Molecular engineering of safe and efficacious oral basal insulin
Hubálek, Frantisek, Refsgaard, Hanne H. F., Gram-Nielsen, Sanne, Madsen, Peter, Nishimura, Erica, Münzel, Martin, Brand, Christian Lehn, Stidsen, Carsten Enggaard, Claussen, Christian Hove, Wulff, Erik Max, Pridal, Lone, Ribel, Ulla, Kildegaard, Jonas, Porsgaard, Trine, Johansson, Eva, Steensgaard, Dorte Bjerre, Hovgaard, Lars, Glendorf, Tine, Hansen, Bo Falck, Jensen, Maja Kirkegaard, Nielsen, Peter Kresten, Ludvigsen, Svend, Rugh, Susanne, Garibay, Patrick W., Moore, Mary Courtney, Cherrington, Alan D., Kjeldsen, Thomas
Published in Nature communications (27.07.2020)
Published in Nature communications (27.07.2020)
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Journal Article
Insights into the Mode of Inhibition of Human Mitochondrial Monoamine Oxidase B from High-Resolution Crystal Structures
Binda, Claudia, Li, Min, Hubálek, Frantisek, Restelli, Nadia, Edmondson, Dale E., Mattevi, Andrea
Published in Proceedings of the National Academy of Sciences - PNAS (19.08.2003)
Published in Proceedings of the National Academy of Sciences - PNAS (19.08.2003)
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Journal Article
Demonstration of Isoleucine 199 as a Structural Determinant for the Selective Inhibition of Human Monoamine Oxidase B by Specific Reversible Inhibitors
Hubálek, Frantisek, Binda, Claudia, Khalil, Ashraf, Li, Min, Mattevi, Andrea, Castagnoli, Neal, Edmondson, Dale E.
Published in The Journal of biological chemistry (22.04.2005)
Published in The Journal of biological chemistry (22.04.2005)
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Journal Article
Author Correction: Molecular engineering of safe and efficacious oral basal insulin
Hubálek, Frantisek, Refsgaard, Hanne H. F., Gram-Nielsen, Sanne, Madsen, Peter, Nishimura, Erica, Münzel, Martin, Brand, Christian Lehn, Stidsen, Carsten Enggaard, Claussen, Christian Hove, Wulff, Erik Max, Pridal, Lone, Ribel, Ulla, Kildegaard, Jonas, Porsgaard, Trine, Johansson, Eva, Steensgaard, Dorte Bjerre, Hovgaard, Lars, Glendorf, Tine, Hansen, Bo Falck, Jensen, Maja Kirkegaard, Nielsen, Peter Kresten, Ludvigsen, Svend, Rugh, Susanne, Garibay, Patrick W., Moore, Mary Courtney, Cherrington, Alan D., Kjeldsen, Thomas
Published in Nature communications (20.08.2020)
Published in Nature communications (20.08.2020)
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Journal Article
An ingestible self-orienting system for oral delivery of macromolecules
Abramson, Alex, Caffarel-Salvador, Ester, Khang, Minsoo, Dellal, David, Silverstein, David, Gao, Yuan, Frederiksen, Morten Revsgaard, Vegge, Andreas, Hubálek, František, Water, Jorrit J, Friderichsen, Anders V, Fels, Johannes, Kirk, Rikke Kaae, Cleveland, Cody, Collins, Joy, Tamang, Siddartha, Hayward, Alison, Landh, Tomas, Buckley, Stephen T, Roxhed, Niclas, Rahbek, Ulrik, Langer, Robert, Traverso, Giovanni
Published in Science (American Association for the Advancement of Science) (08.02.2019)
Published in Science (American Association for the Advancement of Science) (08.02.2019)
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Journal Article
Expression, Receptor Binding, and Biophysical Characterization of Guinea Pig Insulin desB30: A Monomeric Insulin Variant
Engholm, Ebbe, Hansen, Thomas H., Johansson, Eva, Strauss, Holger M., Vinther, Tine N., Jensen, Knud J., Hubálek, Frantisek, Kjeldsen, Thomas B.
