Charge-mediated influence of the antibody variable domain on FcRn-dependent pharmacokinetics
Schoch, Angela, Kettenberger, Hubert, Mundigl, Olaf, Winter, Gerhard, Engert, Julia, Heinrich, Julia, Emrich, Thomas
Published in Proceedings of the National Academy of Sciences - PNAS (12.05.2015)
Published in Proceedings of the National Academy of Sciences - PNAS (12.05.2015)
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Journal Article
DutaFabs are engineered therapeutic Fab fragments that can bind two targets simultaneously
Beckmann, Roland, Jensen, Kristian, Fenn, Sebastian, Speck, Janina, Krause, Katrin, Meier, Anastasia, Röth, Melanie, Fauser, Sascha, Kimbung, Raymond, Logan, Derek T, Steegmaier, Martin, Kettenberger, Hubert
Published in Nature communications (29.01.2021)
Published in Nature communications (29.01.2021)
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Immunoglobulin domain crossover as a generic approach for the production of bispecific IgG antibodies
Schaefer, Wolfgang, Regula, Jörg T, Bähner, Monika, Schanzer, Jürgen, Croasdale, Rebecca, Dürr, Harald, Gassner, Christian, Georges, Guy, Kettenberger, Hubert, Imhof-Jung, Sabine, Schwaiger, Manfred, Stubenrauch, Kay G, Sustmann, Claudio, Thomas, Markus, Scheuer, Werner, Klein, Christian
Published in Proceedings of the National Academy of Sciences - PNAS (05.07.2011)
Published in Proceedings of the National Academy of Sciences - PNAS (05.07.2011)
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Journal Article
Effect of variable domain charge on in vitro and in vivo disposition of monoclonal antibodies
Liu, Shufang, Verma, Ashwni, Kettenberger, Hubert, Richter, Wolfgang F, Shah, Dhaval K
Published in mAbs (01.01.2021)
Published in mAbs (01.01.2021)
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Journal Article
Structure-based prediction of asparagine and aspartate degradation sites in antibody variable regions
Sydow, Jasmin F, Lipsmeier, Florian, Larraillet, Vincent, Hilger, Maximiliane, Mautz, Bjoern, Mølhøj, Michael, Kuentzer, Jan, Klostermann, Stefan, Schoch, Juergen, Voelger, Hans R, Regula, Joerg T, Cramer, Patrick, Papadimitriou, Apollon, Kettenberger, Hubert
Published in PloS one (24.06.2014)
Published in PloS one (24.06.2014)
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Journal Article
Are Biotransformation Studies of Therapeutic Proteins Needed? Scientific Considerations and Technical Challenges
Schadt, Simone, Hauri, Simon, Lopes, Filipe, Edelmann, Martin R, Staack, Roland F, Villaseñor, Roberto, Kettenberger, Hubert, Roth, Adrian B, Schuler, Franz, Richter, Wolfgang F, Funk, Christoph
Published in Drug metabolism and disposition (01.12.2019)
Published in Drug metabolism and disposition (01.12.2019)
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Journal Article
Progress in overcoming the chain association issue in bispecific heterodimeric IgG antibodies
Klein, Christian, Sustmann, Claudio, Thomas, Markus, Stubenrauch, Kay, Croasdale, Rebecca, Schanzer, Jürgen, Brinkmann, Ulrich, Kettenberger, Hubert, Regula, Jörg T., Schaefer, Wolfgang
Published in mAbs (01.11.2012)
Published in mAbs (01.11.2012)
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Journal Article
Assessing developability early in the discovery process for novel biologics
Fernández-Quintero, Monica L., Ljungars, Anne, Waibl, Franz, Greiff, Victor, Andersen, Jan Terje, Gjølberg, Torleif T., Jenkins, Timothy P., Voldborg, Bjørn Gunnar, Grav, Lise Marie, Kumar, Sandeep, Georges, Guy, Kettenberger, Hubert, Liedl, Klaus R., Tessier, Peter M., McCafferty, John, Laustsen, Andreas H.
