.2014)
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