Strain and Near Attack Conformers in Enzymic Thiamin Catalysis: X-ray Crystallographic Snapshots of Bacterial Transketolase in Covalent Complex with Donor Ketoses Xylulose 5-phosphate and Fructose 6-phosphate, and in Noncovalent Complex with Acceptor Aldose Ribose 5-phosphate
Asztalos, Peter, Parthier, Christoph, Golbik, Ralph, Kleinschmidt, Martin, Hübner, Gerhard, Weiss, Manfred S., Friedemann, Rudolf, Wille, Georg, Tittmann, Kai
Published in Biochemistry (Easton) (30.10.2007)
Published in Biochemistry (Easton) (30.10.2007)
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DFT and MP2 studies on the C2 C2α bond cleavage in thiamin catalysis
Friedemann, Rudolf, Tittmann, Kai, Golbik, Ralph, Hübner, Gerhard
Published in Journal of molecular catalysis. B, Enzymatic (01.11.2009)
Published in Journal of molecular catalysis. B, Enzymatic (01.11.2009)
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Conference Proceeding
The crystal structure of pyruvate decarboxylase from Kluyveromyces lactis. Implications for the substrate activation mechanism of this enzyme
Kutter, Steffen, Wille, Georg, Relle, Sandy, Weiss, Manfred S, Hübner, Gerhard, König, Stephan
Published in The FEBS journal (01.09.2006)
Published in The FEBS journal (01.09.2006)
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Amino Acids Allosterically Regulate the Thiamine Diphosphate-dependent α-Keto Acid Decarboxylase from Mycobacterium tuberculosis
Werther, Tobias, Spinka, Michael, Tittmann, Kai, Schütz, Anja, Golbik, Ralph, Mrestani-Klaus, Carmen, Hübner, Gerhard, König, Stephan
Published in The Journal of biological chemistry (29.02.2008)
Published in The Journal of biological chemistry (29.02.2008)
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Steric and electronic properties of the cofactor's amino group control the lifetime of the central carbanion/enamine intermediate in transketolase
Meshalkina, Ludmilla E., Kochetov, German A., Hübner, Gerhard, Tittmann, Kai, Golbik, Ralph
Published in Journal of molecular catalysis. B, Enzymatic (01.11.2009)
Published in Journal of molecular catalysis. B, Enzymatic (01.11.2009)
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Journal Article
Conference Proceeding
The crystal structure of pyruvate decarboxylase from Kluyveromyces lactis
Kutter, Steffen, Wille, Georg, Relle, Sandy, Weiss, Manfred S., Hübner, Gerhard, König, Stephan
Published in The FEBS journal (01.09.2006)
Published in The FEBS journal (01.09.2006)
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Journal Article
New evidence for cofactor’s amino group function in thiamin catalysis by transketolase
Meshalkina, Ludmilla E., Kochetov, German A., Brauer, Johanna, Hübner, Gerhard, Tittmann, Kai, Golbik, Ralph
Published in Biochemical and biophysical research communications (15.02.2008)
Published in Biochemical and biophysical research communications (15.02.2008)
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Glutamate 636 of the Escherichia coli Pyruvate Dehydrogenase-E1 Participates in Active Center Communication and Behaves as an Engineered Acetolactate Synthase with Unusual Stereoselectivity
Nemeria, Natalia, Tittmann, Kai, Joseph, Ebenezer, Zhou, Leon, Vazquez-Coll, Michelle B., Arjunan, Palaniappa, Hübner, Gerhard, Furey, William, Jordan, Frank
Published in The Journal of biological chemistry (03.06.2005)
Published in The Journal of biological chemistry (03.06.2005)
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Effect of coenzyme modification on the structural and catalytic properties of wild‐type transketolase and of the variant E418A from Saccharomyces cerevisiae: Contrasting protonation state requirements of thiamin diphosphate in decarboxylases and transketolases
Golbik, Ralph, Meshalkina, Ludmilla E., Sandalova, Tatjana, Tittmann, Kai, Fiedler, Erik, Neef, Holger, König, Stephan, Kluger, Ronald, Kochetov, German A., Schneider, Gunter, Hübner, Gerhard
Published in The FEBS journal (01.03.2005)
Published in The FEBS journal (01.03.2005)
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Conformational Plasticity and Dynamics in the Generic Protein Folding Catalyst SlyD Unraveled by Single-Molecule FRET
Kahra, Dana, Kovermann, Michael, Löw, Christian, Hirschfeld, Verena, Haupt, Caroline, Balbach, Jochen, Hübner, Christian Gerhard
Published in Journal of molecular biology (26.08.2011)
Published in Journal of molecular biology (26.08.2011)
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The linkage of catalysis and regulation in enzyme action. Solvent isotope effects as probes of protonic sites in the yeast pyruvate decarboxylase mechanism
Alvarez, Francisco J, Ermer, Joachim, Huebner, Gerhard, Schellenberger, Alfred, Schowen, Richard L
Published in Journal of the American Chemical Society (01.02.1995)
Published in Journal of the American Chemical Society (01.02.1995)
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Catalytic power of pyruvate decarboxylase. Rate-limiting events and microscopic rate constants from primary carbon and secondary hydrogen isotope effects
Alvarez, Francisco J, Ermer, Joachim, Huebner, Gerhard, Schellenberger, Alfred, Schowen, Richard L
Published in Journal of the American Chemical Society (01.10.1991)
Published in Journal of the American Chemical Society (01.10.1991)
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