Breast tumor cells with PI3K mutation or HER2 amplification are selectively addicted to Akt signaling
She, Qing-Bai, Chandarlapaty, Sarat, Ye, Qing, Lobo, Jose, Haskell, Kathleen M, Leander, Karen R, DeFeo-Jones, Deborah, Huber, Hans E, Rosen, Neal
Published in PloS one (26.08.2008)
Published in PloS one (26.08.2008)
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Identification and characterization of pleckstrin-homology-domain-dependent and isoenzyme-specific Akt inhibitors
Barnett, Stanley F, Defeo-Jones, Deborah, Fu, Sheng, Hancock, Paula J, Haskell, Kathleen M, Jones, Raymond E, Kahana, Jason A, Kral, Astrid M, Leander, Karen, Lee, Ling L, Malinowski, John, McAvoy, Elizabeth M, Nahas, Debbie D, Robinson, Ronald G, Huber, Hans E
Published in Biochemical journal (15.01.2005)
Published in Biochemical journal (15.01.2005)
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Allosteric Akt (PKB) inhibitors: discovery and SAR of isozyme selective inhibitors
Lindsley, Craig W., Zhao, Zhijian, Leister, William H., Robinson, Ronald G., Barnett, Stanley F., Defeo-Jones, Deborah, Jones, Raymond E., Hartman, George D., Huff, Joel R., Huber, Hans E., Duggan, Mark E.
Published in Bioorganic & medicinal chemistry letters (01.02.2005)
Published in Bioorganic & medicinal chemistry letters (01.02.2005)
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Inhibition of a Mitotic Motor Protein: Where, How, and Conformational Consequences
Yan, Youwei, Sardana, Vinod, Xu, Bei, Homnick, Carl, Halczenko, Wasyl, Buser, Carolyn A., Schaber, Michael, Hartman, George D., Huber, Hans E., Kuo, Lawrence C.
Published in Journal of molecular biology (09.01.2004)
Published in Journal of molecular biology (09.01.2004)
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Glycoengineered Pichia produced anti-HER2 is comparable to trastuzumab in preclinical study
Zhang, Ningyan, Liu, Liming, Dan Dumitru, Calin, Cummings, Nga Rewa Houston, Cukan, Michael, Jiang, Youwei, Li, Yuan, Li, Fang, Mitchell, Teresa, Mallem, Muralidhar R., Ou, Yangsi, Patel, Rohan N., Vo, Kim, Wang, Hui, Burnina, Irina, Choi, Byung-Kwon, Huber, Hans E., Stadheim, Terrance A., Zha, Dongxing
Published in mAbs (01.05.2011)
Published in mAbs (01.05.2011)
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Tumor cell sensitization to apoptotic stimuli by selective inhibition of specific Akt/PKB family members
DeFeo-Jones, Deborah, Barnett, Stanley F, Fu, Sheng, Hancock, Paula J, Haskell, Kathleen M, Leander, Karen R, McAvoy, Elizabeth, Robinson, Ronald G, Duggan, Mark E, Lindsley, Craig W, Zhao, Zhijian, Huber, Hans E, Jones, Raymond E
Published in Molecular cancer therapeutics (01.02.2005)
Published in Molecular cancer therapeutics (01.02.2005)
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An allosteric Akt inhibitor effectively blocks Akt signaling and tumor growth with only transient effects on glucose and insulin levels in vivo
Cherrin, Craig, Haskell, Kathleen, Howell, Bonnie, Jones, Raymond, Leander, Karen, Robinson, Ronald, Watkins, Aubrey, Bilodeau, Mark, Hoffman, Jacob, Sanderson, Philip, Hartman, George, Mahan, Elizabeth, Prueksaritanont, Thomayant, Jiang, Guoqiang, She, Qing-Bai, Rosen, Neal, Sepp-Lorenzino, Laura, Defeo-Jones, Deborah, Huber, Hans E.
Published in Cancer biology & therapy (01.04.2010)
Published in Cancer biology & therapy (01.04.2010)
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Journal Article
Discovery of 2,3,5-trisubstituted pyridine derivatives as potent Akt1 and Akt2 dual inhibitors
Zhao, Zhijian, Leister, William H., Robinson, Ronald G., Barnett, Stanley F., Defeo-Jones, Deborah, Jones, Raymond E., Hartman, George D., Huff, Joel R., Huber, Hans E., Duggan, Mark E., Lindsley, Craig W.