Published in mAbs (2023)
Published in mAbs (2023)
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Journal Article
Internalization of therapeutic antibodies into dendritic cells as a risk factor for immunogenicity
Siegel, Michel, Bolender, Anna-Lena, Ducret, Axel, Fraidling, Johannes, Hartman, Katharina, Looney, Cary M, Rohr, Olivier, Hickling, Timothy P, Kettenberger, Hubert, Lechmann, Martin, Marban-Doran, Céline, Kraft, Thomas E
Published in Frontiers in immunology (28.08.2024)
Published in Frontiers in immunology (28.08.2024)
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Journal Article
Diphthamide affects selenoprotein expression: Diphthamide deficiency reduces selenocysteine incorporation, decreases selenite sensitivity and pre-disposes to oxidative stress
Mayer, Klaus, Mundigl, Olaf, Kettenberger, Hubert, Birzele, Fabian, Stahl, Sebastian, Pastan, Ira, Brinkmann, Ulrich
Published in Redox biology (01.01.2019)
Published in Redox biology (01.01.2019)
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Journal Article
Germline-Dependent Antibody Paratope States and Pairing Specific VH-VL Interface Dynamics
Fernández-Quintero, Monica L., Kroell, Katharina B., Bacher, Lisa M., Loeffler, Johannes R., Quoika, Patrick K., Georges, Guy, Bujotzek, Alexander, Kettenberger, Hubert, Liedl, Klaus R.
Published in Frontiers in immunology (10.08.2021)
Published in Frontiers in immunology (10.08.2021)
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Journal Article
Architecture of Initiation-Competent 12-Subunit RNA Polymerase II
Armache, Karim-Jean, Kettenberger, Hubert, Cramer, Patrick
Published in Proceedings of the National Academy of Sciences - PNAS (10.06.2003)
Published in Proceedings of the National Academy of Sciences - PNAS (10.06.2003)
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Journal Article
Impact of charge patches on tumor disposition and biodistribution of therapeutic antibodies
Stüber, Jakob C., Rechberger, Karin F., Miladinović, Saša M., Pöschinger, Thomas, Zimmermann, Tamara, Villenave, Remi, Eigenmann, Miro J., Kraft, Thomas E., Shah, Dhaval K., Kettenberger, Hubert, Richter, Wolfgang F.
Published in AAPS open (15.02.2022)
Published in AAPS open (15.02.2022)
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Journal Article
TriFabs--Trivalent IgG-Shaped Bispecific Antibody Derivatives: Design, Generation, Characterization and Application for Targeted Payload Delivery
Mayer, Klaus, Baumann, Anna-Lena, Grote, Michael, Seeber, Stefan, Kettenberger, Hubert, Breuer, Sebastian, Killian, Tobias, Schäfer, Wolfgang, Brinkmann, Ulrich
Published in International journal of molecular sciences (17.11.2015)
Published in International journal of molecular sciences (17.11.2015)
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Journal Article
Crystal structure of an anti-Ang2 CrossFab demonstrates complete structural and functional integrity of the variable domain
Fenn, Sebastian, Schiller, Christian B, Griese, Julia J, Duerr, Harald, Imhof-Jung, Sabine, Gassner, Christian, Moelleken, Joerg, Regula, Joerg Thomas, Schaefer, Wolfgang, Thomas, Markus, Klein, Christian, Hopfner, Karl-Peter, Kettenberger, Hubert
Published in PloS one (17.04.2013)
Published in PloS one (17.04.2013)
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Journal Article
Impact of Molecular Processing in the Hinge Region of Therapeutic IgG4 Antibodies on Disposition Profiles in Cynomolgus Monkeys
STUBENRAUCH, Kay, WESSELS, Uwe, REGULA, Joerg Thomas, KETTENBERGER, Hubert, SCHLEYPEN, Julia, KOHNERT, Ulrich
Published in Drug metabolism and disposition (01.01.2010)
Published in Drug metabolism and disposition (01.01.2010)
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Journal Article
Comparing Antibody Interfaces to Inform Rational Design of New Antibody Formats
Fernández-Quintero, Monica L, Quoika, Patrick K, Wedl, Florian S, Seidler, Clarissa A, Kroell, Katharina B, Loeffler, Johannes R, Pomarici, Nancy D, Hoerschinger, Valentin J, Bujotzek, Alexander, Georges, Guy, Kettenberger, Hubert, Liedl, Klaus R
Published in Frontiers in molecular biosciences (26.01.2022)
Published in Frontiers in molecular biosciences (26.01.2022)
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