Small Molecules Drive Big Improvements in Immuno‐Oncology Therapies
Huck, Bayard R., Kötzner, Lisa, Urbahns, Klaus
Published in Angewandte Chemie International Edition (09.04.2018)
Published in Angewandte Chemie International Edition (09.04.2018)
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Journal Article
Discovery of Evobrutinib: An Oral, Potent, and Highly Selective, Covalent Bruton’s Tyrosine Kinase (BTK) Inhibitor for the Treatment of Immunological Diseases
Caldwell, Richard D, Qiu, Hui, Askew, Ben C, Bender, Andrew T, Brugger, Nadia, Camps, Montserrat, Dhanabal, Mohanraj, Dutt, Vikram, Eichhorn, Thomas, Gardberg, Anna S, Goutopoulos, Andreas, Grenningloh, Roland, Head, Jared, Healey, Brian, Hodous, Brian L, Huck, Bayard R, Johnson, Theresa L, Jones, Christopher, Jones, Reinaldo C, Mochalkin, Igor, Morandi, Federica, Nguyen, Ngan, Meyring, Michael, Potnick, Justin R, Santos, Dusica Cvetinovic, Schmidt, Ralf, Sherer, Brian, Shutes, Adam, Urbahns, Klaus, Follis, Ariele Viacava, Wegener, Ansgar A, Zimmerli, Simone C, Liu-Bujalski, Lesley
Published in Journal of medicinal chemistry (12.09.2019)
Published in Journal of medicinal chemistry (12.09.2019)
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Journal Article
Corrigendum to “Discovery of 4-aminopyrimidine analogs as highly potent dual P70S6K/Akt inhibitors” [Bioorgan. Med. Chem. Lett. 50 (2021) 128352]
Xiao, Yufang, Huck, Bayard R., Lan, Ruoxi, DeSelm, Lizbeth, Chen, Xiaoling, Qiu, Hui, Neagu, Constantin, Johnson, Theresa, Mochalkin, Igor, Gardberg, Anna, Jiang, Xuliang, Tian, Hui, Dutt, Vikram, Santos, Dusica, Head, Jared, Jackson, Jennifer, Syed, Sakeena, Lin, Jing, Wilker, Erik, Ma, Jianguo, Clark, Anderson, Machl, Andreas, Bankston, Donald, Jones, Christopher C.V., Goutopoulos, Andreas, Sherer, Brian
Published in Bioorganic & medicinal chemistry letters (01.07.2022)
Published in Bioorganic & medicinal chemistry letters (01.07.2022)
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Journal Article
Discovery of 4-aminopyrimidine analogs as highly potent dual P70S6K/Akt inhibitors
Xiao, Yufang, Huck, Bayard R., Lan, Ruoxi, DeSelm, Lizbeth, Chen, Xiaoling, Qiu, Hui, Neagu, Constantin, Johnson, Theresa, Mochalkin, Igor, Gardberg, Anna, Jiang, Xuliang, Tian, Hui, Dutt, Vikram, Santos, Dusica, Head, Jared, Jackson, Jennifer, Syed, Sakeena, Lin, Jing, Wilker, Erik, Ma, Jianguo, Clark, Anderson, Machl, Andreas, Bankston, Donald, Jones, Christopher C.V., Goutopoulos, Andreas, Sherer, Brian
Published in Bioorganic & medicinal chemistry letters (15.10.2021)
Published in Bioorganic & medicinal chemistry letters (15.10.2021)
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Journal Article
Protein prosthesis: β‐peptides as reverse‐turn surrogates
Arnold, Ulrich, Huck, Bayard R., Gellman, Samuel H., Raines, Ronald T.
Published in Protein science (01.03.2013)
Published in Protein science (01.03.2013)
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Journal Article
M2698 is a potent dual-inhibitor of p70S6K and Akt that affects tumor growth in mouse models of cancer and crosses the blood-brain barrier
Machl, Andreas, Wilker, Erik W, Tian, Hui, Liu, Xiaohong, Schroeder, Patricia, Clark, Anderson, Huck, Bayard R
Published in American journal of cancer research (01.01.2016)
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Published in American journal of cancer research (01.01.2016)
Journal Article
The expanding role for small molecules in immuno-oncology
Offringa, Rienk, Kötzner, Lisa, Huck, Bayard, Urbahns, Klaus
Published in Nature reviews. Drug discovery (01.11.2022)
Published in Nature reviews. Drug discovery (01.11.2022)
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Journal Article
Stereochemical Control of Hairpin Formation in β-Peptides Containing Dinipecotic Acid Reverse Turn Segments
Chung, Yong Jun, Huck, Bayard R, Christianson, Laurie A, Stanger, Heather E, Krauthäuser, Susanne, Powell, Douglas R, Gellman, Samuel H
Published in Journal of the American Chemical Society (03.05.2000)
Published in Journal of the American Chemical Society (03.05.2000)
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Journal Article
The identification and optimization of a N-hydroxy urea series of flap endonuclease 1 inhibitors
Tumey, L. Nathan, Bom, David, Huck, Bayard, Gleason, Elizabeth, Wang, Jianmin, Silver, Daniel, Brunden, Kurt, Boozer, Sherry, Rundlett, Stephen, Sherf, Bruce, Murphy, Steven, Dent, Tom, Leventhal, Christina, Bailey, Andrew, Harrington, John, Bennani, Youssef L.
Published in Bioorganic & medicinal chemistry letters (17.01.2005)
Published in Bioorganic & medicinal chemistry letters (17.01.2005)
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Journal Article
Secondary Structural Preferences of 2,2-Disubstituted Pyrrolidine-4-carboxylic Acid Oligomers: β-Peptide Foldamers that Cannot Form Internal Hydrogen Bonds
Huck, Bayard R, Fisk, John D, Guzei, Ilia A, Carlson, Heather A, Gellman, Samuel H
Published in Journal of the American Chemical Society (30.07.2003)
Published in Journal of the American Chemical Society (30.07.2003)
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Journal Article
The design and synthesis of a tricyclic single-nitrogen scaffold that serves as a 5-HT2C receptor agonist
HUCK, Bayard R, LLAMAS, Luis, BENNANI, Youssef L, ROBARGE, Michael J, DENT, Thomas C, JIANPING SONG, HODNICK, William F, CRUMRINE, Chris, STRICKER-KRONGRAD, Alain, HARRINGTON, John, BRUNDEN, Kurt R
Published in Bioorganic & medicinal chemistry letters (01.08.2006)
Published in Bioorganic & medicinal chemistry letters (01.08.2006)
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Journal Article
The identification of pyrimidine-diazabicyclo[3.3.0]octane derivatives as 5-HT2C receptor agonists
HUCK, Bayard R, LLAMAS, Luis, BENNANI, Youssef L, ROBARGE, Michael J, DENT, Thomas C, JIANPING SONG, HODNICK, William F, CRUMRINE, Chris, STRICKER-KRONGRAD, Alain, HARRINGTON, John, BRUNDEN, Kurt R
Published in Bioorganic & medicinal chemistry letters (01.06.2006)
Published in Bioorganic & medicinal chemistry letters (01.06.2006)
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Journal Article