Published in Bioorganic & medicinal chemistry letters (15.02.2005)
Published in Bioorganic & medicinal chemistry letters (15.02.2005)
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Journal Article
Kinesin spindle protein (KSP) inhibitors. Part 1: The discovery of 3,5-diaryl-4,5-dihydropyrazoles as potent and selective inhibitors of the mitotic kinesin KSP
Cox, Christopher D., Breslin, Michael J., Mariano, Brenda J., Coleman, Paul J., Buser, Carolyn A., Walsh, Eileen S., Hamilton, Kelly, Huber, Hans E., Kohl, Nancy E., Torrent, Maricel, Yan, Youwei, Kuo, Laurence C., Hartman, George D.
Published in Bioorganic & medicinal chemistry letters (15.04.2005)
Published in Bioorganic & medicinal chemistry letters (15.04.2005)
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Liver-targeted polymeric prodrugs of 8-aminoquinolines for malaria radical cure
Srinivasan, Selvi, Roy, Debashish, Chavas, Thomas E.J., Vlaskin, Vladimir, Ho, Duy-Khiet, Pottenger, Ayumi, LeGuyader, Clare L.M., Maktabi, Mahdi, Strauch, Pamela, Jackson, Conner, Flaherty, Siobhan M., Lin, Hsiuling, Zhang, Jing, Pybus, Brandon, Li, Qigui, Huber, Hans E., Burke, Paul A., Wesche, David, Rochford, Rosemary, Stayton, Patrick S.
Published in Journal of controlled release (10.03.2021)
Published in Journal of controlled release (10.03.2021)
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Characterization of Notch1 antibodies that inhibit signaling of both normal and mutated Notch1 receptors
Aste-Amézaga, Miguel, Zhang, Ningyan, Lineberger, Janet E, Arnold, Beth A, Toner, Timothy J, Gu, Mingcheng, Huang, Lingyi, Vitelli, Salvatore, Vo, Kim T, Haytko, Peter, Zhao, Jing Zhang, Baleydier, Frederic, L'Heureux, Sarah, Wang, Hongfang, Gordon, Wendy R, Thoryk, Elizabeth, Andrawes, Marie Blanke, Tiyanont, Kittichoat, Stegmaier, Kimberly, Roti, Giovanni, Ross, Kenneth N, Franlin, Laura L, Wang, Hui, Wang, Fubao, Chastain, Michael, Bett, Andrew J, Audoly, Laurent P, Aster, Jon C, Blacklow, Stephen C, Huber, Hans E
Published in PloS one (08.02.2010)
Published in PloS one (08.02.2010)
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MTL-CEBPA, a Small Activating RNA Therapeutic Upregulating C/EBP-α, in Patients with Advanced Liver Cancer: A First-in-Human, Multicenter, Open-Label, Phase I Trial
Sarker, Debashis, Plummer, Ruth, Meyer, Tim, Sodergren, Mikael H, Basu, Bristi, Chee, Cheng Ean, Huang, Kai-Wen, Palmer, Daniel H, Ma, Yuk Ting, Evans, T R Jeff, Spalding, Duncan R C, Pai, Madhava, Sharma, Rohini, Pinato, David J, Spicer, James, Hunter, Sarah, Kwatra, Vineet, Nicholls, Joanna P, Collin, David, Nutbrown, Robert, Glenny, Helen, Fairbairn, Sonia, Reebye, Vikash, Voutila, Jon, Dorman, Stephanie, Andrikakou, Pinelopi, Lloyd, Peter, Felstead, Steve, Vasara, Jenni, Habib, Robert, Wood, Chris, Saetrom, Pal, Huber, Hans E, Blakey, David C, Rossi, John J, Habib, Nagy
Published in Clinical cancer research (01.08.2020)
Published in Clinical cancer research (01.08.2020)
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Liver-targeted polymeric prodrugs delivered subcutaneously improve tafenoquine therapeutic window for malaria radical cure
Pottenger, Ayumi E, Roy, Debashish, Srinivasan, Selvi, Chavas, Thomas E J, Vlaskin, Vladmir, Ho, Duy-Khiet, Livingston, Vincent C, Maktabi, Mahdi, Lin, Hsiuling, Zhang, Jing, Pybus, Brandon, Kudyba, Karl, Roth, Alison, Senter, Peter, Tyson, George, Huber, Hans E, Wesche, David, Rochford, Rosemary, Burke, Paul A, Stayton, Patrick S
Published in Science advances (19.04.2024)
Published in Science advances (19.04.2024)
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Kinesin Spindle Protein (KSP) Inhibitors. 9. Discovery of (2S)-4-(2,5-Difluorophenyl)-N-[(3R,4S)-3-fluoro-1-methylpiperidin-4-yl]-2-(hydroxymethyl)-N-methyl-2-phenyl-2,5-dihydro-1H-pyrrole-1-carboxamide (MK-0731) for the Treatment of Taxane-Refractory Cancer