Published in Chembiochem : a European journal of chemical biology (13.04.2015)
Published in Chembiochem : a European journal of chemical biology (13.04.2015)
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Journal Article
Molecular Engineering of Insulin Icodec, the First Acylated Insulin Analog for Once-Weekly Administration in Humans
Kjeldsen, Thomas B, Hubálek, František, Hjørringgaard, Claudia U, Tagmose, Tina M, Nishimura, Erica, Stidsen, Carsten E, Porsgaard, Trine, Fledelius, Christian, Refsgaard, Hanne H. F, Gram-Nielsen, Sanne, Naver, Helle, Pridal, Lone, Hoeg-Jensen, Thomas, Jeppesen, Claus Bekker, Manfè, Valentina, Ludvigsen, Svend, Lautrup-Larsen, Inger, Madsen, Peter
Published in Journal of medicinal chemistry (08.07.2021)
Published in Journal of medicinal chemistry (08.07.2021)
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Journal Article
Oral delivery of systemic monoclonal antibodies, peptides and small molecules using gastric auto-injectors
Abramson, Alex, Frederiksen, Morten Revsgaard, Vegge, Andreas, Jensen, Brian, Poulsen, Mette, Mouridsen, Brian, Jespersen, Mikkel Oliver, Kirk, Rikke Kaae, Windum, Jesper, Hubálek, František, Water, Jorrit J., Fels, Johannes, Gunnarsson, Stefán B., Bohr, Adam, Straarup, Ellen Marie, Ley, Mikkel Wennemoes Hvitfeld, Lu, Xiaoya, Wainer, Jacob, Collins, Joy, Tamang, Siddartha, Ishida, Keiko, Hayward, Alison, Herskind, Peter, Buckley, Stephen T., Roxhed, Niclas, Langer, Robert, Rahbek, Ulrik, Traverso, Giovanni
Published in Nature biotechnology (01.01.2022)
Published in Nature biotechnology (01.01.2022)
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Journal Article
Investigation of the Physico-Chemical Properties that Enable Co-Formulation of Basal Insulin Degludec with Fast-Acting Insulin Aspart
Havelund, Svend, Ribel, Ulla, Hubálek, František, Hoeg-Jensen, Thomas, Wahlund, Per-Olof, Jonassen, Ib
Published in Pharmaceutical research (01.07.2015)
Published in Pharmaceutical research (01.07.2015)
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Journal Article
Purification and Identification of High Molecular Weight Products Formed During Storage of Neutral Formulation of Human Insulin
Hjorth, Christian Fogt, Hubálek, František, Andersson, Jonatan, Poulsen, Christian, Otzen, Daniel, Naver, Helle
Published in Pharmaceutical research (01.06.2015)
Published in Pharmaceutical research (01.06.2015)
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Journal Article
Molecular and pharmacological characterization of insulin icodec: a new basal insulin analog designed for once-weekly dosing
Nishimura, Erica, Pridal, Lone, Glendorf, Tine, Hansen, Bo Falk, Hubálek, František, Kjeldsen, Thomas, Kristensen, Niels Rode, Lützen, Anne, Lyby, Karsten, Madsen, Peter, Pedersen, Thomas Åskov, Ribel-Madsen, Rasmus, Stidsen, Carsten Enggaard, Haahr, Hanne
Published in BMJ open diabetes research & care (19.08.2021)
Published in BMJ open diabetes research & care (19.08.2021)
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Journal Article
Enhanced disulphide bond stability contributes to the once-weekly profile of insulin icodec
Hubálek, František, Cramer, Christian N., Helleberg, Hans, Johansson, Eva, Nishimura, Erica, Schluckebier, Gerd, Steensgaard, Dorte Bjerre, Sturis, Jeppe, Kjeldsen, Thomas B.
Published in Nature communications (20.07.2024)
Published in Nature communications (20.07.2024)
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Journal Article
Insulin analog with additional disulfide bond has increased stability and preserved activity
Vinther, Tine N., Norrman, Mathias, Ribel, Ulla, Huus, Kasper, Schlein, Morten, Steensgaard, Dorte B., Pedersen, Thomas Å., Pettersson, Ingrid, Ludvigsen, Svend, Kjeldsen, Thomas, Jensen, Knud J., Hubálek, František
Published in Protein science (01.03.2013)
Published in Protein science (01.03.2013)
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Journal Article
Engineering of Orally Available, Ultralong-Acting Insulin Analogues: Discovery of OI338 and OI320
Kjeldsen, Thomas B., Hubalek, Frantisek, Tagmose, Tina M., Pridal, Lone, Refsgaard, Hanne H. F., Porsgaard, Trine, Gram-Nielsen, Sanne, Hovgaard, Lars, Valore, Henrik, Munzel, Martin, Hjorringgaard, Claudia U., Jeppesen, Claus Bekker, Manfe, Valentina, Hoeg-Jensen, Thomas, Ludvigsen, Svend, Nielsen, Peter Kresten, Lautrup-Larsen, Inger, Stidsen, Carsten E., Wulff, Erik M., Garibay, Patrick W., Kodra, Janos T., Nishimura, Erica, Madsen, Peter
Published in Journal of medicinal chemistry (14.01.2021)
Published in Journal of medicinal chemistry (14.01.2021)
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Journal Article
The role of citric acid in oral peptide and protein formulations: Relationship between calcium chelation and proteolysis inhibition
Welling, Søren H., Hubálek, František, Jacobsen, Jette, Brayden, David J., Rahbek, Ulrik L., Buckley, Stephen T.
Published in European journal of pharmaceutics and biopharmaceutics (01.04.2014)
Published in European journal of pharmaceutics and biopharmaceutics (01.04.2014)
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Journal Article
A microneedle platform for buccal macromolecule delivery
Caffarel-Salvador, Ester, Kim, Soyoung, Soares, Vance, Tian, Ryan Yu, Stern, Sarah R, Minahan, Daniel, Yona, Raissa, Lu, Xiaoya, Zakaria, Fauziah R, Collins, Joy, Wainer, Jacob, Wong, Jessica, McManus, Rebecca, Tamang, Siddartha, McDonnell, Shane, Ishida, Keiko, Hayward, Alison, Liu, Xiewen, Hubálek, František, Fels, Johannes, Vegge, Andreas, Frederiksen, Morten Revsgaard, Rahbek, Ulrik, Yoshitake, Tadayuki, Fujimoto, James, Roxhed, Niclas, Langer, Robert, Traverso, Giovanni
Published in Science advances (01.01.2021)
Published in Science advances (01.01.2021)
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Journal Article
Structure, Aggregation, and Activity of a Covalent Insulin Dimer Formed During Storage of Neutral Formulation of Human Insulin
Hjorth, Christian Fogt, Norrman, Mathias, Wahlund, Per-Olof, Benie, Andrew J., Petersen, Bent O., Jessen, Christian M., Pedersen, Thomas Å., Vestergaard, Kirsten, Steensgaard, Dorte B., Pedersen, Jan Skov, Naver, Helle, Hubálek, František, Poulsen, Christian, Otzen, Daniel
Published in Journal of pharmaceutical sciences (01.04.2016)
Published in Journal of pharmaceutical sciences (01.04.2016)
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