Design, Synthesis, and Evaluation of Dihydropyranopyrazole Derivatives as Novel PDE2 Inhibitors for the Treatment of Alzheimer’s Disease
Zhou, Yan, Li, Jinjian, Yuan, Han, Su, Rui, Huang, Yue, Huang, Yiyou, Li, Zhe, Wu, Yinuo, Luo, Haibin, Zhang, Chen, Huang, Ling
Published in Molecules (Basel, Switzerland) (19.05.2021)
Published in Molecules (Basel, Switzerland) (19.05.2021)
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Absolute Binding Free Energy Calculation and Design of a Subnanomolar Inhibitor of Phosphodiesterase-10
Li, Zhe, Huang, Yiyou, Wu, Yinuo, Chen, Jingyi, Wu, Deyan, Zhan, Chang-Guo, Luo, Hai-Bin
Published in Journal of medicinal chemistry (28.02.2019)
Published in Journal of medicinal chemistry (28.02.2019)
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Journal Article
The discovery, complex crystal structure, and recognition mechanism of a novel natural PDE4 inhibitor from Selaginella pulvinata
Huang, Yiyou, Liu, Xin, Wu, Deyan, Tang, Guihua, Lai, Zengwei, Zheng, Xuehua, Yin, Sheng, Luo, Hai-Bin
Published in Biochemical pharmacology (15.04.2017)
Published in Biochemical pharmacology (15.04.2017)
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Journal Article
Discovery of Novel Phosphodiesterase-2A Inhibitors by Structure-Based Virtual Screening, Structural Optimization, and Bioassay
Zhang, Chen, Feng, Ling-Jun, Huang, Yiyou, Wu, Deyan, Li, Zhe, Zhou, Qian, Wu, Yinuo, Luo, Hai-Bin
Published in Journal of chemical information and modeling (27.02.2017)
Published in Journal of chemical information and modeling (27.02.2017)
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Journal Article
Asymmetric Total Synthesis and Biological Evaluation of the Natural PDE4 Inhibitor Toddacoumalone
Hou, Ke-Qiang, Chen, Xue-Ping, Huang, Yiyou, Chan, Albert S. C, Luo, Hai-Bin, Xiong, Xiao-Feng
Published in Organic letters (17.01.2020)
Published in Organic letters (17.01.2020)
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Journal Article
Discovery of novel purine nucleoside derivatives as phosphodiesterase 2 (PDE2) inhibitors: Structure-based virtual screening, optimization and biological evaluation
Qiu, Xiaoxia, Huang, Yiyou, Wu, Deyan, Mao, Fei, Zhu, Jin, Yan, Wenzhong, Luo, Hai-Bin, Li, Jian
Published in Bioorganic & medicinal chemistry (01.01.2018)
Published in Bioorganic & medicinal chemistry (01.01.2018)
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Journal Article
Crystal Structures of Candida albicans Phosphodiesterase 2 and Implications for Its Biological Functions
Yao, Ting, Huang, Yiyou, Zhang, Meng, Chen, Yujuan, Pei, Hairun, Shi, Jianyou, Wang, Huanchen, Wang, Yousheng, Ke, Hengming
Published in Biochemistry (Easton) (23.10.2018)
Published in Biochemistry (Easton) (23.10.2018)
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Journal Article
Crystal structures of Candida albicans phosphodiesterase-2 and implication on its biological functions
Yao, Ting, Huang, Yiyou, Zhang, Meng, Chen, Yujuan, Pei, Hairun, Shi, Jianyou, Wang, Huanchen, Wang, Yousheng, Ke, Hengming
Published in Biochemistry (Easton) (04.10.2018)
Published in Biochemistry (Easton) (04.10.2018)
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Chemical constituents of Aloe barbadensis Miller and their inhibitory effects on phosphodiesterase-4D
Zhong, Jiasheng, Huang, Yiyou, Ding, Wenjing, Wu, Xiaofang, Wan, Jinzhi, Luo, Haibin
Published in Fitoterapia (01.12.2013)
Published in Fitoterapia (01.12.2013)
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