Cox, Christopher D, Coleman, Paul J, Breslin, Michael J, Whitman, David B, Garbaccio, Robert M, Fraley, Mark E, Buser, Carolyn A, Walsh, Eileen S, Hamilton, Kelly, Schaber, Michael D, Lobell, Robert B, Tao, Weikang, Davide, Joseph P, Diehl, Ronald E, Abrams, Marc T, South, Vicki J, Huber, Hans E, Torrent, Maricel, Prueksaritanont, Thomayant, Li, Chunze, Slaughter, Donald E, Mahan, Elizabeth, Fernandez-Metzler, Carmen, Yan, Youwei, Kuo, Lawrence C, Kohl, Nancy E, Hartman, George D
Published in Journal of medicinal chemistry (24.07.2008)
Published in Journal of medicinal chemistry (24.07.2008)
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Allosteric inhibitors of Akt1 and Akt2: A naphthyridinone with efficacy in an A2780 tumor xenograft model
Bilodeau, Mark T., Balitza, Adrienne E., Hoffman, Jacob M., Manley, Peter J., Barnett, Stanley F., Defeo-Jones, Deborah, Haskell, Kathleen, Jones, Raymond E., Leander, Karen, Robinson, Ronald G., Smith, Anthony M., Huber, Hans E., Hartman, George D.
Published in Bioorganic & medicinal chemistry (01.06.2008)
Published in Bioorganic & medicinal chemistry (01.06.2008)
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Journal Article
Allosteric inhibitors of Akt1 and Akt2: Discovery of [1,2,4]triazolo[3,4-f][1,6]naphthyridines with potent and balanced activity
Li, Yiwei, Liang, Jun, Siu, Tony, Hu, Essa, Rossi, Michael A., Barnett, Stanley F., Defeo-Jones, Deborah, Jones, Raymond E., Robinson, Ronald G., Leander, Karen, Huber, Hans E., Mittal, Sachin, Cosford, Nicholas, Prasit, Peppi
Published in Bioorganic & medicinal chemistry letters (01.02.2009)
Published in Bioorganic & medicinal chemistry letters (01.02.2009)
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Journal Article
Development of potent, allosteric dual Akt1 and Akt2 inhibitors with improved physical properties and cell activity
Zhao, Zhijian, Robinson, Ronald G., Barnett, Stanley F., Defeo-Jones, Deborah, Jones, Raymond E., Hartman, George D., Huber, Hans E., Duggan, Mark E., Lindsley, Craig W.
Published in Bioorganic & medicinal chemistry (2008)
Published in Bioorganic & medicinal chemistry (2008)
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Journal Article
Rapid assembly of diverse and potent allosteric Akt inhibitors
Wu, Zhicai, Robinson, Ronald G., Fu, Sheng, Barnett, Stanley F., Defeo-Jones, Deborah, Jones, Raymond E., Kral, Astrid M., Huber, Hans E., Kohl, Nancy E., Hartman, George D., Bilodeau, Mark T.
Published in Bioorganic & medicinal chemistry (15.03.2008)
Published in Bioorganic & medicinal chemistry (15.03.2008)
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Journal Article
Kinesin spindle protein (KSP) inhibitors. Part V: Discovery of 2-propylamino-2,4-diaryl-2,5-dihydropyrroles as potent, water-soluble KSP inhibitors, and modulation of their basicity by β-fluorination to overcome cellular efflux by P-glycoprotein
Cox, Christopher D., Breslin, Michael J., Whitman, David B., Coleman, Paul J., Garbaccio, Robert M., Fraley, Mark E., Zrada, Matthew M., Buser, Carolyn A., Walsh, Eileen S., Hamilton, Kelly, Lobell, Robert B., Tao, Weikang, Abrams, Marc T., South, Vicki J., Huber, Hans E., Kohl, Nancy E., Hartman, George D.
Published in Bioorganic & medicinal chemistry letters (15.05.2007)
Published in Bioorganic & medicinal chemistry letters (15.05.2007)
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Journal Article
Optimization of 2,3,5-trisubstituted pyridine derivatives as potent allosteric Akt1 and Akt2 inhibitors
Hartnett, John C., Barnett, Stanley F., Bilodeau, Mark T., Defeo-Jones, Deborah, Hartman, George D., Huber, Hans E., Jones, Raymond E., Kral, Astrid M., Robinson, Ronald G., Wu, Zhicai
Published in Bioorganic & medicinal chemistry (15.03.2008)
Published in Bioorganic & medicinal chemistry (15.03.2008)
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