Discovery and Characterization of a New Class of C5aR1 Antagonists Showing In Vivo Activity
Hubler, Francis, Renneberg, Dorte, Siendt, Hervé, Stamm, Simon, Hilpert, Kurt, Caroff, Eva, Delahaye, Stephane, Froidevaux, Sylvie, Murphy, Mark J.
Published in Journal of medicinal chemistry (14.03.2024)
Published in Journal of medicinal chemistry (14.03.2024)
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Journal Article
Selatogrel, a reversible P2Y12 receptor antagonist, has reduced off-target interference with haemostatic factors in a mouse thrombosis model
Crescence, Lydie, Darbousset, Roxane, Caroff, Eva, Hubler, Francis, Riederer, Markus A., Panicot-Dubois, Laurence, Dubois, Christophe
Published in Thrombosis research (01.04.2021)
Published in Thrombosis research (01.04.2021)
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4‑((R)‑2-{[6-((S)‑3-Methoxypyrrolidin-1-yl)-2-phenylpyrimidine-4-carbonyl]amino}-3-phosphonopropionyl)piperazine-1-carboxylic Acid Butyl Ester (ACT-246475) and Its Prodrug (ACT-281959), a Novel P2Y12 Receptor Antagonist with a Wider Therapeutic Window in the Rat Than Clopidogrel
Caroff, Eva, Hubler, Francis, Meyer, Emmanuel, Renneberg, Dorte, Gnerre, Carmela, Treiber, Alexander, Rey, Markus, Hess, Patrick, Steiner, Beat, Hilpert, Kurt, Riederer, Markus A
Published in Journal of medicinal chemistry (10.12.2015)
Published in Journal of medicinal chemistry (10.12.2015)
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Journal Article
Discovery of novel bridged tetrahydronaphthalene derivatives as potent T/L-type calcium channel blockers
Renneberg, Dorte, Hubler, Francis, Rey, Markus, Hess, Patrick, Delahaye, Stephane, Gatfield, John, Iglarz, Marc, Hilpert, Kurt
Published in Bioorganic & medicinal chemistry letters (15.09.2015)
Published in Bioorganic & medicinal chemistry letters (15.09.2015)
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혈관염 및 염증성 질환을 치료하기 위한 C5A 수용체 조절제로서의 2,4,6,7-테트라히드로-피라졸로[4,3-D]피리미딘-5-온 유도체 및 관련 화합물
RENNEBERG DORTE, MURPHY MARK, HUBLER FRANCIS, FROIDEVAUX SYLVIE, STAMM SIMON
Year of Publication 10.09.2020
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Year of Publication 10.09.2020
Patent
CCR6 수용체 조절인자로서의 아제티딘-3-일메탄올 유도체
HUBLER FRANCIS, MEYER EMMANUEL, RICHARD BILDSTEIN SYLVIA, CAROFF EVA, ALLEMANN OLIVER, CROXFORD ANDREW, CHAVANTON ARPEL ALEXIA, JACOB LOIC
Year of Publication 10.01.2023
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Year of Publication 10.01.2023
Patent
4-(( R )-2-{[6-(( S )-3-Methoxypyrrolidin-1-yl)-2-phenylpyrimidine-4-carbonyl]amino}-3-phosphonopropionyl)piperazine-1-carboxylic Acid Butyl Ester (ACT-246475) and Its Prodrug (ACT-281959), a Novel P2Y 12 Receptor Antagonist with a Wider Therapeutic Window in the Rat Than Clopidogrel
Caroff, Eva, Hubler, Francis, Meyer, Emmanuel, Renneberg, Dorte, Gnerre, Carmela, Treiber, Alexander, Rey, Markus, Hess, Patrick, Steiner, Beat, Hilpert, Kurt, Riederer, Markus A.
Published in Journal of medicinal chemistry (10.12.2015)
Published in Journal of medicinal chemistry (10.12.2015)
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테트라히드로피라졸로피리미디논 화합물을 포함하는 약학 조성물
RENNEBERG DORTE, MURPHY MARK, FOURNIER ELVIRE, FRAICHARD AMANDINE, HUBLER FRANCIS, FROIDEVAUX SYLVIE, GEISELER OLIVER, AMBUEHL MICHAEL, HERRMANN CHARLYSE, VON RAUMER MARKUS, STAMM SIMON
Year of Publication 18.03.2022
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Year of Publication 18.03.2022
Patent
The reversible P2Y12 antagonist ACT‐246475 causes significantly less blood loss than ticagrelor at equivalent antithrombotic efficacy in rat
Rey, Markus, Kramberg, Markus, Hess, Patrick, Morrison, Keith, Ernst, Roland, Haag, Franck, Weber, Edgar, Clozel, Martine, Baumann, Martine, Caroff, Eva, Hubler, Francis, Riederer, Markus A., Steiner, Beat
Published in Pharmacology research & perspectives (01.10.2017)
Published in Pharmacology research & perspectives (01.10.2017)
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Journal Article
INDOLE CARBOXAMIDE DERIVATIVES AS P2X7 RECEPTOR ANTAGONISTS
RENNEBERG DORTE, HUBLER FRANCIS, KIMMERLIN THIERRY, STAMM SIMON, HILPERT KURT
Year of Publication 17.08.2015
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Year of Publication 17.08.2015
Patent
HETEROCYCLIC AMIDE DERIVATIVES AS P2X7 RECEPTOR ANTAGONISTS
RENNEBERG DORTE, HUBLER FRANCIS, KIMMERLIN THIERRY, STAMM SIMON, HILPERT KURT
Year of Publication 23.09.2014
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Year of Publication 23.09.2014
Patent
The reversible P2Y 12 antagonist ACT-246475 causes significantly less blood loss than ticagrelor at equivalent antithrombotic efficacy in rat
Rey, Markus, Kramberg, Markus, Hess, Patrick, Morrison, Keith, Ernst, Roland, Haag, Franck, Weber, Edgar, Clozel, Martine, Baumann, Martine, Caroff, Eva, Hubler, Francis, Riederer, Markus A, Steiner, Beat
Published in Pharmacology research & perspectives (01.10.2017)
Published in Pharmacology research & perspectives (01.10.2017)
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